Medicinal and Biomolecular Chemistry articles for China

Time frame: 1 June 2025 - 30 May 2026

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Count: 299

Article ‘Count’ for Medicinal and Biomolecular Chemistry.

Journal Count Share
8 7.11
Programmable DNA Folding Modulates Phase Behavior and Dynamics of DNA/Peptide Condensates 0.29
Precisely Staging Diabetic Nephropathy by a Gold-Based Artificial Filtration Biomarker through Computed Tomography and Blood Testing of the Glomerular Filtration Rate 1.00
Mesoporous PdPt Nanozymes with Target Peptides and Cascade Reactive Oxygen Species Scavenging for Boosting Alzheimer’s Disease Treatment 1.00
Mapping the Functional Architecture of Influenza A Virus-Induced Phase Separation through m6A Proximity Labeling 0.90
RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction 1.00
Interfacial Silicification Efficiently Drives Osteogenic Differentiation of Mesenchymal Stem Cells without Any Exogenous Osteoinductive Factor 1.00
Molecular Engineering of DNA Condensates: Harnessing Phase Transitions for Precise Control of Catalytic Functions 1.00
Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition 0.92
2 1.82
Targeting injury-triggered grancalcin from senescent macrophages enhances aged bone healing 1.00
Bioactive glass-induced B cell depletion remodels the osteoimmunological microenvironment to enhance osteogenesis 0.82
6 6.00
Identification of a Bioactive Domain in Type II Collagen That Promotes Bone Repair via EGFR Signaling 1.00
Modulation of Ice Formation and Removal Dynamics by Antifreeze Protein-Inspired Large-Area Films 1.00
ZnS/Au Composites Advance Comprehensive Characterization of Low-Molecular-Weight Compounds Toward Pharmaceutical Analysis of Traditional Chinese Medicine 1.00
Bone‐Homing Cellular Backpacks Integrating Metabolic Intervention and Synergistic Osteogenesis to Treat Bone Metastasis and Promote Diabetic Bone Repair 1.00
Deep Learning-Driven Co-Assembly of Naturally Sourced Compound Nanoparticles for Potentiated Cancer Immunotherapy 1.00
Poly-Lipoic Acid Trisulfide Particles: A New Donor With Continuous and Steady H2S Supply 1.00
3 2.39
Bioinspired, Mitochondria-Targeted Single-Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​ 1.00
A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment 1.00
Natural Design of a Stabilized Cross-β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats 0.39
31 29.75
PROTAC-Based Proteomics Strategy Uncovers Arsenic-Binding Proteomes 1.00
Cysteine-Triggered Hydrogen Sulfide Nanoprodrug for Real-Time Imaging and Therapeutic Evaluation of Acute Kidney Injury 1.00
Chemical Redirection of Protein Folding Landscapes via Lysine-Targeted Induction of Helix-to-Sheet Transitions 1.00
A Brain-Permeable Selenocyanate Near-Infrared (NIR) Probe Platform for H2S Dynamics Imaging: Insights into Redox Homeostasis and Antiepileptic Therapy 1.00
Five-in-One Neurodetoxification-Guardian-Type Near-Infrared Carbon Dots for Synergistic Blockade of Alzheimer’s Disease Pathological Cascade 1.00
A Novel RNA-Light Probe for Structured-Illumination Microscopy Super-Resolution Imaging of Nucleolar Ultrastructure and Analysis of Nucleolar Dynamics 1.00
Screening of Ruthenium Complexes as the Protein Light Switches for Protein Detection 1.00
In Situ Study of p53, MDM2, and MDMX Protein Interaction in Living Cells Using Fluorescence Triple Correlation Spectroscopy 1.00
MOSCAT: Aldehyde-Selective Chemical Proteomics for Site-Specific Profiling of Cinnamaldehyde Targets in Living Cells 1.00
A Covalent Targeted Platform for Protein Dynamic Tracking 1.00
Beyond Binding Affinity: Detailed Profiling of Protein–Ligand Interactions with Time-Resolved FRET 1.00
Nonmodified Strategy Enabled Proteome-Wide Mapping of Catechol Derivatives Interactome 1.00
