Medicinal and Biomolecular Chemistry articles

Time frame: 1 May 2025 - 30 April 2026

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Count: 972

Article ‘Count’ for Medicinal and Biomolecular Chemistry.

Journal Count
17
Emergence of Anisotropic Subcompartments via Coassembly of Hierarchically Ordered G-Quadruplexes and Fluid Polylysine in Droplet-Based Compartments
Precisely Staging Diabetic Nephropathy by a Gold-Based Artificial Filtration Biomarker through Computed Tomography and Blood Testing of the Glomerular Filtration Rate
Mesoporous PdPt Nanozymes with Target Peptides and Cascade Reactive Oxygen Species Scavenging for Boosting Alzheimer’s Disease Treatment
Mapping the Functional Architecture of Influenza A Virus-Induced Phase Separation through m6A Proximity Labeling
Multivalent Interactions between Chaperone and Ribosome-Nascent Chain Complex Revealed by High-Speed AFM and MD Simulations
Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids
RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction
Hierarchical Structural Organization in Bioinspired Peptide Coacervate Microdroplets
Selective Identification of Allosteric Inhibitors and Co-Drug Combinations Targeting Kinases by Using a Nanopore Tweezer Approach
Drug-Induced Reversible Lysosomal Changes Tracked in Live Cells by Holo-Tomographic Flow Cytometry
Controlling Amyloid Assembly Dynamics Using Spin Interfaces
Interfacial Silicification Efficiently Drives Osteogenic Differentiation of Mesenchymal Stem Cells without Any Exogenous Osteoinductive Factor
Self-Assembly of Accumulated Sphingolipids into Cytotoxic Fibrils in Globoid Cell Leukodystrophy and Their Inhibition by Small Molecules In Vitro
Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition
Molecular Engineering of DNA Condensates: Harnessing Phase Transitions for Precise Control of Catalytic Functions
Spatial and Temporal Single-Cell Profiling of RNA Compartmentalization in Neurons with Nanotweezers
6
Conformation-driven mechanical duality: viscoelastic and poroelastic switching in protein hydrogels
Targeting injury-triggered grancalcin from senescent macrophages enhances aged bone healing
The human osteocyte lacunocanalicular network structure in osteons of the iliac crest of elderly women depends on mineral content but not individual age
Spatio-temporal characterization of compositional and cellular properties in the murine fracture callus
Bioactive glass-induced B cell depletion remodels the osteoimmunological microenvironment to enhance osteogenesis
Apolipoprotein E as a potential regulator of osteoclast-osteoblast coupling in material-induced bone formation
8
Identification of a Bioactive Domain in Type II Collagen That Promotes Bone Repair via EGFR Signaling
Modulation of Ice Formation and Removal Dynamics by Antifreeze Protein-Inspired Large-Area Films
ZnS/Au Composites Advance Comprehensive Characterization of Low-Molecular-Weight Compounds Toward Pharmaceutical Analysis of Traditional Chinese Medicine
Bone‐Homing Cellular Backpacks Integrating Metabolic Intervention and Synergistic Osteogenesis to Treat Bone Metastasis and Promote Diabetic Bone Repair
pH‐Tunable Material Properties of Glycine‐Rich Condensates from Tick Bioadhesive
The Anisotropic Adsorption of De Novo Allosteric Two-Component Protein Fibers on Mica Surfaces
Deep Learning-Driven Co-Assembly of Naturally Sourced Compound Nanoparticles for Potentiated Cancer Immunotherapy
Poly-Lipoic Acid Trisulfide Particles: A New Donor With Continuous and Steady H2S Supply
4
Bioinspired, Mitochondria-Targeted Single-Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​
A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide
Natural Design of a Stabilized Cross-β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats
59
Advanced NMR Characterization and Sensitive Detection of Isoaspartate in Proteins
Five-in-One Neurodetoxification-Guardian-Type Near-Infrared Carbon Dots for Synergistic Blockade of Alzheimer’s Disease Pathological Cascade
Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA–Protein Cross-Links: Formation and Repair in Human Cells
A Novel RNA-Light Probe for Structured-Illumination Microscopy Super-Resolution Imaging of Nucleolar Ultrastructure and Analysis of Nucleolar Dynamics
Screening of Ruthenium Complexes as the Protein Light Switches for Protein Detection
Revealing Structure-Reporting Patterns of Pyruvylation Effects on 13C NMR Chemical Shifts in Natural Saccharides
In Situ Study of p53, MDM2, and MDMX Protein Interaction in Living Cells Using Fluorescence Triple Correlation Spectroscopy
MOSCAT: Aldehyde-Selective Chemical Proteomics for Site-Specific Profiling of Cinnamaldehyde Targets in Living Cells
Elucidation of the Effects of Electrostatic Interactions on Protein Structures at Buried Solid/Liquid Interfaces: A Combined Study with Experiment, Simulation, Isotope Labeling, and Spectra Calculation
Studying Collagen Architecture in Solution by Raman Optical Activity Spectroscopy
Bead-Ejection Scenario in Electrospray Ionization of Multidomain Nucleic Acids
A Covalent Targeted Platform for Protein Dynamic Tracking
Development of an Accurate Double Isotopic Standard LC–MS/MS Method for Hyaluronic Acid Quantification in Biological Matrices
Cross-Linking and Covalent Labeling Mass Spectrometry Reveal Proteoform-Driven Conformational Changes in Alpha Synuclein
Beyond Binding Affinity: Detailed Profiling of Protein–Ligand Interactions with Time-Resolved FRET
Nonmodified Strategy Enabled Proteome-Wide Mapping of Catechol Derivatives Interactome
TIPP: A Novel Iodoacetamide Reaction-Induced Protein Precipitation Approach for Proteome-Wide Ligand-Target Identification
Characterization of Cell–Surface Interactions of Ligands Using 19F NMR and DNP Hyperpolarization
Clickable Multitargeting Cross-Linkers Based on SuFEx for In Vivo Cross-Linking Mass Spectrometry
Three Conformations of Polyglutamic Acid Monitored by Vibrational Optical Activity
Study of the Aggregation Behavior of Proteins Related to Neurodegenerative Diseases Based on the Photoluminescence of Perovskite Nanocrystals
Ultrasensitive Biocoded SERS Immunoassay for Tracing Molecular Gatekeeper Mfn2 Expression within Single Cells during Stem Cell Differentiation
NanoBRET-Based Biosensor for High-Throughput Screening of RAB11A–FIP2 Interaction Inhibitors
Stabilizing Proteins by Chemical Cross-Linking: Insights into Conformation, Unfolding, and Aggregation Using Native Ion Mobility Mass Spectrometry
Effects of Charged Surface on Electrochemical Sensitivity to Protein Dimerization
Lasso Peptide Syanodin I: Loop-Pulling Two-Step Thermal Unthreading Mechanism
Toward-Automated Etalon Artifacts Elimination in Dual-Wavelength Raman Spectroscopy for In Vivo Applications
Selective Probing of Acidic Amino Acid Residues for Protein Structural Analysis by Covalent Labeling and Mass Spectrometry
Mapping Protein-ssDNA Interactions at Single Nucleotide Resolution by Dual Nucleases-Assisted Next-Generation Sequencing
Heat-Induced Protein Oxidation as an Impediment for Thermal Stability Measurements: A Case Study on Cytochrome c
Cocktail Chemical Labeling for In-Depth Surfaceome Profiling of Bone-Marrow-Derived Dendritic Cells
Streamlined Methods for Profiling Targeted Michael Acceptor Molecules Reveal Natural PTP1B Covalent Inhibitors
Cell Permeability and Target Engagement of Middle-Sized Molecules Quantified by In-Cell NMR
Specific Lung-Targeting Shortwave Infrared Luminescence Nanoprobe: Precisely Delineating Sepsis-Induced Acute Lung Injury
Sulfoxide-diazirine (SODA) as a Cleavable Photoaffinity Group To Enable the Identification of Photolabeled Modification Sites via LC–MSsup3/sup
Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures (NECEEM)-Enabled Mechanistic Analysis of Cooperative Binding: Application to C-Reactive Protein–SOMAmer Complexes
Clear Native Gel Electrophoresis for the Purification of Fluorescently Labeled Membrane Proteins in Native Nanodiscs
Gold Nanoparticle Aggregation Pathways Probed by Evanescent Wave Cavity Ringdown Spectroscopy: The Role of Guanidine Hydrochloride and scpl/scp-Tryptophan
Beyond Traditional airPLS: Improved Baseline Removal in SERS with Parameter-Focused Optimization and Prediction
Acrolein as an Alternative Broadly Reactive Activity-Based Probe for Activity-Based Protein Profiling of Cysteinome
Robust Chemical Cross-linking of Proteins and Protein Complexes via SuFEx Click Chemistry
Paired Analyses of Nuclear Protein Targets and Genomic DNA by Single-Cell Western Blot and Single-Cell PCR
Peroxynitrite-Activated Conditional Chemical Probe for the Affinity-Based Protein Modification
Novel Urazole-Derived MS-Cleavable Cross-Linkers Targeting Tyrosine/Lysine Residues for Protein Structural Analysis
Molecular Optimization of a Near-Infrared Fluorogenic Probe for Hydrogen Polysulfide Imaging in Acute Liver Injury
Stable Isotope Labeling in Bacteria Enables Characterization and Quantification of Frataxin Protein in a Friedreich’s Ataxia Zebrafish Model
Differentiating Molecular Weights of Supramolecular Polymers in Lower Monomer Concentrations by Coreaction Accelerator-Regulated Electrochemiluminescence
Chemoproteomic Profiling of Isoprenoid Pyrophosphate Interacting Proteins with Photoaffinity Probes
FRAP4ICBS: FRAP Analysis Method to Evaluate Dominant Effects for Biomolecular Condensate Formation
Spatially Resolved Multibait Mapping of Stress Granule and Processing Body Transcriptome
Arg-C Ultra Simplifies Histone Preparation for LC-MS/MS
