Immunology articles for United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

View topic

Count: 852

Article ‘Count’ for Immunology.

Journal Count Share
7 4.46
Universal Nanovial Screening Enables Functional Discovery of Metabolite-Reactive T-Cell Receptors for Cancer Therapy 1.00
Drug-free Immunotherapeutic Biomimetic Nanoparticles for Treating Triple-Negative Breast Cancer 0.11
Cellular Nanoparticle–Probiotic Biohybrid for Multimodal Oral Therapy of Food Allergy 1.00
Lipid Nanoparticle Library Screen Reveals Lymphatic Endothelial Cell-Targeting Lipid Nanoparticle for Delivering Vascular Endothelial Growth Factor C mRNA after Lymphatic Injury 0.93
Natural Macrophage Membrane-Coated Nanoparticles as a Multifaceted Sepsis Therapeutic to Sequester Inflammatory and Toxic Mediators 1.00
mRNA-Based Vaccination Drives in Vivo Dendritic Cell Reprogramming and Selective Cytotoxic T Lymphocyte Modulation for Enhanced Antitumor Immunity 0.33
In Situ Tumor Surface Modification with Antibody Fragments for Antigen-Independent Versatile Cancer Immunotherapy 0.08
1 1.00
Tunable Wrinkled Topographies Direct Dendritic Cell Maturation and Immune Phenotypes 1.00
2 1.00
Nanodisc-Based Platform for HLA Antibody Identification 0.94
Sonodynamic/Mechano‐Induced cGAMP Biosynthesis Enables In Situ STING Activation for Enhanced Cancer Immunotherapy 0.07
2 2.00
Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming 1.00
Macrophages Mediate Mesoscale Brain Mechanical Homeostasis 1.00
1 0.56
Thyroid autoimmunity and the subsequent development of islet and celiac autoimmunity in the TEDDY study 0.56
1 0.69
Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles 0.69
3 1.94
Macrophages Are Critical Inducers of Bleomycin-Induced Fibrosis in a Systemic Scleroderma Model 0.27
PGE2 signaling triggers CD31-independent transendothelial migration in vitro and in vivo. 0.67
Characterizing Kupffer Cell Production of CD5L and Its Function on Regulating Migration of Natural Killer T Cells 1.00
5 3.36
Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: A multicenter, randomized, double-blind, Phase 3A Clinical Trial (NIMBLE) 0.31
Interleukin-6 is a mediator of therapeutic efficacy in acute lung injury 0.10
Self-propagating nature of pathogenic extracellular vesicles associated with smoking and chronic obstructive pulmonary disease 1.00
STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome 1.00
ARDS Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes. 0.95
1 0.08
Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors 0.08
3 1.41
DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study 0.09
Pro-Inflammatory c-Met+ CD4 T Cells in Multiple Sclerosis 0.32
Comparative Safety Profiles of Ocrelizumab and Rituximab in Multiple Sclerosis Treatment Using Real‐World Evidence 1.00
5 2.42
A pathogenic gut lipoglycan drives systemic thromboinflammation in lupus nephritis 0.94
Frequent genetic alterations in myositis autoantigen genes in cancer-associated dermatomyositis 0.06
Clinical and biologic predictors of thrombosis in persistently antiphospholipid antibody-positive patients: Prospective analysis of the International APS ACTION Clinical Database and Repository (‘Registry’) 0.35
IL-2 signalling sustains pathogenic age-associated B cell homeostasis in lupus 0.15
Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome 0.92
9 7.41
The potential role of synovial T‐cell infiltration following knee joint injury in symptoms and progression to osteoarthritis 0.18
Anti-Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap-Mediated Bone Loss in Rheumatoid Arthritis 0.80
Type I Interferon Signature is Associated With Lung Disease, Drug‐Associated Immune Reactions, and Genetic Variation in Interferon‐Linked Pathways in Still Disease 1.00
Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function 1.00
Molecular stratification of antiphospholipid syndrome through integrative analysis of the whole‐blood RNA transcriptome 1.00
Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome 0.89
Diagnostic implications and correlates of plasma ADA2 activity and ADA2 variants 0.61
Sustained Interferon Signature Suppression With Anifrolumab in a Patient With STING‐Associated Vasculopathy with Onset in Infancy Refractory to scpJAK/scp Inhibitor and Dazukibart Therapy 0.93
Loss of Tripartite Motif–Containing Protein 21 and UVB-Induced Systemic Inflammation by Regulating DNA-Sensing Pathways 1.00
16 11.40
Heme-induced ITAM signaling exacerbates malaria-associated neuropathogenesis through activation of platelet mTOR 0.89
DC-SIGN binding to the surface immunoglobulin oligomannose-type glycans promotes follicular lymphoma cell adhesion and survival 0.15
Plasmin modulates neutrophilic inflammation and alveolar macrophage function, protecting mice from pneumococcal pneumonia 0.12
Silencing of PAI-1 using siRNA-lipid nanoparticles reduces thrombosis and prolongs life span in murine models 0.84
Targeting donor XCR1+ and CD11b+ dendritic cells prevents Th1- and Th17-dependent GVHD within the gastrointestinal tract 0.91
The C/EBPα-(PU.1-LOUP) regulatory circuit regulates monocyte/macrophage development and immune functions 1.00
Predicting development of pediatric chronic immune thrombocytopenia at disease onset using a statistical risk model 1.00
RGI-2001 for the prophylaxis of acute graft-versus-host disease after allogeneic HCT 0.80
A single dose of a CD137 antibody–drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD 1.00
Outcomes of allogeneic HCT in Hodgkin lymphoma in the era of checkpoint inhibitors: a joint CIBMTR and EBMT analysis 0.50
The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice 1.00
Phase 1/2 study of high-dose palifermin for GVHD prophylaxis in patients undergoing HLA-matched unrelated donor HCT 1.00
Plasminogen as a Ribonucleoprotein: Regulatory small RNA Cargo Modulates Fibrinolysis and Inflammation 1.00
Clinical and molecular features of immunodeficiency in patients with telomere biology disorders 0.94
RhoA GAP Myo9b regulates β2-integrin activity and neutrophil recruitment during murine acute kidney injury. 0.07
Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study 0.19
11 7.78
Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer 0.98
CCL3 is produced by aged neutrophils across cancers and promotes tumor growth 0.29
Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance 0.75
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth 1.00
IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma 0.92
Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche 0.80
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage 0.11
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas 1.00
DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps 0.04
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity 1.00
A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis 0.89
17 9.16
LINE-1 Retrotransposon Protein ORF1p Forms Condensates That Drive cGAS-Induced Immune Evasion in Lung Squamous Cell Carcinoma 0.15
Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells 0.03
circADAMTS12 Inhibits the Antitumor Activity of Microglia to Enable Metastatic Colonization in the Brain 0.08
Surgery-Induced Neutrophil Extracellular Traps Promote Tumor Metastasis by Reprogramming Cancer Cell Lipid Metabolism 0.91
Artificial Intelligence and Multimodality Data Integration Decipher Tertiary Lymphoid Structure Maturity in Gastric Cancer. 0.12
Hypoxia Induces Immunosuppression by Silencing STING in Cancer 1.00
ChREBP-Mediated Choline Deprivation and Chemokine Secretion Shape Tumor-Associated Macrophages to Promote Immune Evasion 0.07
Response to Immune Checkpoint Blockade is Enhanced in the Presence of Hematopoietic TET2 Inactivation. 0.04
Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer. 0.93
ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes. 0.10
Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis. 1.00
A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression 0.96
Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma that Drives Antitumor Immunity. 1.00
Targeting Innate Immune Checkpoint TREX1 Is a Safe and Effective Immunotherapeutic Strategy in Cancer 1.00
Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T-cell–Mediated Tumor Control 0.61
Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells. 1.00
Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin 0.16
17 13.80
Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function 1.00
STING signaling modulation by COPII cargo recognition 1.00
Stochasticity in cancer immunotherapy stems from rare but functionally critical Spark T cells 0.75
In vivo detection of immune responses via cytokine activity labeling 0.75
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses 0.86
Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense 1.00
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity 1.00
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy 0.29
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells 0.38
Generation of antigen-specific paired-chain antibodies using large language models 0.83
CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success 1.00
