Genetics articles

Time frame: 1 May 2025 - 30 April 2026

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Count: 1237

Article ‘Count’ for Genetics.

Journal Count
1
Silicon Carbide Nanowires Impair Mucociliary Clearance-Mediated Innate Immunity in Primary Human Bronchial Epithelial Cells
2
Dynamic Bionic Organelle-Migrating Fluorescence Probe for Mitochondrial and Nuclear Parallel G4 DNA Imaging and Enhanced Cancer Therapy
Quantitative Label‐Free Surface‐Enhanced Raman Spectroscopic Transcriptome‐Wide Profiling of RNA Adenosine Methylation
1
Paternal healthy lifestyle and preterm birth among married Chinese couples planning to conceive: a population-based cohort study
13
Genome-wide detection of human 5′ UTR variants that impact protein translation
Palindrome-mediated 16p13.3 triplications cause a recognizable neurodegenerative disorder with ataxia
Genetic variants in ESRRG are associated with a dominant non-progressive congenital movement disorder with ataxia
Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila
Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans
Distinguishing syndromic and nonsyndromic cleft palate through analysis of protein-altering de novo variants in 818 trios
Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders
Bi-allelic deleterious variants in SNAPIN, which encodes a retrograde dynein adaptor, cause a prenatal-onset neurodevelopmental disorder
Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy
Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models
Bi-allelic variants in TM2D3 cause a severe syndromic neurodevelopmental disorder associated with endoplasmic reticulum and mitochondrial abnormalities
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children
Variants in BSN, encoding the presynaptic protein Bassoon, result in a distinct neurodevelopmental disorder with a broad phenotypic range
1
Folliculin deletion in the mouse kidney results in cystogenesis of the loops of Henle via aberrant TFEB activation
24
Isomerization Transmission to G-Quadruplex (IT2G4) for Discriminating Natural Isoquinoline Alkaloid Isomers
Characterizations of G-Quadruplex RNA-Protein Interactions in Living Cells
Chemical-Assisted Ligation-qPCR for Locus-Specific Detection of RNA N4-Acetylcytidine and 5-Formylcytidine
MBD-Functionalized Magnetic Nanoparticles for Direct Enrichment of Plasma Methylated DNA in High-Sensitivity Liquid Biopsy
Fluorogenic Ligand Enables Identification of NSD3-Overexpressed Tumors by Targeting the PWWP1 Domain of NSD3
Quantitative and Visual Detection of Pseudouridine at Specific Sites Using Bisulfite-Assisted Rolling Circle Amplification
Logic-Gated Iontronic Sensor with Cascaded Signal Amplification for Simultaneous Detection of m5C-DNA and m6A-RNA
Single-Cell Multimodal Profiling of m6A mRNA Modification under Oxidative Stress
Target-Combined Enhanced Coordination and Steric Hindrance Enable One-Pot Visual Rapid Quantification of Histone
Development of a Label-Free Fluorescence Strategy for Sensitive and Site-Specific Measurement of RNA Inosine Modification in Breast Tissues
Scaling Peptide-Barcode Approach for Parallel Evaluation of Protein Expression from Multiple mRNA Variants
Spatial Mapping and Interactome Profiling of m6A-Modified R-Loops via Chemically Inducible Split-APEX2 Proximity Labeling
Construction of a Bifunctional Single-Quantum Dot Nanosensor for Enzyme-Free Detection of N6-Methyladenosine Demethylase in Breast Cancer
MnO2@Mn3O4 Heterojunction as a Coreactant Catalyst Collaborated with T-Shaped DNA Cycling–CRISPR/Cas12a Cascade Amplification for Locus-Specific N6-Methyladenosine RNA Modification Detection
Ultrasensitive Detection of m6 A-Modified RNA Using CRISPR/Cas12a-Integrated Iontronic Biosensor with Hydrophobized Nanochannels: Toward Early Cancer Diagnosis by Machine Learning
Controllable Assembly of a DNAzyme Feedback Nanowire for Single-Molecule Detection of Fat Mass and Obesity-Associated Protein in Clinical Breast Cancer Samples
Loop Site Mutation-Enhanced Sensing Performance of G-Triplex Probe: Preliminary Exploration on Its Stability and “Structure-Efficiency” Relationship
Setup and Evaluation of the TRACT Assay Principle for the iIn Vitro/i Functional Characterization of Modulators of the Serotonin Transporter and the Serotonin 2A Receptor
Exploring Site-Specific N6-Methyladenosine Modifications as New Cancer Biomarkers via SERS-Based Single-Cell Assay and Histopathological Imaging
Synthesis of a Light-Up Probe with a Trioxazole Skeleton for Tracking G-Quadruplex Dynamic Behavior
Insight into the G-Quadruplex Topologies: A Rapid Separation and Identification Method of Multiple Coexisting Conformations by Capillary Zone Electrophoresis
Selective Recognition and Ultra-Sensitive Detection of i-Motif DNA Using a Novel Fluorescent Probe with PCA-Enhanced Quantification
Single-Molecule Detection on Intrastrand Interactions among G4 Clusters
Preamplification-Free Detection of RNA N6-Methyladenosine Modification at Single-Base Resolution Using the CRISPR Tandem Assay
17
Chemically Synthesized H3K14Ub Unveils Clr4's IDR-Mediated Multivalent Nucleosome Recognition in H3K9 Methylation
Unraveling Synthetase's Mode of Action: The Pyrrolysyl-tRNA Synthetase Dimer Uses Secondary Binding Sites in the Cell
Discovery of a Potent and Selective Cell‐Active Inhibitor of Histidine‐N1 Methyltransferase METTL9
Phototriggered Morphological and Compositional Change of UGGAA Repeat RNA Foci by Photoswitchable RNA-Binding Ligand
Building Ligand-Responsive Artificial Signaling Pathways Through Programmable Trans-Acting RNA Circuits in Mammalian Cells
Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening
The Effect of Cap Structure and Poly(A) Positioning on mRNA Translation Efficiency
Degradation of G‐Quadruplex‐Binding Proteins by G4L‐PROTAC via Quaternary Complex Formation
Glycoconjugated Metallohelices Eliminate Cancer Stem‐Like Cells via Modulating G‐Quadruplex Surrounding Transcriptional Start Site of Sox2 Gene
Identification of a Selective YTHDF1 Inhibitor Targeting the msup6/supA Recognition Domain for Breast Cancer
Conformational Change in a Four-Tetrad DNA G-Quadruplex upon Intercalation of a Small-Molecule Ligand PyDH2
Self‐Promoting Targeted Delivery of Epigenetic Immunostimulants to Activate Breast Cancer Immunity via HDACs Downregulation and PD‐L1 Upregulation
Machine Learning‐Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands
Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes
In Quest of Chemical Probes for DNA Methylation Reader Proteins: Nucleoside and Dimer Analogues of 5‐Methylcytosine Interact with MBD2
Supramolecular Recognition of a DNA Four-Way Junction by an M2L4 Metallo-Cage, Inspired by a Simulation-Guided Design Approach
Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex
6
The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin
Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target
Diverse Genetic Etiologies of Unilateral Polymicrogyria
Non-Synaptic Function and Localization of Syntaxin-Binding Protein 1 in a Mouse Model of STXBP1-Related Epileptic Encephalopathy
Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis
Biallelic Truncating Variants in SCN3B Encoding Nav Channel Subunit β3 Lead to Neurodevelopmental Phenotype with and without Epilepsy and Ataxia
1
METTL1-mediated internal m7G methylation of cathepsin B mRNA promotes synovial aggression in rheumatoid arthritis
1
Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis
2
Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG mutated blood cancer
An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
10
Long-read sequencing identifies FGF14 repeat expansions in Parkinson’s disease
Compound heterozygous mutations in the iSSPOP/i gene lead to epilepsy and developmental disorders
Epilepsy concordance in monozygotic twins: the role of common genetic variants
Microgliosis and aberrant interferon response in Adar Mavs brain are rescued by PKR removal
TSC2 loss in neural progenitor cells suppresses mRNA translation of neurodevelopmental genes
Oxytocin seals the blood–brain barrier, improving 22q11.2 deletion syndrome trajectories
POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population
Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder
The genetic and phenotypic spectrum of iGABRB1/i-related disorders
Biallelic iLGI1/i and iADAM23/i variants cause hippocampal epileptic encephalopathy via the LGI1–ADAM22/23 pathway
8
Interaction and Reciprocal Stabilization of H3.3 and PARP1 Promote DNA Damage Repair and Tumor Progression in Small Cell Lung Cancer
Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer.
Disrupting Paraspeckle Stability by Targeting WTX-NONO Phase Separation Enhances Chemotherapy Efficacy in Gastric Cancer.
ZC3H13 Loss Drives Cancer Metastatic Progression by Disrupting m6A RNA Methylation.
LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma.
Loss of SETD8 Impairs Mitochondrial Homeostasis to Suppress Leukemia Stem Cell Function in t(8;21) Acute Myeloid Leukemia.
METTL14 Enhances Anti-Tumor Immunity through m6A-dependent loss of PD-1.
CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
17
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
FOCAS: Transcriptome-wide screening of individual m6A sites functionally dissects epitranscriptomic control of gene expression in cancer
Zebrafish use spectral information to suppress the visual background
Unveiling conformation-selective regulation of the norepinephrine transporter
Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis
Replisome passage through the cohesin ring
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation
Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation
Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses
Bivalent chromatin instructs lineage specification during hematopoiesis
Adaptive radiation and social evolution of the ants
Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes
Inheritance of acquired adaptive cold tolerance in rice through DNA methylation
Repeat-element RNAs integrate a neuronal growth circuit
m6A alters ribosome dynamics to initiate mRNA degradation
1
Paternal exercise confers endurance capacity to offspring through sperm microRNAs
5
Species-specific chromatin architecture and neurogenesis mediated by a human enhancer
Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming
Multi-omic analysis reveals retinoic acid molecular drivers for dermal fibrosis and regenerative repair in the skin
8
Targeted detection method for locus-specific m6A modifications in low-abundance transcripts based on chemical conversion
An isaindigotone-based NIR fluorogenic probe for visualizing mitochondrial DNA G-quadruplexes in living cells
Amyloid-based biomaterials: addressing global health, food security and environmental challenges
A guanosine-containing nucleopeptide self-assembles at the Hoogsteen face to act as a peroxidase mimetic
An antiparallel G-quadruplex structure with a 5′-end overhang forms predominantly at the human telomeric ds–ss DNA junction
Evaluation of the effects of G4 ligands on the interaction between G-quadruplexes and their binding proteins
Advances in the detection of RNA modification
Construction of polymethine chain-modified pentamethylene cyanine dyes for G-quadruplex imaging in live cells
8
Platinum-based phosphorescent lifetime probes for the visualisation of G-quadruplex DNA in cells
Structural dynamics of DNA mimic foldamers
Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7
Identification and structural insights into RNA motifs targeted by a CAG repeat DNA-binding small molecule
Direct sequencing of DNA 5-methylcytosine by engineered dioxygenase NTET-assisted eNAPS
Elucidating the solution structure of the monomolecular BCL2 RNA G-quadruplex: a new robust NMR assignment approach
Synthetic RNA ligands as activators of type I toxin–antitoxin systems: a novel antimicrobial strategy targeting Helicobacter pylori
Direct single-nucleotide resolution sequencing of DNA 5-methylcytosine using engineered DNA methyltransferase-mediated CMD-seq
4
DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow-Induced Atherosclerosis.
Histone Lactylation–Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation
An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.
DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases.
26
Antagonism between blue- and red-light signaling controls thallus flatness in Marchantia polymorpha
Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis
Oligomerization and positive feedback on membrane binding stabilize PAR-3 asymmetries in the C. elegans zygote
Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans
Repeated evolution of supergenes on an ancient social chromosome
Tetrahymena JanusA gene encodes a polo kinase whose loss triggers a dorsal/ventral intracellular homeosis
X chromosome dosage in respiratory stem cells is critical for post-embryonic development and survival
De novo meristem development in Marchantia polymorpha requires light and an apical auxin signaling minimum
The B-class auxin response factor MpARF2 is essential for meristem organization in free-living plant gametophytes
A reference brain for the clonal raider ant
Genomic evidence of a complex supergene system linking dispersal to social polymorphism
Spatiotemporal dynamics of CYCLOIDEA expression during early floral development in monkeyflower
Targeted cannibalism of queens mediated by worker signals in fire ants
A genetic circuit that extends the useful range of a BMP morphogen arose alongside insect wing evolution
Revised evolutionary relationships within Brachycera and the early origin of bicoid in flies
Robust branch patterning in moss shoots via symplasmic auxin diffusion
Crossover designation recruits condensin to reorganize the meiotic chromosome axis
Mitochondria transported by Kinesin-3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death
Divergent origin of the insect cephalic endoskeleton and the trachea from a homologous metameric structure
A switch to non-proliferative growth sustains Drosophila wing development during the early pupal stage
The cytochrome P450 enzyme MpCYP78E1 inhibits meristem initiation and activity in Marchantia polymorpha
Insulin signaling activity in the somatic gonad controls dauer entry via the germ line in C. elegans
Negative feedback equalizes polarity sites in a multi-budding yeast
Dynamic control of Argonautes by a rapidly evolving immunological switch
Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos
Cell fate ratios are encoded by transcriptional dynamics in the Drosophila retina
12
Host-transposon mutualism supports regeneration in planarians
An H3K4me3 reader recruits the positive transcription elongation factor B complex to facilitate transcription elongation in Arabidopsis
A plant histone H3.3-specific amino acid safeguards the deposition of H3K36 methylation for proper development and stress responses
Pulsatile dynamics propagate crystalline order in the developing Drosophila eye
Signaling-dependent refinement of cell fate choice during tissue remodeling in Drosophila pupal wings
Preventing CpG hypermethylation in oocytes safeguards mouse development
Temperature-responsive N-acetylcytidine mRNA modification controls thermosensory flowering in Arabidopsis
Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center
The histone variant H3.14 is an early player in the abiotic stress response of Arabidopsis
Repeated extrinsic and anisotropic mechanical inputs promote C. elegans polarized adherens junction elongation
Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila
3
Primary cell cultures from deceased harbor porpoises to study effects of polystyrene nanoplastics on gene expression
Environmental nano-particulates induced pre-implantation embryonic toxicity in pluripotent stem cell-derived blastoids
Prenatal Exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) and the Risk of Autism Spectrum Disorders in Children Aged 16 to 37 Months: A Prospective Cohort Study
3
Chronic Fatigue Syndrome Induced by Environmental Toxic Exposure: Effects of Polyhexamethyleneguanidine Phosphate Exposure on Mitochondrial Function and Neural Health
Epigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence
Prenatal Heat and Air Pollution Exposure Alter Progesterone and Child Behavior: A Longitudinal Study
1
Bisphenol S Induced Transgenerational Lipid Accumulation by Triggering Intestine-to-Germline Histone H3K4me3 Modification in Caenorhabditis elegans
1
Deletion of METTL14, a key methylation regulator, attenuates vascular ageing
18
MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling
DAXX directs dual modes of H3.4-to-H3.3 histone replacement in the male germline
A dual role for cGAS in shaping cellular and organismal responses to genomic instability
Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
A lncRNA drives developmentally timed decay of all members of an essential microRNA family
Chromatin binding and N-terminal domains of DNMT3B1 confer specificity for developmentally regulated CpG island methylation
The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity
Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylation
Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates
Multiple human enhancer RNAs contain long translated open reading frames
Dominant-negative effects of Weaver syndrome-associated EZH2 variants
A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family
24
Epigenetic characterization of pseudogenes across human tissues
Age-dependent mutational loads in human tRNA genes are tumor-specific and result in chimeric tRNA sequences that could disrupt the genetic code
ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells
Haplotype-resolved telomere-to-telomere genome of Aphelenchus avenae implicates P5CS in nematode desiccation stress response
A transcriptome-wide systematic search does not detect A-to-I RNA editing in cis-antisense RNA duplexes
Mapping and quantifying nascent transcript start sites using TT-TSS-seq
Transposable elements contribute to the evolution of host shift–related genes in cactophilic Drosophila species
Cell type-specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease
Landscape of microRNA and target expression variation and covariation in single mouse embryonic stem cells
MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes
Transcriptomic landscape of transposable elements reveals LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma
A versatile type VI CRISPR-based approach for targeted m6A demethylation in mRNAs
Epigenomics of embryogenesis in turbot
Nanopore direct RNA sequencing reveals METTL2A-mediated m3C sites in poly(A) RNA
Autism spectrum disorder–risk genes have convergent effects on transcription and neuronal firing patterns in primary neurons
Synergistic regulation by H3K36 and H3K27 methylation defines the chromatin landscape to control virulence and secondary metabolism in a fungal pathogen
Quadrupia provides a comprehensive catalog of G-quadruplexes across genomes from the tree of life
Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression
Interspecies systems biology links bacterial metabolic pathways to nematode gene expression, chemotaxis behavior, and survival
Developmental transcriptomics iniPristionchus/ireveals the environmental responsiveness of a plasticity gene-regulatory network
Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-kB binding
Birth of protein-coding exons by ancient domestication of LINE-1 retrotransposon
Charting the regulatory landscape of TP53 on transposable elements in cancer
Continuous infiltration and evolutionary trajectory of nuclear organelle DNA iniOryza/i
1
NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis
3
A de novo C-terminal truncation mutation in NUP205 as a key factor in premature ovarian insufficiency
Genome-wide analysis highlights epigenetic link to age at menarche
SWS1-complex in premature ovarian insufficiency: iSWSAP1/i as a new POI gene
2
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
1
Risk of Cardiovascular Disease in Parents of Children Diagnosed With Neurodevelopmental Disorders
1
Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia
55
HIRA-SETDB1-H3K9me3 axis regulates chromatin architecture in leukemia cells
The dynamic pool of Rec8-cohesin is crucial for meiotic recombination and transcription regulation in the yeast Saccharomyces cerevisiae
The chromatin reader ZMYND8 recruits the NuRD component GATAD2A through its MYND domain to regulate MAPT213 long noncoding RNA transcription
Cleavage of histone H2A during embryonic stem cell differentiation destabilizes nucleosomes to counteract gene activation
Structural basis for the mechanism and stability of the EEPD1 5′ endonuclease
KDM5A methylation modulates its genomic demethylase and transcriptional actions
IFIT3-DVL interaction promotes malignant progression of lung squamous cell carcinoma and large-cell lung carcinoma via canonical WNT signaling
TOP1 and TOP2 complementarily maintain DNA replication fork progression in vertebrates
Mapping the temporality and structural impacts of modifications in Escherichia coli tRNAs
A monofunctional-like mutant of DNA glycosylase NTHL1 changes the dynamics of DNA repair during acute oxidative stress
Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids
Mechanisms of DNA methyltransferase 3A1-mediated DNA methylation of nucleosomes
The RNA methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) on IL1B mRNA to promote transcript stability
Structural Insights into Specific Recognition of the Histone Variant H2A.Z by the YL1 Subunit of SRCAP Chromatin-remodeling Complex
A tryptophan-phenylalanine binding motif for the histone methyltransferases MLL4 and MLL3
A disease-causing Isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response
Deficient mitochondrial tRNA modifications arising from TRMU mutation led to the liver-specific failure
BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication
Global discovery of RNA modifications and functional analysis of m5C methylome in cyanobacteria
Methyl-CpG-binding protein 2 reads histone methylation via an aromatic cage to regulate gene expression and chromatin association
Targeted delivery of rhodopsin’s assembled core is required for outer segment extension in mouse rod photoreceptors
Dynamic and extensive A-to-I RNA recoding in immunoglobulin shapes myeloid neoplasm transcriptome
A-to-I RNA editing impairs miR-376b-3p repression of RYBP in skeletal muscle satellite cells
Rapid DNA Cleavage by the LINE-1 Endonuclease Proximal to DNA Ends and at Mismatches
4E-BP1 differentially regulates translation of a subset of human mRNAs
Multiple modes of transcriptional regulation by the nuclear hormone receptor RARγ in human squamous cell carcinoma
Structural basis for E3 ubiquitin ligase UHRF1 binding to nucleosome core particle and histone H3 ubiquitination
Conserved +1 translational frameshifting in the Saccharomyces cerevisiae gene encoding YPL034W
Distal tip cell migration mutants of Caenorhabditis elegans are rescued by bioequivalent outputs from chondroitin and N-glycosylation pathways
Structural Interactions of Ankyrin B with NrCAM and β2 Spectrin
The m6A reader YTHDF1 facilitates nasopharyngeal carcinoma proliferation and migration via c-MYC
DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation
Jade1 and the HBO1 histone acetyltransferase complex are spatial-selective cofactors of the pluripotency transcription factor Oct4
Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1)
The bacterial tRNA-modifying enzyme tRNAIle lysidine synthetase is genetically conserved but catalytically variable
APE1 active site residue Asn174 stabilizes the AP site and is essential for catalysis
SET7/9 exhibits sigmoidal kinetics on nucleosomes, hyperbolic kinetics on histones by an ordered sequential mechanism, and methylates lysine and arginine
Identification of ALKBH6 as a nucleotide demethylase with a distinct substrate preference
DHX9 phosphorylation at S321 by ATM regulates DHX9 retention at DNA double-strand break sites and interaction with BRCA1
WTAP-mediated m6A methylation of circRNA_404908 promotes esophageal squamous cell carcinoma progression
Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons
Myeloid loss of scaffolding protein menin promotes liver fibrosis via H3K36me3 reprogramming
Molecular determinants of nucleic acid recognition by an RNA-targeting ADP-ribosyltransferase toxin
Polyamines stimulate the protein synthesis of the translation initiation factor eIF5A2, participating in mRNA decoding, distinct from eIF5A1
A repertoire of visible light–sensitive opsins in the deep-sea hydrothermal vent shrimp Rimicaris hybisae
Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3
YEATS2 O-GlcNAcylation promotes chromatin association of the ATAC complex and lung cancer tumorigenesis
Characterization of the activity of KTX-1001, a small molecule inhibitor of multiple myeloma SET domain using surface plasmon resonance
High-Throughput Epigenetic Profiling Immunoassays for Accelerated Disease Research and Clinical Development
Identification of substrates and sequence requirements for CARNMT1-mediated histidine methylation of C3H zinc fingers
Orthologues of the human protein histidine methyltransferase METTL9 display distinct substrate specificities
Post-transcriptional regulation of H19 by m6A reader proteins: H19 stability versus miR-675 biogenesis
Regulatory helix plays a key role in genetic ON–OFF switching for the 2′-deoxyguanosine-sensing mRNA element
Structural and functional insights into the substrate specificity of the pseudouridine monophosphate phosphatase HDHD1A
Biochemical Impact of p300-Mediated Acetylation of Replication Protein A: Implications for DNA Metabolic Pathway Choice
8
Early resolution of sister chromatids during C. elegans meiosis
Actomyosin cortex integration with complex plasma membrane topography in the early Drosophila embryo
Maspardin/SPG21 controls lysosome motility and TFEB phosphorylation through RAB7 positioning
Steady and escort cyst cells regulate Drosophila germline stem cell differentiation and death
Arc controls organ architecture through modulation of Crb and MyoII
PLK-1 suppresses centrosome maturation and microtubule polymerization to ensure faithful oocyte meiosis
CNTD1 is crucial for crossover formation in female meiosis and for establishing the ovarian reserve
The reaction mechanism for glycolysis side product degradation by Parkinson’s disease–linked DJ-1
1
Evolving Genetic Influences on Infant Growth: Linking Polygenic Scores, IGF-I, and Growth in Infancy
10
T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis
In vivo CRISPR screens identify CBX4 as an epigenetic regulator for cancer immunotherapy
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria
Methyltransferase complex subunit METTL3 maintains genome stability of erythroid cells via MTHFD1-mediated nucleotide biosynthesis
MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling
Functional consequence of pathogenic GABRA3 variants determines whether X-linked inheritance is dominant or recessive
EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway
Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas
Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression
2
The Landscape and Regulatory Determinants of A-to-I RNA Editing in Escherichia coli and Pseudomonas aeruginosa Isolated From Patients With Urinary Tract and Ear Infections
Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A (UBASH3A) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis
7
Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons
Kv4.2V404M Mutation Induces Epileptiform Activity and Multiple Behavioral Abnormalities in Heterozygous Knock-in Mice
Baker–Gordon Syndrome-Associated Synaptotagmin-1 Mutations Reduce Synaptic Strength in Mouse Primary and Human-Induced Neuronal Culture Models
A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion of Scn1b
Potentiation of Nigra–Striatal Dopaminergic Projection Underpins Core Autism-Like Behaviors in Valproate-Exposed Mice
Disruption of grin2A, an Epilepsy-Associated Gene, Produces Altered Spontaneous Swim Behavior in Zebrafish
Sequence diversity and encoded enzymatic differences of monocistronic L1 ORF2 mRNA variants in the aged normal and Alzheimer’s disease brain
3
Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans
Saltatory axonal conduction in the avian retina
MicroRNA‐138‐5p suppresses excitatory synaptic strength at the cerebellar input layer
13
Enzyme-Mediated Covalent Labeling Enables In Situ Imaging of RNA Modification States
Elucidating HLTF-Mediated DNA Fork Remodeling via Native Mass Spectrometry
Protein–Protein Cross-Linking by a DNA Damage-Derived Histone Modification
YY1 Interacts with Promoter R-Loops to Regulate Transcription
Assembling Ternary Dead-End Complex for Covalent Trapping of Protein Lysine Methyltransferases
Detection of Epigenetically Important 5-Formylcytosine Modifications Using Novel Photoreactive Oligonucleotides Containing a Trioxsalen-Conjugated Guanosine
Facilitating Quantitation of Mitochondrial G-Quadruplex DNA with an Iridium(III) Two-Photon Phosphorescence Lifetime Imaging Probe
An Unexpected Adenosine-Alkylating Ribozyme Emerged by Target Site Relocation during in Vitro Selection
Synthesis of Precisely Modified Ribonucleic Acid to Reveal the Site-Specific Effect of Modification on Message Ribonucleic Acid Translation
Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch
Catalytic Photooxygenation Demonstrates Therapeutic Efficacy in Transthyretin Amyloidosis
Methylation of Cytidine 1407 Increases the Lifetimes of the A-Site Ground and Excited States of E. coli 16S Ribosomal RNA
Designing Reversible Photoswitching Azobenzene-Modified Nucleotide for Controlling Biological Function
1
Association of Early Life Risk Factors and scpAPOE/scp ε4 With Incident Dementia: Evidence From 14 Years of U.S. Data
5
Genetic Determinants of Steroid Responsiveness in IgA Nephropathy
Testican-2 Interaction with the Extracellular Matrix and Podocyte Protection.
Hmx2 and Dmrt2 Coordinate the Differentiation of Intercalated Cell Subtypes in Kidney.
Podocyte-Specific Deletion of STAT3 in KLF4-Related Experimental Podocytopathy.
Krüppel-Like Factor 6 Induces RNA Polymerase II Subunit RPB1 to Promote Kidney Injury.
3
METTL3-targeted intervention on nuclear factors RORA/RORγt suppressing pathogenic T helper 17 cell differentiation and restores kidney damage in lupus nephritis
Fibrillin-1 is a novel ligand of the epidermal growth factor receptor promoting mesangial cell activation and glomerulosclerosis
The m7G methyltransferase METTL1 promotes acute kidney inflammation by disrupting mitochondrial function
29
Deciphering the dual effects of transcription on DNA replication elongation by replication-associated Micro-C
H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
Nucleosome spacing regulates linker methylation by DNMT3A2/3B3
Global mapping of circRNA-target RNA interactions reveal P-body-mediated translational repression
Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria
GCN2 monitors mRNA translation termination
Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation
NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA
A role for human senataxin in contending with pausing and backtracking during transcript elongation
The Piwi-piRNA complex initiates transposon silencing via transcription termination factors PNUTS and Senataxin
Transcription-replication conflict resolution by nuclear RNA interference
Dcr1 senses R-loops for RNAPII termination at sites of replication stress and repair pathway choice
A network of P-body and Whi3 condensates adjusts cell fate decisions to cellular context
The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity
A conserved PIWI silencing complex detects piRNA-target engagement
SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation
Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer
The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks
The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells
The RNA-stability-independent role of the RNA m6A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance
Synaptic activity causes minute-scale changes in BAF complex composition and function
CRAMP1 drives linker histone expression to enable Polycomb repression
Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation
57
Gut microbiome alterations are sex-dependently associated with brain abnormalities in a mouse model of Neurofibromatosis type I
Ceruloplasmin deficiency drives a fusiform-centric lipid–myelin pathology underlying a visual subtype in autism
Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na+ channel dynamics in human neurons
Genome-wide tandem repeat expansions modify schizophrenia risk in the presence of a 22q11.2 deletion
Analysis of rare coding variants in schizophrenia-associated genes and generalised cognition in the UK Biobank
Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank
SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression
Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer’s disease-related phenotypes
Ythdf2/Setd1b regulatory axis is essential for cerebellar development through regulating epigenetic reprogramming
Inflammation increases the penetrance of behavioral impairment in haploinsufficiency mice — can it explain the behavioral regression in Autism?