The Critical Need for Implementing RRF in the Accurate Assessment of Impurities in Peptide Therapeutics
Research on the Extraction of Characteristic Information and Similarity Evaluation Method for Relative Intensity Information between Characteristic Peaks in Raman Spectra
Unraveling Ribonucleic Acid Unfolding: A Quantitative Comparison of Solution and Gas-Phase Unfolding
Detection of Protein Polysulfidation Using a β-(4-Hydroxyphenyl)ethyl Iodoacetamide-Derived Biotin Tag HPB
Ponceau S as a Targeted Modulator for Protein Liquid–Liquid Phase Separation
Stabilization of Protein Interactions through Electrospray Additives in Negative Ion Mode Native Mass Spectrometry
A Ratiometric Fluorescent Probe with Reversible Redox-Response for Monitoring Dynamic Release of H2S Donors
A Kidney-Targeted Rapid Photoacoustic Probe Activated by Sulfur Dioxide for 3D Visual Diagnosis of Iodinated Contrast-Induced Acute Kidney Injury
56
Photochemically Generated Sulfenylnitrene Unlocks Chemoselective Activation of Conventional Thioglycosides for Stereocontrolled Furanosylations
Profiling the Structural Heterogeneity of Monomeric α‐Synuclein From the Single‐Molecule Level Using MspA Nanopores
Modular Synthesis of Neisseria meningitidis Lipooligosaccharide Inner Core Oligosaccharide Library to Identify Broadly Reactive Antigenic Epitopes
Ansamer‐Controlled Bicyclic Peptides as Integrin αvβ6 Targeting Agents
Glycinamide-Driven Coumarin Construction (GDCC): A Mild Strategy for Fluorescent Labeling and Macrocyclization of Peptides
Elucidating the Stereodirecting Effect of C-4 Acyl Groups on Galactosyl Donors
Expeditious Synthesis of 2‐Deoxy‐2‐perfluoroalkyl Glycosides
Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases
Programmable DNA Nanostructures for hTERT Compartmentalization and Translocation in Living Cells
Side-Chain Engineering Guides the Design of β-Sheet Inhibitor to Anchor Protein-Protein Interaction Interfaces
Fibril Structure of Desiccation-Protective Tardigrade Protein CAHS-8
A Convergent Hybrid Gram-Scale Synthesis of Tirzepatide: Tangential Flow Filtration Assisted Native Chemical Ligation-Desulfurization Approach
Site-Selective Ligand Selection by Mutational Profiling for Covalent RNA Targeting
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation
Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship
Coexistence of G‐Quadruplex and i‐Motif Within a DNA Duplex is Tolerated by a PCBP2‐Assisted Replisome
Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities
In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking
Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides
Cyclometalated Gold(III)-Mediated Cysteine Arylation: A Bioorthogonal Platform for Covalent Targeting of Intrinsically Disordered Proteins
Fully‐Functionalized Natural Product Probes to Expand the Chemical Tractability of the Human Proteome
Synergistic SuFEx-Driven Covalent Cancer Therapy Using a HER2/EGFR Bivalent Affinity Protein Drug
Simultaneous Induction and Self‐Reporting of Nucleolar Stress by a Nucleolus‐Targeted Platinum(II) Complex via Lifetime Imaging
De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor
A Picolyl-Based Cys Caging/Uncaging Strategy Facilitates Protein Synthesis
Discovery of a Cryptic Pocket in EcDsbA Opens New Opportunities for Antibacterial Discovery
Studies of α′,β′-Epoxyketone Synthesis by Small-Molecule Flavins and Flavoenzymes
Carbonothioate‐Triggered Cascade Cyclization Enables High‐Specificity Fluorescence Imaging of Hydrogen Polysulfides
High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly
Electrochemical Late-Stage Stitching of Tryptophan Peptides via N─S Bond Formation
Iron-Catalyzed Highly Stereospecific Glycosylation with Glycal Epoxides
Topologically Tunable α‐Helix Mimetics for Targeting Protein–Protein Interactions
Total Synthesis of Feglymycin Using Umpolung Amide Synthesis
Activity‐Based Ubiquitin Probes Capture the Sulfenylated State of Deubiquitinases
Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases
Cell‐Active, Irreversible Covalent Inhibitors Targeting a Surface‐Exposed Non‐Catalytic Lysine on Aurora a Kinase by Using Squarate Chemistry
Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE
Divergent Synthesis of ΔAA‐Peptides Using a Bioorthogonal ipro/i‐Amino Acid and Aqueous Flavin Photocatalyst: Green Light Enhances Catalyst Performance and Product Selectivity
Amide Chemistry Enables Redox Locking of Cyclic Disulfides for Polypeptide Assembly
Pd-Catalyzed Stereospecific and Ligand-Controlled Regiodivergent Suzuki–Miyaura Cross-Coupling for the Synthesis of 3-C-Glycals and 2,3-Unsaturated C-Glycosides
Reengineering of a Proteomimetic Pan‐Ras Inhibitor into a Ras Degrader
Bulk Measurement of Membrane Permeability for Random Cyclic Peptides in Living Cells to Guide Drug Development
Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins
Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding
Intramolecular Thiol‐Promoted Decomposition of Cysteine Ester (ITPDC): A General Platform for Controllable Release of Reactive Sulfur Species
Visible‐Light‐Controlled Lysine‐Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells
Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain
Conformationally Locked Peptide–DNA Nanostructures for CRISPR‐Amplified Activity‐Based Sensing
Proteome‐Wide Data Guides the Discovery of Lysine‐Targeting Covalent Inhibitors Using DNA‐Encoded Chemical Libraries
Deciphering and Predicting Thermal and pH Stabilities of Triplex DNA Under Multifactorial Conditions
Superfast Protein Desulfurization Triggered by Low‐Energy Visible Light
Tandem Biocatalysis to Generate Hydrogen Sulfide and Promote Endogenous Antioxidant Response
Fluorophores Nucleate and Stabilize Collagen Triple Helices – En Route to Better Diagnostic Tools for Fibrosis and Tissue Repair
Highly Stereoselective 1,2-cis-Xylosylation Enabled by Reagent Modulation, Remote Participation, and Electron-Withdrawing Synergistic Effects
A DNP-Supported Solid-State NMR Approach to Study Nucleic Acids In Situ Reveals Berberine-Stabilized Hoogsteen Structures in Mitochondria
Tunable Light‐Activated Platform for Controlled Hydrogen Sulfide Release with Tracking
1
Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood
1
Cystathionine γ‐Lyase‐Dependent S‐Sulfhydration of Smad3: A Novel Target to Alleviate Fibrosis in Systemic Sclerosis
1
Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways
9
Nuclear speckles enable processing of RNA from GC-rich isochores
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
Metabolically regulated proteasome supramolecular organization in situ
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2
Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses
1
Mitochondrial dysfunction reveals H2S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects
23
Strategic alkene incorporation into peptide backbones to prevent enzymatic hydrolysis by evading molecular recognition
Conformational plasticity of holliday junctions tunes histone H1–mediated liquid–liquid phase separation
Chiral biphenanthrene-diol-based lanthanide cubanes
Protein migration via dissolution of ATP-stabilized condensate in a gradient of AMP
Chemoenzymatic synthesis of sulfated O-glycopeptides from human CD34
Photochemical HAT-mediated site-selective C(sp3)–H aminoalkylation of cubanes catalyzed by TBADT
Forces behind N- and C-capping of peptidic helices
The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides
Acetylacetone-modified ubiquitin C-terminus enables specific capture of sulfenylated deubiquitinases
β-barrels from short macrocyclic peptides
Photoswitchable inhibitors: temporally regulated inhibition of the IDO1 enzyme using photoactive merocyanine derivatives
Backbone nitrogen substitution restricts the conformation of glycine residues in β-turns
Base-mediated alkynyl-cubane to Cu8-alkynide cluster transformation
Foldamer engineering with squaramide and phenanthroline motifs: synthesis, characterisation, and structural insights
Conditional disorder in proteins: functional transitions between order and disorder
An esterase-sensitive persulfide/hydrogen sulfide generating fluorogenic probe enhances antioxidant response
Direct Measurement of SARS-CoV-2 Spike RBD Binding to Integrin αvβ6 by Single-Molecule Force Spectroscopy
Backbone cleavage of peptides and proteins ivia/i cysteine iS/i-fluoroacetylation
One-pot, chemoselective desulfurative functionalization of cysteine containing peptides using pyridinium salts
Iron-catalyzed iodonium ion promoted activation of conventional thioglycosides for stereoselective 1,2-icis/i furanosylations
Thioglycoside functionalization ivia/i chemoselective phosphine acceleration of a photocatalytic thiol–ene reaction
Exceptional mechanical stability of the spider silk C-terminal domain
Comparative analysis of sulfated l-idose and l-iduronic acid in neoproteoglycan cell surface engineering
31
Pd-catalyzed stereoretentive synthesis of reversed C-acyl glycosides: access to rare l-sugars and higher-carbon sugars
Deciphering the molecular origin of the 19.3 eV electronic excitation energy of H3+
Mass spectrometry detects folding intermediates populated during urea-induced protein denaturation
Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media
How electronic and steric effects in acceptor alcohols shape SN1- and SN2-type glycosylation reactions
Amyloidogenic oligomers derived from TDP-43 LCD promote the condensation and phosphorylation of TDP-43
Guanine nucleotide directed co-assembly with Pt-complexes for tailoring chiroptical properties and multimodal molecular recognition
Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils
Yeast [FeFe]-hydrogenase-like protein Nar1 binds a [2Fe–2S] cluster
Simulations reveal a balance between protein–protein and protein–lipid interactions during condensation on membrane surfaces
Engineering β-sheet morphologies via metal cross-linking and side chain modifications
DNA aggregation and resolubilization in the presence of polyamines probed at the single molecule level using nanopores
Impact of vibrational strong coupling on liquid–liquid phase separation in supramolecular polymers
Unprecedented allosteric inhibition of E. coli malate dehydrogenase by silver(i) from atomic resolution analysis
The ‘ins’ and ‘outs’ of amidines in β-sheet folding and fibril disaggregation
Light responsive hydrogen selenide (H2Se)/hydrogen diselenide (H2Se2) donors: applied for protein S-selenylation on PRDX6
From concept to chemistry: integrating protection group strategy and reaction feasibility into non-natural amino acid synthesis planning
Identification, occurrence and prevention of aspartimide-related byproducts in chemical protein synthesis
Europium probe binding to serum albumin and αsub1/sub-AGP, key importance of configuration, charge and size complementarity
Macrocyclization of backbone iN/i-methylated peptides by a prolyl oligopeptidase with a distinctive substrate recognition mechanism
Intracellular evaluation of protein droplet-forming capability using self-assembling peptide tags
Phylogeny-guided discovery of a promiscuous P450 macrocyclase for the production of diverse atropopeptides
Selectively triggered: ROS-activated Michael acceptor prodrug strategy to enhance tumor targeting efficacy
Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives
Design and characterisation of photoactivatable and lysine reactive io/i-nitrobenzyl alcohol-based crosslinkers
Synthesis and functionalization of vinyl sulfonimidamides and their potential as electrophilic warheads
The contribution of cyclic imide stereoisomers on cereblon-dependent activity
Water entropy at the threonine-rich surface of antifreeze and ice-nucleating proteins: small changes make a big difference
Bottom-up design of peptide shapes in water using oligomers of N-methyl-l/d-alanine
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
Single-molecule nanopore sensing of proline icis/i/itrans/i amide isomers
1
Growth Differentiation Factor-15 Improves Prognostic Accuracy of Risk Stratification in Pulmonary Arterial Hypertension
1
Disrupted hippocampal replay is associated with reduced offline map stabilization in an Alzheimer’s mouse model
2
Insolubilome profiling defines molecular features that influence protein insolubility with aging
Nuclear lamina phase separation orchestrates stress-induced transcriptional responses in plants
1
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli
1
Kinetics of methanethiol oxidation by oxygen under aqueous conditions
1
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease
2
Squaramide-Based MOF Enables Hydrogen-Bond-Directed Ultraselective Guanine Detection and Drug Monitoring
Synthesis and Structural Characterization of a Glycoconjugated Re(CO)3+ Complex and Its Tendency for CO Release
1
A new proof of Chen’s theorem for Markoff graphs
62
Insights into the Role of Internal Catalysts in Asparagine‐to‐Succinimide Conversion in a Hyperthermophilic Glutamine Amidotransferase
Calcium-loaded acylated segment controls membrane penetration capacity of repeats-in-toxin cytolysins
Actin’s functional “switch”: Constraining C-terminal conformational flexibility disrupts functionally important communication networks
Biosensor-Guided Discovery of Peptide Inhibitors Targeting the Ribosomal Protein uS5-PDCD2 Chaperone Interaction
Direct interaction between human DDX1 and SARS-CoV-2 Nucleocapsid protein is regulated by phosphorylation
Protein loops are major contributors to DNA strand separation and high-fidelity substrate recognition for DNA methyltransferase CcrM
Cleavage at the nsp5/nsp6 site of SARS-CoV-2 main protease intermediate precursor is faster from a monomer than a dimer form
The crystal structure of the herpes virus ICP8 protein in complex with single-stranded DNA reveals the molecular determinants of nucleotide recognition
Stability and interaction defects in the Sin3A-PAH1 αα-hub domain associated with loss-of-function variants
Transcriptome-guided discovery and active-site gatekeeper engineering of a Viola arcuata asparaginyl ligase with superior catalytic performance
The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation
Human Pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4–NOT deadenylase complex to repress mRNAs
P-bodies act as dynamic control hubs for RNA processing and storage
Domain-selective folding of the tandem β-propeller protein Coronin 7 (Coro7) by the chaperonin CCT/TRiC
Phosphorylation-dependent regulation of serine/arginine-rich proteins and U2AF1 interactions in early spliceosome assembly
Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E. coli
The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate–binding domain
Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro
Hydrogen sulfide increases intracellular oxygen and inhibits the HIF response
Hyaluronic acid regulates cellular UDP-GlcNAc levels through CD44 to affect glycosylation and cell biological functions
Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates
PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS
Regulation of the orphan G-protein–coupled receptor GPRC5B by MLC1 and the cell adhesion molecule GlialCAM in megalencephalic leukoencephalopathy
Spontaneous Dimerization of the Hepatitis C Virus 3′X RNA
Bacillus subtilis encodes three N-acetylcysteine deacetylase enzymes that can catalyze the final step in S-(2-succino)cysteine breakdown
Structural and biophysical insights into RomR, MglB, and MglC interactions involved in regulating cell polarity in Myxococcus xanthus
Hsp90 co-chaperone FKBP4 facilitates CCT8 folding and connects Hsp90 to chaperonin-dependent proteostasis
A split luciferase system for studying coronavirus Mpro dimerization in vitro and in living cells
Mapping the intracellular HMGB1 interactome and alterations induced by Toll-like receptor 4 activation
A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases
J-domain proteins cooperate with Hsp70 to drive multiphase separation of RNA-binding-deficient TDP-43
Distinct liquid-liquid phase separation properties of end-binding proteins EB1 and EB3
Sp100A isoform promotes localization of the histone chaperone HIRA to PML nuclear bodies
Pre-N and C-terminal extension regions of Arabidopsis HSP90.7 regulate the chaperone activity and ER stress response
Missense mutations in intrinsically disordered protein regions link pathogenicity and phase separation
APP family is a regulator of endo-lysosomal membrane vulnerability
IRE1/Xbp1 promotes the clearance of poly(GR) dipeptide repeats in amyotrophic lateral sclerosis
Structural basis for L-isoaspartyl-containing protein recognition by the human PCMTD1 cullin-RING E3 ubiquitin ligase
The trypanosome vault particle is composed of multiple major vault protein paralogs and harbors vault RNA
Cryo-EM study and in vivo chemical mapping of the Methanosarcina acetivorans ribosome and its dimerization via a repurposed enzyme and translation factor
Hydrogen sulfide–dependent activation of human sulfide quinone oxidoreductase
Key roles in copper efflux and protein homeostasis of the intrinsically disordered region of a bacterial outer membrane channel
Deciphering mutational effects on inducible NO synthase conformational dynamics via quantitative cross-linking mass spectrometry and AlphaFold2 subsampling
BR-bodies facilitate adaptive responses and survival during copper stress in Caulobacter crescentus
Lipid bilayer properties govern substrate engagement and extraction by the AAA+ ATPase Msp1
Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides
Nuclear basket proteins Nup2 and Mlp1 drive heat shock–induced 3D genome restructuring downstream of transcriptional activation
Molecular determinants of picornavirus 3C protease binding to phosphoinositide-enriched lipid membranes
Negatively charged α-synuclein condensate modulates partitioning of molecules
Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug binding
The impact of RNA chemical probing reagents on RNA-binding proteins
Bioluminescence-based assays for quantifying endogenous protein interactions in live cells
Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS
How short is too short for amyloid fibrils?: molecular dynamics of oligomers of infectious prion core structures
Acyl chains stabilize the acylated domain and determine the receptor-mediated interaction of the Bordetella adenylate cyclase toxin with cell membrane
Molecular consequences of SCA5 mutations in the spectrin-repeat domains of β-III-spectrin
The phosphatase activity of the PPP2R5D-PP2A holoenzyme modulates liprin-α1 liquid-liquid phase separation
A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)
A glycine at position 105 leads to clavulanic acid and avibactam resistance in class A β-lactamases
Topological isomers of a potent wound healing peptide: structural insights and implications for bioactivity
Setdb1 and Atf7IP form a hetero-trimeric complex that blocks Setdb1 nuclear export
1
Of Mice and Men: Temporal Comparison of Femoral Shaft Fracture Healing After Intramedullary Nailing: Retrospective Observational Study of Modified Radiographic Union Scores for Tibia.
