Summary
Cardiovascular medicine addresses a spectrum of diseases affecting the heart, blood vessels and circulatory system, including coronary artery disease, heart failure, valvular disorders and arrhythmias, underpinned by processes such as atherosclerosis, inflammation and neurohumoral dysregulation. Advances in imaging and interventional techniques—from echocardiography and cardiac magnetic resonance to transcatheter valve therapies and ventricular assist devices—have transformed diagnostic precision and therapeutic outcomes. Haematology focuses on the cellular and molecular biology of blood and haemostasis, encompassing erythropoiesis, leukocyte function, platelet aggregation and coagulation pathways. Disorders range from anaemias and haemoglobinopathies to bleeding diatheses and thrombotic syndromes. Integration of molecular diagnostics, targeted anticoagulant strategies and blood‐component innovations, including haemoglobin‐based oxygen carriers, has reshaped patient management. The intersection of these fields is exemplified by thrombotic complications in cardiovascular disease and perioperative blood management, emphasising the need for multidisciplinary care that spans prevention, acute intervention and long‐term rehabilitation on a global scale.
Research from Nature Portfolio
Control‐oriented phenomenological models are now capable of predicting viscoelastic clot properties from rapid measurements of plasma protein concentrations. These models forecast key thromboelastography outputs in minutes, paving the way for automated coagulation monitoring in surgical and critical‐care settings. Quantitative analysis of thrombin at clot time across simultaneous thrombin‐generation and fibrin‐formation assays has shown that clot‐time thrombin levels provide complementary insight into procoagulant phenotype, varying with peak thrombin and revealing distinct plasma profiles. Foundational work on thrombin dynamics has further elucidated how variations in prothrombin conversion and inactivation, driven mainly by factor X and antithrombin levels, govern thrombin generation in conditions such as liver cirrhosis and renal failure.
Topic trend for the past 5 years
The graph below shows the article count in Nature Index journals for cardiovascular medicine and haematology.
* The ‘Current Index’ represents data for a 12-month rolling window, the current window is 1 May 2025 - 30 April 2026.
Technical terms
Atherosclerosis: Chronic inflammatory disease of arterial walls marked by lipid deposition, fibrous plaque formation and risk of plaque rupture.
Thrombosis: Pathological blood clot formation within the vasculature, leading to vessel occlusion and tissue ischaemia.
Haemostasis: The coordinated process of vascular constriction, platelet plug formation and coagulation that arrests bleeding.
Heart failure with preserved ejection fraction (HFpEF): A syndrome of diastolic dysfunction in which left ventricular ejection fraction remains ≥ 50% but ventricular relaxation and filling are impaired.
Thromboelastography (TEG): A viscoelastic assay that measures the kinetics and strength of clot formation in whole blood.
Haemoglobin‐based oxygen carrier (HBOC): A therapeutic agent composed of modified or encapsulated haemoglobin designed to transport oxygen independently of red cells.
cGMP–PKG axis: A signalling pathway in which cyclic guanosine monophosphate activates protein kinase G to mediate vasodilation and myocardial compliance.
Phenomenological model: A simplified mathematical representation that captures system behaviour based on observed relationships rather than detailed mechanistic kinetics.
Notable articles in cardiovascular medicine and haematology
- A wearable cardiac ultrasound imager. Nature (2023).
- Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nature Communications (2016).
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell (2016).
- Cellular senescence mediates fibrotic pulmonary disease. Nature Communications (2017).
About these summaries
This Nature Research Intelligence Topic summary is created with the cited references and a large language model. We take care to ground generated text with facts, and have systems in place to gain human feedback on the overall quality of the process in line with our AI principles. We strive to create accurate and useful summaries for people unfamiliar with the research topic and that supports this goal. These pages are a beta release and will be updated as we learn how best to help people gain value from a research topic summary.
Research
Position of Cardiovascular Medicine and Haematology in Nature Index by Count
Leading institutions
| Institution | Count | Share |
|---|---|---|
| Harvard University | 233 | 69.6 |
| Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) | 64 | 24.62 |
| Mayo Clinic | 73 | 20.21 |
| Stanford University | 78 | 18.6 |
| Shanghai Jiao Tong University (SJTU) | 41 | 16.98 |
| Imperial College London (ICL) | 95 | 14.53 |
| Vanderbilt University (VU) | 62 | 14.27 |
| University of Toronto (U of T) | 65 | 14.14 |
| University of Pennsylvania (Penn) | 74 | 14.11 |
| Johns Hopkins University (JHU) | 67 | 13.78 |
Leading countries/territories
| Countries/territories | Count | Share |
|---|---|---|
| United States of America (USA) | 893 | 586.49 |
| China | 361 | 292.01 |
| United Kingdom (UK) | 323 | 113.19 |
| Germany | 237 | 72.94 |
| Canada | 205 | 64.12 |
| France | 154 | 51.82 |
| Australia | 145 | 47.74 |
| Netherlands | 165 | 46.49 |
| South Korea | 76 | 45.81 |
| Italy | 171 | 40.69 |
Collaboration
Top 5 leading collaborators in Cardiovascular Medicine and Haematology
Collaborating institutions
Note: Hover over the bars to view details about each institution's Share.
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