Oncology and Carcinogenesis articles for Chinese Academy of Sciences (CAS), China

Time frame: 1 June 2025 - 30 May 2026

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Count: 311

Article ‘Count’ for Oncology and Carcinogenesis.

Journal Count Share
33 10.70
Ferritin-Based Mild Magnetic Hyperthermia Therapy for Bladder Cancer: A Synergistic Anti-Inflammatory Strategy 0.43
Ultrasound-Triggered Localized Surface Plasmon Resonance Enhances Electron Transfer for Melanoma Sonodynamic Therapy 0.35
Clickable Universal Tumor-Antigen Equipping Strategy for Remedial Chimeric Antigen Receptor T Cells to Destroy Solid Tumors 0.18
Combinatorial Design of Fatty Acid-Incorporated Plasmid Lipid Nanoparticles Drives Dendritic Cell Hyperactivation for Enhanced Cancer Immunotherapy 0.53
Engineered Bacillus Calmette-Guérin Mediated Immunotherapy of Triple-Negative Breast Cancer 0.03
Synergizing Pt–O–Mo Coupling and Electron Gradient: A Nanozyme Paradigm for Low-Dose Tumor Radiosensitization 0.35
Piezocatalytic Nanoplatform Drives Mg2+-Release-Amplified Ferroptosis-Immune Synergy for Tumor Microenvironment Reprogramming 0.11
In Situ Self-Reinforcing Fully Active Nanodrugs: Excitation/Oxygen-Free Redox Disruption Therapy through Metabolite-Driven Reactive Oxygen Species Cascades 0.17
Axially Polarized O–Fe–N4 Single-Atom Enzyme Drives Clearance of Tumor-Resident Intracellular Microbiota and Potentiates Immunotherapy 0.59
Triplet π-Conjugated Oligomer Nanoparticles with High Intersystem Crossing Efficiency for 808 nm Laser-Activated Photodynamic Therapy 0.10
Probiotic-Driven Therapeutic Vaccine for in Vivo Reprogramming of Tumor Cells To Elicit Postoperative Antitumor Immunity 0.04
Immunological Conversion of Solid Tumors Using an Outer Membrane Vesicle Based Checkpoint Nanoinhibitor for Cancer Immunotherapy 0.58
Highly Active Strontium Peroxide Nanoparticles Induce Alkalization/Oxidation to Potentiate Cancer Immuno-Metabolic Therapy 0.05
Brain-Targeting Metal–Organic Framework Nanoplatform Reprogramming Ferroptosis Sensitivity of Glioblastoma 0.33
Albumin Nanoparticles Co-Loaded with Dual Drugs for Enhanced Ferroptosis-Based Cancer Therapy through Modulating Cholesterol Metabolism 0.41
Engineering Microwave-Activatable Nanoenergic Converters with Energy Cascade Structures for On-Demand Microwave Dynamic Therapy 0.72
Cysteine Metabolism Reprogramming-Motivated Catalytic Immunotherapy for Orthopedic Biofilm Infections 0.14
Ultrasmall Manganese-Doped TiO2–x Overcomes the Efficacy–Safety Dilemma of Sonodynamic Therapy via Tumor Microenvironment-Responsive Reactive Oxygen Species Amplification and Clearance 1.00
Nanomotor-Promoted In Situ Vaccination for Deep-Seated Cancer Immunotherapy 0.50
Self-Adjuvanting Gel for Hierarchical Delivery to Tumors and Lymph Nodes in Liver and Colon Tumor Immunotherapy 0.32
Calreticulin Enhances Therapeutic Immune Responses of Dry Thermostat-Stressed Hepatocellular Carcinoma Cell Vaccine 0.03
Nebulized Inhalation of Engineered Extracellular Vesicles to Destruct Pre-metastatic Niche and Inhibit Postoperative Lung Metastasis in a Mouse Model 0.12
Three-Dimensional Afterglow Luminescence–MRI Fusion Tomography with Magnetically Targeted Luminescent-Magnetic Nanoparticles for Deep-Seated Tumor Imaging 0.07
A Spatiotemporally Controllable DNA Hydrogel Mesh for Focused Antimetastasis Therapy of Cancer 0.08
Ascorbic Acid-Derived Supramolecular Gels Induce Immunogenic Ferroptosis in Cancer Cells to Potentiate Tumor Immunotherapy 0.78
A Cyclized Bivalent Aptamer-Based Protein Degrader Targeting Receptor Tyrosine Kinases Overcomes Resistance to Inhibitors in Lung Cancer 0.05
Using the Electronic Grab-Transport Mechanism to Construct Metal–Organic Frameworks with Type I/II Dual Sonodynamic Therapy Reinforcement 0.67
Phosphorylated Neuropeptides Regulate Glioblastoma Proliferation and Invasion via Chiral Amino Acids 0.77
In Situ Ultrasound-Triggered Bioluminescence for Combined Sono/Photodynamic Immunotherapy 0.22
Overcoming Radiotherapy Resistance in Chordoma through the Synergistic Action of Selenium-Containing Nanoparticles and THZ1 0.05
Bacterial Membrane Vesicles as Heteroantigen Reservoirs for Potentiated Colorectal Cancer Immunotherapy 0.35