TIPP: A Novel Iodoacetamide Reaction-Induced Protein Precipitation Approach for Proteome-Wide Ligand-Target Identification 1.00
Clickable Multitargeting Cross-Linkers Based on SuFEx for In Vivo Cross-Linking Mass Spectrometry 1.00
Study of the Aggregation Behavior of Proteins Related to Neurodegenerative Diseases Based on the Photoluminescence of Perovskite Nanocrystals 1.00
Ultrasensitive Biocoded SERS Immunoassay for Tracing Molecular Gatekeeper Mfn2 Expression within Single Cells during Stem Cell Differentiation 1.00
Toward-Automated Etalon Artifacts Elimination in Dual-Wavelength Raman Spectroscopy for In Vivo Applications 0.15
Mapping Protein-ssDNA Interactions at Single Nucleotide Resolution by Dual Nucleases-Assisted Next-Generation Sequencing 1.00
Cocktail Chemical Labeling for In-Depth Surfaceome Profiling of Bone-Marrow-Derived Dendritic Cells 1.00
Streamlined Methods for Profiling Targeted Michael Acceptor Molecules Reveal Natural PTP1B Covalent Inhibitors 0.67
Specific Lung-Targeting Shortwave Infrared Luminescence Nanoprobe: Precisely Delineating Sepsis-Induced Acute Lung Injury 1.00
Acrolein as an Alternative Broadly Reactive Activity-Based Probe for Activity-Based Protein Profiling of Cysteinome 1.00
Robust Chemical Cross-linking of Proteins and Protein Complexes via SuFEx Click Chemistry 1.00
Novel Urazole-Derived MS-Cleavable Cross-Linkers Targeting Tyrosine/Lysine Residues for Protein Structural Analysis 1.00
Molecular Optimization of a Near-Infrared Fluorogenic Probe for Hydrogen Polysulfide Imaging in Acute Liver Injury 1.00
Differentiating Molecular Weights of Supramolecular Polymers in Lower Monomer Concentrations by Coreaction Accelerator-Regulated Electrochemiluminescence 1.00
Chemoproteomic Profiling of Isoprenoid Pyrophosphate Interacting Proteins with Photoaffinity Probes 1.00
FRAP4ICBS: FRAP Analysis Method to Evaluate Dominant Effects for Biomolecular Condensate Formation 1.00
Spatially Resolved Multibait Mapping of Stress Granule and Processing Body Transcriptome 1.00
Research on the Extraction of Characteristic Information and Similarity Evaluation Method for Relative Intensity Information between Characteristic Peaks in Raman Spectra 1.00
Detection of Protein Polysulfidation Using a β-(4-Hydroxyphenyl)ethyl Iodoacetamide-Derived Biotin Tag HPB 0.93
26 23.24
Ferritin Iron Mineralisation: Route of Fe3+ Transfer From the Ferroxidase Centre to the Inner Cavity of Human H-Chain Ferritin 0.08
Total Chemical Synthesis of Interleukin-15 and Interleukin-2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy 1.00
Precise Synthesis of Highly Branched Angelica dahurica Polysaccharides up to 66 Units Reveals a Minimal Motif for Wound Repair 0.92
Profiling the Structural Heterogeneity of Monomeric α‐Synuclein From the Single‐Molecule Level Using MspA Nanopores 1.00
Modular Synthesis of Neisseria meningitidis Lipooligosaccharide Inner Core Oligosaccharide Library to Identify Broadly Reactive Antigenic Epitopes 1.00
Ansamer‐Controlled Bicyclic Peptides as Integrin αvβ6 Targeting Agents 0.85
Glycinamide-Driven Coumarin Construction (GDCC): A Mild Strategy for Fluorescent Labeling and Macrocyclization of Peptides 0.88
Expeditious Synthesis of 2‐Deoxy‐2‐perfluoroalkyl Glycosides 1.00
Programmable DNA Nanostructures for hTERT Compartmentalization and Translocation in Living Cells 1.00
Side-Chain Engineering Guides the Design of β-Sheet Inhibitor to Anchor Protein-Protein Interaction Interfaces 0.95
Coexistence of G‐Quadruplex and i‐Motif Within a DNA Duplex is Tolerated by a PCBP2‐Assisted Replisome 0.96
In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking 1.00
Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides 0.13
