Medicinal and Biomolecular Chemistry articles

Time frame: 1 July 2025 - 30 June 2026

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Count: 1000

Article ‘Count’ for Medicinal and Biomolecular Chemistry.

Journal Count
17
Programmable DNA Folding Modulates Phase Behavior and Dynamics of DNA/Peptide Condensates
Emergence of Anisotropic Subcompartments via Coassembly of Hierarchically Ordered G-Quadruplexes and Fluid Polylysine in Droplet-Based Compartments
Precisely Staging Diabetic Nephropathy by a Gold-Based Artificial Filtration Biomarker through Computed Tomography and Blood Testing of the Glomerular Filtration Rate
Mesoporous PdPt Nanozymes with Target Peptides and Cascade Reactive Oxygen Species Scavenging for Boosting Alzheimer’s Disease Treatment
Mapping the Functional Architecture of Influenza A Virus-Induced Phase Separation through m6A Proximity Labeling
Multivalent Interactions between Chaperone and Ribosome-Nascent Chain Complex Revealed by High-Speed AFM and MD Simulations
Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids
RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction
Hierarchical Structural Organization in Bioinspired Peptide Coacervate Microdroplets
Selective Identification of Allosteric Inhibitors and Co-Drug Combinations Targeting Kinases by Using a Nanopore Tweezer Approach
Drug-Induced Reversible Lysosomal Changes Tracked in Live Cells by Holo-Tomographic Flow Cytometry
Controlling Amyloid Assembly Dynamics Using Spin Interfaces
Interfacial Silicification Efficiently Drives Osteogenic Differentiation of Mesenchymal Stem Cells without Any Exogenous Osteoinductive Factor
Self-Assembly of Accumulated Sphingolipids into Cytotoxic Fibrils in Globoid Cell Leukodystrophy and Their Inhibition by Small Molecules In Vitro
Molecular Engineering of DNA Condensates: Harnessing Phase Transitions for Precise Control of Catalytic Functions
Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition
6
Conformation-driven mechanical duality: viscoelastic and poroelastic switching in protein hydrogels
Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice
Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits
Targeting injury-triggered grancalcin from senescent macrophages enhances aged bone healing
The human osteocyte lacunocanalicular network structure in osteons of the iliac crest of elderly women depends on mineral content but not individual age
Spatio-temporal characterization of compositional and cellular properties in the murine fracture callus
9
Multifunctional Gold Nanocluster-Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease
Identification of a Bioactive Domain in Type II Collagen That Promotes Bone Repair via EGFR Signaling
Modulation of Ice Formation and Removal Dynamics by Antifreeze Protein-Inspired Large-Area Films
ZnS/Au Composites Advance Comprehensive Characterization of Low-Molecular-Weight Compounds Toward Pharmaceutical Analysis of Traditional Chinese Medicine
Bone‐Homing Cellular Backpacks Integrating Metabolic Intervention and Synergistic Osteogenesis to Treat Bone Metastasis and Promote Diabetic Bone Repair
pH‐Tunable Material Properties of Glycine‐Rich Condensates from Tick Bioadhesive
The Anisotropic Adsorption of De Novo Allosteric Two-Component Protein Fibers on Mica Surfaces
Deep Learning-Driven Co-Assembly of Naturally Sourced Compound Nanoparticles for Potentiated Cancer Immunotherapy
Poly-Lipoic Acid Trisulfide Particles: A New Donor With Continuous and Steady H2S Supply
3
Bioinspired, Mitochondria-Targeted Single-Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​
A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide
1
The interstitial collagenases MMP13 and MMP14 are dispensable for the early onset of skin morphogenesis, but modulate endochondral ossification
63
Native Mass Spectrometry Analysis of Cullin-RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation
Structural Localization of Mass-Degenerate Intact tRNAPHE Species by Ion-Pair UHPLC–HRMS and CID–MS3
Systematic Mapping of Protein Interactions Underlying IL-2 Secretion in Human T Cells
AirNet: A Deep Learning-Driven Auto Baseline Correction Algorithm Balancing Global Smoothness and Local Fidelity
Organelle-Specific Interactome Mapping via Enzyme-Responsive Cross-Linking and Proximity Labeling
A Mitochondria-Targeting Probe for Extended Imaging of H2S and Viscosity in Rheumatoid Arthritis
Correlating Molecule Counts with Stress Granule Size Using Novel Platinized Carbon Nanopore Electrodes
PROTAC-Based Proteomics Strategy Uncovers Arsenic-Binding Proteomes
Cysteine-Triggered Hydrogen Sulfide Nanoprodrug for Real-Time Imaging and Therapeutic Evaluation of Acute Kidney Injury
Nanopipettes Enable Native Mass Spectrometry Studies of the Intrinsically Disordered Protein α-Synuclein in Biochemical Buffers
Chemical Redirection of Protein Folding Landscapes via Lysine-Targeted Induction of Helix-to-Sheet Transitions
Tracking Protein Misfolding and Oligomerization: A Temperature-Controlled Ion Mobility-Mass Spectrometry Approach
Assessment of Protein Conformation via Diazirine-Promoted Oxidation of Methionine and Tryptophan Residues
A Brain-Permeable Selenocyanate Near-Infrared (NIR) Probe Platform for H2S Dynamics Imaging: Insights into Redox Homeostasis and Antiepileptic Therapy
Advanced NMR Characterization and Sensitive Detection of Isoaspartate in Proteins
Five-in-One Neurodetoxification-Guardian-Type Near-Infrared Carbon Dots for Synergistic Blockade of Alzheimer’s Disease Pathological Cascade
Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA–Protein Cross-Links: Formation and Repair in Human Cells
A Novel RNA-Light Probe for Structured-Illumination Microscopy Super-Resolution Imaging of Nucleolar Ultrastructure and Analysis of Nucleolar Dynamics
Screening of Ruthenium Complexes as the Protein Light Switches for Protein Detection
Revealing Structure-Reporting Patterns of Pyruvylation Effects on 13C NMR Chemical Shifts in Natural Saccharides
In Situ Study of p53, MDM2, and MDMX Protein Interaction in Living Cells Using Fluorescence Triple Correlation Spectroscopy
MOSCAT: Aldehyde-Selective Chemical Proteomics for Site-Specific Profiling of Cinnamaldehyde Targets in Living Cells
Elucidation of the Effects of Electrostatic Interactions on Protein Structures at Buried Solid/Liquid Interfaces: A Combined Study with Experiment, Simulation, Isotope Labeling, and Spectra Calculation
Studying Collagen Architecture in Solution by Raman Optical Activity Spectroscopy
Bead-Ejection Scenario in Electrospray Ionization of Multidomain Nucleic Acids
A Covalent Targeted Platform for Protein Dynamic Tracking
Development of an Accurate Double Isotopic Standard LC–MS/MS Method for Hyaluronic Acid Quantification in Biological Matrices
Beyond Binding Affinity: Detailed Profiling of Protein–Ligand Interactions with Time-Resolved FRET
Cross-Linking and Covalent Labeling Mass Spectrometry Reveal Proteoform-Driven Conformational Changes in Alpha Synuclein
Nonmodified Strategy Enabled Proteome-Wide Mapping of Catechol Derivatives Interactome
TIPP: A Novel Iodoacetamide Reaction-Induced Protein Precipitation Approach for Proteome-Wide Ligand-Target Identification
Characterization of Cell–Surface Interactions of Ligands Using 19F NMR and DNP Hyperpolarization
Clickable Multitargeting Cross-Linkers Based on SuFEx for In Vivo Cross-Linking Mass Spectrometry
Three Conformations of Polyglutamic Acid Monitored by Vibrational Optical Activity
Study of the Aggregation Behavior of Proteins Related to Neurodegenerative Diseases Based on the Photoluminescence of Perovskite Nanocrystals
Ultrasensitive Biocoded SERS Immunoassay for Tracing Molecular Gatekeeper Mfn2 Expression within Single Cells during Stem Cell Differentiation
NanoBRET-Based Biosensor for High-Throughput Screening of RAB11A–FIP2 Interaction Inhibitors
Stabilizing Proteins by Chemical Cross-Linking: Insights into Conformation, Unfolding, and Aggregation Using Native Ion Mobility Mass Spectrometry
Effects of Charged Surface on Electrochemical Sensitivity to Protein Dimerization
Lasso Peptide Syanodin I: Loop-Pulling Two-Step Thermal Unthreading Mechanism
Toward-Automated Etalon Artifacts Elimination in Dual-Wavelength Raman Spectroscopy for In Vivo Applications
Selective Probing of Acidic Amino Acid Residues for Protein Structural Analysis by Covalent Labeling and Mass Spectrometry
Mapping Protein-ssDNA Interactions at Single Nucleotide Resolution by Dual Nucleases-Assisted Next-Generation Sequencing
Heat-Induced Protein Oxidation as an Impediment for Thermal Stability Measurements: A Case Study on Cytochrome c
Cocktail Chemical Labeling for In-Depth Surfaceome Profiling of Bone-Marrow-Derived Dendritic Cells
Streamlined Methods for Profiling Targeted Michael Acceptor Molecules Reveal Natural PTP1B Covalent Inhibitors
Specific Lung-Targeting Shortwave Infrared Luminescence Nanoprobe: Precisely Delineating Sepsis-Induced Acute Lung Injury
Cell Permeability and Target Engagement of Middle-Sized Molecules Quantified by In-Cell NMR
Sulfoxide-diazirine (SODA) as a Cleavable Photoaffinity Group To Enable the Identification of Photolabeled Modification Sites via LC–MSsup3/sup
Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures (NECEEM)-Enabled Mechanistic Analysis of Cooperative Binding: Application to C-Reactive Protein–SOMAmer Complexes
Gold Nanoparticle Aggregation Pathways Probed by Evanescent Wave Cavity Ringdown Spectroscopy: The Role of Guanidine Hydrochloride and scpl/scp-Tryptophan
Clear Native Gel Electrophoresis for the Purification of Fluorescently Labeled Membrane Proteins in Native Nanodiscs
Beyond Traditional airPLS: Improved Baseline Removal in SERS with Parameter-Focused Optimization and Prediction
Acrolein as an Alternative Broadly Reactive Activity-Based Probe for Activity-Based Protein Profiling of Cysteinome