Combretastatin A4-Based Albumin Nanoparticles Remodeling the Tumor Immune Microenvironment to Enhance T Cell Immunotherapy in Colon Cancer 0.01
A Metal–Organic Framework-Based Immune-Regulating Nanocarrier Depot for Enhanced Combination Cancer Immunotherapy 0.59
11 2.90
Bovine serum albumin-stabilized nano-delivery system potentiates targeted anti-angiogenic therapy and synergistic photo-immunotherapy to restrict lung cancer metastasis 0.41
Endoplasmic Reticulum-Targeting Prodrug Nanoassemblies for Potent Ferroptosis Therapy via Concurrent Glutathione Depletion and Arachidonic Acid Accumulation 0.09
A biodegradable theranostic sonosensitizer for afterglow-guided sonodynamic therapy 0.18
Cascade-amplified iron-doped bismuth sulfide biomimetic nanoplatform for synergistic therapy and multimodal imaging of triple-negative breast cancer 0.65
T-cell Hitchhiking Nanodrug Activates the cGAS-STING Signaling Pathway for Enhanced Cancer Immunotherapy 0.05
Biomechanical Profiles and Molecular Regulation of Clinical Cancer Stem Cells and Tumor Cells: Implications for Tumorigenicity and Metastasis of Lung Cancer 0.31
MIL-100(Fe)-based Co-Delivery Platform as Cascade Synergistic Chemotherapy and Immunotherapy Agents for Colorectal Cancer via the cGAS-STING Pathway 0.08
Calcium phosphate-mineralized nanoplatform for enhanced ferroptosis and synergistic anti-PDL1 therapy in triple-negative breast cancer through multi-pathway targeting 0.13
Controlled Delivery of C-C Motif Chemokine Ligand 25 by a Hydrogel for Tumor Microenvironment Remodeling in Triple Negative Breast Cancer 0.05
Enhancing inter-system crossing efficiency of NIR-II emitting type-I photosensitizers for tumor ferroptosis induction 0.60
Construction of TiO2@Ag2O p-n junctions for synergistic sonodynamic/sonothermal tumor therapy with enhanced efficacy 0.36
11 3.34
Ultrasound-Responsive Bimetallic Hydroxide for Inducing Pyroptosis and Reversal of Immunosuppressive Microenvironment 0.83
Enhanced Catalytic Therapy by Modulating Substrate Adsorption and Local Electron Density through Coordinatively Unsaturated Cu-N2 Single-Atom Sites on Carbon Dots 0.50
SR-B1-Targeted Cholesterol Depletion Nanosystem Synergizes Cholesterol Metabolic Reprogramming and Immunotherapy for Clear Cell Renal Cell Carcinoma 0.19
Electronic Structure Modulation of Zn–Y Dual Single-Atom Sites for Synergistic Sonodynamic/Catalytic Cancer Therapy: “One Heart (Zn) and One Mind (Y)” 0.27
High-Concentrated Reactive Oxygen Species from Chiral Thyroxine for Piezocatalytic Antitumor Therapy 0.13
Amplifying ER Stress via Biodegradable Pseudo-Conjugated Polymer Nanoparticles for Enhanced Sonodynamic Immunotherapy 0.09
Electric‐Field‐Mediated In Situ Electrocatalysis for Enhanced Chemodynamic Therapy and Immunotherapy via 3D Electrode Arrays 0.10
Urchin-Like Sulfate Radical Nano-Generator Based on MoS2/Bi2S3 Heterostructure for Enhanced Anticancer Therapy 0.63
A Responsive Hydrogel Containing Bimetallic MOF Enabling Amplified Ferroptosis for Cancer Therapy via Dual Cellular Homeostasis Disruption 0.39
An ‘AND’ Logic Gate Nanoreactor for Metabolic Remodeling in Starvation-Ferroptosis-Immunotherapy of Pancreatic Cancer 0.11
Ultrasound‐ and Magnet‐Enhanced Blood‐Brain Barrier Transport for Self‐Augmented Piezo‐Fenton Glioblastoma Therapy 0.09
22 6.15
Bone-Targeted Nanoparticles Enable Metabolic Reprogramming via cGAS Lactylation Suppression to Restore Chemosensitivity and Antitumor Immunity in Osteosarcoma 0.09
Wireless Electro-Fenton Overcomes Tumor Electric Field Treatment Resistance 0.05
G-Quadruplex-Modular CpG Nanoplatform Drives Multi-Pathway Immunity for Abscopal Chemoimmunotherapy 0.34
Bi‐Target Nanomodulator for Glioma‐Associated Myeloid Cells Polarization by Inducing Pyroptosis and Regulating Tryptophan Metabolism to Reshape Immunosuppressive Microenvironment of IDH‐Mutant Gliomas 0.21
Thread‐Designed Vascular Scaffold with Magneto‐Optical Probes Capture and Elimination of Circulating Tumor Cells In Vivo 0.33
Optimized Lipid Nanoparticles for Co‐Delivery of mRNA and siRNA Therapeutics in Refractory Liver Cancer 0.28
Liquid Metal Nanoparticles-Mediated Mitochondrial Damage Enhances Immunogenic Cell Death for Cancer Vaccine Therapy 0.36
Redirecting Tryptophan Metabolism Through Host‐Microbial Crosstalk to Enhance Precise Bioorthogonal Chemoimmunotherapy 0.50