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV 0.86
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity 1.00
Highly conserved Betacoronavirus sequences are broadly recognized by human T cells 0.83
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis 1.00
Structure of gut microbial glycolipid modulates host inflammatory response 0.64
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity 0.61
9 6.91
Bacterial 2′,3′-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication 1.00
Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues 1.00
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis 0.12
An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut 1.00
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier 0.95
Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity 0.87
Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance 1.00
Veillonella intestinal colonization promotes C. difficile infection in Crohn’s disease 0.06
Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism 0.91
1 1.00
Posttransplant Cyclophosphamide Reduces Bronchiolitis Obliterans Syndrome Risk Through Chronic Graft vs Host Disease Prevention 1.00
2 1.38
HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance. 0.83
Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. 0.55
9 7.27
Respiratory Syncytial Virus Vaccination in Solid Organ Transplant Recipients: Interim Findings From a Phase 3 Trial of mRNA-1345 0.77
Integrating genomic data into test-negative designs for estimating lineage-specific COVID-19 vaccine effectiveness 1.00
Safety and Immunogenicity of a Fourth Dose of Omicron-BA.1-Adapted BNT162b2 COVID-19 Vaccines in Adults 18‒55 Years Old 0.75
Infections After Kidney Transplantation From Donors With Human Immunodeficiency Virus (HIV) to Recipients With HIV 0.90
Cytomegalovirus-specific cell-mediated immunity for prediction of post-prophylaxis CMV disease in a phase 3 trial of letermovir vs valganciclovir prophylaxis in donor CMV-seropositive recipient CMV-seronegative kidney transplant recipients 0.56
An Analysis of Cytomegalovirus-Specific Cell-Mediated Immunity in a Phase 3, Randomized, Placebo-Controlled Trial of Letermovir Prophylaxis in Cytomegalovirus-Seropositive Recipients of an Allogeneic Hematopoietic Cell Transplant 0.80
IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes 1.00
A Phase 3, Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Conjugate Vaccine, in Pneumococcal Vaccine-Naïve Adults 18–64 Years of Age at Increased Risk of Pneumococcal Disease, STRIDE-8 0.50
Safety, Tolerability, and Immunogenicity of Revaccination With mRNA-1345, an mRNA Vaccine Against RSV, Administered 12 Months Following a Primary Dose in Adults Aged ≥50 Years 1.00
2 1.96
Prognostic Relevance of Inflammatory Subphenotypes in Immunocompromised Patients With Sepsis. 0.96
Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure. 1.00
1 1.00
Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi 1.00
2 2.00
Use of Teplizumab to Modulate Stage 2 Type 1 Diabetes in Two Individuals With Autoimmune Polyendocrine Syndrome 1. 1.00
DNA Methylation Smoking Scores and Risk of Islet Autoimmunity and Type 1 Diabetes. 1.00
1 1.00
Preliminary insights into methylation patterns in Agent Orange exposed thyroid cancers: a pilot study 1.00
2 1.08
Oxidative Stress as a Pathway Linking Maternal Phthalate and Bisphenol Exposure to Childhood Allergy and Lung Function: Mediation and Interaction Analyses 0.08
Associations of Serum PFAS with COVID-19 Antibody Levels among Fully Vaccinated Adults 1.00
4 1.20
Conformation of CD40LG and ANXA5 as Key Events of 2,7-Dibromocarbazole-Induced Cardiotoxicity Using in Vivo and in Vitro Models 0.11
Challenging Additivity: Comparing Predicted and Observed AhR Activity of Polycyclic Aromatic Compound (PAC) Mixtures Containing Active and Inactive Constituents 0.88
Genetic Polymorphisms in Nuclear Receptors Drive Variations in Responses to Environmental Exposures 0.17
Beyond Competitive Binding: New Biochemical Insights Challenge Endocrine Disrupting Chemical Screening Paradigms 0.05
1 0.38
Neutrophil extracellular traps and peptidylarginine deiminase 4–mediated inflammasome activation link diabetes to cardiorenal injury and heart failure 0.38
2 2.00
Blockade of Tumor TAK1 Induces DNA Damage and Immunogenic cGAS–STING Pathway Activation in Pancreatic Cancer 1.00
Quorum-Sensing Molecules Are Elevated in Long-Standing Ulcerative Colitis and Are Linked to the Development of Colitis-Associated Cancer 1.00
2 1.89
Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance 0.89
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus 1.00
2 1.86
A genome-wide survey reveals that a diverse array of enhancers coordinates the Drosophila innate immune response 1.00
Genotyping of selected germline adaptive immune system loci using short-read sequencing data 0.86
2 0.19
The endogenous peptide GPR15L shapes the intestinal microbiota to counteract colitis 0.12
RNA binding protein CAPRIN1 suppresses STAT1 translation and interferon signalling to promote HBV replication 0.07
4 1.94
BMN 349, a small molecule inhibitor of Z alpha-1 antitrypsin polymerization, increases secretion and reduces intrahepatic inclusions in a mouse model of disease. 0.82
CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis. 0.96
Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 Axis to prevent MASH. 0.04
Serum amyloid A1-Induced intrahepatic regulatory T cell dysfunction drives autoimmune hepatitis progression. 0.13
1 0.86
Oncostatin-M: a novel leukocyte-derived factor facilitating the ovulatory process in the human ovary 0.86
46 38.84
Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging 1.00
Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells 0.04
Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation 1.00
Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer 0.86
Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches 0.04
Organ injury in systemic autoimmunity is mediated by stem-like CD8+ T cells arising from tissue-draining lymph nodes 0.94
Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity 1.00
Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration 0.97
Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection 1.00
Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis 1.00
HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung 0.17
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes 1.00
Antibody-mediated feedback modulates interclonal competition in the germinal center 0.88
The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors 1.00
Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation 0.90
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes 0.86
Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation 0.96
Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo 1.00
Opposing functions of distinct regulatory T cell subsets in colorectal cancer 1.00
Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells 1.00
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils 0.81
Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients 0.93
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells 1.00
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry 0.97
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program 0.13
Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma 0.97
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response 1.00
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors 1.00
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors 0.31
Primate resident memory T cells activate humoral and stromal immunity 0.95
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells 1.00
Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes 0.88
Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function 0.94
Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity 0.11
Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence 1.00
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1 test 1.00
Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites 1.00
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment 1.00
The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells 0.89
Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity 1.00
Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells 0.98
DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis 0.80
Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets 1.00
A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response 1.00
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction 0.85
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction 0.70
1 1.00
Early-life exposure to ambient temperature and polycystic ovary syndrome: a nationwide cohort study 1.00
1 0.39
Risk Factors for the Development of Food Allergy in Infants and Children 0.39
2 1.79
Precision Immunotherapy to Improve Sepsis Outcomes 0.81
Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment 0.97
21 16.20
SARS-CoV-2 5′-UTR stem-loops activate the antiviral protein oligoadenylate synthetase 1 (OAS1) 1.00
Structural determinants of ligand response specificity in the mast cell activating GPCR, MRGPRX2 0.75