Synergistic SuFEx-Driven Covalent Cancer Therapy Using a HER2/EGFR Bivalent Affinity Protein Drug 1.00
Simultaneous Induction and Self‐Reporting of Nucleolar Stress by a Nucleolus‐Targeted Platinum(II) Complex via Lifetime Imaging 1.00
A Picolyl-Based Cys Caging/Uncaging Strategy Facilitates Protein Synthesis 1.00
Carbonothioate‐Triggered Cascade Cyclization Enables High‐Specificity Fluorescence Imaging of Hydrogen Polysulfides 1.00
Electrochemical Late-Stage Stitching of Tryptophan Peptides via N─S Bond Formation 1.00
Activity‐Based Ubiquitin Probes Capture the Sulfenylated State of Deubiquitinases 1.00
Cell‐Active, Irreversible Covalent Inhibitors Targeting a Surface‐Exposed Non‐Catalytic Lysine on Aurora a Kinase by Using Squarate Chemistry 0.77
Pd-Catalyzed Stereospecific and Ligand-Controlled Regiodivergent Suzuki–Miyaura Cross-Coupling for the Synthesis of 3-C-Glycals and 2,3-Unsaturated C-Glycosides 0.83
Intramolecular Thiol‐Promoted Decomposition of Cysteine Ester (ITPDC): A General Platform for Controllable Release of Reactive Sulfur Species 1.00
Visible‐Light‐Controlled Lysine‐Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells 1.00
Proteome‐Wide Data Guides the Discovery of Lysine‐Targeting Covalent Inhibitors Using DNA‐Encoded Chemical Libraries 1.00
Deciphering and Predicting Thermal and pH Stabilities of Triplex DNA Under Multifactorial Conditions 0.88
Superfast Protein Desulfurization Triggered by Low‐Energy Visible Light 1.00
1 1.00
Cystathionine γ‐Lyase‐Dependent S‐Sulfhydration of Smad3: A Novel Target to Alleviate Fibrosis in Systemic Sclerosis 1.00
1 0.95
Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways 0.95
2 1.95
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2 0.95
Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity 1.00
1 1.00
Mitochondrial dysfunction reveals H2S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects 1.00
7 7.00
Conformational plasticity of holliday junctions tunes histone H1–mediated liquid–liquid phase separation 1.00
Chiral biphenanthrene-diol-based lanthanide cubanes 1.00
Chemoenzymatic synthesis of sulfated O-glycopeptides from human CD34 1.00
Photochemical HAT-mediated site-selective C(sp3)–H aminoalkylation of cubanes catalyzed by TBADT 1.00
Acetylacetone-modified ubiquitin C-terminus enables specific capture of sulfenylated deubiquitinases 1.00
Direct Measurement of SARS-CoV-2 Spike RBD Binding to Integrin αvβ6 by Single-Molecule Force Spectroscopy 1.00
Exceptional mechanical stability of the spider silk C-terminal domain 1.00
7 5.95
Design of permeability-optimized target-binding macrocycles via direct preference optimization 1.00
Pd-catalyzed stereoretentive synthesis of reversed C-acyl glycosides: access to rare l-sugars and higher-carbon sugars 1.00
Guanine nucleotide directed co-assembly with Pt-complexes for tailoring chiroptical properties and multimodal molecular recognition 1.00
Impact of vibrational strong coupling on liquid–liquid phase separation in supramolecular polymers 0.29
Unprecedented allosteric inhibition of E. coli malate dehydrogenase by silver(i) from atomic resolution analysis 1.00
Europium probe binding to serum albumin and αsub1/sub-AGP, key importance of configuration, charge and size complementarity 0.67
Selectively triggered: ROS-activated Michael acceptor prodrug strategy to enhance tumor targeting efficacy 1.00
1 1.00
Growth Differentiation Factor-15 Improves Prognostic Accuracy of Risk Stratification in Pulmonary Arterial Hypertension 1.00
1 0.25
Nuclear lamina phase separation orchestrates stress-induced transcriptional responses in plants 0.25
1 1.00
Squaramide-Based MOF Enables Hydrogen-Bond-Directed Ultraselective Guanine Detection and Drug Monitoring 1.00
5 4.18