NIR-II Photoactivatable Cobalt(III) Nanoparticles for Photoactivated Metal Chemo-Immunotherapy 0.21
A New Strategy for Controlled In Situ Release of IL-2 from Tumor Spheroids Using a NIR-II Light-Mediated Optogenetic Manipulation System 0.34
Proton‐Driven Deformability Enables Nanozyme‐Integrated Vaccine for Enhanced Tumor Immunotherapy 0.04
Polymer‐PARPi Conjugates Delivering USP1i for Maximizing Synthetic Lethality to Stimulate STING Pathway in High‐Grade Serous Ovarian Cancer 0.13
Molecularly Engineered Nanoagents with Efficient Free Radicals Generation and Photothermal Conversion Performance for Enhanced Tumor Photoimmunotherapy via Targeting Lactate Metabolism-Immune Circuit Rewiring 0.30
An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano‐Immunotherapy 0.08
Defect Engineering‐Driven Electron Spin Polarization and Charge Transfer in MOFs for Enhanced Sonocatalytic Therapy 0.02
Nanozyme‐Based Biomimetic Intelligent Immune Organelles for the Treatment of Bladder‐Metastasized Tumors 0.06
Personalized 3D Vaccine Integrates Immunotherapy and Antiangiogenic Therapy to Prevent Oral Squamous Cell Carcinoma Recurrence 0.42
Dynamic Size‐Change Nanovaccine for Enhancing Lymph Node Deep Penetration and Eliciting Robust Antitumor Immune Responses 0.81
A Dendritic Cell‐Nanogel Conjugate for Tumor‐Draining Lymph Node‐Specific PD‐L1 Blockade 0.55
Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ‐Mediated Immunotherapy 0.22
Biomimetic Engineering of Hybrid Radiosensitizers to Boost Radiotherapy against Cancer Metastasis 0.78
Dual‐Defect Nitrogen‐Rich Carbon Nitride‐Based Heterostructural Nanocatalyst for Improving the Therapeutic Efficacy of iα/iPD‐1 via Tumor Immune Microenvironment Remodelling 0.04
11 3.22
Selection and Optimization of a High-Affinity FGFR4 Aptamer that Blocks FGF19–FGFR4 Signaling 0.36
Point-of-Care Detection of Dual Methylation Genes for Rapid Bladder Cancer Diagnosis and Prognosis 0.07
Ultrasensitive and Rapid Screening of Tumor-Associated Extrachromosomal Circular DNA by Selective Real-Time Rolling Circle Amplification 0.29
Plant-Derived Polysaccharide Ultrafast Purification Reinvented: A Green Aqueous Two-Phase System with Deep Eutectic Solvents for Simultaneous Decolorization and Deproteinization 0.64
Super-Resolution Fluorescence Imaging Reveals the Role of CD24 Clusters in NSCLC Proliferation 0.28
TROP2 Promotes Tumor Cell Migration through Downregulation of DSG2 Revealed by Super-Resolution Fluorescence Imaging 0.59
Molecularly Engineered Dual-Lock Activatable NIR-II Fluorogenic Probe for Precision Tumor Resection and Real-Time Chemotherapy Response Monitoring 0.06
A Covalent Click Chemistry Chip for Highly Efficient Capture and Brightfield Identification of Circulating Tumor Cells 0.25
Ultrasensitive Electrochemiluminescence Multiplex Immunoassays of Circulating Tumor Cells via Cerasomes within MXene-Modified Single-Electrode Electrochemical Systems 0.13
First Fluorescent Probe for TREX1 Enables Real-Time Tracking of DNA Repair and Immune Regulation in Cancer Cells 0.33
Microfluidics-Based High-Throughput Single-Cell Analysis of Reactive Oxygen Species and T Cell Exhaustion 0.22
10 2.63
Long-Acting Dynamic Therapy Using X-Ray Activated Organic Nanoparticles for Afterglow Imaging Guided Deep Tumor Treatment 0.15
Precise Modulation of Excited-State Energy Flow via Consecutive Twisted Intramolecular Charge Transfer (ConTICT) for Autophagy-Blocking Photothermal Therapy 0.06
Charge‐Tunable Dense Dual‐Atom Nanozymes Reprogram Biothiol Metabolism Through Multi‐Enzyme‐Mimetic Catalysis to Synergistically Induce Ferroptosis and Disulfidptosis 0.40
Zinc‐Complex Orchestrating Pyroptosis for Hypoxia‐Tolerant Photoimmunotherapy 0.05
Screening Metal Ions to Tailor Carrier Dynamics in Porphyrin‐Based Covalent Organic Polymers for Enhanced Sonocatalytic Pyroptosis and Immunotherapy 0.70
Biodegradable Nano‐Regulator Reprograms Glioblastoma Immunosuppression: Pyroptosis‐Metabolism‐Immunity Crosstalk for Cascading Immune Activation 0.27
Fe−O−Mo Site‐Activated Nanozymes for Bienzymatic/Upconversion Synergistic Catalytic Anticancer Therapy 0.10
Cyclometalating Ligand Affords NIR Absorption in Ruthenium Complexes for Type‐I Photodynamic Therapy 0.12