7
IQSEC2/BRAG1 may modulate postsynaptic density assembly through Ca2+-induced phase separation
Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins
Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways
CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization
A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells
Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics
Pex30-dependent membrane contact sites maintain ER lipid homeostasis
1
Enhancing essential oil extraction from orange peels using ultrasound-assisted hydro-distillation: A sustainable approach
1
Identification of a Novel Compound Heterozygous Variant in the ALPL Gene Linked to Hypophosphatasia in a Chinese Family
5
The liver regulates ectopic calcification in Abcc6-deficient models of Pseudoxanthoma Elasticum
Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness
Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis
The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies
4
Restoration of sFRP3 preserves the neural stem cell pool and spatial discrimination ability in a mouse model of Alzheimer’s disease
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer’s Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration
Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed FXN Gene in Friedreich Ataxia
Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits
1
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks
129
Probing Supramolecular Motion with Nuclear Magnetic Resonance in Bioactive Scaffolds that Promote Neural Regeneration in the Central Nervous System
OptoChaperoneA Biohybrid Tool for Regulating Protein Condensates in Cells and In Vitro
Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent Ribonucleic Acid Modulation
Bridging Heterocycle-Mediated Hydrogen Bonding Facilitates Permeability of Polar Macrobicycles
Nicotine-Inspired, De Novo-Designed SARS-CoV‑2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad
A Versatile Strategy for Head-to-Tail Macrocyclization and Traceless Backbone Editing of Short Peptides
Beyond a Passive Tether: Structural Insights into the Disordered Tail of Hsp90
Determination of α‑Synuclein Protein Interactions by μMap Photoproximity Labeling
RaPID Selection of α-Hydrazino Acid-Containing Macrocyclic Peptides
Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation
Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape
Quantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass Spectrometry
Discovery of Ultrapotent Heterodimeric Peptide Ligands Using Library-vs-Library RaPID Selections
Molecular Dynamics-Guided Design and Chemoproteomic Profiling of Covalent Kinase Activity Probes
Directional Engineering of Cyclic β-Hairpin Peptides for PET/CT Imaging of PD-L1
Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity
Partially Protected N-Acetylglycosamine Donors Enable Direct β-O-Glycosylation: Applications and Mechanistic Insights
OaAEP1-Mediated Ligation of Mirror-Image Peptides via Acyl Donor Substrate Engineering
Hijacking Actin-Pre-Liquid–Liquid Phase Separation Suppresses Malignant Tumor Invasion and Growth
Repositioning the Leader Peptide in Graspetide Biosynthesis
Macrocyclic Peptides Containing an Imidazopyridinium (IP+) Unit Display Enhanced Passive Cell Permeability
Distinct Effects of the Extracellular Domain and Antibody Binding on HER2 Transmembrane and Juxtamembrane Regions Unveiled by NMR and EPR
Structural Sensitivity without Chirality: Observation of Magnetic Raman Optical Activity outside Resonance
Aromatic Interactions Select for Homodimeric Assembly in a Quadruply Hydrogen-Bonded DADA 1,2-Azaphosphinine Dimer
Total Synthesis of the Glycoside Antibiotic Paulomycin A
TAV2b Peptide Derivatives Underwind and Stabilize Double-Stranded RNA upon Binding
Accessing Underexplored Biosynthetic Potential by Initiation Unit Engineering of Nonribosomal Peptide Synthetases in Proteobacteria
Structural Heterogeneity and Hydrodynamics of an Intrinsically Disordered Protein Condensate
Single-Cell Native Mass Spectrometry for In Situ Detection of Protein–Drug Complexes in Live Cells
A Tandem Bioorthogonal Retro-Cope and Cope Elimination for the Activation of Covalent Inhibitors with an Acrylamide or Vinylsulfonamide Warhead in Live Cells
Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting
Mesostructured Water Enhances Stability of ProteinMPNN-Designed Ubiquitin-Fold Proteins
Monooxygenase Activity of Indoleamine 2,3-Dioxygenase
Polysaccharide Meets Polyoxazoline: Regio- and Stereodefined β-1,2-Linked Pseudo-polysaccharides via Controlled Cationic Ring-Opening Polymerization
Measurement and Control of Crossed Potentials in a Flavoprotein
Group Competition Strategy for Covalent Ligand Discovery
Chemical Protein Synthesis via Direction-Switching One-Pot Peptide Ligation Enabled by Orthogonal Cysteinyl Protection
Linkage-Editing of β-Glucosylceramide and β-Glucosylcholesterol: Development of β-Selective C-Glucosylation and Potent Mincle Ligands
H+ Ions and ATP Reshape the Conformational Landscape of an RNA Recognition Motif and Regulate Its Fibrillation
Terminal Conjugation Enables Nanopore Sequencing of Peptides
Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology
DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions
Monomer Isolation from Oligomeric Proteins within Coordination Cages to Study Interface Ligand Binding
Peptidyl Asparaginyl Ligase-Mediated Orthogonal Ligation at Non-Asx Peptide Bonds for d-Peptide Cyclization and Antibody Dual Labeling
Total Synthesis of the TIM-1 IgV Domain via N-to-C Serine/Threonine Ligation Enabled by Knorr Pyrazole Synthesis-Mediated Regeneration of Salicylaldehyde Esters
Merging Enzymatic Catalysis with Iron Catalysis for Highly Stereoselective Heparan Sulfate Oligosaccharide Assembly
Dioxazolones as Masked Isocyanate Electrophiles for Global Profiling of Lysine Reactivity and Ligandability
In-Cell Residue-Resolved NMR of Micromolar α-Synuclein and Tau at 310 K
Inertial Agitation in an NMR Magnet: Real-Time Monitoring of Protein Aggregation at High Resolution
Sustainable Peptide Synthesis by Photoredox-Catalyzed Picoc-SPPS
The [4Fe-4S] Cluster of HydF Is Essential for [FeFe]-Hydrogenase Maturation
Multiplexed Analysis of Multicomponent Biomolecular Condensates without Any Tag
Development, Scope, and Catalyst Selection in Boron-Catalyzed Iterative Glycosylation
Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA
Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation
Structural Heterogeneity of the Membrane-Interacting Region of the HIV-1 Envelope Glycoprotein
Decoding Arginine Dimethylation Isomers via pH-Tuned Reactivity with Methylglyoxal: A Chemical Approach for Functional Proteomics
Evolution of Hydrogen-Bonding Networks in Glycerol Dimer and Trimer: How Close Are They to Water Clusters?