Stress-induced glucocorticoid signaling impairs enteric neurotrophin BDNF–TrkB pathway and drives gastrointestinal dysmotility 0.94
Extracellular ATP drives tryptophan metabolism and aryl hydrocarbon receptor activation to promote cellular senescence 1.00
The ASC-c isoform as a modulator of inflammasome activation: insights into molecular mechanisms and therapeutic applications 1.00
Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens 1.00
HIF-2α induction in de novo lipogenesis in metabolic dysfunction-associated steatohepatitis is dependent on IL-21 signaling 1.00
Cytosolic nucleic acid sensing triggers type I interferon activation via the Hippo kinase LATS1 1.00
The long non-coding RNA MALAT1 encodes a micropeptide that promotes influenza A virus replication by suppressing innate immune responses 0.07
A CD25–chemokine receptor complex initiates noncanonical IL-2 signaling 1.00
The Hippo Kinases MST1/2 Integrate Sterile and Infectious Signals to Regulate Macrophage Cell Death 1.00
MARCH8-mediated ubiquitination regulates expression of the antiviral protein IFITM3 0.06
Nitric oxide attenuates PI4P accumulation at the ER membrane to inhibit encephalomyocarditis virus replication selectively in β-cells 1.00
Annexin A2 interferes with complement regulation within the glomerulus 0.79
Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus 0.14
Identification and characterization of nanobodies specific for the human ubiquitin–like ISG15 protein 0.60
Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2 0.94
Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain 1.00
Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison 1.00
Prediction of KIR3DL1 and human leukocyte antigen binding 0.14
The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA 0.78
3 2.05
uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells 0.05
CD47 inhibits phagocytosis through Vav dephosphorylation 1.00
Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis 1.00
2 1.24
Relative maternal protection against type 1 diabetes: A combined analysis of 5 observational studies 0.24
Relationship Between Hypothyroidism, Risk of Small Intestinal Bacterial Overgrowth, and Duodenal Microbiome Alterations 1.00
43 32.67
MVA.tHIVconsvX vaccination-evoked T cell expansion inversely associates with age in people with HIV-1 on antiretroviral therapy 0.90
CXCR6+ CD127– Tr1 cells balance immunity and persistence in Plasmodium falciparum infection 0.68
Conventional type-1 DC density is associated with checkpoint inhibitor response across multiple types of cancer 0.17
Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis 0.92
T cell–intrinsic VISTA expression promotes resistance to CTLA-4 blockade by restricting CD8+ T cell responses 1.00
Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients 0.75
TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress 0.10
Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling 0.06
CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic and tolerogenic properties 0.87
Pathobiont-triggered induction of goblet cell response drives regional susceptibility to Inflammatory Bowel Disease 1.00
Galectin-3 mediates lysosome-related inflammation within monocyte-derived macrophages in a mouse model of ischemic brain injury 1.00
Inflammation- and resolution-programmed myeloid circuits govern therapeutic resistance in epithelial and mesenchymal triple-negative breast cancer 1.00
The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers 1.00
Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development 0.68
Mutant p53 promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment 0.93
UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes 1.00
Immobilized IgG-containing immune complexes require platelets to recruit neutrophils during inflammation 0.07
Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation 1.00
A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis 0.60
Molecular glue degrader function of SPOP enhances STING-dependent immunotherapy efficacy in melanoma models 1.00
Aryl hydrocarbon receptor restrains tonic cytokine responses by inhibiting microbiota sensing in monocytes 0.21
S-acyl transferase ZDHHC13 modulates tumor microenvironment interactions to suppress metastasis in melanoma models 0.90
Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes 0.20
Maintenance DNA methylation is required for induced Treg reparative function following viral pneumonia in mice 1.00
A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection 0.91
Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9 1.00
A20’s linear ubiquitin–binding motif restrains pathogenic activation of Th17 cells and IL-22–driven enteritis 1.00
Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis 0.06
SAA1/FPR2 signaling between keratinocytes and neutrophils sustains chronic inflammation in Sweet syndrome 1.00
Loss of tumor cell MHC class II drives MAPK inhibitor insensitivity of BRAF-mutant anaplastic thyroid cancers 0.94
TET3 is a common epigenetic immunomodulator of pathogenic macrophages 0.72
ST8Sia6 overexpression protects pancreatic β cells from spontaneous autoimmune diabetes in nonobese diabetic mice 1.00
CDK12/13 inactivation triggers STING-mediated anti-tumor immunity in pre-clinical models 0.89
Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection 0.03
Treg activation during allograft tolerance induction requires mitochondrial-induced TGFβ1 in type 1 conventional dendritic cells 1.00
ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis 1.00
Type 1 Classical Dendritic Cells Govern Long-term Cardiac Allograft Acceptance 1.00
Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine 1.00
Tumoral RCOR2 promotes tumor development through dual epigenetic regulation of tumor plasticity and immunogenicity 1.00
Blocking immune checkpoint LAIR1 with antibody blockade or 3-in-1 CAR T cells enhances antitumor response 1.00
Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity 1.00
Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines 1.00
Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice 0.06
6 5.94
Randomized, Placebo-Controlled Trial of B-Cell Depletion for Prevention of Corticosteroid-Requiring Chronic Graft-Versus-Host Disease. 1.00
Safety and Clinical Outcomes of Pooled Donor, Nonengrafting Expanded Progenitor Cells in Single-Unit Cord Blood Transplantation. 1.00
Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant. 0.95
Sirolimus and Cyclosporine With Post-Transplant Cyclophosphamide or Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis in Unrelated Donor Hematopoietic Cell Transplantation. 1.00
Primary Results From Blood and Marrow Transplant Clinical Trials Network 1702: Clinical Transplant-Related Long-Term Outcomes of Alternative Donor Allogeneic Transplantation. 1.00
Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation. 0.98
44 24.93
Basophils drive the resolution and promote wound healing in adult and aged mice 0.08
IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens 0.11
DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses 0.07
Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity 0.26
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself 1.00
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation 1.00
The STING HAQ haplotype and clinical non-penetrance in COPA syndrome 0.03
Central neurons encode interleukin-1β signals and mediate stress-induced inflammation 1.00
Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes 0.08
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells 0.74
REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis 0.50
Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis 0.07
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes 0.18
A circadian checkpoint relocates neutrophils to minimize injury 0.13
Notch interaction with RUNX factors regulates initiation of the T-lineage program 0.04
Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity 1.00
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms 0.24
Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans 0.09
Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells 0.93
Identification of lymphatic vessels in skull periosteum but not bone marrow reveals skull channel heterogeneity 1.00
DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts 1.00
Human CD4+ T cells recognize iMycobacterium tuberculosis/i–infected macrophages amid broader responses 0.95
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation 1.00
Dominant negative iADA2/i mutations cause ADA2 deficiency in heterozygous carriers 0.15
Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages 0.95
TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming 0.93
Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action 0.49
The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency 0.81
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine 0.60
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity 0.15
ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma 0.33
Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection 1.00
Epitope and HLA specificity of human TCRs against iPlasmodium falciparum/i circumsporozoite protein 0.33