Circular RNA-Based Molecular Computation Enhances Plasma Biomarker Detection in Biliary Tract Cancer 0.23
Multipath ROS Storm and Immune Activation via Sulfur Vacancy-Optimized ZnIn2S4 Nanosheets for Piezocatalytic Tumor Therapy 0.57
1 0.14
Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis 0.14
9 1.22
Cancer stem cells orchestrate immune evasion through extracellular vesicle-mediated non-canonical signaling pathways 0.04
Molecular insights into early malignant transition of hepatocellular carcinoma 0.11
Candida albicans synergizes with Fusobacterium nucleatum in colorectal cancer progression via the Flo9-RadD interaction 0.11
Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases 0.33
Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer 0.09
Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer 0.07
Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production 0.04
A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers 0.09
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps 0.33
7 0.50
AKT3-Driven Epithelial–Mesenchymal Plasticity Governs Ovarian Metastasis in Colorectal Cancer via Tumor Microenvironment Remodeling 0.07
Targeting LRRC15 in Cancer-Associated Fibroblasts Modifies the Extracellular Matrix and Enhances Tumor Immune Responses to Suppress Lung Cancer Progression 0.02
CCL5hiCD4+ T Cells Regulate Macrophage Polarization and Promote Immunotherapy Response in Bladder Cancer 0.01
Cortactin Suppresses mTOR-Dependent Senescence in Circulating Tumor Cells 0.06
Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progression of Breast Cancer 0.02
SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts. 0.13
Perivascular Niche–Resident Alveolar Macrophages Promote Interstitial Pneumonitis Related to Trastuzumab Deruxtecan Treatment 0.19
2 0.67
Ferritin aggregation cell engager for CAR T avidity engineering against refractory leukemias 0.53
Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors 0.14
2 0.36
UBE2O-mediated monoubiquitination licenses NLRP6 inflammasome activation in the intestine 0.31
Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins 0.05
2 0.56
The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice 0.48
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation 0.08
3 1.22
Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasis 0.01
Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models 0.79
A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy 0.42
1 0.50
Design of TNFR peptide agonists for inducing receptor oligomerization and cell apoptosis 0.50
6 1.14
Zero-trigger ultrafast charge-transfer J-aggregates via Se/π-directed assembly enable synchronous ROS/heat amplification for NIR-II photoimmunotherapy 0.08
A unimolecular near-infrared fluorescent probe for in vivo imaging of enzymes with minimized false-negative signals 0.08
A bioorthogonal-catalytic artificial antigen-presenting cell for chemo- and immuno-therapy 0.44
A nuclear targeted type-I photosensitizer for anti-tumor therapy 0.06
An activatable unimolecular phototheranostic agent for synergistic chemo-photodynamic therapy 0.10
Detecting microsatellite instability in cancer via multiplexed orthogonal gap-enhanced Raman tags 0.38
2 0.20
The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi 0.18
Cloche/Npas4l is a pro-regenerative platelet factor during zebrafish heart regeneration 0.02
1 0.11
Sustainable remediation of tetracycline-contaminated soil: A Fe-g-C3N4 nanozyme driven abiotic-biotic strategy 0.11
3 1.32
Establishing a Genetically Stable COS7-RXRα Cell Model for Screening Emerging Contaminants with RXRα Modulatory Effects 0.34
Mitochondrial Metabolomics Reveals the Mechanism of SCCP Induced Energy Metabolism Inhibition 0.75
Profiling the Chemical Exposomic Landscape of Esophageal Squamous Cell Carcinoma 0.22
1 0.07
Adaptation of centromeres to breakage through local genomic and epigenomic remodeling in wheat 0.07
4 0.24
KRAS mutation-driven O-GlcNAcylation of CLDN18.2 enhances the progression of pancreatic cancer and reduces the efficacy of CLDN18.2-targeted therapy 0.04
Dynamic urinary proteomics integrates single-cell and spatial transcriptomics to reveal tumour microenvironment and predict immunotherapy response in biliary tract cancer 0.02
