Pharmacology and Pharmaceutical Sciences articles

Time frame: 1 May 2025 - 30 April 2026
Count: 1777

Article ‘Count’ for Pharmacology and Pharmaceutical Sciences.

Journal Count
127
Cosurfactant-Induced Disorder in Polymersome Membrane Enhances Diffusion of Cargo Molecules
Concurrent P-Selectin Targeting Nanoparticle Orchestrates Tumor-Immune Dynamics for Advanced Immunochemotherapy
Reversing Cuproptosis Tolerance with Twinborn Metallic Polymer Nanoparticles for Enhancing Efficacy of Chemo-Immunotherapy
A Topology-to-Therapy Map for Prodrug Nanoassemblies
MicroRNA-Governed Autocatalytic Fenton Nanoplatform for Cancer-Selective Theranostics
A Bone Marrow-Targeted Nanomodulator as a Histone Lactylation Inhibitor for Reversing Immune Tolerance in Multiple Myeloma
Chiral Bismuth Molybdate Nanoparticles Recruiting and Activating Group 3 Innate Lymphoid Cells to Suppress Gastric Cancer
Spatiotemporally Orchestrated Cardiac Microneedle Patch Modulates Post-Infarction Immunity and Fibrosis
Cationic Polymer–Photothermal Agent Conjugates with Enhanced Light Absorption and Tumor Accumulation for Efficient Phototherapy of Osteosarcoma
Triple-Targeted Peptide–Photosensitizer–Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma
Insights into the Structure of Ultrasmall Fluorescent Core–Shell Silica Nanoparticles
Accelerating Multi-Elemental Catalyst Discovery with Interpretable Machine Learning and Automated Experimentation
<atl>Tumor-Selective Autophagy Blockade of Renal-Clearable Bi sub2/sub S sub3/sub Nanoflowers for Precise Photothermal Therapy</atl>
Deciphering Apolipoprotein A4 in the Protein Corona of Ligand-Modified Liposomes for Tumor Targeting and Penetration
In Vivo-Assembled Artificial Base-Albumin Platform for Tumor-Targeted General Drug Delivery
Coassembled Prodrug Nanoparticles Mitigating the Acquired Resistance to Protein Degradation Therapy
Atorvastatin-Driven Methuosis in Glioblastoma: A Biomimetic Nanodrug for Targeted Tumor Therapy
Enhanced Immunotherapy for Glioblastoma Using a Cholesterol Oxidase-Loaded, Pd-Doped Cu3N Nanozyme-Based Multimodal Nanoplatform
Biodegradable Iodinated Polymeric Nanoparticle as a Computed Tomography Contrast Agent for Direct Imaging of Cerebral Thrombus
Biomimetic Microenvironment Nanomodulators for Reactive Oxygen Species-Responsive T1-T2 Dual-Modal Magnetic Resonance Imaging and Visualized Treatment of Atherosclerosis
Triterpenoids Bend and Bind Lipid Membranes into 20 nm Stable Nanocages
The Impact of Polyethylene Glycol Lipid Anchors on the Physicochemical Properties, Protein Corona, Function, and Biodistribution of Lipid Nanoparticles
Cellular Adaptive Component-Mediated Targeting of Chylomicron-Mimic Nanoemulsion to Hepatic Stellate Cells for Liver Fibrosis
Immune Modulatory Oxysterols Produced from Cholesterol-Containing Lipid Nanoparticles Regulate Tumor Growth
Engineered Peptide Coassembly Enables Precision Delivery of As(III)-Peptide Complexes and Counteracts Inflammation-Dependent Therapeutic Resistance in High-Risk Neuroblastoma
In Situ Needle-Free Injection of Multiretention Micelles for Melanoma Therapy with Multiomics Insights into Tumor Targeting and Immune Modulation
A Redox-Responsive Selenium-Containing Nanomedicine Enables Dual Antioxidant System Inhibition to Overcome Platinum Resistance and Enhance Immunotherapy in Bladder Cancer
A Multifunctional Calcium Phosphate Nanoplatform Inducing Synergistic Copper/Calcium Overload and Antiangiogenesis for Enhanced Cancer Therapy
Natural Antioxidant Lipoic Acid Constructed Nanodrug for Oral Therapy of Inflammatory Bowel Disease
Intranasal Conformal Patch for Sustained Levodopa Delivery and Reactive Oxygen Species Scavenging in Parkinson’s Disease
High-Entropy Oxide-Phosphomolybdic Acid Ultrathin Nanoleaves with Lattice Strain and Periodic Heterostructures for Enhanced Synthetic Catalytic/Sonodynamic/Immune Therapy
Chiral Polyproline Enables Functional Stealth for Simultaneous Long Circulation and Endoplasmic Reticulum-Targeted Antigen Presentation
Structure-to-Therapeutic Transformation of Nanohydrogels Triggers Calcium Overload for Potentiated Boron Neutron Capture Therapy
Utilizing Constrained Bicyclic Peptides for In Vitro Diagnostics
In Vivo Programmed Assembly of Polymer–Peptide Conjugates to Overcome Multistage Drug Delivery Barriers
Water Confinement in Hollow Fe-TA Nanoparticles Synergistically Enhances Photothermal-MRI Theranostics
Redefining Tumor Vascular Permeability through Deep Learning-Guided Microneedle Delivery
Natural Compound-Driven Nano-Self-Assembly for Multimechanistic Transdermal Antiobesity Therapy
Stiffness-Tunable Phenolic Nanocapsules Loaded with J-Aggregates for Near-Infrared II Imaging-Guided Phototherapy of Bacterial Infections
Deciphering the Hepatic Cellular Interactions of PEGylated Iron Oxide Nanoparticles
Phase-Separation Engineered Nanomotors Enable Spleen-Tumor Dual Targeting to Reverse T-Cell Exhaustion
Dynamic Covalent Dual Prodrug Assemblies for Endometritis Therapy via Inflammation Alleviation, Tissue Repair, and Reproductive Function Restoration
A Dual Glutathione-Depleting Nanoparticle Loaded with Porcine Pancreatic Elastase for Neoadjuvant Chemotherapy of Triple Negative Breast Cancer
Self-Propelled Nanoreactors for Enhanced Cascade Catalytic Cancer Therapy through NIR-II Fluorescence Imaging-Guided Readministration
Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery
Supramolecular Metallacycle Enables Esterase-Responsive and Endoplasmic Reticulum-Associated Pathway Activation for Synergistic Photothermal Immunotherapy
Assembling Lipid Membrane Scaffolds on Microgel-Based Artificial Cells through Vesicle Fusion onto the Hydrogel Network
Fusion Aptamer-Lactoferrin Delivery System for Targeted Delivery to Adipose Tissue and the Amelioration of Obesity
Jigsaw Puzzle-Designed Polyphenol-Macromolecular Supramolecular Networks for Noninvasive Therapy of Deep-Tissue Oral Disease
Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries
Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy
Precision-Architected Drug-Stabilized Cu5 Clusters Mediate Multimodal Therapeutic Intervention in Colitis
Central Nervous System Targeting Nanovesicles for Trans-Barrier Delivery and Spinal Cord Injury Treatment
Remodeling the Tumor Microenvironment: An Emerging Paradigm for Reinvigorating Immunologically Cold Tumors and Advancing Cancer Immunotherapy
Enzyme-Loaded Microcapsules as Intracellular Organelles for the Degradation of Nanoplastics by Cells
Optimizing Exosome Lipid Hybrid Nanoparticles for Enhanced siRNA Delivery and Improved Therapeutic Anticancer Efficacy In Vivo
Transporting via Neutrophil as a Key Mechanism for Nanoparticle Redistribution to Tumor and Spleen
Anti-Aggregation System for the Enhanced Transdermal Delivery of Cell Membrane-Coated Nanoparticles
Coupling Adoptive Cell Therapy with Boron Neutron Capture Therapy: Using Functional Tumor-Infiltrating Lymphocytes for Tumor Delivery of Boron Carbide Nanoparticles
Controlling Polymerization-Induced Phase Separation in the Synthesis of Porous Gels
Tuning the Needling Length of Copper Single-Atom Nanozyme for Enhanced Cellular Uptake and Chemodynamic Therapy
Precise Ratiometric Drug Delivery for the Treatment of Triple-Negative Breast Cancer
Piezoelectricity-Potentiated Bioorthogonal Catalysis Disrupts Cholesterol Metabolism for Tumor Immunotherapy
An In Situ Self-Solidifying Poly(Lipoic-Acid) Liquid Adhesive Forms Pathogen-Resistant Barrier for Ulcerative Colitis Therapy
Trafficking Glycogen Nanoparticles through Lymph Node Tissues for the Delivery of Small and Large Bioactive Molecules
Biomimetic Self-Guiding Nanomotors Boost Active Immunotherapy
Dual-Action Cellular Nanoparticles for Effective Lead (Pb2+) Detoxification
Amyloid-like Protein-Metal Sulfide Nanocoatings for Synergistic Photothermal and Antibacterial Implant Surface Protection
Injectable Microparticle-Nanoliposome Hydrogel for Extended Release of Small Hydrophilic Molecules
A CRISPR-Customizable Copper-Coordinated DNA Nanoplatform Potentiates Cuproptosis Through Circadian and Metabolic Pathway Manipulation
Endogenously Activated Multiple DNAzyme-Encoded Nanoflowers for High-Contrast Imaging of Long Noncoding RNA and Cancer Therapy
Engineered Magnetic Resonance Nanoprobes for Visualizing Tumor Programmed Cell Death Ligand 1 Level and Enhancing Synergistic Radio Immunotherapy
Role of Serum Stability and Lipoprotein Interactions in Lipid Structure–Tumor Accumulation Relationship
Meta-Analysis and Machine Learning Prediction of Protein Corona Composition across Nanoparticle Systems in Biological Media
Maintaining Shell Disorder with Kinked or Branched Ligands Stabilizes Apolar Nanoparticles
Nanoparticle-Mediated “Cut-Off and Clean-Up” Strategy for Neutrophil Manipulation in Acute Lung Injury Therapy
Fluorinated Proteolysis Targeting Chimeras-Sorafenib Nanoassembly for Epigenetic Remodeling to Combat Multi-Pathway Drug Resistance in Hepatocellular Carcinoma
X-ray-Activated Nanoneutrophils for Orthotopic Glioma Immunotherapy
Solvation-Layer Mediated Interfacial Assembly for Surface Topological Engineering of Mesoporous Microcarriers
AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism
Manufacturing mRNA-Loaded Lipid Nanoparticles with Precise Size and Morphology Control
Endolysosomal Sequestration Effects Controlled Release of BRAF Paradox Breaker Nanoparticles
Tannic Acid–Iron Complex-Based Nanozyme Ameliorates Parkinson’s Disease via Relieving Oxidative Stress and Neuroinflammation
TuNa-AI: A Hybrid Kernel Machine To Design Tunable Nanoparticles for Drug Delivery
Nanoparticles Induce Protein Corona Conformational Change to Reshape Intracellular Interactome for Microglial Polarization
Metallothionein 2A-Silencing Antimonene-Based Nanoagonist for Amplifying the Photothermal Immunotherapy of Gynecologic Malignancy
Self-Driven, Stretchable Drug Delivery Electronics for Acne Treatment
Carrier-Free Nanoprodrug Mediating Laser-Activable Chemotherapeutic Immunomodulation against Cancer
Programmable Nanostructure Assembly of a Paclitaxel Derivative Enables Tunable Anticancer Therapy via Hydrogen Bond Engineering
Mucoadhesive and Self-Assembled Chitosan Oligosaccharide-Glycyrrhizin Nanoparticle for Oral Nanotherapeutic in Inflammatory Bowel Disease
Surface-Engineered Nanoshuttles Hijack Macrophages In Vivo to Boost Blood–Brain Barrier Penetration and Immunomodulation for Targeted Glioblastoma Therapy
Machine Learning-Driven Optimization of Therapeutic Substance Composition for High-Hardness, Fast-Dissolving Microneedles for Androgenetic Alopecia Treatment
Protein Corona-Detachable Microwave Ablation Amplifiers Actuate Pyroptosis to Repolarize Immortal Cancer into Senescent Ones
Biomineralized Albumin-Macrocyclic Conjugates for Synergistic Metal Ion-Based Combination Therapy in Cancer Treatment
A Colon-Targeted Oral Nanosystem Disrupts the Inflammatory Loop in Enteric Glia to Alleviate Ulcerative Colitis
Molecular Stacking@Infinite Coordination Polymer Nanocomposites for Tumor Continuous High-Intensity Photothermal–Thermodynamic Alternate Cycle Therapy and Chemotherapy
Ce6-DNAzyme-Loaded Metal–Organic Framework Theranostic Agents for Boosting miRNA Imaging-Guided Photodynamic Therapy in Breast Cancer
Biomimetic Immunoregulators for the Multi-Target Inflammation Interruption in Autoimmune Diseases
Near-Infrared-IIb Fluorescent Nanozymes with Surface Charge Flipping Ability for Imaging-Guided Therapy of Inflammatory Bowel Disease
Glucose-Responsive Polyzwitterionic Nanoparticles with Enhanced and Targeted Intestinal Epithelial Absorption for Oral Insulin Delivery
Data-Driven Prediction of Nanoparticle Biodistribution from Physicochemical Descriptors
Photodynamic-Photothermal Switching in Osmium-Ferritin Nanoplatform Activates Near Infrared-Driven Tumor Immunity Reprogramming
Acoustofluidic Fabrication of Calcium Pyrophosphate-Enzyme Nanocatalysts for Oral Treatment of Metabolic Disorders
Biomimetic Nanoparticles Simultaneously Targeting Modulation of Lipid Metabolism and Phenotype of Macrophages for Programmed Atherosclerosis Management