Uncoupling memory impairments from autism-associated behaviors in Chd2 deficient mice
Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice
Phenotypic diversity is caused by non-linear genetic interactions between two SNAREopathy genes
The novel role of GADD45A in the etiology of autism: modulating neuronal excitability via TET1/R-loop dependent regulation of KCNQ5
Nitric Oxide-Mediated S-Nitrosylation of TSC2 Drives mTOR dysregulation across Shank3 and Cntnap2 Models of Autism Spectrum Disorder
miR126-mediated alteration of vascular integrity in Rett syndrome
Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer’s disease
Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries Syndrome
UBE3A isoform-selective and non-selective contributions to Angelman syndrome phenotypes
“ deficiency alters early progenitor dynamics and reveals shared pathways with neurodegeneration”
Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling
Associations between mosaic loss and schizophrenia or bipolar disorder of young age
Shared neurogenetic architecture links adolescent neurodevelopmental deviations to adult psychopathological procrastination
RO4938581, a GABAA-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome
Elevated brain glutamine levels in adults with autism spectrum disorder: A 7T MRS study
Aberrant expression of long non-coding RNAs and their regulatory role in chromatin-mediated gene expression changes in the prefrontal cortex of major depressive disorder subjects
Disrupted Development of the mPFC-Thalamic Circuit in Shank3–/– mice, an autism-associated model
Genetic and functional insights into long noncoding RNAs in schizophrenia
A co-culture model of dopaminergic and glutamatergic neurons derived from patients with idiopathic schizophrenia reveals a hypodopaminergic phenotype
3D genetic architecture of schizophrenia risk across three neuronal subtypes
Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice
Shared and divergent alteration of whole-brain connectivity and sensory deficits in multiple autism mouse models
Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention
Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation
Interactive effects of genotype with prenatal stress on DNA methylation at birth
Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder
Effect sizes of APOE e4 on the same general cognitive ability test taken by the same people from age 11 to age 90: The Lothian Birth Cohorts 1921 and 1936
Increased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation
Polygenic Risk and Exposure Severity Predict Trajectories of PTSD: A Prospective Cohort Study
Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons
Longitudinal multi-omics analysis of umbilical cord blood and childhood serum in Autism
Maternal depression and offspring neurodevelopmental impairments in wild rodents induced by ecologically relevant prenatal stress
A phenome-wide association and Mendelian randomization study for suicide attempt within UK Biobank
Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization
Aberrant neural stem cell quiescence is the gateway to autism development linked to Arid1b
Loss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP
Extracellular matrix dysfunction and synaptic alterations in schizophrenia
Environmental context modulates sociability in ube3a zebrafish mutants via alterations in sensory pathways
Probiotics derived sodium benzoate improves social behavior of offspring exposed in the maternal immune activation through regulation of histone lysine benzoylation in astrocytes
Bcl11a deficiency in cerebellar Purkinje cells causes ataxia and autistic-like behavior by altering Vav3
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies
Cadherin 11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit
Neurobiological subtypes of adolescent depression: a multimodal integration of morphometric similarity network and spatial transcriptomics
Distinct and shared intrinsic resting-state functional networks in children with idiopathic autism spectrum disorder and fragile X syndrome
Functional defects in FOXG1 variants predict the severity of brain anomalies in FOXG1 syndrome
Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum
Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in , a shared risk gene for bipolar disorder and schizophrenia
33
Developmental organization of sensory and sympathetic ganglia
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation
Mechanism of co-transcriptional cap snatching by influenza polymerase
DICER cleavage fidelity is governed by 5′-end binding pockets
Nucleotide signals coordinate activation and inhibition of bacterial immunity
Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness
Developmental convergence and divergence in human stem cell models of autism
PAF15–PCNA exhaustion governs the strand-specific control of DNA replication
Four camera-type eyes in the earliest vertebrates from the Cambrian Period
Oxygen-free metabolism in the bird inner retina supported by the pecten
A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation
CFAP20 salvages arrested RNAPII from the path of co-directional replisomes
An RNA splicing system that excises DNA transposons from animal mRNAs
Viral RNA blocks circularization to evade host codon usage control
An ancient recombination desert is a speciation supergene in placental mammals
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Transcriptional interferences ensure one olfactory receptor per ant neuron
KCTD10 is a sensor for co-directional transcription–replication conflicts
A human-specific regulatory mechanism revealed in a pre-implantation model
Protecting double Holliday junctions ensures crossing over during meiosis
Holliday junction–ZMM protein feedback enables meiotic crossover assurance
CRISPR activation for SCN2A-related neurodevelopmental disorders
DNA2 enables growth by restricting recombination-restarted replication
Excised DNA circles from V(D)J recombination promote relapsed leukaemia
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
Mechanism of cytarabine-induced neurotoxicity
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Dynamic assemblies and coordinated reactions of non-homologous end joining
Structural insights into human Pol III transcription initiation in action
Subnucleosome preference of human chromatin remodeller SMARCAD1
A human-specific enhancer fine-tunes radial glia potency and corticogenesis
Divergent DNA methylation dynamics in marsupial and eutherian embryos
3
Quantification and transcriptome profiling reveal abundant, dynamic and translatable dephospho-CoA-capped RNAs
Programmable initiation of mRNA translation by trans-RNA
RNA structure modulates Cas13 activity and enables mismatch detection
15
ATM counteracts chromatin-bound cGAS during DNA replication
Mosaic gastruloids reveal a temporal restriction for developmental cell competition
-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93
DOT1L provides transcriptional memory through PRC1.1 antagonism
ER remodelling is a feature of ageing and depends on ER-phagy
Escape from X inactivation is directly modulated by Xist noncoding RNA
Transcription factors instruct DNA methylation patterns in plant reproductive tissues
Reprogramming of H3K36me2 guides lineage-specific post-implantation de novo DNA methylation
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control
Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis
REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes
A lysosomal surveillance response to stress extends healthspan
Crossover patterning through condensation and coarsening of pro-crossover factors
11
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO
Complex-specific inhibitors for interrogating ATAC histone acetyltransferase complex
Allosteric activation of RNF20/RNF40–RAD6A-mediated H2BK120 monoubiquitylation by H2BS112 GlcNAcylation
Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding
Designing small molecules targeting a cryptic RNA binding site through base displacement
The PARP1–EXD2 axis orchestrates R-loop resolution to safeguard genome stability
Programmable RNA acetylation with CRISPR–Cas13
Nuclear m6A modification regulates satellite transcription and chromosome segregation
1
KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9
305
Crystallized and fluid cognitive abilities have different genetic associations with neuropsychiatric disorders
Structural and molecular basis of specialized translation mediated by the ribosome mRNA-binding channel
Targeting of the nuclear RNA exosome to chromatin by HP1 affects the transcriptional programs of liver cells
Aging-associated modulation of UFMylation impairs proteostasis in
Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity
Retinoic acid drives cell fate specification, maturation and retinal regionality in human retinal organoids
RNA-induced PRC2 inhibition depends on the sequence of bound RNA
MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes
Host insulin hijacking by a nematode receptor mediates developmental plasticity and sex ratio shifts
Functional requirement for Dicer helicase arginine methylation in 26 G siRNA biogenesis and oocyte meiotic program
Identification of hot spring Obelisk-like RNA replicons and expanded diversity of the Obelisk superfamily
MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation
Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance
haploinsufficiency attenuates microglial phagocytosis through dysregulated TREM2-SGK3-GSK3β signaling and recapitulates ASD-like behaviors in mice
The effect of the fitness gradient on fixation probability
The genetic basis for DNA methylation variation across tissues and development
POMC neuron METTL14/m6A/YTHDC1/YTHDF2 pathways safeguard energy balance, body weight, and metabolism
Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids
Chondrocytes reprogram chromatin in hypoxic microenvironments to activate CADM1-AS1/HDAC1 complex-mediated anti-inflammation signals
SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation
Molecular pathogenesis and gene therapy-based intervention of GTPBP3-related mitochondrial disease
Vitamin B12 induces memory of predation through vitellogenin provisioning
Astrocyte fatty acid metabolism as a driver of risk for major depressive disorder
Establishment of DNA methylation during primate germ cell development
Experimental and modeling demonstration of stronger population suppression by gene drive targeting from dominant female-sterile resistance alleles
Recruitment of Mre11 to recombination sites during meiosis
High-resolution mapping reveals features of bacterial NAD-capped RNAs and stress-responsive transcription initiation
PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers
Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia
Mechanisms of human mitochondrial leaderless mRNA translation initiation
Targeting IP6 signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance
Exonic enhancers are a widespread class of dual-function regulatory elements
Genetic architecture of sleep in a genome wide association study of device measured sleep traits
Trisomy 21 Drives Overexpression and Premature RNA Recoding in the Developing Fetal Brain
Targeting notch signaling to restore neural development and behavior in mouse models of ASD
Proton signaling links epithelial sensing to neural control of host defense in C. elegans
An unbiased approach to measure aberrant DNA methylation alterations
A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR
Genetic nurture in intergenerational transmission of substance use
Hh and EGFR-Ras signaling promote distinct steps of tumor progression in the Drosophila follicle epithelium
Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes
RNA functional modulation by Mitoxantrone via RNA structural ensemble repartitioning
Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modifications
Engineering ligands for theophylline riboswitches expands its regulatory dynamic range in prokaryotic and eukaryotic systems
Pre-splicing conformation and stepwise circularization of a group I intron in Azoarcus pre-tRNA
Membrane interfacial potential governs surface condensation and fibrillation of α-Synuclein in neurons
Systematic identification of variant-specific RNA structure-small molecule interactions exemplified by RNA G-quadruplexes
RPA directly stimulates Mer3 helicase processivity to ensure normal crossover formation in meiosis
tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans
Hypusination of the translation factor eIF5A regulates mitochondrial tRNA processing to promote prostate cancer aggressiveness
Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning
Integrated small and long RNA sequencing reveals piRNA mediated transposon repression during human oogenesis
Translational regulation by oxidative desulfuration of tRNA modifications
p38 MAPK orchestrates cross-tissue potassium homeostasis for survival
Gene expression dynamics of human and mouse craniofacial development at the single-cell level
AMR-GNN: a multi-representation graph neural network framework to enable genomic antimicrobial resistance prediction
TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants
Integrative epigenomic landscape of Alzheimer’s Disease brains reveals oligodendrocyte molecular perturbations associated with tau
Unifying non-Markovian dynamics and agent heterogeneity in scalable stochastic networks
Quantitative mapping of pseudouridines in bacterial RNA
Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response
Male obesity causes adipose mitochondrial dysfunction in F mouse progeny via a let-7-DICER axis
SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability
Single-cell and spatial transcriptomics define 20E-driven developmental reprogramming in silkworm wing disc
PRMT5 in mitochondria regulates mtDNA stability through TFAM arginine methylation
Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity
Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes
Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression
Cooperative clamp-mediated promoter recognition by poxviral RNA polymerase and its TBP/TFIIB-like partner
A slight mismatch between a gene’s codon usage and the cellular tRNA supply is beneficial