KIF1Bβ suppresses hepatocellular carcinoma by transporting and secreting FBLN5 to attenuate the integrin pathway 0.09
Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer 0.09
1 0.58
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease 0.58
1 0.03
Fluorescein-Functionalized Iridium(III) Complexes as Dual-Mode Type I Photosensitizers for Hypoxia-Tolerant Photodynamic and X-ray-Induced Therapy 0.03
6 2.18
TRIM25 enhances hypoxia signaling by catalyzing K11-linked polyubiquitination and stabilization of HIF-α 0.52
Allosteric zinc inhibition and interdomain regulation govern the catalytic mechanism of the E3-independent ubiquitin-conjugating enzyme hUBE2O 0.60
RhoE down-regulation leads to enhanced cholesterol biosynthesis and sorafenib resistance in hepatocellular carcinoma 0.35
The pyruvate dehydrogenase complex in concert with the DNA/RNA-binding protein YBX1 regulates cell senescence and tumorigenesis 0.56
BCI inhibits MKP3 by targeting the kinase-binding domain and disrupting ERK2 interaction 0.14
Structural insights into the substrate transport mechanism of the amino acid transporter complex 0.02
1 0.61
SCFFBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury 0.61
1 0.08
US-guided Nanosecond Pulsed Electric Field Ablation of Low-risk PTMC: Interim Results of a Prospective Multicenter Study 0.08
6 0.88
HER2 deficiency causes a developmental disorder with growth retardation and craniofacial malformations 0.01
Therapy-induced cholesterol biosynthesis drives lung cancer dormancy and drug resistance 0.40
Proteogenomic characterization of cervical cancer identifies molecular subtypes predictive of clinical outcomes and subtype-specific targets 0.03
EGFR activation disrupts immunotherapy response via SHP2-mediated suppression of tumor-intrinsic response to IFN-γ 0.01
C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling 0.36
PIM3-mediated phosphorylation stabilizes myeloid leukemia factor 2 to promote metastasis in osteosarcoma 0.06
2 0.03
Transarterial Chemoembolization Combined With Camrelizumab and Rivoceranib for Unresectable Hepatocellular Carcinoma (CHANCE2005/CARES-005): A Randomized Phase II Trial. 0.02
Neoadjuvant Osimertinib for Resectable EGFR-Mutated Non-Small Cell Lung Cancer. 0.02
3 0.48
Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function 0.06
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice 0.07
Integrated screens identify AURKB dependency in advanced gastrointestinal stromal tumors 0.34
1 0.05
Neddylation E1 obligatory subunit Nae1 is critical to neuromuscular junction development and maintenance 0.05
1 0.26
Pathologic response and nodal status guide adjuvant immunotherapy in non–small cell lung cancer after neoadjuvant chemoimmunotherapy: An eastern Asian cohort study 0.26
12 3.83
Dual-Targeting Multivalent Aptamer-Drug Hybrids for Synergistic Cancer Immunotherapy 0.41
Discovering Targetable Conformation of RhoA Mutant by Integrating Native Mass Spectrometry, Ultraviolet Photodissociation, and X-ray Diffraction 0.43
NIR-II Nanomedicine Engineered CAR-NK Cells for Precision Navigation and Potentiating Lung Cancer Immunotherapy by Remodeling Tumor Microenvironment 0.08
Long-Acting Fractionated Sonodynamic Therapy Enabled by Fused-Trianthracene Nanoparticles with Ultra-Bright Ultrasound-Induced Afterglow Luminescence 0.06
Defective Single-Site Nanozymes with Exposed Unsaturated Cu–N2 Sites for Antitumor Immunotherapy via Innate Immune-Checkpoint Blockade 0.50
Succinylated D-Type Neuropeptide Integrated with Iron-Based Probes for Regulating Mitochondrial Function and Homeostasis in Breast Cancer 0.71
MSA-2 Loaded Three-Dimensional Metal Covalent Organic Framework for Synergistic Radiosensitization and Innate Immune Activation 0.03
Highly Expressive Bienzyme and Photothermal Effect Co-Enabled by the Co–O–Mn Bridge for Potentiating 1550 nm Light-Triggered Photodynamic Therapy 0.15
Ultrasound-Triggered Type I Supramolecular Photosensitizer for Precise In Situ Chemiluminescence-Based Photodynamic Cyclic Therapy 0.63
pH-Isomerizable Acylhydrazone-Based Ionizable Lipids for Spleen-Targeted mRNA Vaccines 0.41
Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1 0.07
Engineering of Sono-Activatable Immunogels for Immunometabolism Disorder Normalization Therapy of Breast Cancer 0.35
4 0.53