Transcytosis-Enabled Paclitaxel Prodrugs for Potentiated Chemotherapy
Mature Dendritic Cell-Derived Extracellular Vesicles are Potent Mucosal Adjuvants for Influenza Hemagglutinin Vaccines
Tetrahedral Deoxyribonucleic Acid-Engineered Multivalent Lysosome-Targeting Chimera for Enhanced and Dual Membrane Protein Degradation
Integration of Bone-Targeted Delivery and Crosstalk Modulation of Liver-Bone Axis for Improved Osteoporosis Therapy
Oral Administration of a Tetrahedral Framework DNA-Based Nanoshot Attenuates Liver Fibrosis via Targeting Galectin-3
Cancer Cell Membrane-Coated Homodimer Prodrug Nanoassemblies to Simultaneously Deliver Prodrugs and Immune Adjuvants for Combined Chemo-Immunotherapy
Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping
Specific Stimulation and Multiplex Secretion Analysis of T Cells Using a Suspendable Hydrogel Platform Enables Immunophenotyping at the Single-Cell Scale
Mesoporous Silica-Based Nanomotors Loaded with Rapamycin for Synergistic Treatment of Rheumatoid Arthritis
Near-Infrared Light-Triggered In Situ Construction of 3D “Fishing Net” Polymer Networks Using Upconversion Nanoparticles for Tumor Therapy
Direct Modulation of Host Cells and Gut Microbiota by Orally Delivered Antioxidant Nanocages for Colitis Treatment
Harnessing Surface Hydrophilicity of Inhalable Nanoparticles for Precision Delivery of Glucagon-like Peptide-1 Receptor Agonists or Anti-Asthmatic Therapeutics
Outer Membrane Vesicles from Caulobacter crescentus: A Platform for Recombinant Antigen Presentation
Inflammatory Macrophage-Targeted Atherosclerosis Treatment by miRNA-Delivered, MRI-Visible, and Anti-Inflammatory Nanomedicine
Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment
Phosphatidylcholine Chain-Length of Bioinspired Lipoprotein Modulates Interactions with Collagen for Intratumor Delivery in Pancreatic Cancer
Layered-Responsive Multivalent Tetrahedral DNA Framework-Decorated CRISPR-Cas12a Nanocapsule Enables Precise and Enhanced Tumor Chemotherapy
Targeting Ischemic Myocardium: Nanoparticles Loaded with Long Noncoding RNA AK156373 siRNA Alleviate Myocardial Infarction
Multivalent Aptamer Assembly Enhances Tumor-Specific Degradation of Transforming Growth Factor-Beta to Remodel the Stromal and Immunosuppressive Cancer Microenvironment
Apoptotic Cell-Mimicking Nanocarriers Enhance Splenic Red Pulp Delivery through Lipid Pool Modulation
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis
Yeast-Derived Manganese and Zinc Metal–Organic Framework Composite as a Vaccine Adjuvant for Enhanced Humoral and Cellular Immune Responses
X-ray-Responsive Semiconducting Polymer siRNA Nanosystems for Orthotopic Glioma Treatment via Silencing the Immunosuppressive Signal
44
Ultrasound-responsive bacteria-nanocomplex reverses tumor resistance to sensitize chemotherapy/chemodynamic therapy in triple-negative breast cancer
Chaotrope-guided protein microneedles with high drug-loading capacity, ultrafast dissolution, and high mechanical strength
Chirality of Poly(γ-glutamic acid) Directs Calcium Nanoparticle Assembly and Adjuvant-Like Immune Activation
Antimicrobial-potentiated colorectal cancer therapy with synchronized tumoricidal immunity via a self-deliverable nanopeptide
Macroporous-channel hollow microneedles enable vacuum-free interstitial fluid sampling and on-patch sensing
Biomimetic zwitterionic micelles for efficient mucus penetration and pulmonary targeting in acute lung injury
Multifunctional pH-responsive nanocarrier for targeted azithromycin delivery and immune modulation in bacterial sepsis
Transmucosal delivery of a dendritic cell-targeting intranasal nanovaccine boosts HIV-1 specific mucosal and systemic immune responses
Size-Transformable Amphiphilic Dendrimer-based Drug Nanomicelles for Enhanced Tumor Penetration in Cancer Chemotherapy
Visible tumor-targeting biohybrid vehicles reprogram cancer-associated fibroblasts to potentiate photothermal immunotherapy
A Metal-Free Cascade Nanoreactor Reprograms the Cystine-Glutathione Axis for Disulfidptosis-Pyroptosis Therapy
DNA damage-driven cGAS-STING activation via a nuclear-targeted probe enables potent near-infrared theranostics in breast cancer
Sulfatase-responsive phase-separating peptide coacervates target stress granules to reverse sorafenib resistance in hepatocellular carcinoma
Engineered acid-regulating liposomal nanovesicles for synergistic photodynamic pyroptosis and immunotherapy
Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo
ROS-sensitive nanocarriers for synergistic X-PDT/chemo/immunotherapy of triple-negative breast cancer and metastasis
Trojan horse natural killer cells enhance targeted drug delivery and boost memory T cell-mediated immune responses in triple-negative breast cancer
The hydrophilic amorphous layer around bone apatite promotes osteogenesis
Injectable NIR-II-Responsive Nanocomposite Hydrogels containing Gold Nanoparticle-decorated Carbon Nanotubes for Controllable Drug Delivery and Tumor Therapy
A solvent-free ropivacaine-loaded composite hydrogel assembled from pH-sensitive micelles and a thermosensitive injectable hydrogel for prolonged local anesthesia
Gadolinium nanoparticle-enhanced, radiopaque, and resorbable inferior vena cava filters for improved in vivo applications
Virus-inspired nanocages potentiate glioblastoma sonochemotherapy via structure-function mimicry
Tuning the polyethylene glycol-lipid anchor length of lipid nanoparticles to enhance brain-targeted siRNA delivery
Sulfhydryl-modified nanocarriers enhance corneal retention and ocular anti-inflammatory efficacy in dry eye therapy
Gastrointestinal distribution of engineered biodegradable urease-powered nanomotors
Dual-mechanism mucoadhesive hydrogel integrating pH-independent barriers and autophagy-driven immunotherapy for the treatment of ulcerative colitis
A pH-responsive polycarbonate nanoplatform enables sequential drug release for enhanced apoptotic cascade synergy in non-small cell lung cancer therapy
Interaction Mechanisms Between Antibiotics and Calcium Phosphate Cements as Pharmacologically Active Bone Graft Substitutes
Toward preclinical evaluation of a thermosensitive PEG-poly(L-alanine) hydrogel: A study on sterilization, storage stability, and in vivo performance
A Co-Catalytic Nanosystem Based on Molybdenum Disulfide and Prussian Blue for Synergistic Chemodynamic and Photothermal Therapy through Mitochondrial Damage and Ferroptosis
Self-Emulsifying Drug Delivery Systems: A Comparison of Dry and Wet Reverse Micelles
Genetically engineered sericin hydrogels for the delivery of human adiponectin in treating ulcerative colitis in mice
Effective in vivo delivery of diphtheria toxin using protein cage nanoparticles for targeted cancer therapy
A Drug Reservoir Strategy for Long-Acting Cancer Therapy Using Morphologically Transformed Amphiphilic Polymeric Nanoparticles
Redox-responsive dendritic copolymer-drug conjugates enhance therapeutic mitophagy through coordinated microtubule destabilization for synergistic triple-negative breast cancer therapy
A biomimetic nanoplatform mediates hypoxia-adenosine axis disruption and PD-L1 knockout for enhanced MRI-guided chemodynamic-immunotherapy
Enhanced delivery of camptothecin to colorectal carcinoma using a tumor-penetrating peptide targeting p32
PCL-PEtOx-based Crystalline-core Micelles for the Targeted Delivery of Paclitaxel and Trabectedin in Ovarian Cancer Therapy
A Self-Assembling Chimeric Peptide Gear-Set with "Three-in-One" Function for Precision Photodynamic Therapy
Metabolic reprogramming by chemo-gene co-delivery nanoparticles for chemo-immunotherapy in head and neck squamous cell carcinoma
Phosphorous dendrimer-mediated biomineralization for synergistic blockade therapy and hypoxia-activated chemotherapy of tumors
Engineered bioorthogonal cell delivery system for in situ antimicrobial peptide recruitment during systemic bacterial infection
An injectable in situ gel formed by ropivacaine with small lipid molecules to achieve long-term postoperative analgesia
pH-responsive photothermal effect and heterojunction formation for tumor-specific pyroelectrodynamic and nanozyme-catalyzed starvation therapy
78
Co‐Delivery of Cationic Polymeric Sonosensitizer and Antimicrobial Peptide Mimic by Polymeric Nanoparticle for Enhanced Therapy of Lethal Bacterial Pneumonia
Structural Topology of Prodrug Nanoassembly: First Steps Toward Nano‐QSAR
Stem Cell‐Laden Magnetic Hydrogels for Liver Fibrosis Reversal via Synergistic Magneto‐Mechanical Stimulation
Seleno‐Amino Acid Nanotherapeutics Upregulates Selenoproteins to Inhibit Oxidation and Neuroinflammation for Spinal Cord Injury Recovery
Hydrophilic Ligand-Assisted Synthesis of Water-Dispersible Transition Metal Sulfide Nanoparticles
A Magnetic Resonance Imaging Reportable Strategy for In Situ CuET and Mn2+ Generation to Boost Antitumor Immunity
Responsive Liquid Crystal Double Emulsion for On-Demand Cargo Release and Its Application in Bacteria Detection and Elimination
Mitochondrial-Targeting DNA Origami Delivering TIPE-2 mRNA for Microglial Metabolic Reprogramming and Neurological Recovery in Intracerebral Hemorrhage
ReDESigning Hydrogels for Biomedicine: Tuning Transport Control and Biological Functionality in Biocompatible, Antibacterial Eutectogels
Kinetics-By-Design: On-Demand Fabrication of Personalized Drug-Release Profiles Using Multi-Material 3D Printing
Deciphering Small Molecule Diffusion Parameters Across Light Responsive Polymersome Membranes
Ginsenoside‐Engineered Lipid Nanoparticles in Microbeads Enable Oral siRNA Delivery and Targeted Therapy for Ulcerative Colitis
Natural Microgels Overcome Nanoparticle Retention Barriers for Hyperthermia and Tumor Regression
Aggregation-Induced NIR-II Emission Luminogens Integrated into Cu2+-Phenolic Nanoparticles for Mild-Temperature Photothermal Eradication of Bacterial Biofilms
Rational Design of a Multifunctional Copper-Cobalt Sulfide Nanozyme for Cholesterol Depletion and Thermo-Resistant Tumor Ablation
4D-Printable Poly(Thio)urethane Photoresins With Reactive Oxygen Species Responsiveness and Anti-Inflammatory Functionality
Dual-Scale Targeting of Myofibroblasts and Mitochondria via Oral Cascade Delivery Systems Alleviate Intestinal Fibrosis
A Potent Nickel‐Based STING Agonist Nanodrug Against Prostate Cancer Bone Metastasis
Hypoxia‐Activated Radical Anions to Trigger Reactive Oxygen Species Burst for Chemoimmunotherapy
5-Aminosalicylic Acid-Derived Carbon Dots Nanozyme for Ulcerative Colitis Treatment via Inhibiting NF-κB/AGE-RAGE Pathway and Modulating Arachidonic Acid Metabolism
Peptide‐Modified Fluorinated Polymeric Carriers for Targeted Delivery of β‐GP to Enhance Bone Regeneration
A Natural Self-Assembled Hydrogel Alleviates Inflammatory Bowel Disease by Targeting Mitochondrial Dysfunction and NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis
Spontaneous Bio-Derived Porous Hydrogels for Sustainable Pollutant Removal from Contaminated Water
A Probiotic-Derived Oral Dual-Triggered Platform for Synergistic Anti-Inflammatory and Microbiota Modulation Therapy of Inflammatory Bowel Disease
A Bioresorbable Neural Interface for On-Demand Thermal Pain Block
Spleen-Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle-Fused Lipid Nanoparticles
A Multifunctional NIR‐II Rare‐Earth Nanoagent for In Vivo Monitoring Cancer Revascularization and Prognosis
Oral Dosed Organo-Silica Nanoparticles Restore Glucose Homeostasis and β-Cell Function in Diabetes Rats
Effective HA-Loading Strategy in Internal Dome-Assisted Suction Cups for Enhanced Transdermal Delivery Under Vertical Adhesion and Vibration
Bioinspired Multi-Gradient Structure Enables Environment-Adaptive Personal Respiratory Protection and Moisture Management for Biodegradable Poly(lactic acid) Meta-Membranes
Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy
A One‐Two Punch Strategy Against Cancer: Simultaneously Inducing and Eliminating Senescent Tumor Cells
An In Situ Self‐Responsive Nano‐Prodrug to Enable Tumor Chemo‐Metalloimmunotherapy
Reprogramming Tumor Cell Death via Processing Natural Drug to Carbon Dots Overcomes Collagen Barrier and Activates Antitumor Immunity