H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants
Quantitative analysis of small RNA pseudouridylation reveals interplay of PUS enzymes in tRNA anticodon stem-loop
Structures of the eIF4G-binding RNA domains among picornaviral IRES types are topologically conserved
Blood-based epigenetic instability linked to human aging and disease
Co-transcriptional folding orchestrates sequential multi-effector sensing by a glycine tandem riboswitch
ATRX loss couples genome instability at a G-rich repeat to dysregulation of human alpha-globin expression
Arms races between selfish genetic elements and their host defence in termites
Extended Shine-Dalgarno motifs govern translation initiation in
Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity
Genetic regulation of methylation across East Asian and European populations
Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features
FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication
Viral mimicry acts as a tumor suppressor in colitis
A common 19 bp APOE enhancer deletion is protective against Alzheimer’s disease in African Americans
Architectural and evolutionary features of TE-derived TSSs shape tissue-specific promoter activity in the human genome
AACRNL evolved from virulence factor to epigenetic parasite driving genome expansion in free-living eukaryotes
Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia
NR6A1 is essential for neural crest cell specification, formation and survival
ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination
Proteomic profiling of UV damage repair patches uncovers histone chaperones with central functions in chromatin repair
The proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth
Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1
Repeatability of gene expression evolution in experimental environmental adaptation
Functional variants at 1p36.23 confer risk of schizophrenia through modulating RERE
Dynamic single-cell transcriptomics reveals -guided neural network formation in male driving female reproduction
Meta-unstable mRNAs in activated CD8 T cells are defined by interlinked AU-rich elements and mA mRNA methylation
Silencing lipid catabolism determines longevity in response to fasting
WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity
DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains
Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation
Biochemical principles of miRNA targeting in flies
G9a-mediated H3K9me2 orchestrates intestinal epithelial regeneration through epigenetic silencing of cell cycle-related genes
Hierarchical mechanisms control the clearance of DNA lesion–stalled RNA polymerase II
Molecular determinants of Smc5/6 association with DNA junctions
DNA end configurations dictate synaptic complex formation during NHEJ-mediated end bridging
Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids
Haldane’s law works through X:Autosome incompatibility in Caenorhabditis briggsae/C. nigoni hybrids
EPOP restricts PRC2.1 targeting to chromatin by directly modulating enzyme complex dimerization
A programmable ribozyme for RNA signal transduction
A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory
Longitudinal metabolome profiling from pregnancy through childhood and risk of neurodevelopmental disorders at age 10
The missense mutation Y65C in PQBP1 causes microcephaly and cognitive deficits through a combination of partial loss-of-function and gain-of-function effects
METTL3 abrogation promotes glioma progression through regulating the ISG15-FASN axis-mediated lipid metabolism in macrophages
Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N-methyladenosine recognition protein YTHDC2
Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing
A chromosome region linked to neurodevelopmental disorders influences locomotor behavior through sex-specific neural circuits
A north-south hemispheric migratory divide in the butterfly Vanessa cardui
Non-parasite genome encoded virus-like RNAs reprogram the pathogenicity of human blood flukes
Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice
Cryo-EM structures of NHEJ assemblies with nucleosomes
Toward single-cell control: noise-robust perfect adaptation in biomolecular systems
The fru gene specifies male cooperative behaviors in honeybee colonies
SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia
Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development
Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats
Designing molecular RNA switches with Restricted Boltzmann machines
H2AK119ub dynamics control hair follicle stem cell quiescence
METTL3 safeguards cell identity and epigenome of human trophoblast stem cells
A cholesterol-responsive hepatic tRNA-derived small RNA regulates cholesterol homeostasis and atherosclerosis development
Cell type-specific functions of the PBAF chromatin-remodeling complex in neuronal diversification
Structure of the 30S translation initiation complex coupled to paused RNA polymerase and its potential for riboregulation
DNA methylation predicts adverse outcomes of coronary artery disease
unctionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy
Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity
Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth
H3K36 Methylation as a Guardian of Epigenome Integrity
NSUN7 is a catalytically inactive RNA m5C methyltransferase essential for sperm flagellum assembly
Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins
Mechanism of RPA phosphocode priming and tuning by CDK1/WEE1 signaling circuit
Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts
ssG4-seq for global profiling of strand-specific G-quadruplex structures in mammalian genomes
Nuclear effects play an important role in determining codon usage-dependent human gene expression
Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy
Discovering the complete enhancer map of human herpesviruses using a natural language processing model
CIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions
Altruistic disease signalling in ant colonies
Dietary lipid content modifies wah-1/AIFM1-associated phenotypes via LRK-1 and DRP-1 expression in C. elegans
Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex
The alkenes Z9-C and Z9-C function as quorum-sensing pheromones stimulating worker reproduction in the bumble bee
Histone acetyltransferase 1 promotes postinfarction inflammatory response by regulation of monocyte histone succinylation
Maternal histone methyltransferases antagonistically regulate autosomal random monoallelic expression (aRMAE) in C. elegans
Interferometric imaging of the reversible rhodopsin dynamics in the living rat eye
Convergent flow-mediated mesenchymal force drives embryonic foregut constriction and splitting
An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics
The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ
Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila
Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading
H3K4me2 orchestrates H2A.Z and Polycomb repressive marks in Arabidopsis
The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters
mop1 affects maize recombination landscapes by modulating methylation of MITEs near genes in open chromatin
Crossover interference mediates multiscale patterning along meiotic chromosomes
Context-dependent serotonin signaling links dietary quality to foraging decisions
tRNA-dependent conformational dynamics and folding coordinate translational regulation by a full-length T-box riboswitch
Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break
Immunological surveillance against cancer across mammals
AtMCM10 facilitates SDSA-mediated intermolecular homologous recombination repair via liquid-liquid phase separation in DNA damage response
Serum Proteomics Reveals Diagnostic Biomarkers and Molecular Pathways in Cerebral Palsy
Estimation of genome-wide coupling in rattlesnake hybrids provides insight into the process of speciation and its progress
Structural basis of Nuclear Factor 1-X DNA recognition provides prototypic insight into the NFI family
DNA replication fork speed acts as a pacer in cortical neurogenesis
YTHDF2 regulates self non-coding RNA metabolism to control inflammation and tumorigenesis
5-Formylcytosine is not a prevalent RNA modification in mammalian cells
Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation
HIRA defines early replication initiation zones independently of their genome compartment
Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseases
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice
Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation
Molecular mechanism of co-transcriptional H3K36 methylation by SETD2
CRL4DCAF12 regulation of MCMBP ensures optimal licensing of DNA replication
DirectRM: integrated detection of landscape and crosstalk between multiple RNA modifications using direct RNA sequencing
A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing over
Different gametogenesis states uniquely impact longevity in Caenorhabditis elegans
Enhancing cap-independent translation of linear mRNA
Dual roles of DEAD-box RNA helicase Brr2 in genome stability regulation
Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner
SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder
ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis
Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution
SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesis
Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA
Mitotic DNA repair by TMEJ suppresses replication stress-induced nuclear envelope reassembly defect
A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes
Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells
Mechanism for the substrate recognition by a eukaryotic DNA N6-adenine methyltransferase complex
X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels
RNA polymerase II is a polar roadblock to a progressing DNA fork
Cryo-EM reveals evolutionarily conserved and distinct structural features of plant CG maintenance methyltransferase MET1
Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies
Structural basis of antiphage defence by an ATPase-associated reverse transcriptase
DNA2 and MSH2 cooperatively repair stabilized G4 and allow efficient telomere replication
Concurrent temporal patterning of neural stem cells in the fly visual system
Multiple independent acquisitions of a metallophore-synthesis gene by plants through horizontal microbial gene transfer
Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation
Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes
SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape
Controlling intermolecular base pairing in Drosophila germ granules by mRNA folding and its implications in fly development
CFP1 promotes germinal center affinity maturation and restrains memory B cell differentiation through H3K4me3 modulation
Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells
Sex-stratified genome-wide association meta-analysis of major depressive disorder
DNA double-strand break end resection factors and WRN facilitate mitotic DNA synthesis in human cells
ERH promotes primary microRNA processing beyond cluster assistance
NSUN2 facilitates DICER cleavage of DNA damage-associated R-loops to promote repair
GraphVelo allows for accurate inference of multimodal velocities and molecular mechanisms for single cells
Structures and mechanisms of U6 snRNA mA modification by METTL16
Nanopore sequencing of intact aminoacylated tRNAs
Adaptive loss of shortwave-sensitive opsins during cartilaginous fish evolution
Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages
Single-cell eQTL mapping of human endogenous retroviruses reveals cell type-specific genetic regulation in autoimmune diseases
Dopamine signaling drives skin invasion by human-infective nematodes
REST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate
Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting
UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
RNAi epimutations conferring antifungal drug resistance are inheritable
CUTTag reveals unconventional G-quadruplex landscape in in response to oxidative stress
A light-resuming strategy as a screening method for selecting Sec61 inhibitors down-modulating PD-L1 expression
The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling
Limits on the computational expressivity of non-equilibrium biophysical processes
Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking
Latent infection of by Orsay virus induces age-dependent immunity and cross-protection
linked myelination deficits and synaptic plasticity alterations drive auditory processing disorders in an ASD mouse model
METTL9 sustains vertebrate neural development primarily via non-catalytic functions
USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4
Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia
Queuosine is incorporated into precursor tRNA before splicing
Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers
The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life
Removal of promoter CpG methylation by epigenome editing reverses silencing
Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures
Somites are a source of nephron progenitors in zebrafish
A complex between IF2 and NusA suggests early coupling of transcription-translation
Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis
The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice
CompasSeq: epitranscriptome-wide percentage assessment of metabolite-capped RNA at the transcript resolution
Identification of functional non-coding variants associated with orofacial cleft
ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis
sperm and oocytes differentially transmit diet-induced adaptations to their progeny
Gut microbiota and brain-resident CD4+ T cells shape behavioral outcomes in autism spectrum disorder
Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition
Comprehensive resolution and classification of the Epstein Barr virus transcriptome
Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor
TIVelo: RNA velocity estimation leveraging cluster-level trajectory inference
RNA-binding protein YebC enhances translation of proline-rich amino acid stretches in bacteria
Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism
A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m5C modification
Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome
A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation
Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans
Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase
Isoform characterization of m6A in single cells identifies its role in RNA surveillance
The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress
DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication
Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryos
BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication
Histone lysine methyltransferases MLL3 and MLL4 direct gene expression to produce platelets efficiently
Discovery of novel non-retroviral endogenous viral elements reveals their long-term integration history in spiders
Maximal response to a mechanical leader at critical group size in ant collectives
Mammalian tRNA acetylation determines translation efficiency and tRNA quality control
Rim4-seeded stress granules connect temperature sensing to meiotic regulation
Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy
Regulation of the developmental programs in Toxoplasma by a novel SNF2L-containing chromatin remodeling complex
Rational development of FMN-based orthogonal riboswitch that functions in response to specific non-cognate ligand
Split RNA switch orchestrates pre- and post-translational control to enable cell type-specific gene expression
DNA methylation protects cancer cells against senescence
USP37 prevents premature disassembly of stressed replisomes by TRAIP
Coordinated action of multiple active histone modifications shapes the zygotic genome activation in teleost embryos
Rewired m6A of promoter antisense RNAs in Alzheimer’s disease regulates neuronal genes in 3D nucleome
Translation suppresses exogenous target RNA-mediated microRNA decay
Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway
Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling
The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells
An RNA transmethylation pathway governs kidney nephrogenic potential
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease
Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function
Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice
High-speed atomic force microscopy and 3D modeling reveal the structural dynamics of ADAR1 complexes
An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination
Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq
The patient-specific mouse model with frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome
Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche
USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X
Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants
High-resolution spatial transcriptomics and cell lineage analysis reveal spatiotemporal cell fate determination during craniofacial development
KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma
Nucleoporins shape germ granule architecture and balance small RNA silencing pathways
m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability
A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation
Revealing the location and dynamics of a concealed binding site in the dopamine transporter
Selective interactions at pre-replication complexes categorize baseline and dormant origins
EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA
Structure and mechanism of human vesicular polyamine transporter
 -methyladenosine modifications stabilize phosphate starvation response–related mRNAs in plant adaptation to nutrient-deficient stress
12
Biallelic variants in cause a remarkably frequent developmental and epileptic encephalopathy
Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation
The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition
Genetics and environment distinctively shape the human immune cell epigenome
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes
Pathogenic variants cause a neurodevelopmental syndrome by impairing synaptic function
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Bryophytes hold a larger gene family space than vascular plants
Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes
Analysis of R-loop forming regions identifies RNU2-2 and RNU5B-1 as neurodevelopmental disorder genes
1
Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy
3
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial
3
Spatial 5mC-seq profiling of embryos and decidua after implantation in mammals
Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance
Mild and ultrafast GLORI enables absolute quantification of mA methylome from low-input samples
7
Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the optic lobe
CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment
Genetic mapping identifies as a developmental modifier of attention
The stroke risk gene maintains brain endothelial cell function via Tie2 signaling
Multi-region mA epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci
to allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development
2
Scaling and self-similarity in the formation of the embryonic epigenome
chemosensing accuracy is not limited by stochastic molecule arrivals
13
Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex
Integrator subunit INTS12 links ribotoxic stress to transcription-coupled nucleotide excision repair
Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity
Cell-cycle-dependent repression of histone gene transcription by histone H4
Human DICER1 hotspot mutation induces both loss and gain of miRNA function
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin
m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics
tRNA as an assembly chaperone for a macromolecular transcription-processing complex
eIF1 and eIF5 dynamically control translation start site fidelity
Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation
Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks
H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes
4
Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models
Protective ApoE variants support neuronal function by effluxing oxidized phospholipids
A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy
Cell-type-specific enrichment of somatic aneuploidy in the mammalian brain
29
Genetic parallelism underpins convergent mimicry coloration in Lepidoptera across 120 million years of evolution
Dietary restriction shapes intergenerational ribosome abundance and early growth of Caenorhabditis elegans offspring
Cell cycle dynamics regulate H3K27 and H3K9 histone modifications in Drosophila
Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe
Comparative embryogenesis of two salp species reveals rogue development and evolutionary divergence from sessile tunicates
Integrated chromatin and transcriptomic profiling reveals sex-specific mechanisms of gene regulation in hepatic nutrient responses
Dynamic auxin maxima regulate male-to-hermaphrodite conversion and de novo meristem formation in the fern Ceratopteris gametophytes
A male-transmitted B chromosome undergoes strong meiotic drag in females of the jewel wasp Nasonia vitripennis
Biased sampling driven by bacterial population structure confounds machine learning prediction of antimicrobial resistance
Bacterial gene 5′ ends have unusual mutation rates that can mislead tests of selection
Low-dose mixtures of dietary nutrients ameliorate behavioral deficits in multiple mouse models of autism
AMPK modulates a DEAH box RNA-helicase to attenuate TOR signaling and establish developmental quiescence in Caenorhabditis elegans
Distinct S-adenosylmethionine synthases link phosphatidylcholine to mitochondrial function and stress survival
PRMT5 regulates alternative splicing of TCF3 under hypoxia to promote EMT and invasion in breast cancer
New retron systems from environmental bacteria identify triggers of anti-phage defense and expand tools for genome editing
Nicotine induces abnormal motor coupling through sensitization of a mechanosensory circuit in Caenorhabditis elegans
XDH-1 inactivation causes xanthine stone formation in Caenorhabditis elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell
Unconventional codon usage bias mediates mRNA translational dynamics in macrophages
Genetic variation influences food-sharing sociability in honey bees
Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior.
Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development
Mutation bias alters the distribution of fitness effects of mutations.
Altered auditory feature discrimination in a rat model of Fragile X Syndrome
Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies
Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma
The m5C reader Ybx1 regulates embryonic cortical neurogenesis by promoting progenitor cell cycle progression.
An animal toxin-antidote system kills cells by creating a novel cation channel
H2A.Z deposition by the SWR complex is stimulated by polyadenine DNA sequences in nucleosomes.
Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation.
56
INS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans
Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating
Chronic replication stress-mediated genomic instability disrupts placenta development in mice
DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A
Mms4 chromosomal association reveals functional relationships between meiotic crossover pathways in budding yeast
PARP-2 catalytic activity drives replication-ICL repair in an allele-specific manner during germline development
Transcriptional repression of reaper by Stand still ensures female germline development in Drosophila
Expanding the fly eye gene regulatory network: From Drosophila to the hoverfly Episyrphus balteatus
The RPA-binding domain and the KKRK motif in Rad26ATRIP cooperate at the perturbed DNA replication fork for initiating checkpoint signalling
The rewiring of a terminal selector regulatory cascade generates convergent neuronal laterality
An essential gene screening identifies yeast Mot1 as a suppressor of R-loops and genome instability
The regenerative period of somatosensory nerves is closed by a DCC signaling axis
A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype
Temperature and genetic background drive mobilization of diverse transposable elements in a global human fungal pathogen
Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations
LINE-1 retrotransposition in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and cell non-autonomous programmed cell death
Crosstalk between cohesins and axis proteins determines meiotic chromosome architecture in Sordaria macrospora
LIPL-1 and LIPL-2 are TCER-1-regulated lysosomal lipases with distinct roles in immunity and fertility
Single-cell transcriptomics reveals stepwise transformation of epithelial cells into Non-Professional Phagocytes
Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental pathology in adult C. elegans
Loss of function of chromatin remodeler OsCLSY4 leads to RdDM-mediated mis-expression of endosperm-specific genes affecting grain qualities
MYCBP interacts with Sakura and Otu and is essential for germline stem cell renewal and differentiation and oogenesis
Modeling the length distribution of gene conversion tracts in humans from the UK Biobank sequence data
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
METTL3 facilitates the translation of CircSIK2 during chicken myogenesis in an m6A dependent manner
The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae
Loss of meiotic double strand breaks triggers recruitment of recombination-independent pro-crossover factors in C. elegans spermatogenesis
Genotype-phenotype characterization and functional reconstitution of pathogenic β-catenin variants from CTNNB1 syndrome patients
Probing the molecular determinants of Ty1 retrotransposon restriction specificity in yeast
A high-resolution crossover landscape in Drosophila santomea reveals rapid and concerted evolution of multiple properties of crossing over control
Stn1 supports Mec1 function in protecting stalled replication forks from degradation
Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk
Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.
Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons
Conserved Calcineurin A splice variants regulate both constitutive and experience-dependent behaviors through tissue-specific signaling.
From paleness to albinism: Contribution of OCA2 exon 10 skipping to hypopigmentation
Meiotic Sex Chromosome Inactivation: Conservation across the Drosophila genus
The Drosophila mauritiana synaptonemal complex protein C(3)G repatterns the recombination landscape of Drosophila melanogaster.
MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans
A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation
SRS2 is required for MUS81-dependent CO formation in zmm mutants
Dynamics of recombination, X inactivation and centromere proteins during stick insect spermatogenesis
Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence
ETS transcription factor pointed controls germline survival in Drosophila
Genetic and environmental influences on the distributions of three chromosomal drive haplotypes in maize
Shaping and interpretation of Dpp morphogen gradient by endocytic trafficking
Cellular imbalance of specific RNA-binding proteins associates with harmful R-loops
Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster
Inheritance bias of deletion-harbouring mtDNA in yeast: The role of copy number and intracellular selection.
Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis
Ubinuclein 2 is essential for mouse development and functions in X chromosome inactivation
Loss of FIC-1-mediated AMPylation activates the UPRER and upregulates cytosolic HSP70 chaperones to suppress polyglutamine toxicity
Maximal inhibitory effect of MOV10 on LINE-1 retrotransposition requires both the MOV10/LINE-1 association and granule formation.
SQST-1/p62-regulated SKN-1/Nrf mediates a phagocytic stress response via transcriptional activation of lyst-1/LYST.
Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans.