ICAM1 mRNA entraps ILF2/ILF3 to inhibit transcription of EIF4E and global protein synthesis 0.15
CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity 0.10
Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response 0.03
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors 0.25
15 4.89
Activatable Polymeric STING Agonist–Gold Nanorod Conjugate Driving STING Signaling and Immunogenic Activation in Colorectal Cancer Immunotherapy 0.44
Rewiring Metal-Dependent Cell Death to Unlock Immunotherapy in Colorectal Cancer 0.07
Bismuthene-Based Nanoplatform for Synergistic Thermogenetic CRISPR and Photothermal Cancer Therapy 0.11
An Integrated NIR-II Fluorescence-Free Reporter for Multimodal Imaging-Guided Breast-Conserving Surgery 0.20
Achieving Efficient Sonopiezoelectric Therapy for Tumor through Electron Spin Modulation via the Chiral-Induced Spin Selectivity Effect 0.37
Tumor-Targeted Bacterial Vaccine Induces In Situ Immunogenic Cell Death for Cancer Immunotherapy 0.45
Nanospiky Copper Peroxide as Lactate-Modulating Nanoadjuvant To Induce Cuproptosis and Pyroptosis for Enhanced Tumor Immunotherapy 0.15
Multiplexed Aptamer-Lattice Nanodevice for One-Step Phenotyping and Functional Quality Control of CAR-T Cells 0.13
Multivalent Metal–Nucleotide Nanoagonists Amplify Innate Immune Activation for Cancer Metalloimmunotherapy 0.45
Systemic Delivery of an mRNA-Encoding, Tumor-Activated Interleukin-12 Lock to Eliminate Tumors and Avoid Immune-Related Adverse Events 0.33
Nanoshield Architecture Harnessing Neoantigen-Targeting Peptides Enables Durable Post-surgical Glioma Immunotherapy 0.19
Overcoming Epithelial–Mesenchymal Transition Challenges in Cancer Detection through a Dual-Targeting Strategy 0.27
Nanohydroxyapatite-Stabilized Pickering-Emulsion-Incorporated Hydrogel Prevents Postoperative Osteosarcoma Recurrence and Promotes Bone Repair 0.77
Oxamate Nanoparticles for Enhanced Tumor Immunotherapy through Blocking Glycolysis Metabolism and Inducing Pyroptosis 0.53
A Metal–Phenolic Network Nanoresensitizer Overcoming Glioblastoma Drug Resistance through the Metabolic Adaptive Strategy and Targeting Drug-Tolerant Cells 0.43
3 0.12
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance 0.00
Intratumoural vaccination via checkpoint degradation-coupled antigen presentation 0.06
Polyclonal origins of human premalignant colorectal lesions 0.06
1 0.04
Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples 0.04
2 0.16
Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy 0.05
YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates 0.11
3 0.59
Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription 0.02
Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers 0.39
Deacetylase-independent HDAC1 condensation defines temozolomide response in glioblastoma 0.19
51 11.31
Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in -deficient triple negative breast cancer 0.04
Iron overload in the tumor microenvironment induces CD8+ T cell ferroptosis and dysfunction 0.05
Acetylated mitochondrial MDH2 regulates CTR2 transcription to induce cuproptosis during Escherichia coli infection 0.07
Distinct phosphorylation mechanisms as dynamic switches for Hsp90 regulation 0.14
BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression 0.17
Hijacking innate immunity to enhance mRNA therapeutics by blocking IFN-P-body-XRN1 axis-mediated degradation 0.07
Dissecting origin factors of lymph node metastasis in non-small cell lung cancer via multimodal omics 0.30
VGLL4-driven TEAD4 multimerization orchestrates DNA binding and YAP recruitment 0.18
NLRP14 modulates the activity of E3 ubiquitin ligases during the oocyte-to-embryo transition 0.03
Structures of ZYG11B-EloB-EloC-substrate complex reveal mechanisms of CRL2ZYG11B assembly and function 0.38
Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs 0.32
Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice 0.08
An ultraconserved pseudo 5’ splice site fine-tunes development by regulating alternative splicing within TOR-related pathways 0.10
Cryo-EM structures of light chain fibrils from abdominal fat biopsies of multiple myeloma patients 0.22
R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers 0.04
Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar 0.06