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum 0.85
A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis 0.08
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency 0.79
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination 1.00
RORγt eTACs mediate oral tolerance and Treg induction 1.00
IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints 1.00
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans 0.96
Factor XII–driven coagulation traps bacterial infections 0.08
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis 0.07
Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits iSalmonella/i 0.92
CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy 0.92
17 13.78
<atl>The tyrosine kinase receptor EphA2 in alveolar macrophages provides a protective role in host defense against iPneumocystis/i pneumonia</atl> 1.00
Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients with HIV 1.00
Impact of COVID-19 Monoclonal Antibody Therapy on Subsequent Vaccine-Elicited SARS-CoV-2 Immune Responses 1.00
<atl>TLR4–MyD88–NF-κB signaling in the airway epithelium promotes iAcinetobacter baumannii/i clearance</atl> 1.00
Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway 0.08
Intracellular Ganciclovir Tri-Phosphate Concentrations in Children with Congenital Cytomegalovirus Infection 1.00
The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children 1.00
A Test-Negative Design for Immune Correlates Approximates a Traditional Exposure Proximal Design but Requires Far Fewer Blood Samples 1.00
Vaccination against pathogens targeting cell-derived cryptic antigens 1.00
National- and state-level SARS-CoV-2 immunity trends from January 2020 to December 2023: a mathematical modeling analysis 1.00
Vaccine-Induced Antibodies to a C-Terminal Plasmodium falciparum Circumsporozoite Protein Epitope Associated With Protection Against Malaria Challenge 1.00
A Multivalent Peptide Vaccine Against Malaria, Targeting iPlasmodium/i Circumsporozoite Protein and Mosquito AgTRIO 1.00
Plasmodium falciparum Parasitemia Does Not Diminish Neutralizing Antibody Responses After mRNA COVID-19 Booster Vaccination in HIV-infected Adults 0.65
Elevated Spleen Tyrosine Kinase in Low-Density Neutrophils During Bacterial Sepsis in a Nonhuman Primate Model 1.00
Sex Differences in Vaccine-Induced Immunity and Protection Against Mycobacterium tuberculosis 0.02
A Functional Polymorphism in IL-36β Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis 0.02
B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients 1.00
3 2.39
Ascl3+ ionocytes in murine salivary gland ducts are innervated sensory cells that display unique calcium signalling characteristics and contribute to the composition of saliva 1.00
Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels 0.89
Control of lymphatic pacemaking and pumping by mechanobiological signals 0.50
1 1.00
Association of Post-Transplant Dialysis and Survival Following Donation after Circulatory Death Heart Transplantation 1.00
1 1.00
Switching between Janus kinase inhibitors for treatment of alopecia areata: A Multi-Center Retrospective Review 1.00
1 0.96
Macromolecular Diamidobenzimidazole Conjugates Can Activate Stimulator of Interferon Genes 0.96
2 1.14
Clinical Relevance of Donor-Derived Cell-Free DNA in Monitoring Kidney Transplant Rejection. 0.14
Effects and Mechanism of 2′-AMP on Renal Vascular Resistance 1.00
6 4.21
A single-arm phase 2 trial of an investigational RNA therapeutic to complement factor B sefaxersen for treatment of IgA nephropathy 0.73
Mechanistic insights from transcript analysis of long-term pig to non-human primate kidney xenografts 1.00
Preclinical evaluation of antigen-specific B-cell depletion for phospholipase A2 receptor membranous nephropathy with chimeric autoantibody receptor T-cells. 1.00
Single-cell spatial transcriptomics reveal intraglomerular cell activation and ligand-receptor relationships in chronic, active antibody mediated rejection 1.00
Revisiting proliferative glomerulonephritis with monoclonal immunoglobulin deposits through immunoglobulin repertoire sequencing 0.28
A systematic literature review and meta-analysis evaluated modifiable risk factors for the development of BK polyoma virus-associated complications 0.20
2 2.00
A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer 1.00
Chromatin folding principles underlying the generation of antibody diversity 1.00
3 0.22
Microbial Legacy: Mycobacterium vaccae ATCC 15483T intergenerationally diversifies the microbiome and enhances stress resilience in male mice 0.12
Comprehensive single-cell transcriptomic atlas of microglia in Alzheimer’s disease mouse models 0.06
Upregulation of adenosine A2A receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits 0.05
1 1.00
DNA Origami Tension Sensors (DOTS) for Single-Molecule Force Measurements at Fluid Intermembrane Junctions 1.00
34 28.74
Submicrometre sampling of living cells by macrophages 1.00
mRNA vaccines engage unconventional pathways in CD8+ T cell priming 1.00
Linear RAG scanning mediates editing of Igκ variable region repertoires 1.00
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity 0.03
Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion 1.00
Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity 0.92
Parasites trigger epithelial cell crosstalk to drive gut–brain signalling 0.35
Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist 1.00
PtdIns(3,5)P is an endogenous ligand of STING in innate immune signalling 1.00
Atlas-guided discovery of transcription factors for T cell programming 1.00
Regulation of STING activation by phosphoinositide and cholesterol 1.00
Ontogeny and transcriptional regulation of Thetis cells 1.00
Environmentally driven immune imprinting protects against allergy 1.00
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 0.09
The transition from monocyte to tissue-resident macrophage requires DHPS 0.59
Neuro-epithelial circuits promote sensory convergence and intestinal immunity 1.00
Erythropoietin receptor on cDC1s dictates immune tolerance 0.84
Architecture of the neutrophil compartment 0.21
iHALT unlocks liver functionality as a surrogate secondary lymphoid organ 1.00
Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells 1.00
Physiology and immunology of pig-to-human decedent kidney xenotransplant 0.84
Multi-omics analysis of a pig-to-human decedent kidney xenotransplant 0.91
Niche-specific dermal macrophage loss promotes skin capillary ageing 1.00
Proteotoxic stress response drives T cell exhaustion and immune evasion 0.98
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling 1.00
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer 1.00
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours 0.94
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition 1.00
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function 0.24
WSTF nuclear autophagy regulates chronic but not acute inflammation 0.91
Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation 0.98
SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunity 1.00
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome 0.98
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells 0.94
4 1.91
T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response 0.86
Target cell cortical tension regulates macrophage trogocytosis 0.83
WDR4 drives tumour-associated macrophage reprogramming and tumour progression via selective translation and membrane cholesterol efflux 0.15
MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy 0.06
3 3.00
Munc13-4–STX7 inhibitors impair endosomal TLR activation and systemic inflammation 1.00
A druggable redox switch on SHP1 controls macrophage inflammation 1.00
Cysteine allostery and autoinhibition govern human STING oligomer functionality 1.00
127 93.95
Molecular mechanisms for subtype selectivity of kinin receptors’ antagonists 0.67
PD-1 regulates latent effector differentiation of thymic cytotoxic CD8 T cells 1.00
Macrophage-derived fibronectin suppresses antitumor immunity via tissue stiffening and immunosuppressive cell induction in cancer mouse models 0.09
TRIM21 facilitates inflammasome assembly and contributes to autoinflammatory disease 1.00
microRNA-25 drives immune checkpoint therapy resistance by repressing innate and humoral immunity via Syndecan-3 1.00
TaRGET II Data Portal: a multi-omics resource for environmental toxicant studies in mice 1.00
Rank-dependent control of tuft and BEST4 cell development in the intestine 0.20
Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution 1.00
All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer 0.83
Efficacy and durability of immediate versus delayed single-dose HPV vaccination for persistent infection among young women in Kenya: a randomized, blinded, cross-over clinical trial 0.66
Cell death modalities modulate inflammatory and regenerative programs in zebrafish sensory organs 1.00
Controlled human malaria infection in adults identify combinations of merozoite antigens associated with clinical immunity 0.12
PTPN2 inhibition unleashes response to STING agonism in head and neck squamous cell cancer 1.00