An Inhalable Spike–Conjugated Gold Nanoparticle for Treating Acute Lung Inflammation
Sono-Controllable Janus Microneedle for Postsurgical Tumor Eradication and Scarless Wound Healing in Melanoma
Hierarchical Precision Nanoplatform for Synergistic Radio‐Immunotherapy in Glioblastoma via Controllable P‐Selectin Targeting
Dual‐Targeted Metabolic Nanovesicles Reprogram Macrophage‐Cardiomyocyte Crosstalk for Myocardial Ischemia‐Reperfusion Therapy
Ferulic Acid Integrated Non-Invasive Microneedle Patches for Localized Bruising Treatment
Mechanistic Insights into a Smart Nanomotor‐Laden Inulin Hydrogel Reprogramming Gut‐Brain Axis for Combinatorial Inflammatory Bowel Disease‐Depression Therapy
Nonclassical Modes to Inhibit β‐Hematin Crystallization
Intracellular Self‐Assembled Fe(II)‐Aniline Mustard NPs for Self‐Enhanced Anti‐Tumor Chemo‐/Chemodynamic Therapy
CDT Prodrug Therapy With Cascade‐Activated PROTAC Delivery Platform for Mutually Reinforced Ferroptosis and Apoptosis‐Based Therapy
Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing
Overcoming Solubility Limitations in Inverse Temperature Crystallization for Universal Growth of High‐Quality Perovskite Single Crystals for X‐Ray Detection
Bioengineered Violet Phosphorus Hybrid Nanoassembly for Pathogen-Specific Eradication of Multidrug-Resistant Bacteria
Sialylated Macrophage Nano-Decoys Mitigate Inflammatory-ROS Microenvironment and Reprogram Endothelial Function in Myocardial Infarction
Surface Fluidic Microneedle Patches for Lymphatic Delivery of Diagnostic and Therapeutic Agents
Precision Cuproptosis Activation via HER2-Targeted Bimetallic MOF Nanoreactors Breaks Metabolic Adaptation in Aggressive Breast Cancers
Free-Form Microfluidic Microneedle Array Patches
Terminal Group‐Determined and Dendrimer‐Encapsulated Perovskite Probes for High‐Contrast Biomedical Imaging
Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection
Multifunctional Nanotherapy Rescues Fetal Growth Restriction via Alleviating Hypoxic Embryonic Microenvironment
Friends Fight the Foes: Synergistic Low‐Temperature Photothermal/Chemo/Gas Therapy for Conquering Cancer Cells
Unleashing the Power of Machine Learning in Nanomedicine Formulation Development
Homologous Membrane‐Camouflaged Pretargeting Synergized with Bioorthogonal Amplification Enables High‐Fidelity Tumor Imaging
Magnetic Navigation of Spatiotemporally Synergistic Delivery to Potentiate Sonodynamic Therapy of Orthotopic Pancreatic Carcinoma
Thermal‐Triggered Polymerizable Hydrogels with Localized Hyperthermia for Shrinkage‐Driven Starvation Therapy
Neutrophil‐Targeting Framework Nucleic Acid Based NETosis‐Inhibiting Nanoplatform Orchestrates Intra‐ and Extra‐tumoral Attack to Suppress Primary Tumor and Liver Metastasis
Breaking the Depth Barrier: Dual‐Activated Radical Storm from a Natural Product‐Based Nanoplatform for Spatiotemporally Controlled Deep Tumor Sonodynamic Therapy
Block Copolymer Microcapsules with Perpendicularly‐Perforated Ultrathin Membranes for Controlled Transmembrane Transport
Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function
ROS‐Activatable Cyclodextrin Nanoparticles Remodel Adenosine‐A2AR Pathway for Augmented Photo‐Immunotherapy
Hypoxia- and pH-Responsive Metal-Phenolic Network-Engineered Ferroptosis-Immuno Microspheres for Transarterial Chemoembolization in Hepatocellular Carcinoma
Phospholipid‐Like Prodrug Liposomes with High Drug‐carrier Affinity and High Tumor Selectivity: Strong Competitors of Paclitaxel Nanomedicines
Evolving Platinum-Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy
Lattice-distortion Induced Niobium-based Perovskite Polarization Cascade Regulates Na+/K+ ATPase to Enhance Pyroptosis for Cancer Treatment
An Intelligent Hyperthermia System with Photothermal Temperature Wall Effect for Programmable Gated Drug Release in Wound Healing
Melittin‐Loaded Multifunctional Nanozyme for Ulcerative Colitis Treatment via Enzyme‐Immunotherapy and Ferroptosis Inhibition
Near‐Infrared‐II Plasmonic Multi‐Enzyme Nanocapsules for Hyperthermia‐Augmented Cascade Catalytic Oncotherapy
Biomimetic Cascade‐Targeted Nanoplatform for Fluorescent Localization and Eradication of Oral Squamous Cell Carcinoma
Dual‐Driven Janus Nanomotors Combined with a Size‐Shrinkage Strategy for Enhanced Tumor Penetration and Synergistic Chemo/Photothermal/Photodynamic Therapy
Four‐Pronged Nanomotor Strategy Achieves Efficient TNBC Treatment via Synergistic Chemo‐Photothermal‐Immune Therapy
Self-Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere-Aggregated Hydrogels in Triple-Negative Breast Cancer Therapy
Armored Superhydrophobic Dental Devices Regulate Oral Microecology via Long‐Term Antifouling
Near‐Infrared Photoaccelerated MicroRNA Response for Image‐Guided Photodynamic‐Chemodynamic Synergistic Cancer Therapy via Nanoprobe Programmed Disassembly
Precise Diffusion of Gaseous H2S “Bomb” Potentiates NIR-II Imaging-Guided Photothermal Therapy by Relieving Heat Tolerance and Disturbing Cellular Homeostasis for Synergistic Orthotopic Glioblastoma Treatment
KMnO4-Laden Hollow Nanoformulations Induce an Oxidative Stress Storm for Cascade Therapy of Tumors
64
A Nano-Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast-Immune Communication via CCL2 Sequestration
Inhalable Polymeric Nanoparticle Vaccine for Lysosome-Targeting Co-Delivery of Antigen and Adjuvant With Enhanced Immunoprotection
Cytosol-Targeting Delivery of Non-Nucleotide STING Agonist Achieves Inhalable Nanoparticle-Based Anthrax Vaccine
Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On‐Demand Osteomyelitis Therapy
A Biomimetic Nanomachine Reprograms Transmembrane ATP Flux to Induce Tumor‐Selective Bioenergetic Crisis
Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy
Potentiating Antibody-Dependent Cell-Mediated Cytotoxicity via Tumor-Specific Anchoring and Activation of Nano-Haptens
In Vivo Target Drug Enrichment Based on Spatiotemporal Acoustic Node Modulation (STANM) for Bladder Cancer Treatment
Inhalable Respiratory Driven Penetration of Porous Microsphere‐Based Mucosal Vaccine for Long‐Term Immune Protection
Microcrystalline-Infused Peptide Hydrogel Enables Sustained Tacrolimus Delivery to Prolong Survival and Prevent Rejection in Kidney Transplantation
Single‐Molecule All‐In‐One (SMALL) Dendritic Dots for Precise Cancer Theranostics
Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue
STAR Therapy: Spatiotemporal Antitumor Regimen via a Size‐Gated DNA Hydrogel Drug Delivery System
High Concentration Antibody Formulations Enabled via Thermostable Ionic Liquids
Epigenetic Metal‐Organic Framework Nanoagonist Overcomes Triple Defenses to Enable Effective Chemo‐Metalloimmunotherapy in Platinum‐Resistant Ovarian Cancer
Modulation of MOF Energy State to Construct Smart Activated Sensitizers for Membrane Directed C–H Ketene Therapy in Tumor Cells
Programming Interfacial Polymerization: Machine Learning Unveils Quantitative Rational Design Rules for Microcapsules and Beyond
Dismantling the Necroptotic Engine: An Oral Theranostic Nanosponge for Ulcerative Colitis
Molecular Gardening for Neuroinflammation via Nose-to-Brain Delivery: A Ca2+ Responsive DNA Nanocage-Hydrogel System With Neuron Targeting and STING Inhibiting
Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract
Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups
Effective Degradation of Wild‐Type and Mutant EGFR Using Self‐Assembling Peptide‐Derived PROTAC Nanoparticles (NanoTACs) for Cancer Therapy
Mitochondria-Targeted Nanomotor: H2S-Driven Cascade Therapy for Hepatocellular Carcinoma
High‐Concentration Antibody Formulation via Solvent‐Based Dehydration
Colloidal Heterostructures Enable Interfacial Transport of Immiscible Molecules in Printable Organohydrogels
Machine Learning‐Assisted Design and Discovery of High‐Performance Cyanine‐Based Photosensitizers for Integrated Theranostic Applications
Amorphous A‐BiOI@PEG Nanoenzyme Targets Imaging and Synergistic Phototherapy in Differentiated Thyroid Cancer
Photo-Controlled MUC1 Ablation via Steric Locking of Turn-On Reactors Enhances Pyroptosis-Immunotherapy of Triple Negative Breast Cancer
Diatomic Mn/Ca Nanozymes with Jaw Vascular Unit Mimicry for Triple-Enzyme Synergistic Therapy of Osteoradionecrosis
Pathology-Driven Design of a Biomimetic Ferromagnetic Nanomedicine for Dual-Mode Treatment of Ulcerative Colitis and Colitis-Associated Colorectal Cancer
Tannin-Mediated Ischemia-Homing-Angiogenesis Nanodots (IHAND) for Synergistic Angiogenesis and Heart Failure Prevention Post-Myocardial Infarction
Targeted Lipid Transfer Nanoshuttle via Lipid-Specific Transcytosis Induces Atherosclerotic Plaque Regression
Metal‐Imidazolate Cages as Porous Ionic Liquids: A Nitric Oxide Delivery Therapeutic Platform for Burn Wound Healing
Heat‐Responsive Phase‐Change Cream Broadly Enhances Transdermal Delivery Through a Mild Photothermal Strategy
Lithium-Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity
All Drug Glassy Microneedle Patches for Instantaneous Transdermal Delivery
A Hypoxia-Activatable Prodrug for Targeted Combination Therapy of Hepatoma
Targeted Cascade Therapy with Multifunctional Nanovesicles Engineered from Synergistic Antibacterial Agents for Precision Treatment of Multidrug‐Resistant Infections and Biofilms
Polyphenol-Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases
Engineered Biomimetic Nanovesicles Derived From Bone Marrow Stromal Cells With Innate Homing Capability for Targeted Delivery
Tumor Microenvironment-Activated Fe3+-Doped Dendritic Mesoporous Organosilica Nanocomposites as Ferroptosis Inducers for Enhanced Immunotherapy
Lipidic Prodrug Co-Crystals: A Platform for Combination Therapy Targeting Fungal Biofilms
Synthetic High‐Density Lipoprotein Mimicking Nanodiscs with Pt(IV) Prodrug Enable Tumor Targeting and cGAS‐STING Pathway Activation for Chemo‐Immunotherapy
Selective Lipolysis by Photoactivation of Chaperone-Mediated Autophagy Using Adipocyte Membrane-Coated Nanoparticle in Hydrogel
Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery
Plaque‐Targeted Delivery of Fluoride‐Free MXene Nanozyme for Alleviating Atherosclerosis via Sonocatalytic Therapy
Signal Transducer Nanoparticles Enable Siglec‐10/G Blockade Immunotherapy for Breast Cancer Treatment
mTORC1 Selective Nano‐Inhibitor by Disrupting the Lysosomal Arginine‐SLC38A9‐ mTORC1‐CDKs Axis for Precision Bladder Cancer Therapy
Enhanced Control of Liposomal Drug Release by Drug–Aptamer Complexes
Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers
Flippase‐Mediated Hybrid Vesicle Division
Activatable Enzymatic Nanoplatform Incorporated into Microneedle Patch for Relieving Tumor Hypoxia Augmented Photodynamic Therapy
Engineered‐Macrophage‐Escorted Rotaxane Nanoscavengers for Precise Diquat Detoxification
Lesional Macrophage‐Targeted Nanomedicine Regulating Cholesterol Homeostasis for the Treatment of Atherosclerosis
Injectable Functional Porous Carbon‐Loaded Hydrogel with Long‐Term Retention and Synergistic Anti‐Tumor Properties for Tumor Therapy
Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer
Bioinspired Heterogeneous Spheres with Tunable Helical Structure for Accurate and Efficient Control of Sugar Blood Level
A Metabolism‐Oriented Strategy to Directly Generate Photosensitizer‐Engineered Extracellular Vesicles from Cancer Cells
Rational Development of a Novel Emulgel Adjuvant for Single‐Shot Effective Vaccination: A Multivariate Analysis Approach
Protein‐Nonfouling and Cell‐Binding Polysulfobetaine Inducing Fast Transcytosis for Tumor‐Active Drug Delivery
Highly Specific Cytokine Receptor-Targeting Chimeras for Targeted Membrane Protein Degradation and Sensitization of Osimertinib in EGFR-Mutated Non-Small-Cell Lung Cancer
Multiplex Methionine Modulating Hydrogel for Cancer Metabolic Therapy
Polyanhydride‐Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single‐Injection Self‐Boosting Vaccines
Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection
1
Blood micronutrients modified associations between blood heavy metals and cognitive decline in a nationally representative cross-sectional study