An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression 0.18
negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing transcription 0.79
Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis 0.53
Osimertinib with or without savolitinib as first-line treatment for MET-aberrant, EGFR-mutant NSCLC: randomized phase 2 trial (FLOWERS) 0.03
Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse model 0.16
Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy 0.33
Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy 0.48
Concurrent PIK3CA mutant promotes cachexia through inflammatory signaling in EGFR mutant lung cancer 0.18
Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA 0.12
Histone acetylation homeodynamics navigates cell survival and apoptosis 0.02
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling 0.10
Tissue-resident microbiota impacts colorectal cancer progression and prognosis 0.03
Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy 0.45
Molecular mechanism of PINK1 regulation by the Hsp90 machinery 0.23
IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer 0.44
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism 0.12
Uncovering the immune mechanisms underlying the emergence of immunotherapy-induced pneumonitis in lung cancer patients 0.41
Substrate recognition diversity and transport dynamics of ABCC1 0.20
TBC1D1 functions as a negative regulator of satellite cells for muscle regeneration 0.22
Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma 0.28
Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT 0.36
FAP+ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus 0.08
αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models 0.47
Direct - mRNA interaction regulates cell proliferation and cancer progression 0.22
Structure and transport mechanism of the human prostaglandin transporter SLCO2A1 0.35
A strategy for challenging tumorous bone regeneration by borosilicate bioactive glass boosting moderate magnetic hyperthermia 0.69
A -natural antisense RNA regulates alternative polyadenylation of under Pi starvation in tomato 0.08
Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors 0.06
Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination 0.12
The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH wild-type diffuse intrinsic pontine glioma results of two phase I clinical trials 0.07
Distinct structural mechanisms of LGR4 modulation by Norrin and RSPOs in Wnt/β-catenin signaling 0.50
Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via radiotherapy-activated TLR7/8 prodrugs in mice 0.09
Single atom engineering for radiotherapy-activated immune agonist prodrugs 0.09
Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial 0.17
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy 0.43
2 0.24
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116+ pericytes in cancer metastasis 0.20
Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma 0.04
1 0.27
Kupffer cell calibration of T cell responses via VSIG4–CD5 interaction promotes tumor evasion 0.27
3 0.19
Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results 0.06
First-line sacituzumab tirumotecan with tagitanlimab in advanced non-small-cell lung cancer: a phase 2 trial 0.00
AI-based large-scale screening of gastric cancer from noncontrast CT imaging 0.13
5 1.42
Enhancing antitumour nanovaccine efficacy via integrated cholesterol modulation in situ 0.23
Nanorobots hold PD-L1 and break membrane of colorectal cancer cells for immunotherapy 0.26
Prevention of acute thrombosis with vascular endothelium antioxidative nanoscavenger 0.41
Iron–silver-modified quantum dots act as efficient catalysts in anti-cancer multitherapy through controlled, ultrasound-induced oxidation 0.22
A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy 0.29
1 0.11
Structural basis of G6P/Pi transport and inhibition in SLC37A4 0.11
1 0.05
6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation 0.05
1 0.64
Asymmetric Total Synthesis and NaV1.8 Inhibitory Evaluation of Villosin B, 17-Hydroxymandarone B, and Their Derivatives 0.64
2 0.15
Acoustic delivery of indocyanine green via biosynthetic gas vesicles for tumor photothermal therapy 0.11
Engineered romidepsin biosynthetic pathways in Escherichia coli Nissle 1917 improve the efficacy of bacteria-mediated cancer therapy 0.04