Molecular architecture of the fungal-specific potassium channel TOK1 1.00
IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control 0.76
Allogeneic hematopoietic cell transplantation in mature T- or NK-lymphomas: a phase II clinical trial 1.00
In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer 1.00
Poor sleep impairs immune responses and influenza vaccine protection 0.92
NKG2A inhibition promotes NK cell-CD8+ T cell interactions to improve anticancer immunity in ovarian carcinoma 0.05
CD4+ T cell protection against murine Salmonella infection is female-specific and estrogen-dependent 1.00
Early life exposure to -nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice 0.92
Multiomics-guided discovery of protective microbiome signatures in lupus-prone mice treated with Faecalibacterium prausnitzii 1.00
β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction 0.71
Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue 1.00
Dissecting PGE2-driven inhibition of T cell activation using single-cell multi-omic and inflammatory bowel disease genetic association analysis 0.89
Tim-3 agonist restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway 1.00
Compartmentalized cytoplasmic tradewinds direct soluble proteins 1.00
Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs 1.00
Antigen-specific immunotherapy with a CD4+ T cell neoepitope restrains CD8+ T cell differentiation in murine pancreatic islet grafts 1.00
CD8+ T cells sustain vaccination-induced immunity against dissemination of contained tuberculosis in immunosuppressed hosts 0.05
Mining antibody functionality via AI-guided structural landscape profiling 0.11
Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells 1.00
TYK2 mediates neuroinflammation in Alzheimer’s disease brains with TDP-43 pathology 0.88
A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine 1.00
Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits 1.00
CD8 T cell loss induces autoinflammation in inborn errors of cell death 0.14
Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma 1.00
Lyn governs the establishment and maintenance of B cell anergy by suppressing PI3K signaling 1.00
Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes 0.64
Idiotype-specific CD4+ T cells chronically stimulate autoreactive B cells to develop into B lymphomas in mice 0.10
Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice 0.93
A multi-center clinical trial of allogeneic hematopoietic stem cell transplantation in transfusion-dependent thalassemia 0.03
RORγt APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens 0.18
STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways 0.96
Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy 1.00
Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression 1.00
Positive cooperativity between RAS-binding and cysteine-rich domains regulates RAF membrane binding kinetics via lateral rebinding 1.00
Human type-1 innate lymphoid cells control leukemia stem cell differentiation and limit acute myeloid leukemia development 1.00
Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA 1.00
Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung 1.00
Intelectin-2 is a broad-spectrum antimicrobial lectin 1.00
Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss 1.00
Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous tracking 1.00
The inflammatory path toward type 1 diabetes begins during pregnancy 0.50
Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming 1.00
Sideways lipid presentation by the antigen-presenting molecule CD1c 0.17
IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production in mice 1.00
Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface 1.00
Distinct gastrointestinal microbial signatures predict parasite levels in controlled Plasmodium infections in both rhesus macaques and humans 1.00
Resistance potential of the HLA-A2-restricted immunodominant SARS-CoV-2-specific CD8+ T cell receptor repertoire to antigenic drift 0.75
Ataxin-2-like promotes translation of nonpolyadenylated reovirus mRNA 1.00
The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex 1.00
Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer 1.00
Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells in mice 1.00
Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease 0.89
Double stranded RNA sensing is silenced during early embryonic development 0.04
Structural basis of PANX1 permeation and positive modulation by mefloquine 1.00
Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes 0.36
Discovery of a small molecule TLR3 agonist adjuvant 1.00
Characterization of Anopheles gambiae immune cells through genetic and functional immunophenotyping 1.00
Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity 0.32
Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice 0.82
A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice 1.00
The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors 0.71
Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability 1.00
Deleterious variants in the autophagy-related gene /FIP200 impair immunity to SARS-CoV-2 0.13
Continuous indices to assess the phenotypic spectrum of kidney transplant rejection 0.16
Atomic mechanisms of full-length ASC-mediated inflammasome assembly 0.13
Epigenetic and transcriptional programming of murine eosinophils in the esophagus 0.90
Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma 0.11
Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults 1.00
A taxon-specific measurement of disruption in a multi-modal study of microbiomes and metabolomes reveals system-wide dysbiosis preceding HIV-1 infection 1.00
Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors 1.00
A monoclonal antibody that inhibits the shedding of CD16a and CD16b and promotes antibody-dependent cellular cytotoxicity against tumors 1.00
Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis 1.00
Gut bacterial dysbiosis in pediatric severe malaria associates with post-discharge mortality 0.62
A Rho GTPase-effector ensemble governs cell migration behavior 0.14
Specification curve analysis of the TEDDY study reveals large variation in microbiome-based T1D predictive performance 1.00
APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signaling 0.87
A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions 0.03
A SARS-CoV-2 variant‑adjusted threshold of protection model for monoclonal antibody pre-exposure prophylaxis against COVID-19 0.67
Global disparities in the introduction, scale-up, and effectiveness evaluation of COVID-19 vaccines 0.17
Selective HLA knockdown and PD-L1 expression prevent allogeneic CAR-NK cell rejection and enhance safety and anti-tumor responses in xenograft mice 1.00
Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV 0.35
Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve–neutrophil axis 0.10
Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation in mice 1.00
A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation 0.72
GM-CSF-dependent CD301b+ mouse lung dendritic cells confer tolerance to inhaled allergens 1.00
Physiologic Homeostasis in a Living Human after Pig Kidney Xenotransplantation 0.98
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes 1.00
NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice 0.20
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor 0.13
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice 0.76
Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3 0.92
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults 0.07
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2 0.11
CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death 1.00
A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis 0.90
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target 0.03
Urinary Complement proteome strongly linked to diabetic kidney disease progression 1.00
The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra 1.00
Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice 0.09
Macrophage-T cell interactions promote SLAMF1 expression for enhanced TB defense 1.00
Integrin CD103 reveals a distinct developmental pathway of autoreactive thymocytes in TCR transgenic mice 1.00
A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection 1.00
Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells 0.80
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells 0.97
Imaging of macrophage accumulation in solid tumors with ultrasound 1.00
Budesonide-incorporated inhalable lipid nanoparticles for antiTSLP nanobody mRNA delivery to treat steroid-resistant asthma 0.40
Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts 0.12
Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responses 1.00
Generating combinatorial diversity via engineered V(D)J-like recombination in Saccharomyces cerevisiae 1.00
Orthosteric STING inhibition elucidates molecular correction of SAVI STING 0.94
Circulating cell-free DNA methylation patterns indicate cellular sources of allograft injury after liver transplant 1.00
Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro 1.00