Chemoselective Tagging of Protein Methacrylation
Cooperation and Competition of Base Pairing and Electrostatic Interactions in Mixtures of DNA Nanostars and Polylysine
Rate-Tunable, Metal-Mediated Amide Bond Cleavage for the Controlled Release of Pharmaceuticals
Chemically Fueled, Active Droplets Prevent the Aging of Peptides into Amyloid-Like Fibers
Ribosomal Elongation of Trans-4-Aminocrotonic Acids into Nascent Peptide Chain
De Novo Discovery of α,α-Disubstituted α-amino Acid-Containing α-helical Peptides as Competitive PPARγ PPI Inhibitors
Traceless 6-O-Lysyl Modification of N-Acetylglucosamine Enables Synthesis and Derivatization of Aggregation-Prone GlcNAcylated Peptides
Programmable Helicity and Macrocycle Symmetry in β-Peptides via Site-Selective Thioamide Substitution
Heterochiral and Heterotypic Self-Assembly of Intrinsically Disordered Peptides Confers Peptide Supercoils with Exceptional Proteolytic Stability
Thiocrown Ether: Reversing SN1 to SN2 Pathways in 1,2-cis Phosphoryl Glycosylation
Anfinsen Redux: Ribonuclease Folding in the Single-Molecule Regime
Responsive Plasmonic Reporters Decrypt Nanoparticle-Induced Single Membrane Protein Degradation
Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy
Nucleotide-Specific RNA Conformations and Dynamics as Precursors to Ribonucleoprotein Condensates
Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design
The Mechanism of Mineral Nucleation and Growth in a Mini-Ferritin
Site-Specific Profiling of RNA-Binding Proteins Enabled by Isotopic Signature-Enhanced Mass Spectrometry
Live-Cell Monitoring and Omics Analysis of Liquid–Solid Transitions of Biomolecular Condensates
β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins
Conformation and Dynamics of Monomeric, Phase-Separated, and Cross-Linked Resilin Biomaterials
Residue-Resolved Liquid-State Hyperpolarized NMR of Peptide Condensate Surfaces
Immunoglobulin-Directed Phase Separation for Cell-Specific Modulation of Receptor Signaling
Retention and Rearrangement of Membrane Protein Complexes’ Higher Order Structure by Collisionally Activated Dissociation- and Electron Capture Dissociation-Mass Spectrometry
Hydration (Hsub2/subO and Dsub2/subO) Dictates the Stabilities and Conformational Entropy of Transthyretin Tetramers
Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders
Discovery of Macrocyclic Peptide Binders, Covalent Modifiers, and Degraders of a Structured RNA by mRNA Display
Cyclic Hydroxylamines for Native Residue-Forming Peptide Ligations: Synthesis of Ubiquitin and Tirzepatide
A Conserved Cia1–Cia2 Interface Mediates Client Recruitment in the Cytosolic Iron–Sulfur Cluster Assembly Pathway
Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization
Beyond the Amyloid Core: Modulation of Aggregate Conformational Diversity by Mutations in the Noncore Regions
On-Cell Saturation Transfer Difference NMR Spectroscopy on Ion Channels: Characterizing Negative Allosteric Modulator Binding Interactions of P2X7
Exploring Phage Peptide Scaffolds: Tyrosinase-Mediated Cyclization for Selective Generation of Bioactive Cyclic Peptides
Atomic Resolution Interactions Regulating Partitioning of a FUS Folded RRM Domain into Model CAPRIN1 Condensates
Radical Propagation via σ-Cleavage Mediates Radical SAM Catalyzed Sulfur-for-Oxygen Swapping Reaction during the Biosynthesis of Albomycin δ2
Intrastrand Peptide Staples That Promote β-Sheet Folding, Self-Assembly, and Amyloid Seeding
Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase
Pushing Sensitivity and Specificity Limits in Native Structural Biology: sup19/supF Multinuclear Dynamic Nuclear Polarization with Magic Angle Spinning
A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates
Direct Cellular Screening of Pd-Mediated Arylation of Cyclic Peptide Binders Targeting Ubiquitin Chains: Toward Modulating NEMO Liquid–Liquid Phase Separation
NMR-Guided Studies to Establish the Binding Interaction between a Peptoid and Protein
A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo
Single-Entity Resolution Single-Cell Nanosensor Reveals Reactive Oxygen Species at Stress Granules Are Formed by Interfacial Redox Chemistry
Ribosomal Incorporation of Fluorosulfonyloxy-l-Phenylalanine into Macrocyclic Peptides for De Novo Target-Specific Covalent Binders
Structural Mechanism of Insect Cuticular Protein Binding to Chitin Revealed by Solid-State NMR
Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates
Small Molecule Catalyst for Peptide Synthesis
Design and Application of Cereblon-Recruiting Prodegraders
Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission
Sequence Programmable Order–Disorder Transitions in Supramolecular Assembly of Peptide Nanofibers
Proline-Mediated Enhancement in Evolvability of Disulfide-Rich Peptides for Discovering Protein Binders
iDe Novo/i Peptides That Induce the Liquid–Liquid Phase Separation of α-Synuclein
μMap-FFPE: A High-Resolution Protein Proximity Labeling Platform for Formalin-Fixed Paraffin-Embedded Tissue Samples
Chaperone-Mediated Regulation of Tau Phase Separation, Fibrillation, and Toxicity
Overcoming the Hydrolytic Susceptibility of Thiol-Reactive Reversible Warheads through the Development of Substituted Phenyl Cyanoacrylamides
An α-Helically Folded α-Aminoisobutyric Acid (Aib) Oligomer That Assembles into a Metal–Peptide Superhelical Nanotube
Controlling Multiphase Coacervate Wetting and Self-Organization by Interfacial Proteins
Elucidating the Curtin–Hammett Principle in Glycosylation Reactions: The Decisive Role of Equatorial Glycosyl Triflates
Structural Basis and Rational Design of Nucleotide Analogue Inhibitor Evading the SARS-CoV-2 Proofreading Enzyme
Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy
β-Thioglycosylation from Unactivated Carbohydrates
Chemically Engineered Affinity Protein Drugs for Covalent Targeted Cancer Therapy
Kinetic Dissection of Proton-Coupled Conformational Transitions in Nucleic Acids by Integrating pH-Dependent NMR and Chemical Modifications
Stabilization of Condensate Interfaces Using Dynamic Protein Insertion
Amyloid Oligomers: Expediting Crystal Growth and Revisiting the Corkscrew Structures
Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET
Design Guidelines to Control Rippled β-Sheets versus Pleated β-Sheets in Mixed-Chirality Peptides
Ultraviolet Photodissociation Mass Spectrometry Captures the Acyl Chain Length-Dependent Conformation Dynamics of Acyl Carrier Protein
Molecular Tweezers Block the Functional Pore of a Protein Machine
Proteome-Wide Covalent Targeting of Acidic Residues with Tunable N-Aryl Aziridines
Conformational Plasticity in dsRNA-Binding Domains Drives Functional Divergence in RNA Recognition
Bilaterally Substituted Terphenyl Molecules Efficiently Inhibit the Interaction between a Protein and a Fully Buried α-Helix in the Malaria Parasite Motor System
1
Mesangial Cell–Derived Extracellular Matrix Protein 1 Is Essential for Maintaining Mesangial Matrix Homeostasis and Glomerular Architecture
1
Heat shock protein 70s are modifiers of endothelial function in Fabry disease
2
Spectroscopic Determination of Ion-Binding Environment in Alkali-Driven Ionically Cross-Linked Hyaluronic Acid Hydrogels
Aging-Directed Structural Evolution of In Situ Formed Polymeric Coacervates and Their Applications in Constructing Hierarchical Assemblies
25
PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes
Condition-dependent amorphous protein agglomerates control cytoplasmic rheology
Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility
2′-O-Methylation maintains ribosome structural and translation integrity
NAC promotes co-translational protein folding at the ribosomal tunnel exit
Herpes simplex virus 1 fluidizes the nucleus, enabling condensate formation
Global profiling of nascent chain interactors reveals TRIM25 as a co-translational E3 ubiquitin ligase
Engineering intrinsically disordered regions for guiding genome navigation
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions
The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
Membrane-protein-mediated phase separation orchestrates organelle contact sites
Mechanical forces regulate the composition and fate of stalled nascent chains
The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs
A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum
Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery
Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations
VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing
Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate
Single-molecule live imaging of subunit interactions and exchange within cellular regulatory complexes
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation
4
Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy
Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer’s disease
Histone demethylase PHF2 regulates inflammatory genes in Alzheimer’s disease
Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms
8
Raman and Terahertz Spectroscopy of Low-Frequency Chiral Phonons in Amino Acids
Structural Dynamics of the Afamin/Wnt3a Complex Mediated by the Afamin Hydrophobic Pocket
Geometric Confinement in Solid-State Nanopores Enables Single-Molecule Discrimination of Ferritin Subunits and Translocation Bias
Reprogramming Chirality in Peptide Self-Assembly via Intramolecular Side Chain-Backbone Hydrogen Bonding
Conformational Adaptability and Thermostability in α/β-Peptide Fibrils Induced by β-Amino Acid Substitution
Cross-Linked Lipoic Acid Trisulfide Nanoparticles: Revisiting H2S Intervention as a Stand-alone Modality for Cancer Therapy
Acidic Amino Acid Induced 5′-Guanosine Monophosphate Fibrillar Nanozyme: A Highly Efficient Metal-Free Intrinsic Peroxidase Mimic
Submolecular Resolution Imaging of Amyloid Aggregation: An STM Approach to Decipher Missense Mutation Effects in α-Synuclein
11
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome
Single-molecule dynamics of the TRiC chaperonin system in vivo
Identification of an allosteric site on the E3 ligase adapter cereblon
NAC controls nascent chain fate through tunnel sensing and chaperone action
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Collective homeostasis of condensation-prone proteins via their mRNAs
Covariation MS uncovers a protein that controls cysteine catabolism
Diffusing protein binders to intrinsically disordered proteins
Mapping and engineering RNA-driven architecture of the multiphase nucleolus
Probing condensate microenvironments with a micropeptide killswitch
Solid phase transitions as a solution to the genome folding paradox
2
Genome-wide mapping of RNA-protein associations through sequencing
Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis
13
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection
RNA-specific local translation is patterned by condensates for multinucleate cell growth
PML targets and resolves structured protein inclusions to mitigate neurodegeneration
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions
The G3BP stress-granule proteins reinforce the integrated stress response translation programme
Proximal proteomics reveals a landscape of human nuclear condensates
Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein
Ca-driven PDIA6 biomolecular condensation ensures proinsulin folding
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis
A multichaperone condensate enhances protein folding in the endoplasmic reticulum
8
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine
High-throughput ligand diversification to discover chemical inducers of proximity
NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation
Photosensitizer proximity labeling captures the lipid and protein interactomes
Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
Phase separation instead of binding strength determines target specificities of MAGUKs
7
Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics
Global profiling of arginine reactivity and ligandability in the human proteome
Profiling the proteome-wide selectivity of diverse electrophiles
Water-detected NMR allows dynamic observations of repeat-expansion RNA condensates
Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines
Immobilized acyl-transfer molecular reactors enable the solid-phase synthesis of sterically hindered peptides
Homotypic RNA clustering accompanies a liquid-to-solid transition inside the core of multi-component biomolecular condensates
184
Competition between protein-RNA clustering and phase separation drives re-entrant phase behavior of hnRNPA1
CSDE1 promotes viral immune evasion through RNA-dependent and phosphorylation-modulated liquid-liquid phase separation
The polymerized protein response (PPR) is activated by genetic variants that polymerize in the ER and is mediated by NFκBp50
Novel CuCLIP-seq for in situ covalently captured protein-binding RNAs
Newton’s cradle-like allosteric mechanism explains regulatory RsmE RNA binding
SMG7 and eIF4A constitute a homeostatic module controlling P-body condensation and function of meiotic bodies
A framework for the exploration of subcellular compartmentalization of RNA-binding proteins
Dynamic recruitment of CaMKII into SHANK3 phase-separated condensates tunes postsynaptic density remodeling during long-term potentiation
The schizophrenia associated protein DISC1 forms a multivalent tetrameric hub via conserved UVR dimers
Folded domains impose structural heterogeneity and attenuated dynamics in biomolecular condensates
Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization
Asymmetric dimeric assembly of Suv3 helicase facilitates processive RNA unwinding
Genotype-by-inhibitor interactions to dissect enterovirus replication
A delayed translocation into the endoplasmic reticulum controls the post-translational modifications of PD-L1
Protein coacervation-driven active forces power protocell dynamics
A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP
Optically driven control of mechanochemistry and fusion dynamics of biomolecular condensates via thymine dimerization
RF-SIRF reveals a replication stress-specific epigenetic code by spatio-temporal mapping of reversed forks
An orthogonal RNA aptamer for targeted RNA regulation in phase-separated subcellular compartments
Enhancer-mediated Etv4 activation stimulates osteogenic differentiation
Oligomerization-competent PIF4 drives thermomorphogenesis through functional redundancy in transactivation and DNA binding
Catalytic Proximal Protein Oligomerization as an Anti-Tumor Strategy Targeting WDR5
NEDAMSS syndrome-related truncating and missense mutations are associated with aberrant liquid-liquid phase separation of IRF2BPL
Dynamic control of IDP interaction network via diverse binding pathways
Structural and functional implications of phase separation of membrane protein LacY in Escherichia coli
Membrane-embedded polar residues target membrane proteins for degradation by the quality control protease FtsH
Identification of ephrin-A1–EphA2 signalling as a potential target for fracture prevention
Detecting glycosyl-oxonium and glycosyl-nitrilium ions using exchange NMR to investigate solvent effects in glycosylation reactions
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6
Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease
Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation
Decoupling phase separation and fibrillization preserves activity of biomolecular condensates
CycloPepper: a machine learning platform for predicting cyclization outcomes and optimizing synthesis of therapeutic cyclopeptides
RiboBright reveals cell-type-specific differences in ribosome organization and movement
Oxygen depletion in biomolecular condensates is dominated by macromolecular density
Direct observation and quantification of single nanocondensates of the low complexity domain of TDP-43
Sclerostin deficiency sensitizes white adipocytes to thermogenic signals that induce beiging in mice
Protein C-terminal variations impact proteostasis
Mechanistic insights into PCBP1-driven unfolding of selected i-motif DNA at G1/S checkpoint
Covalent modification of a glutamic acid inspired by HaloTag technology
Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly
Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota
Structural basis of co-translational N-myristoylation in humans
Co-translational determination of quaternary structures in chaperone factories
From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach
The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb
Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy
A high-throughput, flow cytometry approach to measure phase behavior and exchange in biomolecular condensates
Lucerastat, an oral therapy for Fabry disease: results from a pivotal randomized phase 3 study and its open-label extension
Volumetric compression regulates the phase separation of AXIN and acts as an operational amplifier to bidirectionally modulate Wnt signaling in organoids
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis
Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase
Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates
Chemotherapy-induced adipo-lineage cell senescence drives bone loss
Coordination of chromosome segregation and cell division in the archaeon Sulfolobus acidocaldarius
Single-cell dynamics of genome-nucleolus interactions captured by nucleolar laser microdissection (NoLMseq)
Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response
A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality
Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
Structural and catalytic diversity of coronavirus proofreading exoribonuclease
Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence
Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase
A universal O-glycosylation platform enabled by pyridinium catalysis using gas-releasing oxazolidinone-based carbamates donors
Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration
Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples
A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells
Dynamic Organellar Mapping in yeast reveals extensive protein localization changes during ER stress
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease
Microgliopathy as a primary mediator of neuronal death in models of Friedreich’s Ataxia
Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in mutant mice, a genetic model of schizophrenia and bipolar disorder
Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy
Hierarchical folding-upon-binding of an intrinsically disordered protein
Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer’s disease
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain
Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity
In vivo conformational space and defects of misfolded CFTR variants by covalent protein painting
Controlling interfacial protein adsorption, desorption and aggregation in biomolecular condensates
A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation
Structures of human organellar SPFH protein complexes
Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage
Molecular motor-driven reversible liquid-liquid phase separation of supramolecular assemblies
GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome
FUS nanoclusters are a distinct state within the dilute phase
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain
Development of a targeted BioPROTAC degrader selective for misfolded SOD1
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates
SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation
Determination of key functional structures of an amorphous VHL-based SMARCA2 PROTAC
Automated navigation of condensate phase behavior with active machine learning
Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling
Conformational dynamics, RNA binding, and phase separation regulate the multifunctionality of rabies virus P protein
Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response
Large protein-like leader peptides engage differently with RiPP halogenases and lanthionine synthetases
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules
Zinc finger domains bind low-complexity domain polymers
Molecular landscape of the fungal plasma membrane and implications for antifungal action
Amino acids bind to phase-separating proteins and modulate biomolecular condensate stability and dynamics
COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale
RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma
In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy
Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein
Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression
Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation
CD103CD8 T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling
Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities
The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses
KH–R3H domain cooperation in RNA recognition by the global RNA-binding protein KhpB
Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross--sheet formation
Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging
Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis
4D structural biology–quantitative dynamics in the eukaryotic RNA exosome complex
Visualizing dynamic tubulin folding in chaperonin TRiC from nonnative nucleus to final native state
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation
Quantifying collective interactions in biomolecular phase separation
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits
Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis
Iron-sulfur clusters in SARS-CoV-2 exoribonuclease and methyltransferase complexes: relevance for viral genome proofreading and capping
regulates Yap subcellular localization to maintain bone homeostasis
Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations
YAP charge patterning mediates signal integration through transcriptional co-condensates
Trans-synaptic molecular context of NMDA receptor nanodomains
Structure guided functional analysis of the S. cerevisiae Mre11 complex
A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides
Single-molecule tweezers decode hidden dimerization patterns of membrane proteins within lipid bilayers
Universal peptide synthesis via solid-phase methods fused with chemputation
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration
Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function
mRNA trafficking directs cell-size-scaling of mitochondria distribution and function
Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice
Arrest Peptide Profiling resolves co-translational folding pathways and chaperone interactions in vivo