Robust Chemical Cross-linking of Proteins and Protein Complexes via SuFEx Click Chemistry
Paired Analyses of Nuclear Protein Targets and Genomic DNA by Single-Cell Western Blot and Single-Cell PCR
Novel Urazole-Derived MS-Cleavable Cross-Linkers Targeting Tyrosine/Lysine Residues for Protein Structural Analysis
Peroxynitrite-Activated Conditional Chemical Probe for the Affinity-Based Protein Modification
Molecular Optimization of a Near-Infrared Fluorogenic Probe for Hydrogen Polysulfide Imaging in Acute Liver Injury
Stable Isotope Labeling in Bacteria Enables Characterization and Quantification of Frataxin Protein in a Friedreich’s Ataxia Zebrafish Model
Differentiating Molecular Weights of Supramolecular Polymers in Lower Monomer Concentrations by Coreaction Accelerator-Regulated Electrochemiluminescence
FRAP4ICBS: FRAP Analysis Method to Evaluate Dominant Effects for Biomolecular Condensate Formation
Chemoproteomic Profiling of Isoprenoid Pyrophosphate Interacting Proteins with Photoaffinity Probes
57
Structural Control of Dual Emission in Coumarin Fluorophores for Visualizing Protein Droplet Maturation
4-Formyl-N-Methylpyridinium-Mediated N-Terminal Cysteine Modification/Removal Facilitates One-Pot Multiplex Peptide Ligation
Post-Translational Isoaspartate Promotes Amyloid Formation in β2-Microglobulin
A 19F MRI/NIR-FL Nanoprobe for “Turn-On” Imaging of β-Secretase (BACE1) Activity in Alzheimer's Disease
Unraveling G-Quadruplex and i-Motif Coexistence Within a Double-Stranded DNA
Ferritin Iron Mineralisation: Route of Fe3+ Transfer From the Ferroxidase Centre to the Inner Cavity of Human H-Chain Ferritin
A Non-Covalent [4Fe–4S]/[2Fe] Interface in HydF Guides [FeFe]-Hydrogenase Maturation
3-Deoxy-3-Fluoro Mannuronic Acid Alginates: Stereoselective Automated Synthesis and Conformational Behaviour
Enzymatic Encoding of Topology in an Intrinsically Disordered Single‐Chain Protein
Total Chemical Synthesis of Interleukin-15 and Interleukin-2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy
Generalized Analysis of Electrophilic Small Molecules
DNA‐Induced Entropic Gain Triggers an Allosteric Switch for Biomolecular Condensation of Heat Shock Transcription Factor 1
Cyclo‐Polyproline: Chameleonic All‐Peptide Macrocycles With Induced‐Fit Host‐Guest Recognition
Precise Synthesis of Highly Branched Angelica dahurica Polysaccharides up to 66 Units Reveals a Minimal Motif for Wound Repair
Photochemically Generated Sulfenylnitrene Unlocks Chemoselective Activation of Conventional Thioglycosides for Stereocontrolled Furanosylations
Profiling the Structural Heterogeneity of Monomeric α‐Synuclein From the Single‐Molecule Level Using MspA Nanopores
Modular Synthesis of Neisseria meningitidis Lipooligosaccharide Inner Core Oligosaccharide Library to Identify Broadly Reactive Antigenic Epitopes
Ansamer‐Controlled Bicyclic Peptides as Integrin αvβ6 Targeting Agents
Glycinamide-Driven Coumarin Construction (GDCC): A Mild Strategy for Fluorescent Labeling and Macrocyclization of Peptides
Elucidating the Stereodirecting Effect of C-4 Acyl Groups on Galactosyl Donors
Expeditious Synthesis of 2‐Deoxy‐2‐perfluoroalkyl Glycosides
Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases
Programmable DNA Nanostructures for hTERT Compartmentalization and Translocation in Living Cells
Side-Chain Engineering Guides the Design of β-Sheet Inhibitor to Anchor Protein-Protein Interaction Interfaces
Fibril Structure of Desiccation-Protective Tardigrade Protein CAHS-8
A Convergent Hybrid Gram-Scale Synthesis of Tirzepatide: Tangential Flow Filtration Assisted Native Chemical Ligation-Desulfurization Approach
Site-Selective Ligand Selection by Mutational Profiling for Covalent RNA Targeting
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation
Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship
Coexistence of G‐Quadruplex and i‐Motif Within a DNA Duplex is Tolerated by a PCBP2‐Assisted Replisome
Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities
In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking
Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides
Cyclometalated Gold(III)-Mediated Cysteine Arylation: A Bioorthogonal Platform for Covalent Targeting of Intrinsically Disordered Proteins
Fully‐Functionalized Natural Product Probes to Expand the Chemical Tractability of the Human Proteome
Synergistic SuFEx-Driven Covalent Cancer Therapy Using a HER2/EGFR Bivalent Affinity Protein Drug
Simultaneous Induction and Self‐Reporting of Nucleolar Stress by a Nucleolus‐Targeted Platinum(II) Complex via Lifetime Imaging
De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor
A Picolyl-Based Cys Caging/Uncaging Strategy Facilitates Protein Synthesis
Discovery of a Cryptic Pocket in EcDsbA Opens New Opportunities for Antibacterial Discovery
Studies of α′,β′-Epoxyketone Synthesis by Small-Molecule Flavins and Flavoenzymes
Carbonothioate‐Triggered Cascade Cyclization Enables High‐Specificity Fluorescence Imaging of Hydrogen Polysulfides
High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly
Electrochemical Late-Stage Stitching of Tryptophan Peptides via N─S Bond Formation
Iron-Catalyzed Highly Stereospecific Glycosylation with Glycal Epoxides
Topologically Tunable α‐Helix Mimetics for Targeting Protein–Protein Interactions
Total Synthesis of Feglymycin Using Umpolung Amide Synthesis
Activity‐Based Ubiquitin Probes Capture the Sulfenylated State of Deubiquitinases
Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases
Cell‐Active, Irreversible Covalent Inhibitors Targeting a Surface‐Exposed Non‐Catalytic Lysine on Aurora a Kinase by Using Squarate Chemistry
Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE
Divergent Synthesis of ΔAA‐Peptides Using a Bioorthogonal ipro/i‐Amino Acid and Aqueous Flavin Photocatalyst: Green Light Enhances Catalyst Performance and Product Selectivity
Pd-Catalyzed Stereospecific and Ligand-Controlled Regiodivergent Suzuki–Miyaura Cross-Coupling for the Synthesis of 3-C-Glycals and 2,3-Unsaturated C-Glycosides
Amide Chemistry Enables Redox Locking of Cyclic Disulfides for Polypeptide Assembly
Reengineering of a Proteomimetic Pan‐Ras Inhibitor into a Ras Degrader
Bulk Measurement of Membrane Permeability for Random Cyclic Peptides in Living Cells to Guide Drug Development
Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins
1
Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood
1
Cystathionine γ‐Lyase‐Dependent S‐Sulfhydration of Smad3: A Novel Target to Alleviate Fibrosis in Systemic Sclerosis
3
HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer’s disease
Study of blood linear RNA nominates CD55 and DLD as early-stage biomarkers for Parkinson's disease
Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways
9
Deep learning of functional perturbations from condensate morphology
Nuclear speckles enable processing of RNA from GC-rich isochores
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
Metabolically regulated proteasome supramolecular organization in situ
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2
Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress
1
Mitochondrial dysfunction reveals H2S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects
20
Self-assembly of binary peptide system in the solid state induced by the presence of environmental water – an unusual case of ex vivo peptide cooperation
Strategic alkene incorporation into peptide backbones to prevent enzymatic hydrolysis by evading molecular recognition
Conformational plasticity of holliday junctions tunes histone H1–mediated liquid–liquid phase separation
Chiral biphenanthrene-diol-based lanthanide cubanes
Protein migration via dissolution of ATP-stabilized condensate in a gradient of AMP
Chemoenzymatic synthesis of sulfated O-glycopeptides from human CD34
Photochemical HAT-mediated site-selective C(sp3)–H aminoalkylation of cubanes catalyzed by TBADT
Forces behind N- and C-capping of peptidic helices
The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides
Acetylacetone-modified ubiquitin C-terminus enables specific capture of sulfenylated deubiquitinases
β-barrels from short macrocyclic peptides
Backbone nitrogen substitution restricts the conformation of glycine residues in β-turns
Photoswitchable inhibitors: temporally regulated inhibition of the IDO1 enzyme using photoactive merocyanine derivatives
Base-mediated alkynyl-cubane to Cu8-alkynide cluster transformation
Foldamer engineering with squaramide and phenanthroline motifs: synthesis, characterisation, and structural insights
Conditional disorder in proteins: functional transitions between order and disorder
An esterase-sensitive persulfide/hydrogen sulfide generating fluorogenic probe enhances antioxidant response
Backbone cleavage of peptides and proteins ivia/i cysteine iS/i-fluoroacetylation
Direct Measurement of SARS-CoV-2 Spike RBD Binding to Integrin αvβ6 by Single-Molecule Force Spectroscopy
One-pot, chemoselective desulfurative functionalization of cysteine containing peptides using pyridinium salts
30
Conformational landscapes resolved by ion mobility mass spectrometry reveal mechanisms of polyubiquitin-controlled phase separation
Beyond the two-conformer model: boat conformers provide stereoselectivity in SN1-type glycosylations of manno-type donors
Design of permeability-optimized target-binding macrocycles via direct preference optimization
Core-block engineering enables control of ice recrystallisation inhibition in polymer nanoparticles
Pd-catalyzed stereoretentive synthesis of reversed C-acyl glycosides: access to rare l-sugars and higher-carbon sugars
Deciphering the molecular origin of the 19.3 eV electronic excitation energy of H3+
Mass spectrometry detects folding intermediates populated during urea-induced protein denaturation
Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media
How electronic and steric effects in acceptor alcohols shape SN1- and SN2-type glycosylation reactions
Amyloidogenic oligomers derived from TDP-43 LCD promote the condensation and phosphorylation of TDP-43
Guanine nucleotide directed co-assembly with Pt-complexes for tailoring chiroptical properties and multimodal molecular recognition
Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils
Yeast [FeFe]-hydrogenase-like protein Nar1 binds a [2Fe–2S] cluster
Engineering β-sheet morphologies via metal cross-linking and side chain modifications
Simulations reveal a balance between protein–protein and protein–lipid interactions during condensation on membrane surfaces
DNA aggregation and resolubilization in the presence of polyamines probed at the single molecule level using nanopores
Impact of vibrational strong coupling on liquid–liquid phase separation in supramolecular polymers
Unprecedented allosteric inhibition of E. coli malate dehydrogenase by silver(i) from atomic resolution analysis
The ‘ins’ and ‘outs’ of amidines in β-sheet folding and fibril disaggregation
Light responsive hydrogen selenide (H2Se)/hydrogen diselenide (H2Se2) donors: applied for protein S-selenylation on PRDX6
From concept to chemistry: integrating protection group strategy and reaction feasibility into non-natural amino acid synthesis planning
Identification, occurrence and prevention of aspartimide-related byproducts in chemical protein synthesis
Europium probe binding to serum albumin and αsub1/sub-AGP, key importance of configuration, charge and size complementarity
Macrocyclization of backbone iN/i-methylated peptides by a prolyl oligopeptidase with a distinctive substrate recognition mechanism
Phylogeny-guided discovery of a promiscuous P450 macrocyclase for the production of diverse atropopeptides
Intracellular evaluation of protein droplet-forming capability using self-assembling peptide tags
Selectively triggered: ROS-activated Michael acceptor prodrug strategy to enhance tumor targeting efficacy
Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives
Design and characterisation of photoactivatable and lysine reactive io/i-nitrobenzyl alcohol-based crosslinkers
Synthesis and functionalization of vinyl sulfonimidamides and their potential as electrophilic warheads
1
Growth Differentiation Factor-15 Improves Prognostic Accuracy of Risk Stratification in Pulmonary Arterial Hypertension
1
Disrupted hippocampal replay is associated with reduced offline map stabilization in an Alzheimer’s mouse model
2
Insolubilome profiling defines molecular features that influence protein insolubility with aging
Nuclear lamina phase separation orchestrates stress-induced transcriptional responses in plants
1
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli
3
Deceleration of Proton Exchange between Monosaccharides and Water by Metallocryptand and Related Compounds
Squaramide-Based MOF Enables Hydrogen-Bond-Directed Ultraselective Guanine Detection and Drug Monitoring
Synthesis and Structural Characterization of a Glycoconjugated Re(CO)3+ Complex and Its Tendency for CO Release
65
ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KB
Nar1 binds the cytosolic iron–sulfur cluster assembly targeting complex via bipartite interactions
Stable and Tunable Expression of Human Peripheral Myelin Protein 22 in Rat Schwann Cells
Intragenomic riboregulatory interaction modulates the conformation of the hepatitis C virus 3′X RNA
DNA methylation, nucleic acid structure, and Rett mutations tune MeCP2 binding affinity and cooperativity
The iron-sulfur cluster assembly factor FDX2 is required for tumor initiation but not for growth of established tumors in transplantation models.
Structural basis for selective thymidine binding by the Borrelia burgdorferi substrate-binding protein BmpA
Tail-anchored protein C-terminal domains stimulate ATP hydrolysis by the P5A-ATPase Spf1p
Quantitative FRET FLIM imaging reveals multiple interactions between proteins of the ESYT, ORP, and VAP families at the endoplasmic reticulum membrane
Mechanism-selective inhibition of α-synuclein aggregation by the chaperone-like BRICHOS domain
Insights into the Role of Internal Catalysts in Asparagine‐to‐Succinimide Conversion in a Hyperthermophilic Glutamine Amidotransferase
Calcium-loaded acylated segment controls membrane penetration capacity of repeats-in-toxin cytolysins
Actin’s functional “switch”: Constraining C-terminal conformational flexibility disrupts functionally important communication networks
Biosensor-Guided Discovery of Peptide Inhibitors Targeting the Ribosomal Protein uS5-PDCD2 Chaperone Interaction
Direct interaction between human DDX1 and SARS-CoV-2 Nucleocapsid protein is regulated by phosphorylation
Protein loops are major contributors to DNA strand separation and high-fidelity substrate recognition for DNA methyltransferase CcrM
Cleavage at the nsp5/nsp6 site of SARS-CoV-2 main protease intermediate precursor is faster from a monomer than a dimer form
The crystal structure of the herpes virus ICP8 protein in complex with single-stranded DNA reveals the molecular determinants of nucleotide recognition
Stability and interaction defects in the Sin3A-PAH1 αα-hub domain associated with loss-of-function variants
Transcriptome-guided discovery and active-site gatekeeper engineering of a Viola arcuata asparaginyl ligase with superior catalytic performance
The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation
Human Pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4–NOT deadenylase complex to repress mRNAs
P-bodies act as dynamic control hubs for RNA processing and storage
Domain-selective folding of the tandem β-propeller protein Coronin 7 (Coro7) by the chaperonin CCT/TRiC
Phosphorylation-dependent regulation of serine/arginine-rich proteins and U2AF1 interactions in early spliceosome assembly
Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E. coli
Tryptophan metabolites 3-hydroxykynurenine (3HK) and 3-hydroxyanthranilic acid (3HAA) increase oxidative stress and impair osteoblastic bone formation
Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro
The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate–binding domain
Hydrogen sulfide increases intracellular oxygen and inhibits the HIF response
Hyaluronic acid regulates cellular UDP-GlcNAc levels through CD44 to affect glycosylation and cell biological functions
Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates
PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS
Regulation of the orphan G-protein–coupled receptor GPRC5B by MLC1 and the cell adhesion molecule GlialCAM in megalencephalic leukoencephalopathy
Spontaneous Dimerization of the Hepatitis C Virus 3′X RNA
Bacillus subtilis encodes three N-acetylcysteine deacetylase enzymes that can catalyze the final step in S-(2-succino)cysteine breakdown
Structural and biophysical insights into RomR, MglB, and MglC interactions involved in regulating cell polarity in Myxococcus xanthus
Hsp90 co-chaperone FKBP4 facilitates CCT8 folding and connects Hsp90 to chaperonin-dependent proteostasis
A split luciferase system for studying coronavirus Mpro dimerization in vitro and in living cells
Mapping the intracellular HMGB1 interactome and alterations induced by Toll-like receptor 4 activation
A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases
J-domain proteins cooperate with Hsp70 to drive multiphase separation of RNA-binding-deficient TDP-43
Distinct liquid-liquid phase separation properties of end-binding proteins EB1 and EB3
Sp100A isoform promotes localization of the histone chaperone HIRA to PML nuclear bodies
Pre-N and C-terminal extension regions of Arabidopsis HSP90.7 regulate the chaperone activity and ER stress response
Missense mutations in intrinsically disordered protein regions link pathogenicity and phase separation
APP family is a regulator of endo-lysosomal membrane vulnerability
IRE1/Xbp1 promotes the clearance of poly(GR) dipeptide repeats in amyotrophic lateral sclerosis
Structural basis for L-isoaspartyl-containing protein recognition by the human PCMTD1 cullin-RING E3 ubiquitin ligase
The trypanosome vault particle is composed of multiple major vault protein paralogs and harbors vault RNA
Cryo-EM study and in vivo chemical mapping of the Methanosarcina acetivorans ribosome and its dimerization via a repurposed enzyme and translation factor
Hydrogen sulfide–dependent activation of human sulfide quinone oxidoreductase
Key roles in copper efflux and protein homeostasis of the intrinsically disordered region of a bacterial outer membrane channel
Deciphering mutational effects on inducible NO synthase conformational dynamics via quantitative cross-linking mass spectrometry and AlphaFold2 subsampling
BR-bodies facilitate adaptive responses and survival during copper stress in Caulobacter crescentus
Lipid bilayer properties govern substrate engagement and extraction by the AAA+ ATPase Msp1
Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides
Nuclear basket proteins Nup2 and Mlp1 drive heat shock–induced 3D genome restructuring downstream of transcriptional activation
Molecular determinants of picornavirus 3C protease binding to phosphoinositide-enriched lipid membranes
Negatively charged α-synuclein condensate modulates partitioning of molecules
Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug binding
The impact of RNA chemical probing reagents on RNA-binding proteins
Bioluminescence-based assays for quantifying endogenous protein interactions in live cells
Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS
1
Of Mice and Men: Temporal Comparison of Femoral Shaft Fracture Healing After Intramedullary Nailing: Retrospective Observational Study of Modified Radiographic Union Scores for Tibia.