Androgens inhibit protective CD8 T cell responses against pre-erythrocytic malaria parasites in mice 1.00
CD200R1-CD200 checkpoint inhibits phagocytosis differently from SIRPα-CD47 to suppress tumor growth 0.08
4 2.64
Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis 0.04
High-content CRISPR activation screens identify synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity 1.00
ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity 0.60
Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation 1.00
64 45.70
A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines 0.80
Differential assembly of mouse and human tumor microenvironments 1.00
IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma 0.84
Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets 0.04
BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition 0.86
ZFP148 is a transcriptional repressor of cytolytic effector CD8 T cell differentiation 1.00
MHC class I on target cells regulates CD4 T cell-mediated immunity 1.00
Engineering NK and T cells with metabolite-sensing receptors to target solid tumors 1.00
Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200 Egr2 arthritogenic Th17 cells 0.04
Chemokine-defined macrophage niches establish spatial organization of tumor immunity 1.00
Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome 0.75
Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection 1.00
HLA class I signal peptide variation predicts strength of NKG2A NK cell response to missing-self and risk of human disease 0.67
Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity 0.87
TOX drives CD4 T1 effector function, antitumor immunity and autoimmune pathology 1.00
The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas 1.00
Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice 0.06
2′--Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity 0.06
IL-4–STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing 1.00
Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis 1.00
Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides 1.00
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function 0.12
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID 0.08
Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs 0.90
The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types 1.00
Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy 0.80
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity 0.10
Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury 0.14
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors 0.12
Tissue-resident exhausted and memory CD8 T cells have distinct ontogeny, function and roles in disease 0.99
DC subsets and states unraveled across human juxtatumoral and malignant tissues 0.16
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes 1.00
Neuroepithelial VIP–VIPR1 interactions differentially control enteric type 1 and type 2 immunity 0.05
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate 0.33
Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2 1.00
Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer 0.98
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche 1.00
TSLP links intestinal nutrient sensing with amplification of the ILC2–tuft cell circuit 0.88
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness 1.00
Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion 0.88
The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells 0.12
Transient tissue residency and lymphatic egress define human CD56 NK cell homeostasis 0.33
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells 0.98
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells 1.00
Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV 1.00
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor 0.10
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration 1.00
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity 0.83
Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis 0.98
SATB1 is a key regulator of quiescence in stem-like CD8 T cells 0.97
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation 1.00
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells 1.00
A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity 1.00
TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells 1.00
PD-1 is requisite for skin TRM cell formation and specification by TGFβ 0.83
Secretogranin 2 binds LILRB4 resulting in immunosuppression 1.00
IL-4 impairs the formation of skin-resident memory CD8 T cells 0.86
Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer 0.03
Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis 1.00
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia 1.00
CARD11 signaling regulates CD8+ T cell tumoricidal function 0.06
IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis 1.00
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes 1.00
PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma 0.11
1 1.00
Mechano-induced patterned domain formation by monocytes 1.00
9 4.51
Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial 0.09
Linavonkibart and pembrolizumab in immune checkpoint blockade-resistant advanced solid tumors: a phase 1 trial 1.00
Interpretable inflammation landscape of circulating immune cells 0.13
Immune profiling in a living human recipient of a gene-edited pig kidney 0.85
Influenza vaccine strain selection with an AI-based evolutionary and antigenicity model 1.00
Pig-to-human lung xenotransplantation into a brain-dead recipient 0.07
Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma 0.85
A microRNA-based dynamic risk score for type 1 diabetes 0.03
Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial 0.49
1 1.00
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing 1.00
1 0.93
Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens 0.93
1 1.00
Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development 1.00
1 1.00
Macrophage-mediated refinement of the dural lymphatic regulates social behavior 1.00
5 4.31
Genomic and functional adaptations in the guanylate-binding protein 5 highlight specificities of bat antiviral innate immunity 0.36
Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells 1.00
IL-17 stimulates erythropoiesis in vivo by amplifying the response of erythroid progenitors to erythropoietin 1.00
Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity 0.95
A model of early-life interactions between the gut microbiome and adaptive immunity provides insights into the ontogeny of immune tolerance 1.00
1 1.00
Spatial microenvironments tune immune response dynamics in the Drosophila larval fat body 1.00
1 0.03
Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis: A modelling study. 0.03
1 0.17
Optimal Distributions of Receptors on Arbitrarily Shaped Cell Surfaces 0.17
92 74.34
Transition-state analysis of the arginine-specific human ADP-ribosyltransferase 1 1.00
Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes 1.00
Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation 0.91
Eosinophil-derived COX-2 protects against experimental colitis through the PGE2–IL-22 axis 1.00
Computational design of HLA class I superbinders for broad T cell immunogenicity 0.50
Design principles of the cytotoxic CD8+ T cell response 1.00
The intestinal microbiota impacts nutritional immunity and resistance to Acinetobacter baumannii pneumonia 0.98
Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection 0.95
Deep learning–enabled scaffolding of spatial arrays of PfCSP epitopes 0.93
Single-cell insights: Mosquito Toll activation enhances granulocyte differentiation and immune surveillance via Notch suppression 1.00
Phage display–mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila 1.00
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis 0.68
NLRP1B is an integrated decoy that subverts Shigella flexneri E3 ligase activity to promote effector-triggered immunity 1.00
Inhibition of coronaviral exoribonuclease activity by TRIM-mediated SUMOylation 1.00
KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3 1.00
Spatially structured inflammatory response in the presence of a uniform stimulus 1.00
Tim-3-targeted vaccines overcome tumor immunosuppression and reduce cDC1 dependence to elicit potent anti-tumor immunity 0.80
An autoimmunity-associated allele of PTPN22 enhances innate antiviral immunity to protect against acute coronavirus infection 1.00
C4b-binding protein as an antigenic target in the pathogenesis of antiphosphatidylethanolamine autoantibodies 1.00
Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2 0.11
Invertebrate miRNA pva-small RNA-11881/pva-miR-11881 as a potential RNA-based therapeutic against white spot syndrome virus in infected shrimp 0.33
Immune cells employ intermittent integrin-mediated traction forces for 3D migration 0.01
The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion 0.97
Adhesion forces between macrophages and cancer cells promote early tumor development 0.11
ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering 1.00
Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis 0.68
Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis 1.00
Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease 0.67