Unveiling the hidden interactome of CRBN molecular glues
Coupling chromosome organization to genome segregation in Archaea
Structural insights into the roles of PARP4 and NAD binding in the human vault cage
ATP plays a structural role in Hsp90 function
RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer
Anti-sense oligonucleotide probing as a structural platform for studying ribonucleoprotein complex assembly
Engineering bi-directional chemically-modulated synthetic condensates for cellular control
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma
Structural stabilization of the intrinsically disordered SARS-CoV-2 N by binding to RNA sequences engineered from the viral genome fragment
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
Phase separated condensates of ATRX regulate neural progenitor identity
HP1 loses its chromatin clustering and phase separation function across evolution
Structural basis for catalysis by human lipoyl synthase
Optogenetic storage and release of protein and mRNA in live cells and animals
H2S-mediated protein S-sulfhydration modulates infectivity and autophagy in the rice blast fungus
Small-molecule-induced liquid-liquid phase separation suppresses the carcinogenesis of β-catenin
Thio-NHS esters are non-innocent protein acylating reagents
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis
Structural insights into the human HRD1 ubiquitin ligase complex
Mechanism of nascent chain removal by the ribosome-associated quality control complex
Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models
Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair
Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking
Liquid-liquid phase separation-boosted transmembrane delivery in interactive protocell communities
Emergent mechanics of a networked multivalent protein condensate
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1
Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain
A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones
In vivo structure profiling reveals human cytosolic and mitochondrial tRNA structurome and interactome in response to stress
Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes
An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase
Cyclic peptide structure prediction and design using AlphaFold2
Chromogranin A deficiency attenuates tauopathy by altering epinephrine–alpha-adrenergic receptor signaling in PS19 mice
Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates
LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels
Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure
A novel, covalent broad-spectrum inhibitor targeting human coronavirus M
Proteome-wide determinants of co-translational chaperone binding in bacteria
Spatiotemporal deciphering of dynamic the FUS interactome during liquid-liquid phase separation in living cells
Rational design of 19F NMR labelling sites to probe protein structure and interactions
Targeted disruption of PRC1.1 complex enhances bone remodeling
1
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation
1
Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial
5
Generating 3D models of complex carbohydrates with GLYCAM-Web
Orthogonal RNA-regulated destabilization domains for three-color RNA imaging with minimal RNA perturbation
RNA-stabilized coat proteins for sensitive and simultaneous imaging of distinct single mRNAs in live cells
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq
1
Nanoscale domains govern local diffusion and ageing within fused-in-sarcoma condensates
1
The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport
7
Condensate protein aggregation in ALS/FTD is regulated by GGGGCC-repeat RNA scaffolds
The filamentous ultrastructure of the PopZ condensate is required for its cellular function
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
Phosphorylation-dependent tuning of mRNA deadenylation rates
A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
Remote on–off switching of protein activity by intrinsically disordered region
1
Water-based coupling of amino acids for sustainable solid-phase peptide synthesis
1
Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo
58
An o-Nitroveratryloxycarbonyl-Based Photolabile Solubilizing Tag for the Chemical Synthesis of Poorly Soluble Peptides and Proteins
Sulfonium-Stabilized Phenols as Organocatalysts toward Divergent Stereoselective 2-Deoxy and Ferrier Glycosylation of Glycals
Synthesis of Conjugation-Ready Trisaccharide Repeating Units of Multidrug-Resistant Pathogen Acinetobacter baumannii MG1 and Strain 24
Synthesis of gem-Difluoro Spirocyclic Cyclopropyl Mannosyl-1-phosphate Analogues and Chemoenzymatic Preparation of ADP- and GDP-Spirocyclopropyl-mannose
A Sequential Iodination–Fluorodeiodination of the Cubane Scaffold
Two Triterpenoids with a Cyclobutane Moiety from Mastic: Structural Elucidation and Biological Evaluation
Liquid-Phase Peptide Synthesis of Tropolone–Peptide Hybrid Antimalarials
Development of Nuclear-Targeted Photoaffinity Probes with Cleavable Disulfide Bonds for Enhancing Selectivity in hPTM Interactome Profiling
Access to Rare d- and l-Hexoses from C1 Nucleophiles via Anomeric Acylation
pNZ Removal Aided Aqueous Solid-Phase Peptide Synthesis: A Gateway to Sustainable Synthesis of Complex Peptides
<atl>Scaling Azapeptide with iN/i -Fmoc-Aza-Tripeptide from Resonant Acoustic Mixing of iN/i -Fmoc-Amino Hydrazide and iN/i -Succinimidyl Carbamate</atl>
Toward N-Linked Glycoproteins: Three-Step Synthesis of Glycan-Asparagine Conjugates from Unprotected Sugars
Chemical Protein Synthesis by Hydroxylamine-Involved Ligation of Peptides
User-Friendly Thioglycoside Preactivation via Instant Sulfenyl Chloride Generation
Phenylthioethyl (Pte)/Phenylsulfonylethyl (Pse) as Safety Catch Protecting Groups for Peptide Synthesis
Orthogonal Electrochemical Amine Deprotection: Toward Sustainable Strategies for Peptide Synthesis
Highly Stereoselective 1,2-cis-Glycosylation with 2-Azidofucosyl Donors: Access to the Pentasaccharide Motif from Escherichia coli O4:K6
Regio- and Stereoselective Synthesis of 1-/3-Sulfone Sugars Controlled by the Amount of SnCl4
Modular Synthesis of Nucleoside Diphosphate Sugar Analogues Using Chlorosulfonyl Isocyanate and Dichlorophosphoryl Isocyanate
Photocatalyzed Decarboxylative Thio(seleno)etherification of Redox-Active Uronates Enables Synthesis of Rare Sugar Thio(seleno)glycosides
Stereoselective Assembly of 2-Deoxy-2-fluoroglycosides Enabled by Pyridinium Catalysis
Chemical Synthesis of a Highly Branched Hexasaccharide Fragment from Bordetella pertussis Lipooligosaccharide
Dual Anomeric Stereocontrol in 1,1′-Glycosylation via a Remote Directing 2-(Diphenylphosphinoyl)acetyl Group
Reactivity Tuning by Ring Size: A Glycosylation Protocol Using Thiophene-Scaffolded Glycosyl Donors
Synthesis of Bis-urea-Bridged Cyclopeptides via Stapling of Unprotected Peptides
One-Pot Assembly of the Rare Sugar Containing Trisaccharide Repeating Unit of Pseudomonas putida TSh-18
AuCl3–tBuCN Catalysis in 1,2-trans 2-Deoxy-2-fluoro Glycosidic Bond Formation
Cosolvent Effects Question the Role of Water in Native Chemical Ligation
Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope
Electrochemical 2-Deoxyglycosylation of N-Containing Molecules with β-Stereoselectivity
Stereoselective Organocatalytic Fucosylation with Isothioureas
SN2 Glycosylation Enabled by a Directing-Group-on-Leaving-Group Strategy: Highly Stereoselective Synthesis of Glycosyl Carboxylates
Synthesis of Insulin-desB30 Analogs via an Enzymatically Removable N-Terminal Solubilizing Tag
Phage Display of Graspeptides via SrtA-Mediated Peptide Ligation and Cyclization
Aldehyde Capture Ligation without Involving a Side Chain Functional Group
Thioester Ligation with AAHO Peptides
Aqueous Phase Synthesis of Complex Thiazole-Containing Peptides by Condensation of N-Acyl-α-aminonitriles and Cysteine Derivatives
Chemical Synthesis of Conjugation-Ready Oligosaccharide Haptens of Pseudomonas aeruginasa O11 and Staphylococcus aureus Type 5
C-4 Functional Group-Driven Stereodivergent Synthesis and Late-Stage Diversification of 6-Deoxy l-talo/gulo Rare Sugars
Stereoselective Synthesis of N–O-Linked α-iN/i-Acetylgalactosaminoglycosides via Oxime iO/i-Glycosylation with 2-Nitrogalactals
Sulfonium Stabilized Phenols as Hydrogen Bonding Catalysts toward Diastereoselective Glycosylation of Cyclopropanated Sugars
Palladium-Catalyzed Glycosylation for the Highly Stereoselective ide Novo/i Construction of Trideoxy Glycan Motifs from Pyridapeptides B-E
Investigation of the Reactivities of Halogen-Substituted Bicyclic Sialic Acid Donors and Their Application
Pyranoside-into-Furanoside Rearrangement of Galactose Units within a Preassembled Oligosaccharide Chain
Hydrophobic Tag-Assisted Liquid-Phase Synthesis of Tirzepatide
Total Synthesis of the Conjugation-Ready Tetrasaccharide Repeating Unit of Multidrug-Resistant Pathogen Pseudomonas aeruginosa NCTC 8505 O-Antigen
The Baeyer–Villiger Oxidation of Cubyl Ketones: A Synthetic Route to Functionalized Cubanols
Trifluoroacetic Acid Promotes Ultrafast Peptide Cyclization Mediated with Dimethylolurea
Stereoelectronic Tuning of Heteroaromatic γ-Amino Acids for Turn Mimetic Design
Unlocking the Potential of Ynamide as a Promoter in Copper(II)-Catalyzed O-Glycosylation
Stereoselective Glycosylation of Amino Sugars Enabled by Thiourea/Phosphoric Acid Dual Catalysis
Development of a Diastereoselective Csp2–Csp3 Cross-Coupling Reaction Inspired by Macrocyclic RiPP Natural Products
3-Methylpyrazole-Mediated C-Terminal Protein Modification
Development of Semisynthesis to Achieve Sulfonium Proteins with Diverse Modifications
Stereospecific Oxidative Contraction of Anomeric Nucleophiles
Total Synthesis of Pedopeptin C
Stereoselective Multigram-Scale Tn Antigen Synthesis via the Iron-Catalyzed Glycal 1,2-icis/i-Aminoglycosylation
Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues
15
Polyphosphate modulates the stress-responsive formation of functional RNA-protein condensates in bacteria and mammalian cells
The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms
A novel targeting domain directs essential components of the cytosolic iron–sulfur cluster assembly pathway to the mitochondrion of Toxoplasma parasites
Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents
Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation
RNA-binding protein IMP1/ZBP1 directs local translation in microglial processes to regulate motility and phagocytosis during inflammation
Visualization of Trypanosoma brucei flagellar pocket collar biogenesis identifies two new cytoskeletal structures
Cross‐species rescue reveals sequence requirements for a rapidly evolving intrinsically disordered region
HAPLN2 forms aggregates and promotes microglial inflammation during brain aging in mice
Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization
Ancestral [Fe-S] biogenesis system SMS has a unique mechanism of cluster assembly and sulfur utilization
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation
Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer's disease
3
Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains
Tissue-specific consequences of tag fusions on protein expression in transgenic mice.