14 4.69
Aurora-A drives sorafenib resistance by scaffolding stress granule assembly via phase separation 0.50
Reciprocal regulation of TNF receptor 1–mediated signaling and inflammatory damages by MARCH2 and USP22 0.25
Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent–resistant acute myeloid leukemia 0.41
RIPK1 ubiquitination regulates its kinase-independent function in development and inflammation 0.51
Spatially resolved multiomics reveals the self-enforcing property of the leading-edge multicellular ecosystem of head and neck cancer 0.01
USP1–TRAF2 axis–regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma 0.12
Mechanistic insights into the iron–sulfur cluster-dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2 0.45
NEDD4L induces mitochondrial dysfunction and neurodegeneration by promoting LIPT2 degradation in Huntington’s disease 0.11
The pathogenic factor of ZC4H2-associated rare disorder is a postsynaptic regulator for synaptic activity and cognitive function 0.47
Controlling T cell–tumor cell interaction with a biomimetic physical barrier for cancer immunotherapy 0.55
Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy 0.23
Defining CDK12 as a tumor suppressor and therapeutic target in mouse models of tubo-ovarian high-grade serous carcinoma 0.13
Dual-laser “808 and 1,064 nm” strategy that circumvents the Achilles’ heel of photothermal therapy 0.13
PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis 0.82
1 0.23
ScreenLungNet: Personalized Long-Term Prediction of Lung Cancer Risk from a Single Low-Dose CT Screening. 0.23
1 0.18
Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing 0.18
14 2.07
Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation 0.12
Epithelial plasticity shapes intratumoral heterogeneity and cell lineages in early-stage lung cancer 0.33
Intratumoral Parvimonas micra promotes esophageal squamous cell carcinoma via p-cresol–induced Treg differentiation 0.18
Aneuploidy of chromosome 8 promotes the mesenchymal lineage during cell fate transitions 0.05
Structural insight into the glucose-6-phosphate transport by G6PT1 and inhibition mechanism of CGA 0.17
On-demand cancer immunotherapy via single-cell encapsulation of synthetic circuit–engineered cells 0.14
Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factors 0.03
Enhanced FOS expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure 0.03
Targeting RRM2 with dual-modal theranostic smart nanoresponder overcomes osimertinib resistance and triggers immune remodeling in NSCLC 0.08
USP13 stabilizes NLRP3 to facilitate inflammasome activation by preventing TRIM31-mediated NLRP3 ubiquitination and degradation 0.10
Molecular and neural basis of vomiting behavior in Drosophila melanogaster 0.17
Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection 0.05
Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation 0.03
Plant defense-directed discovery of a natural anti-psoriasis agent targeting GAPDH 0.60
4 0.66
Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia 0.35
Phase separation–based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression 0.11
Site-specific methylation of SRSF2P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome 0.19
Proteogenomic characterization reveals that lipid droplet formation promotes esophageal squamous cell cancer progression 0.01
1 0.01
Sacituzumab tirumotecan versus docetaxel for previously treated EGFR-mutated advanced non-small cell lung cancer: multicentre, open label, randomised controlled trial 0.01
1 0.18
3′UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation 0.18
1 0.03
Evaluation of progression-free status at 24 months as a surrogate endpoint for overall survival in patients with human papillomavirus-positive oropharyngeal cancer: a retrospective cohort study 0.03
2 0.16
CCCH-type zinc finger proteins are required for meiotic progression and RNA clearance in Arabidopsis 0.05
ANAPHASE-PROMOTING COMPLEX/ANAPHASE-PROMOTING COMPLEX/CYCLOSOME coactivators maintain AURORA 1 kinase homeostasis during meiotic chromosome segregationcoactivators maintain AURORA 1 kinase homeostasis during meiotic chromosome segregation 0.11

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