A framework integrating multiscale in silico modeling and experimental data predicts CAR-NK cell cytotoxicity across target cell types 1.00
Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection 0.92
Mapping targetable sites on the human surfaceome for the design of novel binders 0.18
A temporal and spatial atlas of adaptive immune responses in the lymph node following viral infection 1.00
Functionally heterogeneous intratumoral CD4+CD8+ double-positive T cells can give rise to single-positive T cells 1.00
Shigella OspF blocks rapid p38-dependent priming of the NAIP–NLRC4 inflammasome 1.00
Pathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis 0.85
T-bet-expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape 0.91
Design of solubly expressed miniaturized SMART MHCs 0.86
Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection 1.00
Turncoat antibodies unmasked in a model of autoimmune demyelination: From biology to therapy 0.27
Recruiting ESCRT to single-chain heterotrimer peptide MHCI releases antigen-presenting vesicles that stimulate T cells selectively 1.00
IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis 1.00
WDFY4-dependent cross-presentation proceeds via a vacuolar antigen-processing route 1.00
Identification of an IRF–ZBP1–caspase-8–NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease 1.00
Machine learning enables de novo multiepitope design of Plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody 1.00
Endothelial cells sialylate IgG within the FcRn-mediated recycling pathway 1.00
Rroid2 regulates effector-to-memory CD8+ T cell differentiation during infection in vivo 0.45
Modulation of the PGRMC1/NLRP7/HLA-C axis by autophagy is linked to both spontaneous preterm birth and gestational choriocarcinoma 0.08
Using a mental model approach to undercut the effects of exposure to mRNA vaccination misconceptions: Two randomized trials 1.00
Dynamics and variegation in the Treg response to Interleukin-2 1.00
High-throughput screening for class I peptide MHC binding via yeast surface display 1.00
PAK2-driven cytoskeleton–endosome dynamics control macrophage hyperphagia and SIRPA engagement 0.25
cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity 1.00
Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell–generated cGAMP 1.00
Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid–like structures and enhance antitumor immunity 1.00
Local control of T cell fate in lymph nodes safely and durably reverses myelin-driven autoimmunity 1.00
T cell receptor specificity landscape revealed through de novo peptide design 1.00
A time-gated PKA–CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4+ T cells 1.00
Parallel reactions on a single T cell receptor offer a robust kinetic proofreading mechanism 1.00
PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors 1.00
Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation 1.00
C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer’s disease and mediates synapse pruning 1.00
Nanoscale restructuring of the immune synapse with an engager enhances NK cell function 0.38
Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow 0.96
Structurally diverse viral inhibitors converge on a shared mechanism to stall the antigen transporter TAP 1.00
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer 0.95
The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins 0.39
Synovial MS4A4A correlates with inflammation and counteracts response to corticosteroids in arthritis 0.02
Inflammation awakens dormant cancer cells by modulating the epithelial–mesenchymal phenotypic state 0.77
Identification of AMOTL2 as an antiviral factor that enhances the human type I interferon response against Zika virus 1.00
HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes 0.05
CRISPR with Transcriptional Readout reveals influenza transcription is modulated by NELF and can precipitate an interferon response 1.00
Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice 1.00
Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis 1.00
ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability 0.20
Elucidating the role of Campylobacter concisus–derived indole metabolites in gut inflammation and immune modulation 0.95
Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy 1.00
Intranasal measles virus– and mumps virus–based SARS-CoV-2 vaccine candidates prevent SARS-CoV-2 infection and transmission 0.98
Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature 0.83
Early-life human CD8+ T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape 1.00
Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes 1.00
Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan 0.06
Synergy between membrane topography and domains to control signaling protein localization in mast cells facilitates their activation 0.90
A noncanonical cGAS–STING pathway drives cellular and organismal aging 1.00
BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza 1.00
Human milk IgA promotes normal immune development by limiting Th17-inducing Erysipelatoclostridium ramosum in the infant gut 0.08
DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers 0.54
Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy 0.03
Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis 1.00
FcγRIIIa is a noncanonical costimulatory molecule for CD8 T cells 0.86
Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia 1.00
Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices 1.00
Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders 1.00
20 15.91
Pan-cancer spatial atlas of tertiary lymphoid structures 0.93
Disordered protein LAT encodes relative levels of signaling pathways in T cell activation 1.00
Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity 0.98
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering 1.00
Mucosal vaccination in mice provides protection from diverse respiratory threats 1.00
Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response 0.90
Transcription factor Etv3 controls the tolerogenic function of dendritic cells 0.95
Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation 0.07
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity 1.00
Rebalancing viral and immune damage versus repair prevents death from lethal influenza infection 0.88
The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors 1.00
MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists 0.15
Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens 0.94
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice 0.96
Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens 0.92
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway 0.16
Design of high-specificity binders for peptide–MHC-I complexes 1.00
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells 0.19
De novo design and structure of a peptide–centric TCR mimic binding module 1.00
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense 0.89
52 39.29
Mechanisms of ligand recognition and channel opening for P2X2 receptors in lipid nanodiscs 0.83
DHX36 is a regulatory switch in the interferon-mediated antiviral response 0.11
Protein language models accurately predict polymorphic peptide–modulated NK cell receptor–HLA class I interaction strengths 0.86
Dissection of the T cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T cell repertoire 0.18
Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices 1.00
Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center 1.00
Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines 0.55
Persistent antigen is essential for sustaining Leishmania major–specific memory CD4+ T cells and long-term immunity 0.08
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome 0.08
Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling 0.04
KIT supports small intestinal tuft cell hyperplasia 1.00
cPLA2α targeting to exosomes connects nuclear deformation to LTB4-signaling during neutrophil chemotaxis 0.97
Identification of a type 1 diabetes–associated T cell receptor repertoire signature from the human peripheral blood 0.66
Discovery and preclinical evaluation of monoclonal antibodies and bispecific engagers targeting the NKG2A inhibitory receptor 1.00
Longitudinal monitoring of type 1 diabetes progression to disease onset 1.00
TDRD3, a Tudor domain-containing protein, regulates Klf2-dependent Treg differentiation and function to modulate immune tolerance 1.00
Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas 1.00
CD318 expression defines a novel subset of human CD8+ regulatory T cells 0.89
Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance 1.00
Architectural principles of transporter-chaperone coupling within the native MHC I peptide-loading complex 0.13
Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells 1.00
HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors 0.86
STING/type I interferon pathway is required for antigen-containing PLGA nanoparticle- and apoptotic cell–induced CD4+ T cell tolerance 1.00
LPS-induced structural reorganization and polymerization drive noncanonical inflammasome activation 1.00