1
Leukotriene modifying agent chemoprophylaxis for severe influenza illness: A multi-approach study
2
Venous thromboembolism with combined oral contraceptives based on estrogen and progestin content: a disproportionality analysis of the United States Food and Drug Administration Adverse Event Reporting System database
Azithromycin in preterm premature rupture of membranes: population pharmacokinetics and dose optimization
88
Mimotope-Driven lucCage–lucKey Homogeneous Bioluminescent Immunosensor for the Small Molecule Fumonisin B1
Multiplex Detection and Quantification of miRNAs in Drug Delivery Systems Using a Signal-Off Electrochemical Platform
Discovery of Nanobodies against Tetramethylenedisulfotetramine by Integrating Next-Generation Sequencing and Moderate Random Mutagenesis
3D Glioblastoma Molecular Responses to Carbon Dot–Delivered Riluzole Probed by Synchrotron FTIR
In Vivo Negligible Depletion SPME for the Determination of Free and Total Concentrations of Anandamide and 2-Arachidonoylglycerol in the Brain of a Parkinson’s Disease Rat Model
Development of Magnetic Microbeads Equipped with Temperature-Responsive Artificial Antibodies for Efficient Anticancer Drug Administration
Parallel Sequencing of the Two Arms on a Bispecific Antibody by Electron Capture Dissociation on a timsOmni Platform Reveals Several By-products in the Controlled Fab-arm Exchange Process
Characterizing Noncovalent Therapeutics in Biomatrices by Native Affinity Capture Mass Spectrometry: Biotransformation of Antibodies Conjugated with Small Molecules and siRNA
Complete and Rapid NMR Characterization of Therapeutic Monoclonal Antibodies via Differential Labeling of Fab Fragments in Escherichia coli
Logic-Gated NIR-IIb Theranostic Nanozymes for Longitudinal Quantitative Assessment of In-Situ Cytotoxic T Lymphocytes
Database of Chemicals for Organophosphorus (DCOP): An Information Application Platform for Organophosphorus Compounds
Graph Machine Learning Can Estimate Drug Concentrations in Whole Blood from Forensic Screening Results
A Multi-Domain Affinity Metal Organic Polymer-MXene Heterostructure for Superior Advanced Antibody Separation
POx-Lipids as an Alternative to PEG-Lipids? Multimethod Assessment of Chemistry and Structure
Efficient Discovery of Immunoglobulin Genes for Detecting Organophosphorus Pesticides Using a Reverse Virtual Screening Pipeline
Measuring the Degree of Labeling of Antibody-Dye Conjugates with a Single-Molecule-Sensitive Digital Flow Cytometer
Polarity- and Sequence-Dependent Ionization of Therapeutic Antibody–siRNA Conjugates: Enabling Intact Multi-attribute Method for Comprehensive Characterization and Identity Release Assay
Deciphering the In Vivo Metabolism of Polyethylene Glycol by a Polymeromics Approach
Stereochemical and Structural Characterization of Methionine Oxidation in the IgG1 Fc Region by Integrated NMR and LC-MS Analysis
Caspase-3-Instructed Nanosonosensitizer Disassembly for Real-Time NIR-II Feedback of Tumor Sonodynamic Therapy
In Vivo Two-Dimensional Correlation Raman Spectroscopy Unveiling the Reversible Microstructural Changes and Spatially Differential Swelling of the Human Stratum Corneum in Response to Glycerin as a Temporary Penetration Enhancer
Endogenous-Activatable Nanotheranostic Platform for Multimodal Bioimaging-Guided Photodynamic and Gas Synergistic Cancer Therapy
Advanced Quality and Comparability Assessment of mRNA-Loaded Lipid Nanoparticles: Absolute Size Distribution Profiles and Structure from AF4-Coupled Light and X-ray Scattering Measurements
Proximity-Based Phospho-Interactome (Prob-PhI) Characterization Reveals Distinct Signaling Activities of MEK1 and MEK2
Antibody Affinity Modulation Mechanisms via Benzene Ring Spacer Arm Conjugation Sites (Ortho, Meta, Para) in Coating Hapten Design
Hemin-DNA Switch-Assisted Microfluidic Chemiluminescence Immunoimaging for Rapid and Quantitative Screening of Specific Hybridomas
Light-Driven Upconverting Nanoparticles-Based Nanodevice for Accurate Subcellular Dual Molecular Imaging and Combinational Tumor Therapy
A Chemically Inducible Multimerization System for Tunable and Background-Free RTK Activation
Fe–N3S Single-Atom Nanozyme with Asymmetric Coordination for Ultra-Low-Background Colorimetric Immunoassays
In Situ Characterization and Deep Profiling of Engineered Multispecific Nanoparticle Metabolite Coronas for Precise Serum Diagnostics
Toward AI-Assisted Greener Chiral HPLC: Predicting Efficient Enantioseparation–Mobile Phase (EES–MP) Profiles for MP Selection─A Lux Cellulose-1 Case Study
Development of a Sensitive Lateral Flow Immunoassay Using Recombinant Rabbit Single-Chain Variable Fragments Fused to a Nitrocellulose-Binding Protein
AnnoTCM: An Annotation Tool for Multimodal Metabolite–Phenotype Integration in Decoding Bioactive Compounds of Traditional Chinese Medicine
A Novel Ficoll400-Based Signal Amplification Platform for High-Sensitive Cardiac Troponin I Immunoassay
Precision Strike at Lipid Droplets by Spherical Nano-Browning Agents Promotes Obesity Remission
Integrative Real-Time NMR and X-ray Crystallography Reveal Prostaglandin D2 Metabolism
Real-Time Bioconjugation Reaction Monitoring of Antibody–Drug Conjugates with Multiattribute High-Throughput Hydrophobic Interaction Chromatography
Observing Interactions between Lipopolysaccharide Aggregates and a Monoclonal Antibody Using Differential Fluorination and 19F NMR
Artifactual Sequence Variant Induced by Nonspecific Cleavage-Linked Transpeptidation in Peptide Mapping
Unveiling Dopamine and Met-Enkephalin Dynamics: Simultaneous Co-Detection in Rat Striatum
MSformer: A Meta-Structure Based Interpretable Framework for Representation Learning of Natural Products
Engineered Exosomes Disguised NIR-II Nanoaggregates for High-Resolution Photoacoustic Angiography and Robust Photothermal Therapy of Glioblastoma
Real-Time Binding Kinetics of Membrane Protein–Protein Interactions in a Membraneless Setting
Machine Learning Guided by Physicochemical Principles Enables Generalized Prediction of Small-Molecule Subcellular Localization and Discovery of Targeted Molecules
Physicochemical Tuning of Bispecific Antibody Fragment Immobilization for Robust Digital SERS Biosensing
Multiplex and Spatiotemporal Detection of Single-Cell Antibody Secretions Using Protein-Patterned Microwells
A 19F-Labeled Isothiocyanate Derivatizing Agent for the Chiral Discrimination of Cyclic Secondary Amines
Characterization of Hydrogel Drug Delivery System Stability Using Column-Switching Multimodal Liquid Chromatography–Mass Spectrometry
Quantifying Cell Membrane Permeability of Small to Mid-Size Drugs Using Quick Osmotic Cytoplasm Extraction
Advanced Spectroscopic Techniques for Lactose Crystallization Analysis: Investigating Water Participation in Crystal Morphology
Elucidating Molecular Vibrations within the Cocrystal of a Nonsteroidal Anti-Inflammatory Drug and Amino Acid by Temperature-Dependent Terahertz Spectroscopy at 2–17 THz: A Case Study
Development of a Liposome-Based Serological Assay for SARS-CoV-2 Variants with Special Emphasis on Coupling Chemistries Required to Maintain Protein Antigenicity
Dual-Functional Microneedles for In Situ Diagnosis and Biofilm-Targeted Therapy of Diabetic Periodontitis via Biomarker-Responsive Probes and Photothermal NO Nanomotors
Multifunctional Gold Nanoclusters for a Lung Tissue Distribution Study of a Novel Anti-asthma Inhaled Antibody
A Robust Immobilization Method for Membrane Protein SPR Assays Using SpyCatcher–SpyTag
Large Language Model-Empowered Compound Collision Cross-Section Prediction
In-Solution Characterization of Biomolecular Interaction Kinetics under Native Conditions
NMR-Metabologenomics Coupled with Activity-Picking Inspires Discovery of Samsumycins: a Fast-Mining Strategy for Novel Antibiotics
Increasing the Scale of the Mass Spectrometry Query Language Compendium with Explainable AI
Theoretical Framework and Experimental Validation of Multiplexed Analyte Quantification Using Cross-Reactive Affinity Reagents
A Novel Nontargeted Screening Strategy for New Psychoactive Substances: A Case Study of Synthetic Cannabinoids Based on Electron-Activated Dissociation High-Resolution Mass Spectrometry and Intelligent Elucidation
Early Stage Soft Protein Corona Identification on Nanoparticles via Extended Size Exclusion Chromatography
Homo-Tag-Assembler Assay for Full-Length Antibody Sequencing
End-to-End One-Pot Preclinical Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry Workflow for Simultaneous Quantitation of Total and Conjugated Antibody Levels of Antibody-Drug Conjugates with Protease-Cleavable Linkers
From Spectra to Structure: AI-Powered 31P NMR Interpretation
Visualization of Immune Rejection: Noninvasive Imaging/Efficacy Evaluation of Immune Rejection after Liver Transplantation via Stable NIR-II Scaffolds
Two-Cycle Immunoaffinity Enrichment Strategy with Acid Treatment to Enhance Biotherapeutics Assay Sensitivity in Tissues
Rapid and Wash-Free Anti-Drug Antibody Assay Enabled by a Complementary Nanoluciferase Biosensor
Multiple Exposures of Plasma to Nanoparticles: A Novel Tool to Personalize Biomolecular Coronas and Fractionate Fluids
Iodoacetyl Tandem Mass Tag-Based Site-Specific Free Thiol Analysis (TMT-SiFTA) of Monoclonal Antibodies
Serum-Based Detection of Pancreatic and Ovarian Cancer via a Nanoparticle-Enhanced Fluorescence Array and Machine Learning
Analytical Data Review on an Artificial Intelligence Platform for Doping Control in Horse Racing
Dissecting Hidden Liraglutide Oligomerization Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics
Reliable Quantification of Conjugated Peptides from T-DM1 In Vivo by Two-Step Enrichment and Internal Standards from Derivatized Analytes
Dual Ratiometric Single-Molecule Theranostic Probes for Photothermal Therapy and Real-Time Quantitative Evaluation of Therapeutic Efficacy iIn Vivo/i
Active Learning Improves Ionization Efficiency Predictions and Quantification in Nontargeted LC/HRMS
Hydrophilic Interaction Chromatography HRMS with Acrylamide Monolithic Columns: A Novel Approach for Intact Antibody Glycoform Characterization
DNA Hybridization-Accelerated Programmable Immuno-Aggregation of Microbeads Enabling Mix-and-Read Flow Cytometric Protein Analysis
Ultrafast Microdroplet Digestion of Antibodies with Fc-Silencing Mutations
The Structural Fingerprint of Therapeutic Monoclonal Antibodies Determined Using a Combination of Near-UV Circular Dichroism and Statistical Approach for Comparative Analysis
Fate of Stressed Oligoclonal Antibodies Tracked by Fluorescence Cross-Correlation Spectroscopy: IgG Aggregation Proceeds across the Species Barrier
Accurate Identification of MDMB-Type Synthetic Cannabinoids through Design of Dual Excited-State Intramolecular Proton Transfer Site Probe and Deep-Learning
A Potential Mercury Polymer Mass Tag Probe for Mass Cytometry
Virtual Screening Combined with Phase Transition-FRET for Discovery of Small-Molecule FcRn Antagonists
Leukocyte Depletion in Dried Blood Spot Cards Enables Enrichment of Parasite DNA for Improved Sequencing
Immobilizing the Endogenous 5-Hydroxytryptamine Transporter by Ligand-Directed and Proximity-Catalyzed Acyl Imidazole Chemistry for Affinity Chromatographic Analysis
Electronic Effect-Tuned Cooperativity of Multiple Noncovalent Interactions for Specific Detection of ADB-Type Synthetic Cannabinoids
Comprehensive Characterization of IgG2 Disulfide Isoforms Using Native Cation Exchange Chromatography-Mass Spectrometry and Peptide Mapping
4
Effect of Paroxetine or Escitalopram Co-administered with Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia: A Randomized Clinical Trial.
A Novel Role of Dexmedetomidine in the Modulation of Morphine Reward Memory via Gamma-Aminobutyric Acid Transporter-1.
Respiratory and antinociceptive effects of NOP-MOP agonist cebranopadol versus full opioid receptor agonist oxycodone: a comparison in healthy volunteers.
Sensory-selective peripheral and neuraxial nerve blockade with 2',6'-pipecolylxylidine.