Unveiling the intercompartmental signaling axis: Mitochondrial to ER Stress Response (MERSR) and its impact on proteostasis
1
Symmetry analysis of cross-circular and parallel-circular Raman optical activity
2
Antisymmetric Raman Response
Nonequilibrium Structure and Relaxation in Active Microemulsions
1
Torsion-Driven Plectoneme Formation During Nanopore Translocation of DNA Polymers
2
Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco
The chromosome-scale assembly of the Salvia plebeia genome provides insight into the biosynthesis and regulation of rosmarinic acid
79
Exploring PrPC unfolding as a critical step preceding its refolding in the context of PrPSc propagation
Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners
Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519
Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress
Atomic-level architecture and assembly mechanism of high-order structures of RIPK1 fibril revealed by integrated structural biology
Targeted NMR signal enhancement of RNA by site-directed bis-nitroxide labeling
The α-synuclein proteostasis network and its translational applications in Parkinson’s disease
Non-Fickian diffusion within assemblies of the intrinsically disordered protein β-casein
Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates
Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling
Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function
Selective control of ligand binding through a distal mutation that alters the protein native ensemble
CDKL5 modulates the plasticity of excitatory synapses via liquid–liquid phase separation
Accurate conformational ensembles of intrinsically disordered proteins using reweighting based on NMR chemical shifts
The assembly rules guiding hetero-oligomeric bacterioferritin organization and their evolutionary signature
In situ NMR and integrative proteomics reveal the interaction signature of serum α-synuclein
Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium
Coordination of cell organelles to promote metabolon formation
Force-dependent structural dynamics of the giant nesprin-2
Droplet growth, Ostwald’s rule, and emergence of order in Fused in Sarcoma
Slippage reconfiguration of trinucleotide repeat hairpins impedes resolution by human replication protein A
GFP-free live neuron quantitative imaging reveals compartmentalization and growth dynamics of polyQ aggregates
Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization
Measuring bridging forces in protein–DNA condensates
Polymer conformational entropy as the driver of complex coacervation
Polyserine domains are toxic and exacerbate tau pathology in mice
Sticky interactions govern sequence-dependent dynamics in biomolecular condensates
Mass spectrometry footprinting reveals how kinetic stabilizers counteract transthyretin dynamics altered by pathogenic mutations
Nucleic acid base pair open states by hydrogen exchange
Hollow condensates emerge from gelation-induced spinodal decomposition
Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis
Arg–Tyr cation–π interactions drive phase separation and β-sheet assembly in native spider dragline silk
Multiplex mapping of protein–protein interaction interfaces
Interprotomer communication and functional asymmetry in H/ACA snoRNPs
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation
Control of encounter kinetics by chemically active droplets
Probing direct interactions between nuclear proteins in cells with nxReLo
Inhibition of ice recrystallization with designed twistless helical repeat proteins
A machine learning protocol for predicting structural distributions of amyloid-forming proteins from 2D IR spectra
The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster
Molecular drivers of RNA phase separation
The RANK/RANKL axis controls vascular dynamics in the bone marrow
Programming cellular condensates for living materials using an intrinsically disordered protein display platform
Driving forces of RNA condensation revealed through coarse-grained modeling with explicit Mg2+
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing
Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo
Structure of a transient protein-folding intermediate by pressure-jump NMR spectroscopy
An unusual Co–S bond links B12 chaperones in an interprotein complex
In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA
Employing deep mutational scanning in the Escherichia coli periplasm to decode the thermodynamic landscape for amyloid formation
A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system–exported toxins
3D pattern formation of a protein–membrane suspension
CpG-A induces liquid–liquid phase separation of HMGB1 to activate the RAGE-mediated inflammatory pathway
Microglia-to-neuron signaling links APOE4 and inflammation to enhanced neuronal lipid metabolism and network activity
De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases
Diverse thioether macrocyclized peptides through a radical SAM maturase
The functional dynamics of FicD’s TPR domain are modulated by the interaction with ATP and BiP
Definition of the components required for selective packaging of coronavirus genomic RNA
Client–scaffold interactions suppress aggregation of a client protein in model condensates
Immiscible proteins compete for RNA binding to order condensate layers
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
Identification of an on-pathway intermediate illuminates the kinetic competition between protein folding and misfolding
Prg4+ fibroadipogenic progenitors in muscle are crucial for bone fracture repair
Trigger factor accelerates nascent chain compaction and folding
De novo design of D-peptide ligands: Application to influenza virus hemagglutinin
PLAA/UFD-3 regulates P-bodies through its intrinsic disordered domain
The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins
Gut sulfide metabolism modulates behavior and brain bioenergetics
SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses
Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution
Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells
Material properties of biomolecular condensates emerge from nanoscale dynamics
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1
Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments
Activation mechanism of small heat shock protein HSPB5 revealed by disease-associated mutants
Molecular insights into human phosphatidylserine synthase 2 and its regulation of SREBP pathways
Unraveling structural transitions and kinetics along the fold-switching pathway of the RfaH C-terminal domain using exchange-based NMR
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
1
Identification of Biological Subtypes of Friedreich Ataxia with Structural MRI-based Machine Learning.
9
Pearling drives mitochondrial DNA nucleoid distribution
Unstructured transcription factor interactions enable emergent specificity
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Zwitterionic organoboron complexes for overcoming the concentration barrier in chemical protein synthesis
Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders
Design of intrinsically disordered region binding proteins
Sequence-based prediction of intermolecular interactions driven by disordered regions
34
Bacteria use P-body condensates to attenuate host translation during infection
Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling
Bioelectronic synthesis of hydrogen sulfide enables spatiotemporal regulation of protein modification and cellular redox
Functional characterization of dynamic nascent RNA folding ensembles in real time
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
Isothiocyanate-mediated cyclization of phage-displayed peptides enables discovery of macrocyclic binders
Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease
Reversible phase dynamics of PsAF5 regulate mitophagy to balance redox levels in Phytophthora sojae
Highly efficient α-sialylation with ortho-(1-phenylvinyl)benzoates as leaving groups: One-pot assembly of α-sialoglycans
Phosphorylation of shiftless is important for inhibiting the programmed −1 ribosomal frameshift
Total synthesis of zwitterionic PS A2 oligosaccharides from Bacteroides fragilis
Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single workflow
Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy
ASPL couples the assembly of stress granules with their VCP-mediated disassembly
Translation landscape of stress granules
Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism
Cotranslational protein folding through non-native structural intermediates
An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS
The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat
Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles
Para-(3-phenylpropiolamido)phenyl (PPAP) glycosides: Harnessing ipso-cyclization–driven glycosylation for strategic flexibility
CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer’s disease
Sequestration of ribosome biogenesis factors in HSV-1 nuclear aggregates revealed by spatially resolved thermal profiling
ATP13A1 engages SEC61 to facilitate substrate-specific translocation
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
Nucleolar beacon for monitoring nucleolar morphology and proteomics in living cells
Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils
Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression
Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer’s disease
Active transport enables protein condensation in cells
High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy
UFMylation orchestrates spatiotemporal coordination of RQC at the ER
2
Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome
Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease
14
ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences
ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradation
STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation
Bacterial ubiquitin ligase engineered for small molecule and protein target identification
Client recruitment mechanism of the cytosolic Fe-S cluster assembly targeting complex
Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells
Mapping cryptic phosphorylation sites in the human proteome.
Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation.
RABGAP1 is a sensor that facilitates the sorting and processing of amyloid precursor protein.
Dysfunctional mitochondria trap proteins in the intermembrane space.
An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins.
Molecular insights into the effect of 1,6-hexanediol on FUS phase separation
Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system
1
Tryptophan–kynurenine metabolites associate with inflammation and immunologic phenotypes in common variable immunodeficiency
26
Protoporphyrin IX Attenuates Liquid–Liquid Phase Separation of α-Synuclein by Inducing Its Compaction
Universality Encoded in Fano Lineshapes: A Decoupled Phonon Framework for Rapid Raman Parameter Extraction
Decoding Physicochemical Interactions Via Single-Molecule Fluorescence Blinking
Anomalous Effect of Denaturant on Protein Unfolding Dynamics Revealed by Single Molecule Manipulation Experiments
Mechanism of Ag+-Induced Folding of a Bacterial Peptide from Replica-Exchange Molecular Simulations
Infrared Spectra of the Thymidine 13C2 and 13C4 Isotopes in H2O and D2O
Spectral Fingerprints of Hydrogen-Bonding in Water Solvation of Amino Acids
Atomic Structure of GNNQQNY Nanocrystals: A Validated Approach for Polymorphic Amyloids
Probing the Triplet State by Cryogenic Ion Trap IR Spectroscopy─Application to Protonated Lumiflavin
Molecular Insights into the Dual Mechanism of Bepristat 2a on Protein Disulfide Isomerase (PDI) Activity
How the Extent of Protein Folding and Oligomerization Modulate Condensate Formation and Properties
Native Folding Stability of the Main Protease of Coronavirus SARS-CoV-2 on a Gold Surface
Nanoscale Mechanical Force Primes NOD1-LRR for Efficient Pathogen Recognition
Electrostatic Collapse of Intrinsically Disordered Acid-Rich Protein Is Sensitive to Counterion Valency
Density Functional Theory Calculations to Investigate the Role Played by an Aspartate Dyad in Hsp60-Catalyzed ATP Hydrolysis
UV Resonance Raman Spectroscopic Marker Bands of Base Pair Formation During Nucleic Acids Assembly
Single-Molecule Mechanochemical Mapping of Hierarchical Cu Coordination in High-Capacity Copper Storage Protein Csp1
Single-Molecule Fluorescence Spectroscopy of 4-Cyanotryptophan and Its Application in Photoinduced Electron Transfer Fluorescence Correlation Spectroscop
Chiral Matching between Nucleic Acids and Polypeptides Facilitates Liquid–Liquid Phase Separation
Beyond Electrostatic Interactions: H-Bond Dynamics in Arginine- versus Lysine-Rich Biocondensates
AlkD’s Conformational Dynamics Regulated by Protein–DNA Interactions for Effective Target Recognition
RNA Structural Complexity Dictates Its Ion Atmosphere
Emergence of Compact Oligomers inside the Small-World Network of TDP-43 Condensates
Electrostatic Clamp and Loop Dynamics Dictate Caspase-8 Cleavage of the Apoptotic Protein Bid
Investigation of Chemical Properties within Chaperonins in Stabilizing Substrate Protein Conformations Using Biomolecular Environment-Mimicking Model
Protein Conformation Governs Spin-Selective Electron Transmission
1
AAV9-Mediated Gene Therapy for Infantile-Onset Pompe’s Disease
1
Molecular determinants underlying NPH3 condensation and function in phototropism: an integrative approach

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