7
Quantification of Information Flow by Dual Reporter System and Its Application to Bacterial Chemotaxis
Macroscopic Fluctuation-Response Theory and Its Use for Gene Regulatory Networks
Enzyme as Maxwell’s Demon: Steady-State Deviation from Chemical Equilibrium by Enhanced Enzyme Diffusion
Extrinsic Noise or Intrinsic Coupling: Dissecting Correlated Fluctuations in Gene Transcription
Joint Distribution of Nuclear and Cytoplasmic mRNA Levels in Stochastic Models of Gene Expression: Analytical Results and Parameter Inference
Evolutionary Benefits of Fitness-Dependent Mutation Rates
Effective Markovian Dynamics Method for Solving Non-Markovian Dynamics of Stochastic Gene Expression
7
StALKBH10B-Mediated RNA m6A Modification Inhibits Potato Salt Tolerance by Targeting Flavonoids and ABA Signalling Pathways
H3K27me3-Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion
Regulation of DNA Methylation in Peanut Leaves and Roots: Uncovering the Molecular Mechanisms for Increased Yield After Single‐Seed Sowing
Epigenetic regulation modulates seasonal temperature-dependent growth of soybean in southern China
RECQ4 restricts non-interfering crossover formation to fine-tune meiotic recombination rates in rice
Lysine deacetylase TaSRT1 mediates wheat drought tolerance by deacetylating TaDT-A to reduce its protein stability and transcriptional activity
A modulatory role of CG methylation on gene expression in soybean implicates its potential utility in breeding
115
From Drosophila to mammals: The evolutionarily conserved homeodomain protein Engrailed affects the antitumor innate immune response
Mecp2 deficiency induces dysphagia in a preclinical model of Rett syndrome
Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation
YTHDC1 recognizes METTL16-dependent m6A on caRNAs and coordinates cotranscriptional splicing
Exploring functional transitions of the 2’-dG riboswitch aptamer
Simulation-based inference captures non-Markovian effects as exemplified in protein production kinetics through cell division
Antagonism by the type VI secretion system of Bacteroides fragilis is controlled by a TetR family regulator and released small molecule
Hierarchical genotype networks and incipient ecological speciation in Qβ phage quasispecies
Descent from a common ancestor restricts exploration of protein sequence space
Temporal neuronal differentiation programs safeguard neuronal diversity
Cnpy1 is a candidate endoplasmic reticulum chaperone of vomeronasal type 2 GPCRs
The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis–mediated inflammation to exacerbate kidney injury
The conserved fibroblast growth factor receptor–based signaling is required for dendrite regeneration
Active maintenance of meiosis-specific chromosome structures in Caenorhabditis elegans by the deubiquitinase DUO-1
Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish
A KCNC1 variant linked to Rett syndrome disrupts ER to Golgi trafficking of Kv3.1 channel
Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation
Pareto optimality reveals an atlas of cellular archetypes
Loss of function of the chromatin remodeling gene INO80D leads to neurogenic features of schizophrenia
Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress
N6-methyladenine DNA modification modulates pathogen virulence in nematodes
METTL3-mediated N6-methyladenosine modification of Dnajb1 modulates cardiomyocyte ferroptosis during myocardial infarction
A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic N6-methyladenine (6mA)
Pri micropeptide functions as a cell-intrinsic timer controlling the transient phase of cell fate induction
HOP2–MND1 chaperones a diffusing DMC1–ssDNA complex to survey dsDNA for homology recognition during meiotic recombination
The Nemp1–Nesprin complex mediates cellular responses to matrix mechanics
Neuromodulation of swarming behavior in Caenorhabditis elegans: Insights into the conserved role of calsyntenins
A sterility-associated long noncoding RNA involved in honey bee caste determination and adult queen and worker fertility
Stability of epigenetic transgenerational inheritance of adult-onset disease and parturition abnormalities
Pichia-CLM: A language model–based codon optimization pipeline for Komagataella phaffii
Parasitic castration by a viral protein tyrosine phosphatase targeting the host cell cycle checkpoint protein Rad9A
EPOP and MTF2 activate PRC2 activity through DNA-sequence specificity
Ufd2p promotes efficient crossover formation by destabilizing Top2p during meiosis
Evolutionary pathways in epistatic mechanical networks
Germline fate determination by a single ARGONAUTE protein in Ectocarpus
Molecular architecture and diversity of StopGo/2A translational recoding
Evolutionary adaptations to the hormonal regulation of vascular tissue development
ADAR-GPT: A continually fine-tuned language model for predicting A-to-I RNA editing sites
Origin of class B J-domain proteins involved in amyloid transactions
Cell numbers contribute to cell fate during Ciona cardiopharyngeal mesoderm specification
O-acyltransferase genes involved in the production of volatile sex pheromones in Caenorhabditis elegans
Immature Caenorhabditis elegans motor neurons control early embryo behavior via both synaptic and nonsynaptic GABA release
Cotranslational assembly directs the biogenesis of the m6A methyltransferase complex
CHAMP1 complex promotes heterochromatin assembly and reduces replication stress
Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells
Lipid-packing defects are sufficient to modulate membrane insertion and the bound state of α-synuclein
The variability of evolvability: Properties of dynamic fitness landscapes determine how phenotypic variability evolves
CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1
Generative epigenetic landscapes map the topology and topography of cell fates
An electron transport complex required in the gut sensitizes Bacteroides to a pore-forming type VI secretion toxin
Combination of Cas9 and adeno-associated vectors enables efficient in vivo knockdown of precise miRNAs in the rodent and primate brain
Structural insights into the role of eIF3 in translation mediated by the HCV IRES
Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila
Core microRNAs regulate neural crest delamination and condensation in the developing trigeminal ganglion
The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage
S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal
Redox regulation of memory formation by Rrp1 in Drosophila
Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making
METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation
<atl>Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in iDrosophila/i</atl>
Rewarding touch limits lifespan through neural to intestinal signaling
Aberrant X chromosome dosage compensation causes hybrid male inviability in Caenorhabditis
A PHF19-YTHDC1 condensate switches EZH2-mediated gene suppression to activation for prostate cancer progression
HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis
Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors
Polycomb Repressive Complex 1 and USP16 localize to the mitochondrion and influence its function
Mouse X-linked microRNA cluster regulates the meiotic checkpoint and Prdm9-driven hybrid sterility in a copy number–dependent manner
Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer
HISTONE DEACETYLASE-1 is required for epigenome stability in Neurospora crassa
RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation
Duplication of a conserved mitochondrial enzyme gene arms parasitoid wasps with venom cytotoxicity and oogenesis regulation
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons
ALKBH5 demethylates the m6A modification of SOCS3 in microglia/macrophages and alleviates neuroinflammation after brain injury
Favorable epistasis in ancestral diterpene synthases promoted convergent evolution of a resin acid precursor in conifers
Emergence of activation or repression in transcriptional control under a fixed molecular context
Protein-mediated stabilization and nicking of the nontemplate DNA strand dramatically affect R-loop formation in vitro
Pseudouridine prevalence in Kaposi’s sarcoma–associated herpesvirus transcriptome reveals an essential mechanism for viral replication
Adaptation of seed dormancy to maternal climate occurs via intergenerational transport of abscisic acid
Structure of a polymorphic repeat at the CACNA1C schizophrenia locus
Ovarian germline stem cell dedifferentiation is cytoneme dependent
G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes
Asymmetric development and function of paired sperm-storage organs in Drosophila melanogaster
TRPC4 regulates limbic behavior and neuronal development by stabilizing dendrite branches through actomyosin-driven integrin activation
ITAF45 is a pervasive trans-acting factor for picornavirus Type II IRES elements
RNA polymerase III transcription–associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection
Split-YFP-coupled interaction–dependent TurboID identifies new functions of basal cell polarity in Arabidopsis
SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands
Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson’s disease
A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs
The prefusion structure of the HERV-K (HML-2) Env spike complex
Kinetic mechanisms for the sequence dependence of transcriptional errors
Macroevolutionary changes in natural selection on codon usage reflect evolution of the tRNA pool across a budding yeast subphylum
In silico evolution of globular protein folds from random sequences
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
Transgenerational epigenetic effect of kings’ aging on offspring’s caste fate mediated by sperm DNA methylation in termites
The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant
CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity
Abundant piRNA production mediated by the Drosophila GTSF1 homolog Tpp ensures Aubergine localization and germ plasm assembly
Disrupted diencephalon development and neuropeptidergic pathways in zebrafish with autism-risk mutations
Robustness revisited: On the neutral evolution of centrality and localization
Histone variant H2A.W7 represses meiotic crossover formation in Arabidopsis heterochromatin
Biochemical and structural basis of Dicer helicase function unveiled by resurrecting ancient proteins
Dinucleotide preferences underlie apparent codon preference reversals in the Drosophila melanogaster lineage
An RNA-binding regulatory cascade controls the switch from proliferation to differentiation in the Drosophila male germ cell lineage
MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens
UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia
CaMK modulates sensory neural activity to control longevity and proteostasis
Dmrt2 and Hmx2 direct intercalated cell diversity in the mammalian kidney through antagonistic and supporting regulatory processes
Architecture of Pseudomonas aeruginosa glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases
Molecular insights into de novo small-molecule recognition by an intron RNA structure
Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain
Improved synapsis dynamics accompany meiotic stability in Arabidopsis arenosa autotetraploids
METTL3 mediates atheroprone flow–induced glycolysis in endothelial cells
Conversion of social organization in fire ants induced by few colony members: Unmasking indirect genetic effects
18
A shoot at the root? Unique development and evolution of the stigmarian apical meristem
Metabolic consequences of naturally occurring mitochondrial heteroplasmy in bivalves
Diversification of pre-mating behaviours through temporal reordering of components
What kills a society: accumulation of uric acid increases infectious disease risk in termites
Conserved optical adaptations enable amphibious vision in compound eyes
Epigenetic variation can promote adaptation by smoothing rugged fitness landscapes
DNA methylation reflects tissue and caste identity but not parasitism-induced changes in a social insect
Rewired gene interactions during evolution of the analia and genitalia in Drosophila
Drive, suppression and escape from suppression of a selfish chromosome
Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster
Heterogeneous constraint and adaptation across the malaria parasite life cycle
Haplodiploidy accelerates mitogenome evolution in insects
Confounding fuels misinterpretation in human genetics
Better safe than sorry: leg amputations as a prophylactic wound care behaviour in carpenter ants
<atl>Investigating the consequences of the mating system for drug resistance evolution in iCaenorhabditis elegans/i</atl>
The structure of the annual migratory flight activity in a songbird
Autosomally-encoded segregation distortion of sex chromosomes.
Opsin gene expression plasticity and spectral sensitivity in male damselflies could mediate female colour morph detection.