8
Stress-induced nucleolar rejuvenation via chaperone-mediated segregation in a filamentous fungus
IQSEC2/BRAG1 may modulate postsynaptic density assembly through Ca2+-induced phase separation
Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins
Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways
CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization
A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells
Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics
Pex30-dependent membrane contact sites maintain ER lipid homeostasis
1
Enhancing essential oil extraction from orange peels using ultrasound-assisted hydro-distillation: A sustainable approach
1
Identification of a Novel Compound Heterozygous Variant in the ALPL Gene Linked to Hypophosphatasia in a Chinese Family
4
The liver regulates ectopic calcification in Abcc6-deficient models of Pseudoxanthoma Elasticum
Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness
Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis
1
Hydrogen Cyanide Generation by Pseudomonas aeruginosa Blunts the Host Innate Immune Response
4
Trans-dimerization of Amyloid Precursor Protein family members induces pre- and postsynaptic differentiation through distinct signaling pathways
The Intracellular Domain of the Epilepsy Protein PCDH19 Regulates Spine Density in Cortical Neurons In Vivo via Xlr Genes
Restoration of sFRP3 preserves the neural stem cell pool and spatial discrimination ability in a mouse model of Alzheimer’s disease
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer’s Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration
1
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks
140
Alternative Splicing of a Structured Partner Alters the Folding-Upon-Binding Trajectory of an Intrinsically Disordered Protein
Quantification of Binding of Small Molecules to Native Kinases by Flow Cytometry Reveals Divergence from Biochemical Affinities
Chemoenzymatic Synthesis of Asymmetric N-Glycans in Aqueous Solution via Sulfate and Phosphate Orthogonal Protection
Direct Photoredox Synthesis of N-Linked Glycoproteins
Stereoretentive and Regioselective Late-Stage C–H Glycosylation
Interplay of Noncovalent Interactions in Phase Separation Mediated by Tyrosine-Rich and Arginine-Rich Polypeptides
Sulfonyl-γ-AAs as Turn Templates Inducing β-Sheet Conformation in Macrocyclic Peptides
The Cytosolic Zinc Finger Domain Structure of the CCHFV Glycoprotein n Is Maintained in Its Membrane-Bound Form
Photocatalytic Activation of Alkyl Diazirine Probes for In Situ Drug Profiling and Extracellular Vesicle-Based Diagnostics
Towards Sustainable Synthesis of Peptide Therapeutics via Tag-Assisted Peptide Synthesis and Aryl Selenoester Aminolysis Ligation
Total Synthesis of Conjugation-Ready Sulfated Red Algae Carrageenan Oligosaccharides for Sensing Applications
Size of Biomolecular Condensates Dictates Fate in Liquid–Solid Phase Transitions through Amorphous–Amyloid Competition
Site-Specific Raman Probes Reveal Droplet Aging and Residue-Level Fibril Polymorphism in TDP-43CTD
Anomer-Selective Vorbrüggen Reaction for the Catalytic Synthesis of C2-Deoxynucleoside Analogues
Phase Separation Driven by Dynamic Interactions in the N‑Terminal Intrinsically Disordered Region of the DEAD-Box RNA Helicase DDX3X
A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease
Intermolecular β-sheet Formation Guides the Interaction between Ubiquitin-like Modifier FAT10 and Adapter Protein NUB1L
Distinct RNA Physical Microenvironments Shape Unique Properties and Functions within Biomolecular Condensates
Condensates as Conformation Editors of Disordered Client Proteins
Comprehensive Chemoproteomics Unveils Selective HMG-CoA Synthase 1 Inhibitors for Targeting Mevalonate Metabolism in Cancer
Condensate Formation by Structured dsRNA Binding Domains Drives RNA Sequestration in Plants
Mechanism of Aggregation of the NACore of α‑Synuclein: Stable Oligomer Formation Competes with Fibril Formation with Implications for the Etiology of Parkinson’s Disease
Catalyst-Controlled Chemoselective β-Mannosylation of Phenols Via Attractive Noncovalent Interactions
Proximity of the Histone-Acetylation Site to the Termini Shapes Phase Behavior with DNA
Interface Architecture of a VHL-PROTAC Complex with and without Cullin-2
Probing Supramolecular Motion with Nuclear Magnetic Resonance in Bioactive Scaffolds that Promote Neural Regeneration in the Central Nervous System
OptoChaperoneA Biohybrid Tool for Regulating Protein Condensates in Cells and In Vitro
Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent Ribonucleic Acid Modulation
Bridging Heterocycle-Mediated Hydrogen Bonding Facilitates Permeability of Polar Macrobicycles
Nicotine-Inspired, De Novo-Designed SARS-CoV‑2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad
Beyond a Passive Tether: Structural Insights into the Disordered Tail of Hsp90
A Versatile Strategy for Head-to-Tail Macrocyclization and Traceless Backbone Editing of Short Peptides
Determination of α‑Synuclein Protein Interactions by μMap Photoproximity Labeling
RaPID Selection of α-Hydrazino Acid-Containing Macrocyclic Peptides
Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation
Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape
Quantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass Spectrometry
Discovery of Ultrapotent Heterodimeric Peptide Ligands Using Library-vs-Library RaPID Selections
Molecular Dynamics-Guided Design and Chemoproteomic Profiling of Covalent Kinase Activity Probes
Directional Engineering of Cyclic β-Hairpin Peptides for PET/CT Imaging of PD-L1
Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity
Partially Protected N-Acetylglycosamine Donors Enable Direct β-O-Glycosylation: Applications and Mechanistic Insights
OaAEP1-Mediated Ligation of Mirror-Image Peptides via Acyl Donor Substrate Engineering
Hijacking Actin-Pre-Liquid–Liquid Phase Separation Suppresses Malignant Tumor Invasion and Growth
Repositioning the Leader Peptide in Graspetide Biosynthesis
Macrocyclic Peptides Containing an Imidazopyridinium (IP+) Unit Display Enhanced Passive Cell Permeability
Distinct Effects of the Extracellular Domain and Antibody Binding on HER2 Transmembrane and Juxtamembrane Regions Unveiled by NMR and EPR
Structural Sensitivity without Chirality: Observation of Magnetic Raman Optical Activity outside Resonance
Aromatic Interactions Select for Homodimeric Assembly in a Quadruply Hydrogen-Bonded DADA 1,2-Azaphosphinine Dimer
Total Synthesis of the Glycoside Antibiotic Paulomycin A
TAV2b Peptide Derivatives Underwind and Stabilize Double-Stranded RNA upon Binding
Accessing Underexplored Biosynthetic Potential by Initiation Unit Engineering of Nonribosomal Peptide Synthetases in Proteobacteria
Single-Cell Native Mass Spectrometry for In Situ Detection of Protein–Drug Complexes in Live Cells
Structural Heterogeneity and Hydrodynamics of an Intrinsically Disordered Protein Condensate
A Tandem Bioorthogonal Retro-Cope and Cope Elimination for the Activation of Covalent Inhibitors with an Acrylamide or Vinylsulfonamide Warhead in Live Cells
Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting
Mesostructured Water Enhances Stability of ProteinMPNN-Designed Ubiquitin-Fold Proteins
Monooxygenase Activity of Indoleamine 2,3-Dioxygenase
Polysaccharide Meets Polyoxazoline: Regio- and Stereodefined β-1,2-Linked Pseudo-polysaccharides via Controlled Cationic Ring-Opening Polymerization
Measurement and Control of Crossed Potentials in a Flavoprotein
Group Competition Strategy for Covalent Ligand Discovery
Chemical Protein Synthesis via Direction-Switching One-Pot Peptide Ligation Enabled by Orthogonal Cysteinyl Protection
Linkage-Editing of β-Glucosylceramide and β-Glucosylcholesterol: Development of β-Selective C-Glucosylation and Potent Mincle Ligands
H+ Ions and ATP Reshape the Conformational Landscape of an RNA Recognition Motif and Regulate Its Fibrillation
Terminal Conjugation Enables Nanopore Sequencing of Peptides
Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology
DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions
Monomer Isolation from Oligomeric Proteins within Coordination Cages to Study Interface Ligand Binding
Peptidyl Asparaginyl Ligase-Mediated Orthogonal Ligation at Non-Asx Peptide Bonds for d-Peptide Cyclization and Antibody Dual Labeling
Merging Enzymatic Catalysis with Iron Catalysis for Highly Stereoselective Heparan Sulfate Oligosaccharide Assembly
Total Synthesis of the TIM-1 IgV Domain via N-to-C Serine/Threonine Ligation Enabled by Knorr Pyrazole Synthesis-Mediated Regeneration of Salicylaldehyde Esters
Dioxazolones as Masked Isocyanate Electrophiles for Global Profiling of Lysine Reactivity and Ligandability
In-Cell Residue-Resolved NMR of Micromolar α-Synuclein and Tau at 310 K
Sustainable Peptide Synthesis by Photoredox-Catalyzed Picoc-SPPS
Inertial Agitation in an NMR Magnet: Real-Time Monitoring of Protein Aggregation at High Resolution
The [4Fe-4S] Cluster of HydF Is Essential for [FeFe]-Hydrogenase Maturation
Multiplexed Analysis of Multicomponent Biomolecular Condensates without Any Tag
Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA
Development, Scope, and Catalyst Selection in Boron-Catalyzed Iterative Glycosylation
Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation
Structural Heterogeneity of the Membrane-Interacting Region of the HIV-1 Envelope Glycoprotein
Decoding Arginine Dimethylation Isomers via pH-Tuned Reactivity with Methylglyoxal: A Chemical Approach for Functional Proteomics
Evolution of Hydrogen-Bonding Networks in Glycerol Dimer and Trimer: How Close Are They to Water Clusters?