119
Discovery of Perilloxazole Pseudo‐Natural Products Yields a New Sterol Biosynthesis Inhibitor Chemotype
Electrochemical Divergent Synthesis of Azetidines via Strain Release of 1‑Azabicyclo[1.1.0]butanes
Catalytic ROS‐Amplifying Self‐Immolative Linkers Enable Carrier‐Free Prodrugs for Refractory Tumors
A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation
Large‐Scale Profiling of Kinase Degradation by Using Norbornene‐Based Hydrophobic Tag (HyT) Strategy
Second‐Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules
Polyfluoroalkyl-Tagged Cell-Penetrating Peptide-Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction
Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2′,6′-Pipecoloxylidide
Amphiphilic Zwitterionic Polymers Induce Liposome Morphogenesis into Nanodiscs for Deep Glioblastoma Infiltration
Benzaldehyde‐Tagged Cell‐Penetrating Peptides Enable Efficient Cytosolic Delivery of Bioactive Cargos via Dynamic Covalent Anchoring
Genome-Guided Discovery of Antimalarial 4-Amino-2,4-Pentadienoate-Containing Cyclolipodepsipeptides
Self‐Immolative Nanotheranostics with Albumin‐Guided Tumor Targeting for Oxidative Stress‐Amplified Photodynamic Therapy
Programmable Coacervate–Membrane Interactions Direct Internal and Collective Organization in Membranized Protocells
Counterion-Engineered Water-Stable Intravenously Administered Nanoparticles Enable In Vivo Reversal of Ticagrelor
CD44-Assisted Transcytosable Chimeras for Extracellular Protein Depletion in Deep Tumors
Catalytic & Enantioselective Ring Opening of Azabicyclo[1.1.0]Butyl Carbinols via N-Allylation of Strained Tertiary Amines
A Dual-Key Gated Nuclear-DNA-Targeted Photogenerator for Amplified Photodynamic Immunotherapy of Breast Cancer
Kinetically Stereocontrolled Gem-Fluoro(chloro)-Olefination of Carbonyls by an Unprecedented Sulfoximine: Programmable Construction of Challenging Persubstituted Alkenyl Fluorides
Hybrid Computational Strategy for Predicting Complex Ligand–Metal Architectures
Lipid Modified with Pyridinium Betaine Manipulates Liposomal Membrane Fusion Behavior for Spatially Confined Cytoplasmic Delivery
A General Group Testing Strategy for Discovering Chemical Cooperativity
Development of PolyHis‐Targeting PROTAC Degraders
Reaction Discovery Involving Digital co-Expert with a Practical Application in Atom-Economic Cycloaddition
Adhesive Photoinitiator Constructs Polymer Jackets on Enzymes: Direct, Release‐Free Cytosolic Delivery
Split-Deliver-Click: Tumor-Specific Protein Degradation via “AND” Logic-Gated In-Cell Bioorthogonal Clicking of PROTACs
Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight
Synthetic Applicability Domain (SynAD): Navigating Chemical Space for Reliable AI‐Driven Reaction Prediction
Proteasome Cap Targeting Chimeras for Ubiquitination-Independent Targeted Protein Degradation
Tuning pH for the Controlled Formation of Ultrasmall Nanoparticles with Direct Cytosolic Access
Amino Acid Platform for Poly(amino ester)s: Controlled Ring‐Opening Polymerization, Complete Recyclability, and Tunable Polymerizability/Depolymerizability
Synergistic Action of Crystallophore and Imaging‐Crystallophore Enhances the Production and Imaging of Protein Crystals
In Cellulo Multistep Synthesis of Antitumor Zwitterionic Heterocycles Triggered by Cancer-Specific Acrolein
Apoptosis-Amplified Intracellular Paclitaxel Nanoparticle Formation Enhances Microtubule Aggregation and PANoptosis
Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters
Versatile and Selective Biomolecule Pulldown with Combinatorial DNA-Crosslinked Polymers
Meltable Polycarbonate Polymersomes as Photoresponsive Micro‐Analgesia Pumps for Concurrent Tumor Therapy and Pain Relief
Engineering Gas-Releasing Polymersome Nanoreactors for Selective Biocatalytic Activation
Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide-Like Anti-Antibiotics
Physicochemically Informed Axial Chirality Descriptors Enable Accurate Prediction of Atropisomeric Stability
Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues
A Unique CYP450 Enzyme Unlocks Antrodia Camphorata Lanostane Triterpenoid Diversity Through Oxidation and Skeletal Rearrangement
Iodine(I)-Induced Skeletal Rearrangement of α-Bicyclobutanyl Alcohols and Amines: A Universal Approach to 2-Oxabicyclo[2.1.1]hexanes and 2-Azabicyclo[2.1.1]hexanes
In Situ Coordination-Assembly Nano-Drugs/Probes for Enhanced Tumor Retention and Responsive Release
Reverse Lipid Droplet Function for Hepatocellular Carcinoma Immunotherapy
Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders
A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood‐Brain Barrier in Aging Brain
Ionizable Nano-PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression
PSMA‐Triggered Phase Separation of Peptide‐Drug Conjugates Enables Zinc‐Dependent Tumor Inhibition
Click‐Cyclized Cell Penetrating Peptides Containing Hydrophobic Proline Derivatives for Efficient Intracellular Delivery
De Novo Design of Hexamer‐Linker Dual‐Action Nano‐PROTAC for Tumor‐Specific Ferroptosis
Heteromultivalent Nanogels as Highly Potent Inhibitors of Pseudomonas Aeruginosa
On the Nature of Improper Hydrogen Bonding in RCH2F and RCHF2 Motifs
Discovery and Total Synthesis of Crossiguanipyrazines with Potent Activity Against Mycobacterium tuberculosis
Modular Access to sp3-Rich Bicyclo[1.1.1]pentane Bioisosteres via Energy-Transfer-Mediated Carbene Insertion
Development of Indolo-Bicyclo[3.1.1]Heptane as a Carbazole Isostere Through Radical Indolization of Bicyclo[1.1.0]Butanes
Flow‐Enabled, Modular Access to α,α‐Difluoromethylene Amines
Tailored Core‐Shell Nanocarrier for Therapeutic Drug Delivery via Visible Light Activation
Empowering Chemistry Experts with Large Language Models for Literature Interpretation in Single‐Atom Catalysis Toward Advanced Oxidation
A Sonosensitive Heterometallic Polyoxometalate for Highly Efficient Chemo‐Sonodynamic Synergistic Cancer Therapy
Reversible Sandwich-Based Particle Nanoswitch for Continuous Protein Monitoring at Picomolar Concentrations with Automated Calibration
Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells
Difluorinative Cyclopropene Rearrangement by I(I)/I(III) Catalysis: Regio- and Stereoselective Synthesis of Allyl Difluorides
Brain‐Targeted Near‐Infrared Chiral TeSe Nanodrug Against Orthotopic Drug‐Resistant Glioma
Interfacially Mineralized Magnetic Colloidal Gel with Microenvironment-Triggered Disassembly for Interventional Treatment of Hepatocellular Carcinoma
Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation
High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-Specific Protease mUSP18
Defluorinative Fluoro-Aza-Nazarov Cyclization
Skeletal Remodeling of Pyridines Through Nitrogen Atom Transposition
A Self‐Homing Liposomal Nanobot for Active Therapy of Glioblastoma
Chemoenzymatic Synthesis and Protein Engineering Enable Efficient, Scalable Production of Teleocidin Derivatives
Polymerization of L‐Arginine into Nanomicelles for Immunometabolic Engineering of Adoptive Macrophages in Solid Tumor Therapy
Chemical Proteomics Identifies RBBP7 as a New E3 Ligase Supporting Targeted Protein Degradation
Phospholipid‐Drug Conjugates Self‐Organized into Well‐Defined Supramolecular Nanotubes for Efficient Drug Delivery
Rapid and Modular Access to All‐Carbon Quaternary Center‐Containing 2,2‐Disubstituted Bicyclo[1.1.1]pentanes via Cyanocarbene Addition to Bicyclo[1.1.0]butanes
Umpolung Activation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis
Tandem‐Activatable PROTAC Prodrug for Tumor Biomarker‐Driven Near‐Infrared Opto‐Proteolysis
Synthesis of a Library of N-monofluoromethyl Compounds from N-monofluoromethyl Carbamoyl/Thiocarbamoyl Fluorides
In Situ Click Chemistry Screen Facilitated by an On‐Nanoparticle DNA‐Encoded Library Identifies Highly Selective and Potent Peptoid Ligands for a Phosphatase
Light‐Gated Amine Exchange in Diarylethene‐Crosslinked Microgels
Visible‐Light‐Mediated Intramolecular Dearomatization of Naphthalene and Anthracene with Bicyclo[1.1.0]butanes Through Energy Transfer Catalysis
Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups
Stereoselective Nucleophilic Di‐ and Monofluoro(sulfoximidoyl)Methylation of C═C Bonds: Remote Neighboring Group Participation Enables Facile Access to Chiral γ‐Fluorinated Amines
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders
Engineering Mechanostable Anticalin Scaffolds to Enhance Particle Adhesion and Targeting of CTLA‐4 Under Shear Stress
Dual Enzyme‐Responsive Polymer‐Drug Conjugates Induce Diverse Cells Mutual Transcytosis to Achieve Deep Pancreatic Tumor Penetration
Solid-Phase Parallel Synthesis of Photocleavable Bifunctional Molecules Enables Efficient Phenotypic Protein Degrader Discovery
A Neutral Single‐Molecule Carrier for Delivery of Phosphonate Drugs
Deep Supramolecular Language Processing for Co-Crystal Prediction
Crystallization of L‐Cysteine in Heavy Water Induces Intrinsic Fluorescence
Mitigating Molecular Aggregation in Drug Discovery With Predictive Insights From Explainable AI
Ultrasound‐Responsive Lipid Nanosonosensitizers with Size Reduction and NO Release: Synergistic Sonodynamic‐Chemo‐Immunotherapy for Pancreatic Tumors
Native Mass Spectrometry Facilitates Hit Validation in DNA‐Encoded Library Technology
Tumor‐Specific On‐Site Activation of Cisplatin via Cascade Catalytic‐Redox Reactions for Highly Efficient Chemo‐Immunotherapy
On‐Membrane Supramolecular Assemblies Serving as Bioorthogonal Gating for Melphalan
De Novo Design of Structure‐Tunable Multivalent Targeting Chimeras for Tumor‐Targeted PD‐L1 Degradation and Potentiated Cancer Immunotherapy
Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis
Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof
Desolvation‐Induced Network Reformation and Cracking in the Single Crystals of Hydrogen‐Bonded Frameworks Composed of Tetraazaanthraquinone and Anthraquinone Derivatives
Strain‐Enabled Radical‐Polar Crossover Annulation to Access Spiro‐, Fused‐, and Enantioenriched‐Aza/Oxa‐Bicyclo[3.1.1]Heptanes
Supramolecular Host–Guest Assemblies for Tunable and Modular Lysosome‐Targeting Protein Degradation
A Multifunctional Polyester Nanoplatform for the Synergistic Anticancer: Enhanced Photodynamic Therapy and Targeted Gene Silencing
Plasmonic-Hydrogel Hybrid Biomaterials Via In Situ Seeded Growth
Two‐Step Crystal Dissolution: A Molecular Mechanism to Rationalize Empiric Models of Drug Release from API Formulations for Oral Administration
ATP‐Assisted Electron and Proton Transfer Boosting Redox Metabolism‐Induced Ferroptosis and Apoptosis for Cancer Therapy
Spherical Nucleic Acids‐Directed Cryosynthesis of Manganese Nanoagents for Tumor Imaging and Therapy
Direct Conversion of Aromatic Lactones into Bioisosteres by Carbonyl‐to‐Boranol Exchange
New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain
Synthesis of Bicyclo[1.1.1]Pentane Z‐Substituted Enamides, Enol Ethers, and Vinyl Sulfides Using Iodine (III) Reagents
Electron‐Deficient Alkyne Lipids Enable Efficient Synthesis of Comparable Polymer Lipids via Copper‐Free Azide‐Alkyne Cycloaddition
Membrane‐Bounded Intracellular E3 Ubiquitin Ligase‐Targeting Chimeras (MembTACs) for Targeted Membrane Protein Degradation
An Activatable Caged Palladium Nanocomposite for Targeted Cancer Therapy
Cross‐Linking Profiling of Molecular Glue Degrader‐Induced E3 Ligase Interactome to Expand Target Space
SH2 Decarboxylative Monofluoromethylation of Aliphatic Carboxylic Acids Enabled by Nickel/Photoredox Dual Catalysis
Simultaneous Activation of Bicyclobutanes and Indolyl Alcohols with HFIP: Access to Indole‐Fused Bicyclo[3.1.1]Heptanes
Enhancing Immune Responses Through Modulation of Innate Cell Microenvironments in Lymph Nodes with Virus‐Mimetic Vaccines
Unlocking the Potential of Machine Learning in Co-crystal Prediction by a Novel Approach Integrating Molecular Thermodynamics
Nanourchin-like Uricase-Poly(L-proline) Conjugate with Retained Enzymatic Activity, Mitigated Immunogenicity, and Sustained Efficacy Upon Repeated Administrations
Size‐Controlled Self‐Assembly for Bimodal In Vivo Imaging
Universal Albumin Drugs‐Cored Spherical Nucleic Acid (ad‐SNA) Platform for Targeted Drug Delivery
2
Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab’)2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area
Multicenter Trial of the Emergency Department Trigger Tool
4
Ultrasound Guidance Can Reduce IUD Insertion Time
Impact of Pharmacy Technicians on Clinician and Nurse Work Experience in Primary Care
Prescribing Cascades Among Older Community-Dwelling Adults: Application of Prescription Sequence Symmetry Analysis to a National Database in Ireland
Proactive Deprescribing Among Older Adults With Polypharmacy: Barriers and Enablers
6
Comparative Gastrointestinal Safety of Dulaglutide, Semaglutide, and Tirzepatide in Adults With Type 2 Diabetes.
Glucagon-Like Peptide-1 Receptor Agonists and Incidence of Dementia Among Older Adults With Type 2 Diabetes : A Target Trial Emulation.
Glucagon-Like Peptide-1 Receptor Agonists and Risk for Gastroesophageal Reflux Disease in Patients With Type 2 Diabetes : A Population-Based Cohort Study.
Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood : A Nationwide Cohort Study.
Differences Between Trial Populations and Approved Label Populations of New Drugs in the United States and Europe (2012 to 2023) : A Cross-Sectional Study.
Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide.
3
Does Missing Medication Acutely Change Seizure Risk? A Prospective Study
Time to Change the Drug Trial Paradigm for Dravet Syndrome: Designing Trials for the Disease Rather than Squeezing the Disease into the Trial
Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy
1
Super Learner Enhances Postoperative Complication Prediction in Colorectal Surgery.
3
Upadacitinib vs adalimumab in patients with rheumatoid arthritis and a prior inadequate response or intolerance to a tumour necrosis factor inhibitor: 12-week results from the randomised, double-blind, SELECT-SWITCH study
Successful discontinuation of oral glucocorticoids after short-term bridging therapy in patients with newly diagnosed rheumatoid arthritis
Cannabidiol versus placebo in patients with fibromyalgia: a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial
8
Glucagon‐like peptide‐1 receptor agonist therapy is associated with improvement in psoriatic arthritis‐related and metabolic outcomes: A retrospective analysis of two cohorts
Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis
Prescribing of Medication to Prevent Glucocorticoid Harms in Patients With Polymyalgia Rheumatica: A Cross‐Sectional Study and Two Emulated Target Trials in the Clinical Practice Research Datalink Aurum
Weighing dose‐related benefits and risks of hydroxychloroquine treatment in systemic lupus erythematosus patients
Defining Optimally Safe and Effective Blood Levels of Hydroxychloroquine in Lupus: An Important Step toward Precision Drug Monitoring
Are Glucocorticoids Associated with Worse Survival among Rheumatoid Arthritis Patients with Lung Cancer Treated with Immune Checkpoint Inhibitors?