Unconventional CD8+ T cell surveillance of cytomegalovirus via Qa-1/HLA-E–restricted epitope recognition 1.00
VAPB is a negative regulator of STING-mediated innate immune signaling 0.11
Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost 1.00
Small things matter: Lack of extraislet β cells in type 1 diabetes 0.11
TH1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata 1.00
Quantitative and large-scale investigation of human TCR-HLA cross-reactivity 1.00
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma 0.95
Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis 1.00
Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells 0.91
Development of SARS-CoV-2 as a viral vector: A novel intranasal bivalent vaccine for SARS-CoV-2 and RSV 1.00
STK11 coordinates IL-4 signaling with metabolic reprogramming to control M2 macrophage polarization and antitumor immunity 0.95
Bispecific antibodies cross-link and redirect CD8+ T cells to kill cytomegalovirus-infected cells 1.00
Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression 0.86
Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis 0.99
IgM and IgG1 B cell receptors differentially affect B cell fates and dictate the pathogenesis of mature B cell lymphomas 0.89
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems 0.92
A Dapl1+ subpopulation of naïve CD8 T cells is enriched for memory-lineage precursors 1.00
USP30 inhibition augments mitophagy to prevent T cell exhaustion 1.00
A two-step mechanism for RIG-I activation by influenza virus mvRNAs 0.86
The β2-adrenergic receptor (Adrb2) entrains circadian gene oscillation and CD8+ T cell differentiation in response to virus infection 1.00
BLIMP1 negatively regulates IL-2 signaling in T cells 1.00
Complex I inhibition combined with TLR activation in the breast tumor microenvironment educates cytotoxic neutrophils 0.12
Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)–vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial 1.00
Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon 0.75
Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine 0.10
AbEpiTope-1.0: Improved antibody target prediction by use of AlphaFold and inverse folding 0.50
Armored human CAR Treg cells with PD1 promoter-driven IL-10 have enhanced suppressive function 0.07
Fecal metabolite profiling identifies critically ill patients with increased 30-day mortality 0.98
12 10.89
A mitochondrial ROS–dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes 1.00
CD39+CD49a+CD103+ cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice 1.00
Keratin 16 inhibits type I interferon responses in differentiating keratinocytes of stressed and diseased skin 0.80
Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation 1.00
The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost 0.99
Phase 1 and preclinical studies reveal safety, pharmacokinetics, and efficacy of intranasal delivery of the influenza antibody CR9114 0.27
Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy 1.00
Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans 1.00
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo 0.97
Donor-recipient mismatch at the SIRPA locus adversely affects kidney allograft outcomes 0.87
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans 0.99
IFN-γ–resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models 1.00
10 4.86
T-cell protrusions enable fast, localised initiation of chimeric antigen receptor signalling 0.13
FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster 0.08
Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission 0.83
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells 0.10
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 1.00
The twist-and-squeeze activation of CARF-fused adenosine deaminase by cyclic oligoadenylates 0.67
VH-replacement shapes the antibody repertoire by removing the genes of non-functional heavy-chains 0.14
Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells 0.63
Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases 0.29
Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage 1.00
1 0.10
Milk IgA promotes symbionts and limits pathobionts in the early life gut 0.10
36 25.90
Coexistent alterations of BAFF and B cell phenotypes in complicated CVID course 1.00
Long-acting IL-7 restores T-cell reconstitution in a humanized mouse model of lymphopenia 1.00
CXCL16 as a Potential Therapeutic Target to Limit the Activity of Asthmatic CD4 Memory T cells 1.00
Characterization of missense variants in the signal peptide of the C1-esterase inhibitor 0.80
Hereditary Angioedema iPSC Models Implicate ER-Associated Degradation as a Potential Therapeutic Target 0.07
Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis 0.96
AZD8630/AMG 104, an inhaled Anti-TSLP antibody fragment, for moderate-to-severe asthma: a phase 1 randomized controlled trial 0.25
Group 2 innate lymphoid cells program pulmonary adaptive immunity via granulocyte-macrophage colony-stimulating factor 1.00
Allogeneic hematopoietic cell transplantation for partial RAG deficiency in children and adults: Excellent outcomes with a reduced-intensity posttransplantation cyclophosphamide–based approach 0.94
Complement C3 links epithelial remodeling and macrophage metabolic reprogramming in allergic rhinitis 0.45
Comprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata 1.00
Functional assessment of a convergent gene network underlying allergic diseases and IgE 0.12
Heterozygous variants in DOCK2 leading to susceptibility to viral illnesses 1.00
A clinically validated assay for rapid determination of type I and type II interferon activity in systemic inflammatory diseases 0.92
Alpha-gal-specific human IgE promotes both alpha-gal-induced and antigen-independent allergic effector cell activation 1.00
Interactions between host genetics and gut microbiome influence susceptibility to childhood asthma and lung function 1.00
B-cell lymphocytosis and reprogramming due to biallelic CARD11 mutations 0.64
CCR8+ST2+ tissue-resident regulatory T cells constrain type 2 immunity to environmental allergens in the lungs 1.00
IRF1 is an Upstream Regulatory Transcription Factor of Eosinophils in Type 1 Environments 0.91
Fabs targeting a Cε2 epitope disassemble IgE-receptor complexes and suppress anaphylaxis 0.25
Oral immunotherapy suppresses peripheral blood transcriptomic response to peanut in peanut allergy 1.00
Utilization of the All of Us Research Program in study of genetics in Yao syndrome 1.00
Basophils Activate Oncostatin M Receptor-expressing Vagal Sensory Neurons. 0.20
Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation 0.48
High-affinity omalizumab variants with optimized disruptive potency prevent anaphylaxis in vivo 0.33
BTK modulates systemic immune activation to bacterial translocation in primary antibody deficiencies 1.00
Late Effects After Haematopoietic Stem Cell Transplantation in patients with HLH: A Histiocyte Society, PDWP, IEWP and TCWP EBMT Study 0.03
Unraveling Mechanisms of Allergen Sensitization and Allergic Rhinitis via the Nasal Transcriptome 1.00
Effect of Dupilumab on Small Airways Measured by Airway Oscillometry in VESTIGE 0.67
Autosomal dominant Roquin-1 immunodeficiency and hyper-inflammation 0.13
Anti-KIT antibody, briquilimab, induces mast cell apoptosis and depletion in non-human primates 1.00
Autoantibodies in patients with 22q11.2 deletion syndrome and psychosis 0.80
The Bruton’s tyrosine kinase inhibitor acalabrutinib aborts ongoing acute food-induced anaphylactic reactions in humanized mice 1.00
T cell and autoantibody profiling for primary immune regulatory disorders 0.93
Positionally distinct interferon-stimulated dermal immune-acting fibroblasts promote neutrophil recruitment in Sweet’s syndrome 1.00
Mast cells modulate macrophage biology through release of pre-stored CSF1 0.02
1 0.47
Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study 0.47
1 0.13
Non-autoimmune, insulin-deficient diabetes in children and young adults in Africa: evidence from the Young-Onset Diabetes in sub-Saharan Africa (YODA) cross-sectional study 0.13
15 6.77
Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults 0.62
Immunogenicity and Safety of vYF, a Yellow Fever Vaccine — A Phase 2 Trial 0.62
A Phase 2 Randomized Trial of Mezagitamab in Primary Immune Thrombocytopenia 0.46
Iptacopan in IgA Nephropathy — Final 24-Month Data 0.10
Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia 0.38
Ianalumab plus Eltrombopag in Immune Thrombocytopenia 0.12
Prime Editing for p47phox-Deficient Chronic Granulomatous Disease 0.79
Noninferiority of One HPV Vaccine Dose to Two Doses 0.52
Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN 0.30
Engasertib versus Placebo for Bleeding in Hereditary Hemorrhagic Telangiectasia 0.12
Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine 0.89
Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026 0.96
Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency 0.61
RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults 0.26
Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin 0.02

Numerical information only (in the tables above) is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International.