Chemoselective Tagging of Protein Methacrylation
Cooperation and Competition of Base Pairing and Electrostatic Interactions in Mixtures of DNA Nanostars and Polylysine
Rate-Tunable, Metal-Mediated Amide Bond Cleavage for the Controlled Release of Pharmaceuticals
Chemically Fueled, Active Droplets Prevent the Aging of Peptides into Amyloid-Like Fibers
De Novo Discovery of α,α-Disubstituted α-amino Acid-Containing α-helical Peptides as Competitive PPARγ PPI Inhibitors
Ribosomal Elongation of Trans-4-Aminocrotonic Acids into Nascent Peptide Chain
Traceless 6-O-Lysyl Modification of N-Acetylglucosamine Enables Synthesis and Derivatization of Aggregation-Prone GlcNAcylated Peptides
Programmable Helicity and Macrocycle Symmetry in β-Peptides via Site-Selective Thioamide Substitution
Heterochiral and Heterotypic Self-Assembly of Intrinsically Disordered Peptides Confers Peptide Supercoils with Exceptional Proteolytic Stability
Thiocrown Ether: Reversing SN1 to SN2 Pathways in 1,2-cis Phosphoryl Glycosylation
Anfinsen Redux: Ribonuclease Folding in the Single-Molecule Regime
Responsive Plasmonic Reporters Decrypt Nanoparticle-Induced Single Membrane Protein Degradation
Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy
Nucleotide-Specific RNA Conformations and Dynamics as Precursors to Ribonucleoprotein Condensates
Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design
The Mechanism of Mineral Nucleation and Growth in a Mini-Ferritin
Site-Specific Profiling of RNA-Binding Proteins Enabled by Isotopic Signature-Enhanced Mass Spectrometry
Live-Cell Monitoring and Omics Analysis of Liquid–Solid Transitions of Biomolecular Condensates
β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins
Conformation and Dynamics of Monomeric, Phase-Separated, and Cross-Linked Resilin Biomaterials
Residue-Resolved Liquid-State Hyperpolarized NMR of Peptide Condensate Surfaces
Immunoglobulin-Directed Phase Separation for Cell-Specific Modulation of Receptor Signaling
Retention and Rearrangement of Membrane Protein Complexes’ Higher Order Structure by Collisionally Activated Dissociation- and Electron Capture Dissociation-Mass Spectrometry
Hydration (Hsub2/subO and Dsub2/subO) Dictates the Stabilities and Conformational Entropy of Transthyretin Tetramers
Discovery of Macrocyclic Peptide Binders, Covalent Modifiers, and Degraders of a Structured RNA by mRNA Display
Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders
Cyclic Hydroxylamines for Native Residue-Forming Peptide Ligations: Synthesis of Ubiquitin and Tirzepatide
A Conserved Cia1–Cia2 Interface Mediates Client Recruitment in the Cytosolic Iron–Sulfur Cluster Assembly Pathway
Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization
Beyond the Amyloid Core: Modulation of Aggregate Conformational Diversity by Mutations in the Noncore Regions
On-Cell Saturation Transfer Difference NMR Spectroscopy on Ion Channels: Characterizing Negative Allosteric Modulator Binding Interactions of P2X7
Exploring Phage Peptide Scaffolds: Tyrosinase-Mediated Cyclization for Selective Generation of Bioactive Cyclic Peptides
Atomic Resolution Interactions Regulating Partitioning of a FUS Folded RRM Domain into Model CAPRIN1 Condensates
Intrastrand Peptide Staples That Promote β-Sheet Folding, Self-Assembly, and Amyloid Seeding
Pushing Sensitivity and Specificity Limits in Native Structural Biology: sup19/supF Multinuclear Dynamic Nuclear Polarization with Magic Angle Spinning
Radical Propagation via σ-Cleavage Mediates Radical SAM Catalyzed Sulfur-for-Oxygen Swapping Reaction during the Biosynthesis of Albomycin δ2
Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase
A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates
NMR-Guided Studies to Establish the Binding Interaction between a Peptoid and Protein
Direct Cellular Screening of Pd-Mediated Arylation of Cyclic Peptide Binders Targeting Ubiquitin Chains: Toward Modulating NEMO Liquid–Liquid Phase Separation
A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo
Single-Entity Resolution Single-Cell Nanosensor Reveals Reactive Oxygen Species at Stress Granules Are Formed by Interfacial Redox Chemistry
Ribosomal Incorporation of Fluorosulfonyloxy-l-Phenylalanine into Macrocyclic Peptides for De Novo Target-Specific Covalent Binders
Structural Mechanism of Insect Cuticular Protein Binding to Chitin Revealed by Solid-State NMR
Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates
Small Molecule Catalyst for Peptide Synthesis
Proline-Mediated Enhancement in Evolvability of Disulfide-Rich Peptides for Discovering Protein Binders
Sequence Programmable Order–Disorder Transitions in Supramolecular Assembly of Peptide Nanofibers
Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission
Design and Application of Cereblon-Recruiting Prodegraders
iDe Novo/i Peptides That Induce the Liquid–Liquid Phase Separation of α-Synuclein
Overcoming the Hydrolytic Susceptibility of Thiol-Reactive Reversible Warheads through the Development of Substituted Phenyl Cyanoacrylamides
μMap-FFPE: A High-Resolution Protein Proximity Labeling Platform for Formalin-Fixed Paraffin-Embedded Tissue Samples
Chaperone-Mediated Regulation of Tau Phase Separation, Fibrillation, and Toxicity
Elucidating the Curtin–Hammett Principle in Glycosylation Reactions: The Decisive Role of Equatorial Glycosyl Triflates
An α-Helically Folded α-Aminoisobutyric Acid (Aib) Oligomer That Assembles into a Metal–Peptide Superhelical Nanotube
Controlling Multiphase Coacervate Wetting and Self-Organization by Interfacial Proteins
1
Mesangial Cell–Derived Extracellular Matrix Protein 1 Is Essential for Maintaining Mesangial Matrix Homeostasis and Glomerular Architecture
4
Role of the Post-translational ISGylation of Interferon Regulatory Factor 9 in Diabetes-Induced Podocyte Injury
A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
Proteinase 3 drives murine diabetic kidney disease by mediating caspase-3-dependent apoptosis of podocytes
Heat shock protein 70s are modifiers of endothelial function in Fabry disease
3
Generative Multi-Property Refinement of Polymer Chemistries
Spectroscopic Determination of Ion-Binding Environment in Alkali-Driven Ionically Cross-Linked Hyaluronic Acid Hydrogels
Aging-Directed Structural Evolution of In Situ Formed Polymeric Coacervates and Their Applications in Constructing Hierarchical Assemblies
28
Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages
LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance
Alphaviral non-structural protein-host RBP co-condensation as a mechanism to sustain virus replication
Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins
High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects
PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes
Condition-dependent amorphous protein agglomerates control cytoplasmic rheology
Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility
2′-O-Methylation maintains ribosome structural and translation integrity
NAC promotes co-translational protein folding at the ribosomal tunnel exit
Herpes simplex virus 1 fluidizes the nucleus, enabling condensate formation
Global profiling of nascent chain interactors reveals TRIM25 as a co-translational E3 ubiquitin ligase
Engineering intrinsically disordered regions for guiding genome navigation
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions
The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
Membrane-protein-mediated phase separation orchestrates organelle contact sites
Mechanical forces regulate the composition and fate of stalled nascent chains
The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs
A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum
Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery
Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations
VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing
Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate
Single-molecule live imaging of subunit interactions and exchange within cellular regulatory complexes
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function
5
Sex-specific regulation of angiogenin in Alzheimer’s disease
Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy
Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer’s disease
Histone demethylase PHF2 regulates inflammatory genes in Alzheimer’s disease
Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms
8
Myoglobin Amyloid Fibrils Reveal a Hierarchical Principle of Polymorphism and Electrostatic Self-Assembly
Raman and Terahertz Spectroscopy of Low-Frequency Chiral Phonons in Amino Acids
Structural Dynamics of the Afamin/Wnt3a Complex Mediated by the Afamin Hydrophobic Pocket
Geometric Confinement in Solid-State Nanopores Enables Single-Molecule Discrimination of Ferritin Subunits and Translocation Bias
Reprogramming Chirality in Peptide Self-Assembly via Intramolecular Side Chain-Backbone Hydrogen Bonding
Conformational Adaptability and Thermostability in α/β-Peptide Fibrils Induced by β-Amino Acid Substitution
Cross-Linked Lipoic Acid Trisulfide Nanoparticles: Revisiting H2S Intervention as a Stand-alone Modality for Cancer Therapy
Acidic Amino Acid Induced 5′-Guanosine Monophosphate Fibrillar Nanozyme: A Highly Efficient Metal-Free Intrinsic Peroxidase Mimic
10
Large-scale discovery, analysis and design of protein energy landscapes
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome
Single-molecule dynamics of the TRiC chaperonin system in vivo
Identification of an allosteric site on the E3 ligase adapter cereblon
NAC controls nascent chain fate through tunnel sensing and chaperone action
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Collective homeostasis of condensation-prone proteins via their mRNAs
Covariation MS uncovers a protein that controls cysteine catabolism
Diffusing protein binders to intrinsically disordered proteins
Mapping and engineering RNA-driven architecture of the multiphase nucleolus
2
Genome-wide mapping of RNA-protein associations through sequencing
Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis
13
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection
RNA-specific local translation is patterned by condensates for multinucleate cell growth
PML targets and resolves structured protein inclusions to mitigate neurodegeneration
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions
The G3BP stress-granule proteins reinforce the integrated stress response translation programme
Proximal proteomics reveals a landscape of human nuclear condensates
Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein
Ca-driven PDIA6 biomolecular condensation ensures proinsulin folding
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis
A multichaperone condensate enhances protein folding in the endoplasmic reticulum
10
Opposing roles of serine and charge in IDR condensate miscibility
Generation of membrane-permeable cyclic peptides inhibiting protein–protein interaction
HO-free proximity proteomics for exploring dynamic protein complexes in living systems
Posttranslational modifications remodel proteome-wide ligandability
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine
High-throughput ligand diversification to discover chemical inducers of proximity
NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation
Photosensitizer proximity labeling captures the lipid and protein interactomes
Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5
8
Potent and biased agonists of class B1 GPCRs from a heterochiral design strategy
Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics
Global profiling of arginine reactivity and ligandability in the human proteome
Profiling the proteome-wide selectivity of diverse electrophiles