A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis
Associations of specific pesticides and incident rheumatoid arthritis among female spouses in the Agricultural Health Study
3
Distinct contribution of spinal neuropeptide Y and NPY1R neurons to morphine analgesia
Tegmental kappa-opioid receptor neurons modulate opioid withdrawal via the periaqueductal gray
Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer’s disease model
1
Clinical Outcomes Associated with Prior GLP-1 Exposure in Burned Patients
1
A context-augmented large language model for accurate precision oncology medicine recommendations
2
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protein Degradation Approaches
CXCL10 Secreted by Pericytes Mediates TNFα-Induced Vascular Leakage in Tumors and Enhances Extravasation of Nanoparticle-Based Chemotherapeutics
7
Rational design of Gi-biased CB1 agonist with reduced side effects
LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery
Unified modeling of 3D molecular generation via atomic interactions with PocketXMol
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo
Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy
Nutrient competition predicts gut microbiome restructuring under drug perturbations
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain
6
The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors
Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans
Analog of prolactin-releasing peptide reduces body weight primarily through sustained fatty acid oxidation rather than hypophagia
Body-wide multi-omic counteraction of aging with GLP-1R agonism
Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism
Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex
1
Vitamin C conveys geroprotection on primate ovaries
62
Chiral resolution of racemic ibuprofen sodium via diastereomeric ionic cocrystallization with proline
HFIP-Promoted [18F] trifluoromethylation via iodofluorination of gem-difluoroalkenes
Facile access to difluoromethylene-linked strained aliphatic rings from 2-(difluoromethylene)cyclobutyl sulfonium salts (CB-DFAS) and [1.1.1]propellane
Innovative integration of molecular docking and machine learning for drug discovery: from virtual screening to nanomolar inhibitors
A dual-gated polymersome nanoreactor
Photocatalytic surface grafting of hydrophobic shells onto hydrogels
DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy
Polymorphism-dependent room-temperature phosphorescence of a persulfurated benzene
Solvent-triggered breakdown of solid solution behaviour enables direct enantioselective crystallization of RS-phenprocoumon
Enhancing photodynamic therapy effects by a glutathione-responsive SO2 donor as a nanocarrier for cancer therapy
A pH-responsive iron/manganese bimetallic organic framework nanosystem for synergistic therapy of colon cancer
Development of photo-ROS responsive liposome for the delivery of an antibacterial agent by targeting the bacterial membrane
Rotisserie-like motion enables guest transport in a nonporous organic crystal involving a diboron host
A new polar glass–ceramic built from monovalent perrhenate anions and large methyltriphenylphosphonium cations
Mild nanoencapsulation of single mammalian cells by surface initiated polymerization
Liposome-based delivery of DNA aptamers to inhibit erythromycin methyltransferase-mediated antibiotic resistance
Organocatalytic peptide coacervates as microreactors for aqueous aldol additions
Design of heavy-atom-free dipyridomethene boron complexes for singlet oxygen emission with induced chirality
J-aggregates of ethene-bridged aza-BODIPY dimers for bright NIR-II bioimaging and efficient photothermal therapy
Machine learning prediction of multiple distinct high-affinity chemotypes for α-synuclein fibrils
Tumor microenvironment-responsive COF-based core–shell cascade nanoreactor with photocatalytic H2O2 self-supply for improved treatment
Programmable PROTAC delivery for precise and spatiotemporal protein degradation
Manipulating RTP properties of the same organic molecule by polymorphic engineering
Amino acid-modified G-quartet hydrogel for glucose-responsive insulin release in vivo
Supramolecular macrocyclic-mediated logic-gated antitumor therapy nanoplatform
Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells
A GSH-consuming nanoamplifier for synergistic SO2 gas therapy and ferroptosis promotion
Small is different: N,N-chelated organoboron complexes with seven-membered rings
Crystal engineering enables room-temperature triplet-DNP in cocrystals
Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach
Multifaceted reactions of difluorocarbene with amines: synthesis and mechanistic insights
A two-step continuous flow synthesis of multi-tail ionizable lipids
Design and synthesis of ternary multi-component crystals by sublimation
Ionic liquid-based transdermal drug delivery systems for biopharmaceuticals
Carbonic anhydrase-IX targeted copper-doped carbon dots as a theranostic probe for treating triple negative breast cancer
Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED
A fluorogenic probe for screening aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors
Structure revision of meroterpenoid natural products enabled by biomimetic total synthesis
A pillar[5]arene-based polydopamine–prodrug nanoplatform for targeted and synergistic chemodynamic–photothermal–chemotherapy of cancer
A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells
An endoplasmic reticulum-targeted NIR-II type I AIE photosensitiser for triggering pyroptosis
Developing a Zn(ii)-metallovesicle for loading and delivering doxorubicin to kill cancer cells—a multi-drug delivery system
Enhancing deep chemical reaction prediction with advanced chirality and fragment representation
A trident-like multi-cationic photosensitizer with stabilized membrane camouflage for efficient tumor-targeted photodynamic therapy
Solid-phase submonomer synthesis of sequence-defined oligothioetheramides
An ultrasonically sensitive small-molecule chimera for sono-controllable proteolysis
Benzylamine cation-directed introduction of polar structure in stator-rotor crown ether system
Synergistic isoniazid-Mn(ii) mediated non-Fenton-type hydroxyl radical generation for amplifying tumor chemodynamic therapy
Probing polarity structure–function relationships in amine–water mixtures
Cycloaddition of bicyclo[1.1.0]butanes with enamides for the efficient synthesis of 2-amino-bicyclo[2.1.1]hexanes
Photocatalytic difluoroalkylation/cyclization of N-cinnamyl-N-cyanobenzamides with difluoroalkyl bromides toward C2-difluoroalkylated pyrroloquinazolinones
Self-immolative PEGylated dendritic drug conjugates for cancer therapy with enhanced cellular uptake
Nanomorphology tuning in doxorubicin-loaded liposomes ivia/i cooling-induced doxorubicin-crystallization and membrane phase transition
The contrasting impacts of polyethylene glycol on electrochemical behaviors of Fe and Zn metal anodes in aqueous batteries
A self-stabilized amphiphilic fluorescent sensor enables the ratiometric detection of human serum albumin in urine
1,2-Dihydropyrimidine synthesis ivia/i titanium-mediated multicomponent coupling of alkynes, nitriles, and aldehydes
Late-stage lipidation of peptides ivia/i aqueous thiol-michael addition to dehydroalanine (Dha)
A self-assembled fusion hydrophobin-coated nanodiamond system for synergistic targeted therapy of colorectal cancer
A cellulose-stimulated self-assembling solvent for molecular dispersion of cellulose
Dry liquid to Pickering-type emulsion: fabrication of non-spherical environmentally friendly microcapsules
Robotic exploration of amino-acid functionalised molybdenum blue polyoxometalate nanoclusters
Photodynamic ROS inducers delivered via electrostatic antibody targeted (ELART) nanocarriers incorporate into tumour cells and inhibit colony growth
50
Target-agnostic SAR mapping and immunological evaluation of (−)-FR252921 and analogs against primary human immune cells
Machine learning-assisted screening of small-molecule drugs for suppressing protein aggregation and ROS generation based on ECL and CV dual-mode signals amplified by DNA
The underlying synergistic mechanism of co-solvents to fabricate high-quality FAPbI3 perovskite films
Screening pertactin-specific antibodies and evaluating competitive epitope recognition by native mass spectrometry
CBL ubiquitin ligase targets translation as a degrader E3
Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry
Challenges in data-driven catalysis modelling: case study on palladium-NHC catalyzed Suzuki–Miyaura reactions
Structure–activity relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures
B–N axis as a facilitating agent for the synthesis of 3D structures: the paradigmatic case of BN-[4.4.4]propellane
Monitoring structural change and drug release of responsive nanoparticles using polarity-sensitive fluorophores
Protein chirality as a determinant of ligand affinity: insights from l- and d-streptavidin
From polymorphs to cocrystals and salts: successfully predicting axitinib's challenging crystal forms
Towards automatically verifying chemical structures: the powerful combination of 1H NMR and IR spectroscopy
DeepMetab: a comprehensive and mechanistically informed graph learning framework for end-to-end drug metabolism prediction
A structural reorganization-based catalytic hairpin assembly enabling small-molecule monitoring in living cells
Promoting organic nucleation of diclofenac: hydrophobic interfacial interactions drive self-assembly
Regiodivergent Lewis acid catalysis of bicyclo[1.1.0]butanes with 2-naphthols
Data-driven recommendation of agents, temperature, and equivalence ratios for organic synthesis
Molecule generation for target protein binding with hierarchical consistency diffusion model
GSH-responsive magnetic imaging for iin situ/i monitoring of tumor chemodynamic therapy
Thiol-mediated uptake of phosphorothioate liposomes, visualized with fluorescent flippers
Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted 99mTc, 64Cu and 188Re radiotracers
Decoding the limits of deep learning in molecular docking for drug discovery
Design, modular synthesis and screening of 58 shape-diverse 3-D fragments
The development of sulfonated terpyridine ligands for control of regioselectivity in palladium-catalysed fluorination of anilides
Fully dissolved glucose-responsive insulin delivery system based on a self-immolative insulin prodrug and glucose oxidase
Esterase-induced release of a theranostic prodrug in lysosomes for improved therapeutic efficacy and lower systemic toxicity
Effective generation of heavy-atom-free triplet photosensitizers containing multiple intersystem crossing mechanisms based on deep learning
Data-driven discovery of near-infrared type I photosensitizers for RNA-targeted tumor photodynamic therapy
Difluoromethylene cyclobutyl sulfonium salts: versatile reagents for chemodivergent synthesis of difluoroalkylated cyclobutenes and cyclobutanes
Degradable water-soluble polymer prodrugs for subcutaneous delivery of irritant anticancer drugs
High throughput screening for the design of protein binding polymers
Navigating chemical space: multi-level Bayesian optimization with hierarchical coarse-graining
Understanding polymer encapsulation of enzymes: a dissipative particle dynamics simulation study on the regulation of structural characteristics of polymer nanocapsules
Special solvation effects of mixed water and alcohols revealed by molecular aggregation
Cordycepin: a dual-function molecular element for aptamer engineering with enhanced anticancer activity
Guided multi-objective generative AI to enhance structure-based drug design
Single-carbon-atom transfer to para-quinone methides from TMSCF2Br
Highly stereoselective synthesis of polysubstituted housanes and spiro-oxa-housanes: application and mechanistic insights
Strain-release driven spirocyclization of bicyclo[1.1.0]butanes: access to 6,7-diazaspiro[3.4]octanes†
Intermediate knowledge enhanced the performance of the amide coupling yield prediction model
A BODIPY-tagged trivalent glycocluster for receptor-targeting fluorescence imaging of live cells
Synthesis of polysubstituted cyclobutanes through a photoredox strain-release/[3,3]-rearrangement cascade
Multi-objective drug design with a scaffold-aware variational autoencoder
Widespread false negatives in DNA-encoded library data: how linker effects impair machine learning-based lead prediction
High-throughput encapsulated nanodroplet screening for accelerated co-crystal discovery
Retro-forward synthesis design and experimental validation of potent structural analogs of known drugs
(3 + 2)-Cycloaddition of bicyclobutanes and thioketones: access to 2-thiabicyclo[2.1.1]hexanes without the use of catalysts or light
A method to identify small molecule/protein pairs susceptible to protein ubiquitination by the CRBN E3 ligase
Multiple stimulus modulated organic crystal polymorphs with tunable luminescence behavior
3
Young chronic e-cigarette users display cardiopulmonary abnormalities during exercise and blunted recruitment of pulmonary diffusing capacity
Use of and outcomes related to intrapleural enzyme therapy for complicated parapneumonic effusion and empyema in an integrated health system
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT)
1
A Nationwide Factorial Randomized Trial of Electronic Nudges to Patients with Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial.
12
Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study
Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study
Omadacycline Monotherapy in Nontuberculous Mycobacterial Pulmonary Disease Caused by Mycobacterium abscessus: Results From a Phase 2, Double-blind, Randomized, Placebo-controlled Study
Macrolide and non-macrolide resistance after 36 months of mass azithromycin distribution in Burkina Faso: A cluster randomized trial
Pharmacokinetics of Twice-Daily Tenofovir Alafenamide In Adults with HIV-Associated TB on BIC/FTC/TAF and Rifampicin
Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood
Evaluating the Use of Lower Dose Flucytosine for the Treatment of Cryptococcal Meningitis: A Clinical Trial
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post Hoc Analysis of Individual Participant Data From 2 Randomized Trials
Cefepime Concentration-Toxicity Relationship in Hematological Patients Treated With Continuous Infusion: A Prospective Study
A Phase 2a Study of the Early Bactericidal Activity of Rifampicin in Combination With Meropenem Plus Amoxicillin/Clavulanate Among Adults With Rifampicin-Resistant Pulmonary Tuberculosis
Comparative Effectiveness of Azithromycin Versus Doxycycline in Hospitalized Patients With Community-Acquired Pneumonia Treated With Beta-Lactams: A Multicenter Matched Cohort Study
You’ve Got a Friend in Me: Curbside Questions Infectious Diseases Clinicians Ask Infectious Diseases Pharmacists
5
Comparison of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors for Stress Ulcer Prophylaxis in Patients With Septic Shock.
Methylene Blue Administration in Septic Shock: A Retrospective Cohort Study.
Effect of Comprehensive Medication Management on Mortality in Critically Ill Patients.
Clinical Presentation, Laboratory Abnormalities, and Predictors of Outcome in 103 Patients With Acute Paraquat Poisoning: A Prospective Observational Study.
A Multinational Randomized Trial of Mega-Dose Esomeprazole As Anti-Inflammatory Agent in Sepsis.
11
Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly.
Glucagon-Like Peptide 1 Receptor Agonists and Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients With Type 2 Diabetes.
Differential Longitudinal Effects of Glucose-Lowering Medications on Glucagon and C-peptide Responses in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Metabolic Improvement Mediates the Causal Relationship Between GLP-1 Receptor Agonists and Myocardial Infarction: A Mendelian Randomization and Mediation Analysis Study.
INHALE-1: A Multicenter Randomized Trial of Inhaled Technosphere Insulin in Children With Type 1 Diabetes.
GLP-1s Versus DPP-4s and Risk of Dementia in Patients Requiring Hemodialysis: A Target Trial Emulation Study.