Transcriptome-guided discovery and active-site gatekeeper engineering of a Viola arcuata asparaginyl ligase with superior catalytic performance 1.00
IRE1/Xbp1 promotes the clearance of poly(GR) dipeptide repeats in amyotrophic lateral sclerosis 1.00
Negatively charged α-synuclein condensate modulates partitioning of molecules 1.00
Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS 1.00
Topological isomers of a potent wound healing peptide: structural insights and implications for bioactivity 0.18
1 1.00
IQSEC2/BRAG1 may modulate postsynaptic density assembly through Ca2+-induced phase separation 1.00
1 1.00
Identification of a Novel Compound Heterozygous Variant in the ALPL Gene Linked to Hypophosphatasia in a Chinese Family 1.00
1 1.00
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness 1.00
37 31.60
Distinct RNA Physical Microenvironments Shape Unique Properties and Functions within Biomolecular Condensates 1.00
Bridging Heterocycle-Mediated Hydrogen Bonding Facilitates Permeability of Polar Macrobicycles 0.22
Beyond a Passive Tether: Structural Insights into the Disordered Tail of Hsp90 0.09
Directional Engineering of Cyclic β-Hairpin Peptides for PET/CT Imaging of PD-L1 0.93
Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity 1.00
OaAEP1-Mediated Ligation of Mirror-Image Peptides via Acyl Donor Substrate Engineering 1.00
Partially Protected N-Acetylglycosamine Donors Enable Direct β-O-Glycosylation: Applications and Mechanistic Insights 1.00
Hijacking Actin-Pre-Liquid–Liquid Phase Separation Suppresses Malignant Tumor Invasion and Growth 1.00
Distinct Effects of the Extracellular Domain and Antibody Binding on HER2 Transmembrane and Juxtamembrane Regions Unveiled by NMR and EPR 1.00
Total Synthesis of the Glycoside Antibiotic Paulomycin A 1.00
Accessing Underexplored Biosynthetic Potential by Initiation Unit Engineering of Nonribosomal Peptide Synthetases in Proteobacteria 1.00
A Tandem Bioorthogonal Retro-Cope and Cope Elimination for the Activation of Covalent Inhibitors with an Acrylamide or Vinylsulfonamide Warhead in Live Cells 1.00
Group Competition Strategy for Covalent Ligand Discovery 1.00
Total Synthesis of the TIM-1 IgV Domain via N-to-C Serine/Threonine Ligation Enabled by Knorr Pyrazole Synthesis-Mediated Regeneration of Salicylaldehyde Esters 1.00
Dioxazolones as Masked Isocyanate Electrophiles for Global Profiling of Lysine Reactivity and Ligandability 1.00
Sustainable Peptide Synthesis by Photoredox-Catalyzed Picoc-SPPS 1.00
Decoding Arginine Dimethylation Isomers via pH-Tuned Reactivity with Methylglyoxal: A Chemical Approach for Functional Proteomics 1.00
Chemoselective Tagging of Protein Methacrylation 1.00
Traceless 6-O-Lysyl Modification of N-Acetylglucosamine Enables Synthesis and Derivatization of Aggregation-Prone GlcNAcylated Peptides 1.00
Thiocrown Ether: Reversing SN1 to SN2 Pathways in 1,2-cis Phosphoryl Glycosylation 1.00
Responsive Plasmonic Reporters Decrypt Nanoparticle-Induced Single Membrane Protein Degradation 1.00
Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy 1.00
Site-Specific Profiling of RNA-Binding Proteins Enabled by Isotopic Signature-Enhanced Mass Spectrometry 1.00
Live-Cell Monitoring and Omics Analysis of Liquid–Solid Transitions of Biomolecular Condensates 0.12
Immunoglobulin-Directed Phase Separation for Cell-Specific Modulation of Receptor Signaling 1.00
Beyond the Amyloid Core: Modulation of Aggregate Conformational Diversity by Mutations in the Noncore Regions 1.00
Exploring Phage Peptide Scaffolds: Tyrosinase-Mediated Cyclization for Selective Generation of Bioactive Cyclic Peptides 1.00
A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo 1.00