20
Human DHX29 detects nonoptimal codon usage to regulate mRNA stability
Multiple chromosomal inversions modulate continuous local adaptation along a steep thermal cline
Interbreeding between Neanderthals and modern humans was strongly sex biased
Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis
Nutritional specialization and social evolution in woodroaches and termites
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Mechanism of DNA targeting by human LINE-1
mRNA initiation and termination are spatially coordinated
Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity
Lysosomes signal through the epigenome to regulate longevity across generations
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
Early germline sequestration in a basidiomycete fungus
ASB7 is a negative regulator of H3K9me3 homeostasis
A single theory for the evolution of sex chromosomes and the two rules of speciation
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation
92
Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma
COSA-1–SLX-4 interaction directly links crossover designation with Holliday junction resolution
Slow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speed
A panoramic view of the expression and function of the Doublesex/DMRT gene family in C. elegans
Peaceful queen succession in the naked mole rat
C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron
Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution
Morphogenesis of moss leaf-like organs through variations in deeply shared developmental principles
Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD
CLOCK-catalyzed histone H3K37 glutarylation suppresses H3K36 trimethylation pathways in glioblastoma
Artificial embryonic node elucidates the role of flow in left-right symmetry breaking in vertebrates
Mechanism of ribosome stalling by the AMD1 C-terminal tail arrest peptide
Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF
Brain neuronal CG9593/ANGPTL4 activation mediates paternally acquired motor disorders
Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in Arabidopsis
Enhancing plant antiviral responses and productivity through the elimination of m5C methyltransferase
Differential SP4 expression and HSP60 abundance in buccal swabs from patients with schizophrenia
Polycomb repression works without Siesta, the Drosophila ortholog of mammalian PCGF3
miRNA gene mutations commonly disrupt the proper functioning of miRNA genes
CBX7 functions as a methylation-dependent inducer of gene transcription and regulator of cytosolic signaling in lymphoid cells
Opposing insulin signals underlie the same developmental switch across hemipteran insects
Deep-sea fish reveal an alternative developmental trajectory for vertebrate vision
Hybrid female sterility due to cohesin protection errors in mouse oocytes
Multimodal social context modulates larval behavior in Drosophila
Structural basis of transcription-coupled H3K36 trimethylation by Set2 in coordination with FACT
Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence
A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia
Remodeling of XIST regulatory landscape during primate evolution
Quantitative modulation of a spatial enhancer through the biophysical properties of a transcription factor binding site
Nat10-mediated ac4C epitranscriptomics orchestrates hematopoietic stem/progenitor cell fate determination via translation control
An epidermal membrane-associated periodic skeleton restricts endocytosis to stabilize neuron-epidermal attachment and preserve axons
Mechanical control of the insect extracellular matrix nanostructure
Circadian-shaped immune variability predicts infection outcome
Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD
The evolution of cheaper workers facilitated larger societies and accelerated diversification in ants
BE screen reveals METTL3 S2 dephosphorylation sensitizes gastric cancer cells to oxaliplatin by interfering METTL3-eIF3H interaction
Unusual inheritance of a functional cki homolog in the human pathogen Schistosoma mansoni
Conservation of cis-regulatory codes over half a billion years of evolution
HERVH-derived eRNA activates a super-enhancer–driven ALDH1A3/SAT1 axis to promote ferroptosis escape and pancreatic cancer development
Conservation of mRNA operon formation in control of the heat shock response in mammalian cells
Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans
Widespread association of Polycomb complex–deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation
The nonfibrillar multiplexin collagen CLE-1 defines cholinergic synapse identity
Serine tRNAs compete to regulate the mRNA translation of serine-sensitive codons
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
KDM4A serves as an α-tubulin demethylase regulating microtubule polymerization and cell mitosis
Transgenerational adaptation to hypoxia
Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization
Metabolic regulation of behavior by the intestinal enzyme FMO-2
Nuclear 2′-O-methylation regulates RNA splicing through its binding protein FUBP1
Mechanism of USP21 autoinhibition and histone H2AK119 deubiquitination
Nkapl deletion drives cognitive deficits through mPFC interneuron dysfunction in a mouse model of schizophrenia
Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline
KMT2D temporally activates neuronal transcriptional factor genes to mediate cerebellar granule cell differentiation
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
The polymerase-associated factor 1 complex modulates the growth-defense tradeoff in Arabidopsis
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Aplf/Dna2 variants drive chromosomal fission and accelerate speciation in zokors
Human endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM
Reticular thalamic hyperexcitability drives autism spectrum disorder behaviors in the Cntnap2 model of autism
Identification of renal stem cells in zebrafish
FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia
Large-scale protein interactome reveals lineage-specific genes driving plant-parasitic nematode adaptive innovations
An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility
AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance
Acquisition of neural crest promoted thyroid evolution from chordate endostyle
Histone acetylation readers Bdf1 and Yaf9 direct SWR1 remodeler to +1 nucleosome
Isoform-level profiling of m6A epitranscriptomic signatures in human brain
eIF2A regulates cell migration in a translation-independent manner
Spinal motor neuron development and metabolism are transcriptionally regulated by nuclear factor IA
Nonchromatin regulatory functions of the histone variant H2A.B in SWI/SNF genomic deposition
First contact with greater gravity: Moss plants adapted via enhanced photosynthesis mediated by AP2/ERF transcription factors
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A Notch signal required for a morphological novelty in Drosophila has antecedent functions in genital disc eversion
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
Sensing of extracellular l-proline availability by the integrated stress response determines the outcome of cell competition
H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells
Dicer is cleaved by the Leader protease encoded by foot-and-mouth disease virus to promote infection in mammalian cells
VIRMA-mediated m6A modification regulates forebrain formation through modulating ribosome biogenesis
<atl>Regulation of MORC-1 is key to the CSR-1–mediated germline gene licensing mechanism in iC. elegans/i</atl>
Vimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson’s patient–derived midbrain neurons
The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia
Notch controls APC/CFZR-1 to enable accumulation of chromatin regulators in germline stem cells from Caenorhabditis elegans
Mechanistic insights into the stimulation of the histone H3K9 methyltransferase Clr4 by proximal H3K14 ubiquitination
Identification and characterization of the de novo methyltransferases for eukaryotic N6-methyladenine (6mA)
Dual DNA demethylation mechanisms implement epigenetic memory driven by the pioneer factor PAX7
Nucleosomes represent a crucial target for the intra-S phase checkpoint in response to replication stress
Intrinsically weak sex chromosome drive through sequential asymmetric meiosis
LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis
5
Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome
Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models
Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma
Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury
Circulating epigenetic signatures classifying brain insulin resistance in humans
35
The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiation
A spontaneous termination mechanism of RNA polymerase V shapes the DNA methylation landscape in plants
A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems
FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors
Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice
TBP regulates transposable element expression in early mouse embryos
Transcription factor NFYA directs male meiotic entry by regulating accessible chromatin at meiotic promoters in mice
The mechanism of ribosomal recruitment during translation initiation on the Type 2 encephalomyocarditis virus IRES
m6A reader Ythdf proteins control retrotransposon B2 repeat expression and safeguard early embryo development
RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia
ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
Single-nucleotide m⁶A mapping uncovers redundant YTHDF function in planarian progenitor fate selection
Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis
Iron-deplete diet enhances lifespan via oxidative stress response pathways
Evolutionary adaptation of bacterial proteomes to translation-impeding sequences
IGF2BP3 recognizes m6A to regulate histone-to-protamine replacement during mouse sperm development
CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of maternal-to-zygotic transition in teleosts
Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2
A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds.
H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability.
MCM5 UFMylation regulates replication origin firing and fork progression.
The seminal fluid protein SFP-1 regulates mated hermaphrodite aging and fat metabolism in C. elegans.
Germ granule localization of nematode Argonaute WAGO-4 ensures fidelity in small RNA loading.
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization
YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA.
FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons
Sequence and parent-of-origin dependent m6A contribute to allele-specific gene expression.
Genetic polymorphisms lead to major, locus-specific, variation in piRNA production in mouse
Structural basis of RNAPII transcription on the nucleosome containing histone variant H2A.B.
Inhibitors of eIF1A-ribosome interaction unveil uORF-dependent regulation of translation initiation and antitumor and antiviral effects.
The RNA m6A landscape during human oocyte-to-embryo transition.
Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses
Essential angiosperm-specific subunits of HDA19 histone deacetylase complexes in Arabidopsis
A versatile toolbox for determining IRES activity in cells and embryonic tissues
1
Infancy IgE methylation score and childhood wheezing and asthma: Multicohort study
5
Conformational Stability Guided Recognition of Human Telomeric G-quadruplex by Human BRCA1 Protein
Collective RNAP Dynamics Link Transcriptional Strength to Fidelity
Fano Factor as the Key Measure of Sensitivity in Biological Networks
Conformational Pathways of Translational T-box Riboswitch Governing tRNA Recognition for Gene Regulation
Destabilizing Interactions in Human Telomeric G-Quadruplex Multimers
13
FVE and HDA9 form a complex to promote thermomorphogenesis by reducing H2A.Z deposition through histone deacetylation
Small RNA directed DNA methylation by Pol IV and Pol V maintains immune homeostasis in soybean
SlYTH3 regulates tomato leaf senescence via recognition of N6-methyladenosine–modified SlHDZIV2 transcripts
Characterization of the miRNA turnover landscape and its regulation in Arabidopsis
The Arabidopsis PRC2 subunit MSI1 interacts with HY5 to repress hypocotyl elongation through H3K27 tri-methylation
FeM-ID: a biotin labeling-based approach for the dissection of female meiotic chromosome behavior in Arabidopsis thaliana
Domain architecture of plant eukaryotic translation initiation factor 3 subunit E governs interaction with translational cis-elements to regulate pollen tube growth
Structural insights into plant DNA CG methylation maintenance by MET1
Structure and autoinhibitory regulation of MET1 in the maintenance of plant CG methylation
The barley m6A demethylase HvALKBH1B undergoes phase separation to enhance immunity to a plant rhabdovirus
Glutathionylation-mediated degradation of a cap-binding protein enhances Arabidopsis resistance to Plutella xylostella
The histone acetyltransferase GCN5 regulates floral meristem activity and flower development in Arabidopsis
A BRASSINOSTEROID INSENSISTIVE 1 receptor kinase ortholog is required for sex determination in Ceratopteris richardii
1
pH-Gated Activation of Nematodes-Secreted NUC-1 Accelerates Extracellular Antibiotic Resistance Gene Degradation in Aquatic Environments

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