Risk of Acute Pancreatitis and Biliary Events After Initiation of Incretin-Based Medications in Patients With Type 2 Diabetes.
Tirzepatide Treatment and Associated Changes in β-Cell Function and Insulin Sensitivity in People With Obesity or Overweight With Prediabetes or Normoglycemia: A Post Hoc Analysis From the SURMOUNT-1 Trial.
Changes in β-Cell Function and Insulin Sensitivity During Treatment With Dapagliflozin Alone or in Combination With Exenatide in Type 2 Diabetes.
Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment.
Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.
11
The Association of Blood Lead with Cardiovascular Disease Incidence and Mortality: Findings from the Strong Heart Study Cohort
Expanded Tox21 Biological Assay Panel for the Prediction of Drug-Induced Liver Injury and Cardiotoxicity
Time-Varying Exposure to Element Mixtures and Children’s Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study
Exposure to organophosphate ester flame retardants and plasticizers during pregnancy and autism-related outcomes in the ECHO Cohort.
Pesticide Exposure Estimation across Census Tracts in Washington State: Identifying Vulnerable Areas and Populations.
The Association of Arsenic Exposure and Metabolism Biomarkers with Subclinical Measures of Liver Disease: a cross-sectional investigation in the Multi-Ethnic Study of Atherosclerosis.
Expanded Tox21 biological assay panel for the prediction of drug-induced liver injury and cardiotoxicity.
Time-varying exposure to element mixtures and children's cognition at 5 years of age: findings from the New Hampshire Birth Cohort Study.
Statistical methods for chemical mixtures: a roadmap for practitioners using simulation studies and a sample data analysis in the PROTECT cohort.
DeTox: an In-Silico Alternative to Animal Testing for Predicting Developmental Toxicity Potential.
Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening.
54
A GSTM1-null variant modifies blood concentrations of cadmium, aluminum, and lead in chronically exposed adults near a steel company
The interaction of toxic metal exposure and oxidative balance score on semen quality: A cross-sectional study based on Shanghai volunteers, China
Smoking microplastics: Global evidence of microplastic contamination in cigarette tobacco
Linking environmental concentrations to cytotoxic mechanisms in second-hand vapor exposure of electronic cigarette via an integrated approach for in vitro toxicity assessment
Improved health risk management of heavy metals in cigarette smoke from middle Chinese best-selling cigarettes using respiratory tract deposition modeling and simulated lung fluid extraction
Precision occupational lead exposure assessment through medical-informed machine learning
Neurobehavioral toxicity of paroxetine in Gambusia affinis: Dissociated behavioral syndromes and impaired monoaminergic neurotransmission
Polycyclic Aromatic Hydrocarbon Exposure and Mitochondrial DNA Copy Number: Opposing Roles of Oxidative Stress and Inflammation
Formaldehyde Activates the RUNX1–ISX Axis to Promote Leukemic Reprogramming, a Pathway Associated with Poor Prognosis in Pediatric B-ALL
Association of Microcystin-LR and Metals Co-Exposure with Semen Quality and Sperm Telomere Length in Humans
Long-term cigarette butts’ decomposition over 10 years reveals multi-stage microbial, chemical, and toxicological transformations
Prenatal exposure to multiple insecticides and reduced birth weight: a possible mediating role of plasma metabolomic alterations
Childhood dyslexia risk elevated by heavy metal mixtures from e-waste: A machine learning–driven mixture modeling study
DNA methylation-mediated alterations in Copper(I/II) redox equilibrium underlie lead-induced neurotoxicity
Brain concentrations of flame retardants and trace elements related to habitat use and brain measures in an urban-adapted gull
Longitudinal Triglyceride-Glucose Index and Metal Interactions: A Multi-Model Cohort Integrating Synergistic and Antagonistic Indices
Urinary Zinc-Lead and Strontium-Iron Combinations Affect Renal Function via Serum Uric Acid: A Cross-Sectional Study in Chinese Adults
Accelerated Biological Aging Underlies the Link Between Heavy Metal Mixture Exposure and Depression: A Multi-Omics Study
Can urinary OH-PAHs serve as biomarkers for indicating inhalation exposure to PAHs of children: Evidence based on a panel study
Urinary total arsenic, arsenic species, and arsenic methylation capacity: an integrative profiling analysis of microRNAs in plasma and leukocytes
Biomonitoring of DAPs levels in urine and amniotic fluid of pregnant women in Seville (Spain): evaluation of prenatal exposure
Toxicophore-informed machine learning integrating Tox21 assay readouts for organ system–specific carcinogenicity prediction
Enhancing Identification Confidence in Non-Targeted Screening of Emerging Contaminants via an Ensemble Retention Time Prediction Model: Applications in Screening and Ecological Risk Assessment
Cigarette butts: A hidden toxic time bomb for aquatic metabolism and behavior
Human exposure to organophosphate esters (OPEs): A comparison between home and school microenvironments and inter-individual variations
Exposure to mixed metals/metalloids in early childhood: a cross-sectional cohort study in children from Sevilla, Southern Spain
Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability
Hypoxia-Driven Ferroptosis Escape Mediates Lung Injury Induced by Nickel-Refining Fumes via Oxygen-Sensing Signaling PHD1/HIF-1α
Perfluorooctanesulfonic Acid Facilitates the Migration of Choriocarcinoma Cell Line BeWo: Integrins as Potential Target
Intestinal barrier disruption by cadmium and microplastics: Mechanistic insights from integrated metabolomic and proteomic analysis in mice
Residential greenness modifies the association between long-term exposure to PM2.5 components and allergic diseases in schoolchildren: A large-scale study in Southern China
Chronic Sublethal Exposure to Methylmercury Lengthens Telomeres in Developing Zebra Finches
Investigating the potential molecular mechanisms of dibutyltin dilaurate induced brain injury: a network toxicology and molecular docking approach
Time-course physiological and transcriptomic study reveals cadmium effects on antioxidant, apoptosis, and immunity in the kidney of the freshwater snail Pomacea canaliculata
Maternal and paternal dietary arsenic exposure impairs reproduction and development in zebrafish offspring: the role of HPG axis dysregulation and altered DNA methylation
Morphological and cellular effects of lead, cadmium, and perfluorooctanoic acid on Gallus gallus embryonic development: Insights into cephalic region vulnerabilities
Quercetin alleviated cadmium-induced oxidative stress, endoplasmic reticulum stress, and autophagy in chicken kidneys
Novel Graph Neural Network Reveals Binding Mechanisms and Environmental Risks of PAHs Interaction with Estrogen Receptor B
ACR-16/α7-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria
Potential interactive effect of placental heavy metals and gestational diabetes mellitus on neonatal anthropometric measures: a birth cohort study
Quantification of amino-PAHs in human urine using UHPLC- hybrid quadrupole orbitrap high resolution MS (Q-orbitrap-HRMS): Assessing potential carcinogenic risks of Nitro-PAHs
Exposure to toxic trace metals is negatively associated with testis mass in wild male roe deer
Effects of in utero exposure to multiple metal(loid)s on neonatal birth size and hormones in the growth hormone/insulin-like growth factor axis: A mixture analysis
Lead induced intracellular copper redox imbalance with aggravated cellular dysfunction
Independent and joint effects of volatile organic compounds on pulmonary function in U.S. adults from NHANES: the mediating role of platelet-to-lymphocyte ratio
The impacts of smoked cigarette butt leachate on a common freshwater gastropod, Lymnaea stagnalis
Biomarkers reflecting the toxicity of neonicotinoid insecticides to the central nervous system
Insights into immune and oxidative stress in rural homemakers exposed to VOCs during typical solid fuel utilization activities
One Health approach and tiered strategy to assess anticoagulant rodenticides exposure in red foxes (Vulpes vulpes) from Central Italy
“Iron -Free” CdSe/ZnS Quantum Dots Disrupt Neural Differentiation of Embryonic Stem Cells via the Induction of Ferroptosis
Ferroptosis is involved in the benzene-induced hematotoxicity via mitochondrial ROS-ferritinophagy pathway
The Role of SLC7A11 in Arsenite-Induced Oncogenic Phenotypes of Human Bronchial Epithelial Cells: A Metabolic Perspective
A new insight into the mechanism of cadmium-induced nephrotoxicity and antagonism of selenium nanoparticles: modulation of MTF1-MT axis dependent metal homeostasis
Single and joint associations of exposure to polycyclic aromatic hydrocarbons with hypertensive disorders of pregnancy: a nested case-control study
80
Prenatal exposure to metal(loid)s and hormone profile in umbilical cord serum: Evidence of sex-specific association
Associations Between Environmental Metal Mixture Exposure and Urinary DNA Adduct Biomarkers of Oxidative and Alkylative Damage in Adults
Prenatal and early postnatal lead exposure and later adulthood BMI: The Saint Louis Baby Tooth – Later Life Health Study
First-Trimester Profiling of Maternal Plasma Metals and Vitamins in Relation to Gestational Hypertension
Association between gestational and childhood exposures to organophosphate esters and social skill, problem behavior among adolescents
Association between toenail scandium concentrations and incidence of hypertension among American young adults: 28 years of follow-up
Identifying associations and key early life exposure windows for organophosphate esters and adolescent brain morphometry in the HOME study
Age at menarche and exposure to non-persistent pesticides in Spanish girls from the INMA (Environment and Childhood) Project
Associations of pesticide exposures with lipid profiles and mediation by metabolic pathways in children
Prenatal and early life exposure to organophosphate esters and intellectual quotient at age 3, in the SEPAGES cohort
Arsenic exposure at birth, socioeconomic status, and epigenetic aging among adults in northern Chile
Volatile organic compounds exposure and all health outcomes: An umbrella review and evidence map
Chronic exposure to selenium through a natural diet (Lumbriculus variegatus) resulted in endocrine disruption, and reproductive impairment in zebrafish (Danio rerio)
Plasma organophosphate ester exposure-associated microRNA expression profiles and their functional analysis in Chinese healthy adults
A novel framework integrating a coupled mixing rule with deep learning for toxicity prediction and environmental risk assessment of antibiotic mixtures
Pre- and postnatal trace element levels in primary teeth of children with and without an autism spectrum diagnosis
Urinary Cadmium and Growth Faltering in Children Aged 3–6 Years: A Nationwide Cross-sectional Study from China
Urinary arsenic levels and risk of breast cancer among women in the Canadian health measures survey: a population-based prospective study
Advancing screening of aquatic persistent, mobile, and toxic substances via integration of graph convolutional networks and multitask learning
Multimodal-based Crystal Graph Convolution Neural Networks for Predicting Soil Toxicity to Earthworms
Benzene exposure biomarkers are associated with recently smoking tobacco and pumping gasoline in the U.S. population aged 12 and over: NHANES 2017–March 2020
Exposure trends of neonicotinoids from 2008 to 2018 and health risk in a longitudinal study in China
Perinatal exposure to metal mixtures disrupts neuronal function and behavior
Relationship of serum polycyclic aromatic hydrocarbon (PAHs) and lung function in adults: Evidence from a large community-based population in Guangzhou, China
Drinking water arsenic, urinary arsenic biomarkers, and cognitive impairment in the REGARDS Study
Association between Arsenic Levels in Toenails and Urine and Prostate Cancer Risk: Findings from the MCC-Spain study
Prenatal urinary biomarkers of metal and metalloid exposure and child neurodevelopmental outcomes in Puerto Rico
Neglected Plastic Waste from Discarded Cigarette Butts: A Case Study on Hazards Identification in typical regions in China
High pesticide exposure events and subjective cognitive complaints among US farmers
Association between placental single and mixed metals and offspring weight trajectories: a prospective birth cohort study
Extracellular vesicle microRNAs as an epigenetic biosignature of arsenic-associated diabetes in the Strong Heart Study
Early-life arsenic exposure modulates the developing microbiome in a rural cohort
Non-invasive Welding Fumes Exposure Assessment using Exhaled Breath Condensate
Associations of particulate matter size fractions and chemical composition with conjunctivitis and eczema: epidemiological evidence from the Pearl River Delta, China
Interpretable machine learning framework for predicting pesticide phytotoxicity in wastewater reuse: Integrating molecular, quantum, and experimental descriptors
Environmental exposure to heavy metals in Miniopterus schreibersii (Kuhl, 1817) from polluted and reference sites: blood cell impairment as a biomarker of pollution
Occupational exposure to pesticides and epigenetic age acceleration in the Lifelines cohort study
Maternal exposure to trace elements and perfluoroalkyl acids and their associations with alterations of the hypothalamic-pituitary-adrenal axis
Essential and non-essential metals in children’s intellectual functioning: A multi-media biomarker approach from a Mexico City birth cohort
VOCs emission from landfills co-disposed of rural solid waste and sewage sludge: Identification, diffusion, and impact
The influence of ambient air pollution during folliculogenesis, endometrial development, and spermatogenesis on fertility: A study among patients using vitrified donor oocyte in vitro fertilization
QSAR-based prediction of acute inhalation toxicity and SHAP interpretability analysis of fluorocarbon environmental-friendly insulating gases
Postnatal pesticide exposure and executive function in children and adolescents: Findings from South Africa
Prenatal and postnatal exposure to environmental level arsenic declines male reproductive function by affecting spermatogenesis and maturation in offspring
Prenatal exposure to heavy metals and the trajectory of autistic traits in childhood