Ribosomal Incorporation of Fluorosulfonyloxy-l-Phenylalanine into Macrocyclic Peptides for De Novo Target-Specific Covalent Binders 1.00
Single-Entity Resolution Single-Cell Nanosensor Reveals Reactive Oxygen Species at Stress Granules Are Formed by Interfacial Redox Chemistry 0.06
Structural Mechanism of Insect Cuticular Protein Binding to Chitin Revealed by Solid-State NMR 1.00
Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission 0.14
Proline-Mediated Enhancement in Evolvability of Disulfide-Rich Peptides for Discovering Protein Binders 1.00
Chaperone-Mediated Regulation of Tau Phase Separation, Fibrillation, and Toxicity 0.04
Structural Basis and Rational Design of Nucleotide Analogue Inhibitor Evading the SARS-CoV-2 Proofreading Enzyme 1.00
β-Thioglycosylation from Unactivated Carbohydrates 1.00
Chemically Engineered Affinity Protein Drugs for Covalent Targeted Cancer Therapy 1.00
1 1.00
Mesangial Cell–Derived Extracellular Matrix Protein 1 Is Essential for Maintaining Mesangial Matrix Homeostasis and Glomerular Architecture 1.00
1 1.00
Proteinase 3 drives murine diabetic kidney disease by mediating caspase-3-dependent apoptosis of podocytes 1.00
1 1.00
Aging-Directed Structural Evolution of In Situ Formed Polymeric Coacervates and Their Applications in Constructing Hierarchical Assemblies 1.00
5 3.75
Alphaviral non-structural protein-host RBP co-condensation as a mechanism to sustain virus replication 0.79
Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins 1.00
The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis 1.00
Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery 0.09
Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate 0.88
2 1.73
Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy 0.73
Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer’s disease 1.00
5 3.87
Geometric Confinement in Solid-State Nanopores Enables Single-Molecule Discrimination of Ferritin Subunits and Translocation Bias 0.08
Reprogramming Chirality in Peptide Self-Assembly via Intramolecular Side Chain-Backbone Hydrogen Bonding 0.79
Conformational Adaptability and Thermostability in α/β-Peptide Fibrils Induced by β-Amino Acid Substitution 1.00
Cross-Linked Lipoic Acid Trisulfide Nanoparticles: Revisiting H2S Intervention as a Stand-alone Modality for Cancer Therapy 1.00
Submolecular Resolution Imaging of Amyloid Aggregation: An STM Approach to Decipher Missense Mutation Effects in α-Synuclein 1.00
2 1.06
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome 1.00
Diffusing protein binders to intrinsically disordered proteins 0.06
3 2.15
PML targets and resolves structured protein inclusions to mitigate neurodegeneration 1.00
Proximal proteomics reveals a landscape of human nuclear condensates 1.00
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins 0.15
2 2.00
HO-free proximity proteomics for exploring dynamic protein complexes in living systems 1.00
Phase separation instead of binding strength determines target specificities of MAGUKs 1.00
2 2.00
Global profiling of arginine reactivity and ligandability in the human proteome 1.00
Immobilized acyl-transfer molecular reactors enable the solid-phase synthesis of sterically hindered peptides 1.00
56 49.66
A labile sulfur ligand in a three-cysteine-coordinated [2Fe−2S] cluster mediates sulfide sensing in NreB 0.94
Electrostatic bimodality of human cytosolic DNA sensor cGAS-dsDNA condensates revealed by millisecond flashing electrophoretic separation 1.00
Gene-in-gene coding generates dual-isoform Fha condensates to control type VI secretion system assembly 0.83
Pyridium-π interaction preserves -benzylidene thioacetals in acidolysis enabling efficient protein chemical synthesis 1.00
Dynamic monomer-dimer transition regulates DNA-guided RNA cleavage by MbpAgo 1.00