Water-detected NMR allows dynamic observations of repeat-expansion RNA condensates
Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines
Immobilized acyl-transfer molecular reactors enable the solid-phase synthesis of sterically hindered peptides
Homotypic RNA clustering accompanies a liquid-to-solid transition inside the core of multi-component biomolecular condensates
190
Carbene-catalyzed site-selective sulfonylation and modular edition of monosaccharides for hydroxyl group stereoinversion and swapping
Reprogramming the lipid peroxidation product 4-ONE as a chemoselective cleavable crosslinker
Divergent effects of pathological α-synuclein truncations and mutations on phase separation
FKBP8 connects the Hsp70-Hsp90 chaperone machinery to the folding of membrane proteins
Ribosomal allostery as a potential regulator of bacterial dormancy
Structural basis for a filamentous morpheein model of human cystathionine beta-synthase
Stress granule phase separation in stress-responsive cytosolic extract-in-oil droplets
A chemoproteomic atlas of the human purine interactome for regioselective ligand discovery
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Proteome-wide quantification of inositol pyrophosphate-protein interactions
Chromobox 3 assembles an epigenetic complex contributing to cystathionine γ-lyase–mediated protection against aortic aneurysm/dissection
Mapping interactions between disordered regions reveals promiscuity in biomolecular condensate formation
Phytochrome B sets condensate number through graded nucleator states and seeding-site efficacy
Electrostatic bimodality of human cytosolic DNA sensor cGAS-dsDNA condensates revealed by millisecond flashing electrophoretic separation
A labile sulfur ligand in a three-cysteine-coordinated [2Fe−2S] cluster mediates sulfide sensing in NreB
The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking
Gene-in-gene coding generates dual-isoform Fha condensates to control type VI secretion system assembly
Structural basis of signal peptide recognition by the signal peptidase complex
Hierarchical multi-timescale structural dynamics of the disordered N-terminal of p53
Pyridium-π interaction preserves -benzylidene thioacetals in acidolysis enabling efficient protein chemical synthesis
Nanobody-mediated control of long RSH Rel and RelA catalysis by restriction of their conformational landscape
BromoCatch: a self-labelling tag platform for protein modification and live cell imaging
Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1
Dynamic monomer-dimer transition regulates DNA-guided RNA cleavage by MbpAgo
Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations
Competition between protein-RNA clustering and phase separation drives re-entrant phase behavior of hnRNPA1
CSDE1 promotes viral immune evasion through RNA-dependent and phosphorylation-modulated liquid-liquid phase separation
The polymerized protein response (PPR) is activated by genetic variants that polymerize in the ER and is mediated by NFκBp50
Novel CuCLIP-seq for in situ covalently captured protein-binding RNAs
Newton’s cradle-like allosteric mechanism explains regulatory RsmE RNA binding
SMG7 and eIF4A constitute a homeostatic module controlling P-body condensation and function of meiotic bodies
A framework for the exploration of subcellular compartmentalization of RNA-binding proteins
Dynamic recruitment of CaMKII into SHANK3 phase-separated condensates tunes postsynaptic density remodeling during long-term potentiation
The schizophrenia associated protein DISC1 forms a multivalent tetrameric hub via conserved UVR dimers
Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization
Folded domains impose structural heterogeneity and attenuated dynamics in biomolecular condensates
Asymmetric dimeric assembly of Suv3 helicase facilitates processive RNA unwinding
A delayed translocation into the endoplasmic reticulum controls the post-translational modifications of PD-L1
Genotype-by-inhibitor interactions to dissect enterovirus replication
Protein coacervation-driven active forces power protocell dynamics
A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP
Optically driven control of mechanochemistry and fusion dynamics of biomolecular condensates via thymine dimerization
RF-SIRF reveals a replication stress-specific epigenetic code by spatio-temporal mapping of reversed forks
An orthogonal RNA aptamer for targeted RNA regulation in phase-separated subcellular compartments
Enhancer-mediated Etv4 activation stimulates osteogenic differentiation
Oligomerization-competent PIF4 drives thermomorphogenesis through functional redundancy in transactivation and DNA binding
Catalytic Proximal Protein Oligomerization as an Anti-Tumor Strategy Targeting WDR5
NEDAMSS syndrome-related truncating and missense mutations are associated with aberrant liquid-liquid phase separation of IRF2BPL
Dynamic control of IDP interaction network via diverse binding pathways
Structural and functional implications of phase separation of membrane protein LacY in Escherichia coli
Membrane-embedded polar residues target membrane proteins for degradation by the quality control protease FtsH
Identification of ephrin-A1–EphA2 signalling as a potential target for fracture prevention
Detecting glycosyl-oxonium and glycosyl-nitrilium ions using exchange NMR to investigate solvent effects in glycosylation reactions
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6
Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging
Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation
Decoupling phase separation and fibrillization preserves activity of biomolecular condensates
CycloPepper: a machine learning platform for predicting cyclization outcomes and optimizing synthesis of therapeutic cyclopeptides
RiboBright reveals cell-type-specific differences in ribosome organization and movement
Oxygen depletion in biomolecular condensates is dominated by macromolecular density
Direct observation and quantification of single nanocondensates of the low complexity domain of TDP-43
Sclerostin deficiency sensitizes white adipocytes to thermogenic signals that induce beiging in mice
Protein C-terminal variations impact proteostasis
Mechanistic insights into PCBP1-driven unfolding of selected i-motif DNA at G1/S checkpoint
Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly
Covalent modification of a glutamic acid inspired by HaloTag technology
Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota
Co-translational determination of quaternary structures in chaperone factories
Structural basis of co-translational N-myristoylation in humans
From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach
Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy
The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb
A high-throughput, flow cytometry approach to measure phase behavior and exchange in biomolecular condensates
Lucerastat, an oral therapy for Fabry disease: results from a pivotal randomized phase 3 study and its open-label extension
Volumetric compression regulates the phase separation of AXIN and acts as an operational amplifier to bidirectionally modulate Wnt signaling in organoids
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis
Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase
Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates
Chemotherapy-induced adipo-lineage cell senescence drives bone loss
Coordination of chromosome segregation and cell division in the archaeon Sulfolobus acidocaldarius
Single-cell dynamics of genome-nucleolus interactions captured by nucleolar laser microdissection (NoLMseq)
Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response
A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality
Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
Structural and catalytic diversity of coronavirus proofreading exoribonuclease
Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase
Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration
Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples
A universal O-glycosylation platform enabled by pyridinium catalysis using gas-releasing oxazolidinone-based carbamates donors
Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence
A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells
Dynamic Organellar Mapping in yeast reveals extensive protein localization changes during ER stress
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease
Microgliopathy as a primary mediator of neuronal death in models of Friedreich’s Ataxia
Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in mutant mice, a genetic model of schizophrenia and bipolar disorder
Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo
Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy
Hierarchical folding-upon-binding of an intrinsically disordered protein
Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer’s disease
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice
Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity
A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Controlling interfacial protein adsorption, desorption and aggregation in biomolecular condensates
In vivo conformational space and defects of misfolded CFTR variants by covalent protein painting
Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation
Structures of human organellar SPFH protein complexes
Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage
Molecular motor-driven reversible liquid-liquid phase separation of supramolecular assemblies
GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome
FUS nanoclusters are a distinct state within the dilute phase
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain
Development of a targeted BioPROTAC degrader selective for misfolded SOD1
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates
SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation
Determination of key functional structures of an amorphous VHL-based SMARCA2 PROTAC
Automated navigation of condensate phase behavior with active machine learning
Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling
Conformational dynamics, RNA binding, and phase separation regulate the multifunctionality of rabies virus P protein
Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules
Large protein-like leader peptides engage differently with RiPP halogenases and lanthionine synthetases
Zinc finger domains bind low-complexity domain polymers
Molecular landscape of the fungal plasma membrane and implications for antifungal action
COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale
Amino acids bind to phase-separating proteins and modulate biomolecular condensate stability and dynamics
RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma
In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy
Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression
Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein
Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation
CD103CD8 T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling
Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities
The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses
KH–R3H domain cooperation in RNA recognition by the global RNA-binding protein KhpB
Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross--sheet formation
Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging
Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis
4D structural biology–quantitative dynamics in the eukaryotic RNA exosome complex
Visualizing dynamic tubulin folding in chaperonin TRiC from nonnative nucleus to final native state
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation
Quantifying collective interactions in biomolecular phase separation
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits
Iron-sulfur clusters in SARS-CoV-2 exoribonuclease and methyltransferase complexes: relevance for viral genome proofreading and capping
Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis
regulates Yap subcellular localization to maintain bone homeostasis
Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations
YAP charge patterning mediates signal integration through transcriptional co-condensates
Structure guided functional analysis of the S. cerevisiae Mre11 complex
Trans-synaptic molecular context of NMDA receptor nanodomains
A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides
Single-molecule tweezers decode hidden dimerization patterns of membrane proteins within lipid bilayers
Universal peptide synthesis via solid-phase methods fused with chemputation
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies
Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration
mRNA trafficking directs cell-size-scaling of mitochondria distribution and function
Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity
Arrest Peptide Profiling resolves co-translational folding pathways and chaperone interactions in vivo
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice
Unveiling the hidden interactome of CRBN molecular glues
Coupling chromosome organization to genome segregation in Archaea
Structural insights into the roles of PARP4 and NAD binding in the human vault cage
ATP plays a structural role in Hsp90 function
RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer
Anti-sense oligonucleotide probing as a structural platform for studying ribonucleoprotein complex assembly
Engineering bi-directional chemically-modulated synthetic condensates for cellular control
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
Structural stabilization of the intrinsically disordered SARS-CoV-2 N by binding to RNA sequences engineered from the viral genome fragment
Phase separated condensates of ATRX regulate neural progenitor identity
Structural basis for catalysis by human lipoyl synthase
HP1 loses its chromatin clustering and phase separation function across evolution
Optogenetic storage and release of protein and mRNA in live cells and animals
H2S-mediated protein S-sulfhydration modulates infectivity and autophagy in the rice blast fungus
Structural insights into the human HRD1 ubiquitin ligase complex
Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair
Thio-NHS esters are non-innocent protein acylating reagents
Small-molecule-induced liquid-liquid phase separation suppresses the carcinogenesis of β-catenin
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis
Mechanism of nascent chain removal by the ribosome-associated quality control complex
Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models
1
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation
1
Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial
4
Generating 3D models of complex carbohydrates with GLYCAM-Web
Orthogonal RNA-regulated destabilization domains for three-color RNA imaging with minimal RNA perturbation
RNA-stabilized coat proteins for sensitive and simultaneous imaging of distinct single mRNAs in live cells
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues
1
Nanoscale domains govern local diffusion and ageing within fused-in-sarcoma condensates
1
The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport
8
Structures of protein folding intermediates on the ribosome
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD
Condensate protein aggregation in ALS/FTD is regulated by GGGGCC-repeat RNA scaffolds
The filamentous ultrastructure of the PopZ condensate is required for its cellular function
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
Phosphorylation-dependent tuning of mRNA deadenylation rates
A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
1
Water-based coupling of amino acids for sustainable solid-phase peptide synthesis
65
Cleavable and Cysteine-Selective Peptide Stapling Via Bifunctional Aryl Thioethers
An H-Phosphonate-Mediated Synthesis of Nucleotide-Pyranose Glycoconjugates
Stereoselective Synthesis of Glycosyl Phosphonates from Saccharides Via Selenium-Catalyzed Dehydrogenations
A Hydrophobic Tag-Assisted Liquid-Phase Strategy for the Synthesis of Retatrutide
Rapid Access to Human Milk Oligosaccharide Analogues through a Partially Protected N‑Acetylglucosamine Donor
Palladium-Catalyzed Synthesis of S‑Glycosides Via Stereoretentive Cross-Coupling
Chemical Synthesis of Difucosylated Glycopeptide by the Combination of Substituted Benzyl and Levulinoyl Protecting Groups
Identification of Glycosyltransferase AcbI in the Last-Step Biosynthesis of Herbicolin A for Improving Antifungal Activity
Total Chemical Synthesis of the Human Milk Oligosaccharide Disialyllacto-N-tetraose and Its Degradation by Bifidobacterium bifidum Sialidases
Multisegment C‑to‑N Sequential Ser/Thr Ligation Using Mmoc-Protected N‑Terminal Serine/Threonine Peptide Salicylaldehyde Esters
An o-Nitroveratryloxycarbonyl-Based Photolabile Solubilizing Tag for the Chemical Synthesis of Poorly Soluble Peptides and Proteins
Sulfonium-Stabilized Phenols as Organocatalysts toward Divergent Stereoselective 2-Deoxy and Ferrier Glycosylation of Glycals
Synthesis of Conjugation-Ready Trisaccharide Repeating Units of Multidrug-Resistant Pathogen Acinetobacter baumannii MG1 and Strain 24
Synthesis of gem-Difluoro Spirocyclic Cyclopropyl Mannosyl-1-phosphate Analogues and Chemoenzymatic Preparation of ADP- and GDP-Spirocyclopropyl-mannose
A Sequential Iodination–Fluorodeiodination of the Cubane Scaffold
Two Triterpenoids with a Cyclobutane Moiety from Mastic: Structural Elucidation and Biological Evaluation
Liquid-Phase Peptide Synthesis of Tropolone–Peptide Hybrid Antimalarials
Development of Nuclear-Targeted Photoaffinity Probes with Cleavable Disulfide Bonds for Enhancing Selectivity in hPTM Interactome Profiling
Access to Rare d- and l-Hexoses from C1 Nucleophiles via Anomeric Acylation
pNZ Removal Aided Aqueous Solid-Phase Peptide Synthesis: A Gateway to Sustainable Synthesis of Complex Peptides
<atl>Scaling Azapeptide with iN/i -Fmoc-Aza-Tripeptide from Resonant Acoustic Mixing of iN/i -Fmoc-Amino Hydrazide and iN/i -Succinimidyl Carbamate</atl>
Toward N-Linked Glycoproteins: Three-Step Synthesis of Glycan-Asparagine Conjugates from Unprotected Sugars
Chemical Protein Synthesis by Hydroxylamine-Involved Ligation of Peptides
User-Friendly Thioglycoside Preactivation via Instant Sulfenyl Chloride Generation
Phenylthioethyl (Pte)/Phenylsulfonylethyl (Pse) as Safety Catch Protecting Groups for Peptide Synthesis
Orthogonal Electrochemical Amine Deprotection: Toward Sustainable Strategies for Peptide Synthesis
Highly Stereoselective 1,2-cis-Glycosylation with 2-Azidofucosyl Donors: Access to the Pentasaccharide Motif from Escherichia coli O4:K6
Regio- and Stereoselective Synthesis of 1-/3-Sulfone Sugars Controlled by the Amount of SnCl4
Modular Synthesis of Nucleoside Diphosphate Sugar Analogues Using Chlorosulfonyl Isocyanate and Dichlorophosphoryl Isocyanate
Photocatalyzed Decarboxylative Thio(seleno)etherification of Redox-Active Uronates Enables Synthesis of Rare Sugar Thio(seleno)glycosides
Stereoselective Assembly of 2-Deoxy-2-fluoroglycosides Enabled by Pyridinium Catalysis
Chemical Synthesis of a Highly Branched Hexasaccharide Fragment from Bordetella pertussis Lipooligosaccharide
Dual Anomeric Stereocontrol in 1,1′-Glycosylation via a Remote Directing 2-(Diphenylphosphinoyl)acetyl Group
Reactivity Tuning by Ring Size: A Glycosylation Protocol Using Thiophene-Scaffolded Glycosyl Donors
Synthesis of Bis-urea-Bridged Cyclopeptides via Stapling of Unprotected Peptides
Cosolvent Effects Question the Role of Water in Native Chemical Ligation
AuCl3–tBuCN Catalysis in 1,2-trans 2-Deoxy-2-fluoro Glycosidic Bond Formation
One-Pot Assembly of the Rare Sugar Containing Trisaccharide Repeating Unit of Pseudomonas putida TSh-18
Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope
Electrochemical 2-Deoxyglycosylation of N-Containing Molecules with β-Stereoselectivity
Stereoselective Organocatalytic Fucosylation with Isothioureas
SN2 Glycosylation Enabled by a Directing-Group-on-Leaving-Group Strategy: Highly Stereoselective Synthesis of Glycosyl Carboxylates
Synthesis of Insulin-desB30 Analogs via an Enzymatically Removable N-Terminal Solubilizing Tag
Phage Display of Graspeptides via SrtA-Mediated Peptide Ligation and Cyclization
Aldehyde Capture Ligation without Involving a Side Chain Functional Group
Thioester Ligation with AAHO Peptides
Aqueous Phase Synthesis of Complex Thiazole-Containing Peptides by Condensation of N-Acyl-α-aminonitriles and Cysteine Derivatives
Chemical Synthesis of Conjugation-Ready Oligosaccharide Haptens of Pseudomonas aeruginasa O11 and Staphylococcus aureus Type 5
C-4 Functional Group-Driven Stereodivergent Synthesis and Late-Stage Diversification of 6-Deoxy l-talo/gulo Rare Sugars
Stereoselective Synthesis of N–O-Linked α-iN/i-Acetylgalactosaminoglycosides via Oxime iO/i-Glycosylation with 2-Nitrogalactals
Sulfonium Stabilized Phenols as Hydrogen Bonding Catalysts toward Diastereoselective Glycosylation of Cyclopropanated Sugars
Palladium-Catalyzed Glycosylation for the Highly Stereoselective ide Novo/i Construction of Trideoxy Glycan Motifs from Pyridapeptides B-E
Investigation of the Reactivities of Halogen-Substituted Bicyclic Sialic Acid Donors and Their Application
Pyranoside-into-Furanoside Rearrangement of Galactose Units within a Preassembled Oligosaccharide Chain
Hydrophobic Tag-Assisted Liquid-Phase Synthesis of Tirzepatide
Total Synthesis of the Conjugation-Ready Tetrasaccharide Repeating Unit of Multidrug-Resistant Pathogen Pseudomonas aeruginosa NCTC 8505 O-Antigen
The Baeyer–Villiger Oxidation of Cubyl Ketones: A Synthetic Route to Functionalized Cubanols
Stereoelectronic Tuning of Heteroaromatic γ-Amino Acids for Turn Mimetic Design
Trifluoroacetic Acid Promotes Ultrafast Peptide Cyclization Mediated with Dimethylolurea
Unlocking the Potential of Ynamide as a Promoter in Copper(II)-Catalyzed O-Glycosylation
Stereoselective Glycosylation of Amino Sugars Enabled by Thiourea/Phosphoric Acid Dual Catalysis
Development of a Diastereoselective Csp2–Csp3 Cross-Coupling Reaction Inspired by Macrocyclic RiPP Natural Products
3-Methylpyrazole-Mediated C-Terminal Protein Modification
Stereospecific Oxidative Contraction of Anomeric Nucleophiles
Development of Semisynthesis to Achieve Sulfonium Proteins with Diverse Modifications
12
Polyphosphate modulates the stress-responsive formation of functional RNA-protein condensates in bacteria and mammalian cells
The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms
A novel targeting domain directs essential components of the cytosolic iron–sulfur cluster assembly pathway to the mitochondrion of Toxoplasma parasites
Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents
Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation
RNA-binding protein IMP1/ZBP1 directs local translation in microglial processes to regulate motility and phagocytosis during inflammation
Visualization of Trypanosoma brucei flagellar pocket collar biogenesis identifies two new cytoskeletal structures
Cross‐species rescue reveals sequence requirements for a rapidly evolving intrinsically disordered region
HAPLN2 forms aggregates and promotes microglial inflammation during brain aging in mice
Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization
2
Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains
Tissue-specific consequences of tag fusions on protein expression in transgenic mice.