CSDE1 promotes viral immune evasion through RNA-dependent and phosphorylation-modulated liquid-liquid phase separation 1.00
Novel CuCLIP-seq for in situ covalently captured protein-binding RNAs 1.00
A framework for the exploration of subcellular compartmentalization of RNA-binding proteins 0.79
Dynamic recruitment of CaMKII into SHANK3 phase-separated condensates tunes postsynaptic density remodeling during long-term potentiation 1.00
The schizophrenia associated protein DISC1 forms a multivalent tetrameric hub via conserved UVR dimers 0.29
Protein coacervation-driven active forces power protocell dynamics 0.80
An orthogonal RNA aptamer for targeted RNA regulation in phase-separated subcellular compartments 1.00
Enhancer-mediated Etv4 activation stimulates osteogenic differentiation 1.00
Catalytic Proximal Protein Oligomerization as an Anti-Tumor Strategy Targeting WDR5 1.00
Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging 1.00
CycloPepper: a machine learning platform for predicting cyclization outcomes and optimizing synthesis of therapeutic cyclopeptides 1.00
Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota 1.00
Volumetric compression regulates the phase separation of AXIN and acts as an operational amplifier to bidirectionally modulate Wnt signaling in organoids 1.00
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis 0.92
Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase 1.00
Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates 1.00
Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase 1.00
Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence 1.00
A universal O-glycosylation platform enabled by pyridinium catalysis using gas-releasing oxazolidinone-based carbamates donors 1.00
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease 1.00
Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer’s disease 1.00
Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells 1.00
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice 1.00
Molecular motor-driven reversible liquid-liquid phase separation of supramolecular assemblies 0.10
Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates 1.00
SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation 1.00
Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling 1.00
Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response 1.00
Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression 0.96
In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy 1.00
Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation 1.00
Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis 1.00
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation 0.04
regulates Yap subcellular localization to maintain bone homeostasis 1.00
Structure guided functional analysis of the S. cerevisiae Mre11 complex 0.13
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis 1.00
Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity 1.00
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice 1.00
RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer 1.00
Engineering bi-directional chemically-modulated synthetic condensates for cellular control 1.00
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma 0.04
H2S-mediated protein S-sulfhydration modulates infectivity and autophagy in the rice blast fungus 1.00
Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models 1.00
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis 0.90
Small-molecule-induced liquid-liquid phase separation suppresses the carcinogenesis of β-catenin 1.00
Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair 0.79
Structural insights into the human HRD1 ubiquitin ligase complex 1.00
Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking 0.14
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1 1.00
Emergent mechanics of a networked multivalent protein condensate 1.00
Liquid-liquid phase separation-boosted transmembrane delivery in interactive protocell communities 1.00
2 1.03
Generating 3D models of complex carbohydrates with GLYCAM-Web 0.03
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues 1.00
2 2.00
Condensate protein aggregation in ALS/FTD is regulated by GGGGCC-repeat RNA scaffolds 1.00
Remote on–off switching of protein activity by intrinsically disordered region 1.00
32 29.45
Rapid Access to Human Milk Oligosaccharide Analogues through a Partially Protected N‑Acetylglucosamine Donor 1.00
Identification of Glycosyltransferase AcbI in the Last-Step Biosynthesis of Herbicolin A for Improving Antifungal Activity 1.00
Multisegment C‑to‑N Sequential Ser/Thr Ligation Using Mmoc-Protected N‑Terminal Serine/Threonine Peptide Salicylaldehyde Esters 1.00
Two Triterpenoids with a Cyclobutane Moiety from Mastic: Structural Elucidation and Biological Evaluation 1.00
Development of Nuclear-Targeted Photoaffinity Probes with Cleavable Disulfide Bonds for Enhancing Selectivity in hPTM Interactome Profiling 1.00
Chemical Protein Synthesis by Hydroxylamine-Involved Ligation of Peptides 1.00
User-Friendly Thioglycoside Preactivation via Instant Sulfenyl Chloride Generation 0.74
Highly Stereoselective 1,2-cis-Glycosylation with 2-Azidofucosyl Donors: Access to the Pentasaccharide Motif from Escherichia coli O4:K6 1.00
Regio- and Stereoselective Synthesis of 1-/3-Sulfone Sugars Controlled by the Amount of SnCl4 1.00
Stereoselective Assembly of 2-Deoxy-2-fluoroglycosides Enabled by Pyridinium Catalysis 1.00
Photocatalyzed Decarboxylative Thio(seleno)etherification of Redox-Active Uronates Enables Synthesis of Rare Sugar Thio(seleno)glycosides 0.83
Chemical Synthesis of a Highly Branched Hexasaccharide Fragment from Bordetella pertussis Lipooligosaccharide 1.00
Dual Anomeric Stereocontrol in 1,1′-Glycosylation via a Remote Directing 2-(Diphenylphosphinoyl)acetyl Group 1.00
Synthesis of Bis-urea-Bridged Cyclopeptides via Stapling of Unprotected Peptides 1.00
Reactivity Tuning by Ring Size: A Glycosylation Protocol Using Thiophene-Scaffolded Glycosyl Donors 1.00
AuCl3–tBuCN Catalysis in 1,2-trans 2-Deoxy-2-fluoro Glycosidic Bond Formation 0.86
Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope 1.00
Electrochemical 2-Deoxyglycosylation of N-Containing Molecules with β-Stereoselectivity 1.00
Phage Display of Graspeptides via SrtA-Mediated Peptide Ligation and Cyclization 1.00
Aldehyde Capture Ligation without Involving a Side Chain Functional Group 0.33
Thioester Ligation with AAHO Peptides 0.29
Aqueous Phase Synthesis of Complex Thiazole-Containing Peptides by Condensation of N-Acyl-α-aminonitriles and Cysteine Derivatives 1.00
Chemical Synthesis of Conjugation-Ready Oligosaccharide Haptens of Pseudomonas aeruginasa O11 and Staphylococcus aureus Type 5 1.00
Stereoselective Synthesis of N–O-Linked α-iN/i-Acetylgalactosaminoglycosides via Oxime iO/i-Glycosylation with 2-Nitrogalactals 1.00
Palladium-Catalyzed Glycosylation for the Highly Stereoselective ide Novo/i Construction of Trideoxy Glycan Motifs from Pyridapeptides B-E 1.00
Hydrophobic Tag-Assisted Liquid-Phase Synthesis of Tirzepatide 1.00
Trifluoroacetic Acid Promotes Ultrafast Peptide Cyclization Mediated with Dimethylolurea 1.00
Unlocking the Potential of Ynamide as a Promoter in Copper(II)-Catalyzed O-Glycosylation 1.00
Stereoselective Glycosylation of Amino Sugars Enabled by Thiourea/Phosphoric Acid Dual Catalysis 1.00
3-Methylpyrazole-Mediated C-Terminal Protein Modification 1.00
Development of Semisynthesis to Achieve Sulfonium Proteins with Diverse Modifications 1.00