1
Symmetry analysis of cross-circular and parallel-circular Raman optical activity
3
NANOG Assembles into Self-Limiting Aging Micelles That Drive a Sol-Gel Transition and Modulate DNA Dynamics
Antisymmetric Raman Response
Nonequilibrium Structure and Relaxation in Active Microemulsions
1
Torsion-Driven Plectoneme Formation During Nanopore Translocation of DNA Polymers
1
Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco
75
Two-step mechanism of Bruton’s tyrosine kinase membrane recruitment and activation
Proteostasis and unfolded protein response dynamics in human neuron/mouse glia co-cultures reveal a cell-specific maturation response
Genome-wide analysis of mRNA regionalization in a giant single cell
A protective role for APP in nuclear waste clearance via lysosomal exocytosis
Self-activation by a C-terminal domain arginine finger regulates GTP hydrolysis in bacterial zinc metallochaperones
amyloid-predict and LLPS-predict: Predicting phase separation propensities in the intrinsically disordered proteome
A functional map of the human intrinsically disordered proteome
Cysteine thiol-to-sulfonate oxidation induces unfolding for the functional switching of the extracellular HMGB1 protein
NEXT-FRET maps nonequilibrium rerouting of Escherichia coli maltose-binding protein folding by its signal peptide and chaperones
Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains
Exploring PrPC unfolding as a critical step preceding its refolding in the context of PrPSc propagation
Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners
Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519
Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress
Atomic-level architecture and assembly mechanism of high-order structures of RIPK1 fibril revealed by integrated structural biology
Targeted NMR signal enhancement of RNA by site-directed bis-nitroxide labeling
The α-synuclein proteostasis network and its translational applications in Parkinson’s disease
Non-Fickian diffusion within assemblies of the intrinsically disordered protein β-casein
Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates
Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling
Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function
Selective control of ligand binding through a distal mutation that alters the protein native ensemble
CDKL5 modulates the plasticity of excitatory synapses via liquid–liquid phase separation
Accurate conformational ensembles of intrinsically disordered proteins using reweighting based on NMR chemical shifts
The assembly rules guiding hetero-oligomeric bacterioferritin organization and their evolutionary signature
In situ NMR and integrative proteomics reveal the interaction signature of serum α-synuclein
Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium
Coordination of cell organelles to promote metabolon formation
Droplet growth, Ostwald’s rule, and emergence of order in Fused in Sarcoma
Force-dependent structural dynamics of the giant nesprin-2
Slippage reconfiguration of trinucleotide repeat hairpins impedes resolution by human replication protein A
GFP-free live neuron quantitative imaging reveals compartmentalization and growth dynamics of polyQ aggregates
Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization
Measuring bridging forces in protein–DNA condensates
Polymer conformational entropy as the driver of complex coacervation
Sticky interactions govern sequence-dependent dynamics in biomolecular condensates
Polyserine domains are toxic and exacerbate tau pathology in mice
Mass spectrometry footprinting reveals how kinetic stabilizers counteract transthyretin dynamics altered by pathogenic mutations
Nucleic acid base pair open states by hydrogen exchange
Hollow condensates emerge from gelation-induced spinodal decomposition
Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis
Arg–Tyr cation–π interactions drive phase separation and β-sheet assembly in native spider dragline silk
Multiplex mapping of protein–protein interaction interfaces
Interprotomer communication and functional asymmetry in H/ACA snoRNPs
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation
Control of encounter kinetics by chemically active droplets
Probing direct interactions between nuclear proteins in cells with nxReLo
A machine learning protocol for predicting structural distributions of amyloid-forming proteins from 2D IR spectra
Inhibition of ice recrystallization with designed twistless helical repeat proteins
The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster
Molecular drivers of RNA phase separation
The RANK/RANKL axis controls vascular dynamics in the bone marrow
Programming cellular condensates for living materials using an intrinsically disordered protein display platform
Driving forces of RNA condensation revealed through coarse-grained modeling with explicit Mg2+
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing
Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo
Structure of a transient protein-folding intermediate by pressure-jump NMR spectroscopy
An unusual Co–S bond links B12 chaperones in an interprotein complex
In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA
Employing deep mutational scanning in the Escherichia coli periplasm to decode the thermodynamic landscape for amyloid formation
A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system–exported toxins
3D pattern formation of a protein–membrane suspension
CpG-A induces liquid–liquid phase separation of HMGB1 to activate the RAGE-mediated inflammatory pathway
Microglia-to-neuron signaling links APOE4 and inflammation to enhanced neuronal lipid metabolism and network activity
De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases
Definition of the components required for selective packaging of coronavirus genomic RNA
The functional dynamics of FicD’s TPR domain are modulated by the interaction with ATP and BiP
Diverse thioether macrocyclized peptides through a radical SAM maturase
Client–scaffold interactions suppress aggregation of a client protein in model condensates
Immiscible proteins compete for RNA binding to order condensate layers
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
Identification of an on-pathway intermediate illuminates the kinetic competition between protein folding and misfolding
Prg4+ fibroadipogenic progenitors in muscle are crucial for bone fracture repair
Trigger factor accelerates nascent chain compaction and folding
1
Identification of Biological Subtypes of Friedreich Ataxia with Structural MRI-based Machine Learning.
10
Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Pearling drives mitochondrial DNA nucleoid distribution
Unstructured transcription factor interactions enable emergent specificity
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Zwitterionic organoboron complexes for overcoming the concentration barrier in chemical protein synthesis
Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders
Design of intrinsically disordered region binding proteins
29
Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling
Isoform-specific steric zippers drive aberrant assembly and mislocalization of shortened TDP-43
Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis
A balance between nucleating and elongating actin filaments controls deformation of protein condensates
A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity
Bacteria use P-body condensates to attenuate host translation during infection
Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling
Bioelectronic synthesis of hydrogen sulfide enables spatiotemporal regulation of protein modification and cellular redox
Functional characterization of dynamic nascent RNA folding ensembles in real time
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
Isothiocyanate-mediated cyclization of phage-displayed peptides enables discovery of macrocyclic binders
Reversible phase dynamics of PsAF5 regulate mitophagy to balance redox levels in Phytophthora sojae
Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease
Highly efficient α-sialylation with ortho-(1-phenylvinyl)benzoates as leaving groups: One-pot assembly of α-sialoglycans
Phosphorylation of shiftless is important for inhibiting the programmed −1 ribosomal frameshift
Total synthesis of zwitterionic PS A2 oligosaccharides from Bacteroides fragilis
Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single workflow
Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy
ASPL couples the assembly of stress granules with their VCP-mediated disassembly
Translation landscape of stress granules
Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism
Cotranslational protein folding through non-native structural intermediates
An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS
Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles
The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat
Para-(3-phenylpropiolamido)phenyl (PPAP) glycosides: Harnessing ipso-cyclization–driven glycosylation for strategic flexibility
CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer’s disease
2
Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome
Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease
13
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly
Short autoinhibitory sequences control phase separation of an essential bacterial transcription termination factor
ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences
ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradation
STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation
Bacterial ubiquitin ligase engineered for small molecule and protein target identification
Client recruitment mechanism of the cytosolic Fe-S cluster assembly targeting complex
Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells
Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
Mapping cryptic phosphorylation sites in the human proteome.
Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation.
RABGAP1 is a sensor that facilitates the sorting and processing of amyloid precursor protein.
Dysfunctional mitochondria trap proteins in the intermembrane space.
30
Single Amino Acid-Based Control of Fibril Supramolecular Chirality
Coarse-Grained Simulations Reveal Salt- and Length-Dependent Condensation of G4C2 RNA Repeats
Design Principles for β-Solenoid Stability via Covalent and Electrostatic Capping Motifs
Chain Length as a Molecular Determinant of Hydrogen-Bond Dynamics in Biocondensates
Conformational Changes of the Knotted Protein 1O6D during Denaturation
Mechanistic Dissection of PEG-Induced Tuning of β‑Barrel Protein Stability via Chemical Denaturation
Protoporphyrin IX Attenuates Liquid–Liquid Phase Separation of α-Synuclein by Inducing Its Compaction
Universality Encoded in Fano Lineshapes: A Decoupled Phonon Framework for Rapid Raman Parameter Extraction
Decoding Physicochemical Interactions Via Single-Molecule Fluorescence Blinking
Anomalous Effect of Denaturant on Protein Unfolding Dynamics Revealed by Single Molecule Manipulation Experiments
Mechanism of Ag+-Induced Folding of a Bacterial Peptide from Replica-Exchange Molecular Simulations
Infrared Spectra of the Thymidine 13C2 and 13C4 Isotopes in H2O and D2O
Spectral Fingerprints of Hydrogen-Bonding in Water Solvation of Amino Acids
Atomic Structure of GNNQQNY Nanocrystals: A Validated Approach for Polymorphic Amyloids
Probing the Triplet State by Cryogenic Ion Trap IR Spectroscopy─Application to Protonated Lumiflavin
Molecular Insights into the Dual Mechanism of Bepristat 2a on Protein Disulfide Isomerase (PDI) Activity
Native Folding Stability of the Main Protease of Coronavirus SARS-CoV-2 on a Gold Surface
How the Extent of Protein Folding and Oligomerization Modulate Condensate Formation and Properties
Nanoscale Mechanical Force Primes NOD1-LRR for Efficient Pathogen Recognition
Electrostatic Collapse of Intrinsically Disordered Acid-Rich Protein Is Sensitive to Counterion Valency
Density Functional Theory Calculations to Investigate the Role Played by an Aspartate Dyad in Hsp60-Catalyzed ATP Hydrolysis
UV Resonance Raman Spectroscopic Marker Bands of Base Pair Formation During Nucleic Acids Assembly
Single-Molecule Mechanochemical Mapping of Hierarchical Cu Coordination in High-Capacity Copper Storage Protein Csp1
Single-Molecule Fluorescence Spectroscopy of 4-Cyanotryptophan and Its Application in Photoinduced Electron Transfer Fluorescence Correlation Spectroscop
Chiral Matching between Nucleic Acids and Polypeptides Facilitates Liquid–Liquid Phase Separation
Beyond Electrostatic Interactions: H-Bond Dynamics in Arginine- versus Lysine-Rich Biocondensates
RNA Structural Complexity Dictates Its Ion Atmosphere
AlkD’s Conformational Dynamics Regulated by Protein–DNA Interactions for Effective Target Recognition
Emergence of Compact Oligomers inside the Small-World Network of TDP-43 Condensates
Electrostatic Clamp and Loop Dynamics Dictate Caspase-8 Cleavage of the Apoptotic Protein Bid
1
Molecular determinants underlying NPH3 condensation and function in phototropism: an integrative approach

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