Total Synthesis of Pedopeptin C 0.40
4 3.12
The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts 0.57
Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents 1.00
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation 0.64
Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer's disease 0.91
1 0.30
Torsion-Driven Plectoneme Formation During Nanopore Translocation of DNA Polymers 0.30
11 8.23
Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519 1.00
Atomic-level architecture and assembly mechanism of high-order structures of RIPK1 fibril revealed by integrated structural biology 1.00
CDKL5 modulates the plasticity of excitatory synapses via liquid–liquid phase separation 1.00
Force-dependent structural dynamics of the giant nesprin-2 1.00
Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization 0.13
Hollow condensates emerge from gelation-induced spinodal decomposition 1.00
A machine learning protocol for predicting structural distributions of amyloid-forming proteins from 2D IR spectra 0.86
Programming cellular condensates for living materials using an intrinsically disordered protein display platform 0.25
CpG-A induces liquid–liquid phase separation of HMGB1 to activate the RAGE-mediated inflammatory pathway 0.93
De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation 1.00
Prg4+ fibroadipogenic progenitors in muscle are crucial for bone fracture repair 0.07
12 9.48
Isothiocyanate-mediated cyclization of phage-displayed peptides enables discovery of macrocyclic binders 1.00
Reversible phase dynamics of PsAF5 regulate mitophagy to balance redox levels in Phytophthora sojae 1.00
Highly efficient α-sialylation with ortho-(1-phenylvinyl)benzoates as leaving groups: One-pot assembly of α-sialoglycans 1.00
Phosphorylation of shiftless is important for inhibiting the programmed −1 ribosomal frameshift 1.00
Total synthesis of zwitterionic PS A2 oligosaccharides from Bacteroides fragilis 0.90
ASPL couples the assembly of stress granules with their VCP-mediated disassembly 0.04
Translation landscape of stress granules 1.00
The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat 0.11
Para-(3-phenylpropiolamido)phenyl (PPAP) glycosides: Harnessing ipso-cyclization–driven glycosylation for strategic flexibility 1.00
CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer’s disease 0.43
ATP13A1 engages SEC61 to facilitate substrate-specific translocation 1.00
Nucleolar beacon for monitoring nucleolar morphology and proteomics in living cells 1.00
2 2.00
Client recruitment mechanism of the cytosolic Fe-S cluster assembly targeting complex 1.00
Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells 1.00
9 8.01
Conformational Changes of the Knotted Protein 1O6D during Denaturation 1.00
Decoding Physicochemical Interactions Via Single-Molecule Fluorescence Blinking 1.00
Anomalous Effect of Denaturant on Protein Unfolding Dynamics Revealed by Single Molecule Manipulation Experiments 0.86
Molecular Insights into the Dual Mechanism of Bepristat 2a on Protein Disulfide Isomerase (PDI) Activity 0.89
Nanoscale Mechanical Force Primes NOD1-LRR for Efficient Pathogen Recognition 0.95
Single-Molecule Mechanochemical Mapping of Hierarchical Cu Coordination in High-Capacity Copper Storage Protein Csp1 1.00
Single-Molecule Fluorescence Spectroscopy of 4-Cyanotryptophan and Its Application in Photoinduced Electron Transfer Fluorescence Correlation Spectroscop 1.00
AlkD’s Conformational Dynamics Regulated by Protein–DNA Interactions for Effective Target Recognition 0.88
Emergence of Compact Oligomers inside the Small-World Network of TDP-43 Condensates 0.43
1 1.00
AAV9-Mediated Gene Therapy for Infantile-Onset Pompe’s Disease 1.00

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