Associations between exposure to metals, chlorinated pesticides, and PCBs and differential leukocyte profiles in Flemish adolescents
Exposure profile of four classes of emerging pesticides in pet dog and cat serum from Wuhan, China
Prenatal exposure to environmental metal mixtures and social development in early childhood: Evidence from a birth cohort and mechanistic study
Associations of children’s urinary metals with blood RNA N-methyladenosine and 2′-O-methyladenosine
HBM4EU e-waste study – Occupational exposure assessment to chromium, cadmium, mercury and lead during e-waste recycling
Arsenic exposure, genetic susceptibility, lifestyle, and glucose-insulin homeostasis impairment: Revealing the association and interaction in a repeated-measures prospective study
Associations of pre- and postnatal levels of three heavy metals with visual impairment in 3-year-old children
Ambient air pollutants and sperm quality in healthy Italian young men: a multicenter prospective cohort study with repeated measures
Prenatal pesticide exposure and neuroblastoma – A statewide case-control study in California
Comprehensive analysis of the association between volatile organic compound pollutants and chronic kidney disease in hypertensive populations: insights from multi-omics approaches and identification of potential therapeutic targets
Descriptive analysis of whole blood concentrations of toxic, essential, and trace elements in adult females from the MIREC-ENDO study
Association of prenatal and early-life polycyclic aromatic hydrocarbons exposure with dental caries in childhood
Estrogen-containing contraceptive use and blood lead concentrations in a cohort of premenopausal individuals
Associations between PM2.5 components, temperature, and semen quality: Insights from seminal plasma metabolome
QSAR Model for Pesticide Toxicity in Bioluminescent Vibrio qinghaiensis sp.-Q67
Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis
Prenatal exposure to metals and metal mixtures influences birth weight in affected populations in the Republic of Suriname, South America
Volatile organic compounds in various workplaces and during commutes in a Chinese city: occurrence and health risks for different occupations
Real-life metal mixtures: the impact on male reproductive health in Wistar rats
Unprecedented lead tolerance in an urban lizard
Associations of sympathetic activation with exposure to volatile organic compounds: A cross-sectional study
Sources and geographic differences in air releases of benzene in the United States
Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood
Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson's disease
Metal exposure and internalizing and externalizing psychobehavioral problems in a Chinese early adolescent cohort
Impact of prenatal and childhood exposure to pyrethroids and chlorpyrifos on motor skills in 7-year-old children from the Odense Child Cohort
Associations between prenatal exposure to a mixture of lead, mercury and polychlorinated biphenyls and executive function in Inuit adolescents
Ecotoxicological assessment of different choline chloride-based natural deep eutectic solvents: in vitro and in vivo approaches
Telomere length declines with mean blood lead concentration in an urban passerine
Blood metal(loid)s, haemoglobin and goitre in pregnant women from the mercury-exposed and non-exposed environment (Aidarken area vs Kara-Suu area; Kyrgyz Republic)
Prenatal Exposure to Arsenic, Umbilical Cord Blood DNA Methylation, and Child Neurodevelopment: A Prospective Birth Cohort Study
Maternal pre-pregnancy overweight/obesity, in-utero exposure to toxic heavy metals, and offspring age at peak height velocity: A prospective birth cohort study
Linking soil-metal concentrations with children’s blood and urine biomarkers in Syracuse, NY
Variability of urinary metal in short-, mid-, long-term periods and its optimal sampling strategy: A novel epidemiological insight to exposure classification
Low-level arsenic exposures, childhood neighborhood disadvantage, and executive functions in adolescents from Montevideo, Uruguay
58
Intermolecular Interactions as the Bridge: Establishing Structure–Activity Relationships between Microscopic Features of Organophosphorus Compounds (OPCs) and Their Adsorption Performance
Hydrolysis Reaction Rate Prediction Using Machine Learning: WaterDRoP
Molecular Insights into Ocular Exposure Risk of Indoor Smoke Components on the Tear Film
BeeEcoTox: A Large Language Model-Empowered Graph-Learning Framework for Predicting Ecotoxicity of Agrochemicals to Bees
Classification Pretraining Enhances Performance of Target-Based Affinity Prediction for Reproductive Toxicity Assessment
Dynamic Evolution of Fe3O4 Nanoparticles’ Protein Corona during Extracellular to Intracellular Trafficking: The Interference of Integrin αMβ2
Solid-Phase Reactivity-Directed Microextraction Analysis for Identifying Unknown Toxic Disinfection Byproducts
Leveraging Large Language Models for Contextual Prioritization of Contaminants of Emerging Concern in Chemical Mixtures
Probing the Large Discrepancy of Highly Oxygenated Organic Molecules and Secondary Organic Aerosol Formation from Atmospheric Oxidation of Nerolidol by OH, NO3, and O3
Confidently Uncertain: Probabilistic Machine Learning to Predict Soil Biotransformation Half-Lives
Pesticide Exposure Characterization Among Adult Males in a Chilean Agricultural Community Using Paired Silicone Wristbands and Urine Samples
Structure-Informed Comprehensive Screening and Risk Prioritization of Organophosphorus Compounds in Human Serum: Revealing the Hidden Burden and Emerging Risks
A Stacking Ensemble Model for KOC Prediction and Environmental Mobility Assessment of Global Neutral Chemicals
Predifferentiation Neurotoxicity of GenX Exposure on hiPSC-Derived Cortical Neurons
DNAPL-Responsive Hydrogel Nanoreactor Encapsulating nZVI for Enhanced Degradation of Chlorinated Contaminants in Groundwater
Acrylamide Exposure and Type 2 Diabetes in a Prospective Cohort Study of Chinese Adults: Association, Mediation, and Gene–Environment Interaction
Molecular Representation and Closed-Loop Validation for Toxicity Assessment of Organic Compounds in Ambient Air PM2.5
Environmental Dose MEOHP Promotes Bladder Cancer Progress through Hybrid EMT Mechanism: Based on the Adverse Outcome Pathway
Single-Cell Dissection of Dimethomorph-Induced Neurotoxicity in the Gestational Brain: Metabolic Disruption and Blood–Brain Barrier Dysfunction
Integrated Biomonitoring of Organophosphate Mixtures Reveals Food-Driven Exposure and Hormetic Oxidative Responses in Urban Adults
Arsenic Impairs Crab Carapace Sclerotization after Molting by Interfering with Phosphorus Metabolism
Interplay of Metals and Organics in E-Cigarette Aerosols Enhances the Production of Reactive Oxygen Species within Ultrafine Particles: Implications for Passive Vaping Exposures
Bioaccumulation of Psychoactive Contaminants and Their Effects on Brain–Gonad–Sperm Neurotransmitter Networks in Fish
Cadmium Exposure Promotes Atherosclerosis by Disrupting Cholesterol Homeostasis via miR-30d-5p Regulation
ChemBioHepatox: Multimodal Integrating Chemical Structure and Biological Fingerprint for Robust and Interpretable Hepatotoxicity Prediction
Detection of Metal-Containing Particles in FDA-Authorized and New Disposable Electronic Cigarette Aerosols
Microbial Arsenic Methylation and Microbial Reduction of Dimethylarsenate Contribute to the Production of Highly Toxic Dimethylarsenite in Paddy Soil
A Protein Interactome-Based Framework Reveals the General Toxicity of Chemicals
Sex-Specific Associations of Early Life Exposure to the Pesticide Mixture with Cardiometabolic Outcomes in CHAMACOS Young Adults
Ferroptosis Induced by Pb Exposure Causes Parkinson’s Disease-Related Dopaminergic Neuronal Death
Prenatal Insecticide Exposure and Adverse Birth Outcomes: Evidence for Mediation via Disruptions in Amino Acid and Acylcarnitine Metabolism
Reaction-Guided Metabolomics Accelerates High-Throughput Annotation of Xenobiotic Metabolites for Human Exposome
Prenatal Organophosphate Pesticide Exposure and Targeted Maternal Pregnancy Metabolomic Profiles in the NYU CHES Cohort
The Mediation Role of the Placental IGF1 Signaling Pathway on Associations between Prenatal PFAS Exposure and Adverse Birth Outcomes: Evidence from Serial Mediation Models
Systematic Evaluation of iIn Vitro/i Intestinal Permeability Measurements Across Diverse Chemicals: Insights for Advancing New Approach Methods for Chemical Risk Assessment
Multiscale-Information-Embedded Universal Toxicity Prediction Framework
Prenatal OPEs Trimester- and Sex-Specifically Linked to Trajectories of Preschoolers’ Emotional and Behavioral Problems: Insights from Cord Blood Metabolomics
Characterization on Respiratory Bioaccessibility of Organophosphate Esters Based on a Mouth–Throat Model, Exhaled Breath Condensate, and Sputum
Cocrystal Engineering of Low-Melting-Point Pesticides for Replacement of Emulsifiable Concentrates: A Scalable Strategy to Reduce Pesticide-Derived Volatile Organic Compound Emissions
Improving the Ecotoxicological Hazard Assessment of Chemicals by Pairwise Learning
Environmental Exposure to Melamine Derivatives and Early Kidney Injury: Role of Ferroptosis and Oxidative Stress
Oral Exposure of Arsenic-Contaminated Soils Triggers Hepatic Ferroptosis via Iron Dysregulation and Glutathione Metabolism Disruption: From Bioavailability to Mechanisms
m6A-Methylated Taurine Transporter SLC6A6 Promotes Arsenic-Induced Malignant Transformation of Keratinocytes while Enhancing Sensitivity to Cuproptosis
Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial
Innovative Benefit–Risk-Value Assessment for Cadmium and Selenium Coexposure in Black Shale Regions
Episodic Exposure to Eucalyptus Smoke during Sperm Maturation Impairs Sperm Motility in Long Evans Rats
Event-Driven Taxonomy (EDT) Screening: Leveraging Effect-Based Spectral Libraries to Accelerate Semiquantitative Nontarget Analysis of AhR Agonists in Sediment in the Era of Big Data
The Potential Carcinogenicity of Long-Term Polymetallic Exposure on the Development of Primary Liver Cancer: Nested Case-Control Evidence from the Jinchang Cohort Study
Chronic Exposure to Environmentally Relevant Doses of Triphenyl Phosphate Induces Anxiety- and Depression-Like Behaviors in Mice via the Gut–Brain Axis
Single-Nucleus Transcriptomics Reveals Prenatal and Postnatal Pb Exposure-Induced Cell-Specific Neurotoxicity and Dysregulated Microglia-Neuron Communication in Mice Brain
Dimethylmonothioarsenate Is a Key Arsenic Species Driving Rice Straighthead Disease
Occurrence of Current-Use Pesticides in Paired Indoor Dust, Drinking Water, and Urine Samples from the United States: Risk Prioritization and Health Implications
Organic Cation Transporter Mediates the Uptake of Quaternary Ammonium Compounds in iArabidopsis/i
A Liposomal Carrier to Reduce Leaching of Ionic Nutrient Loads in Agricultural Soils
Tunable NPK Release from Surface-Esterified Nanocellulose-Based Prills
Efficient Purification of Multiple Pollutants of Tobacco Smoke via Photocatalytic Oxidation Purifier
Transgenerational Inheritance of Cognitive Deficits Induced by Ancestral Arsenic Exposure in Zebrafish (Danio rerio) via Maternal and Paternal Lineages
Secondhand Exposure to Simulated Cannabis Vaping Aerosols
5
Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity
Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription
GLP-1R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization
Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk
Cardiac transthyretin amyloidosis treatment improves outcomes after aortic valve replacement for severe stenosis
1
Glucagon-like peptide-1 Receptor Agonists and Gastrointestinal Adverse Events: a Systematic Review and Meta-analysis
1
Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells
3
Selenoprotein P deficiency drives hepatocellular carcinoma progression via induction of neutrophil senescence and immunosuppressive microenvironment
Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer
DPP-4 inhibitor alleviates gut-brain axis pathology in Parkinson’s disease
1
GLP-1 receptor agonist-SGLT-2 inhibitor combination and risk of major adverse liver and cardiovascular outcomes in adults with MASLD and type 2 diabetes.
2
Impact of gender-affirming hormone therapy on spermatogenesis: analysis of testicular histological specimens
Fine particulate matter exposure and sperm DNA fragmentation in US men: a spatial cross-sectional study
20
Multiscale Modeling and Experimental Validation of Solvent-Mediated Crystal Morphology Control in Sr(OH)2·8H2O for Industrial Crystallization Processes
Defective Engineered Metal–Organic Frameworks for Tumor Cell-Specific Combined Therapy
Solution Structures and Dynamics of Diamagnetic Lu– and Y–DOTAM/Fluoride Ternary Complexes: The Role of 19F-CEST in the Detection of the Complex Fluoride Speciation
Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity
Water-Induced Reversible Structural Transition Enables Dual Cooperative Switching of Second-Harmonic Generation and Proton Conductivity
Positional Fluorination of Phenylpyridine: Unexpected Electronic Tuning in Bis-Cyclometalated Iridium(III) Acetylacetonate Complexes
Temperature-Induced Polymorphism of LiSc(SO4)2·2H2O Allows the Control of the Yield of Scandium during Precipitation from Diluted Aqueous Solutions
On the Use of Ce[N(SiMe3)2]3(THF)n in Catalysis
Ionic Liquid-Derived Organic–Inorganic Cocrystal: Synthesis, Crystal Structure, and Its Applications toward Dye Removal and Antidiabetic Activities
Understanding the Pseudoflexibility of a Co-btc Coordination Polymer
Ytterbium–Gadolinium Pyrenates: Morphology-Dependent NIR-Emission with Record Quantum Yield in Powder State
Monomeric Sr Complexes Combined with Tetradentate Enaminolate Ligands for Containing Sr Thin-Film Deposition
Story of Quinoline–Naphthalene-Embedded Coordination Polymers: Crystal Engineering, Food Spoilage Detection, and Integration with Smartphone Technologies
Capturing the Elusive: A Snapshot of the Pu(IV) Hexanuclear Cluster Intermediate in the Birth of PuOsub2/sub Colloidal Nanoparticles
A Dual pH-Gated Nanoplatform Enabled by Schiff Base Chemistry on ZIF-90 for a Synergistic Anticancer Effect In Vitro
Mechanochemical and Solvent-Mediated Approach to Polymorphic Control in a Cu3I3 Luminescent Cluster: Combined Functional Studies and Theoretical Calculation
Planar and Nonplanar Polymorphic Forms of Ni(II)-Porphyrin: Photophysical, Photocatalysis, and DFT Study
Zr-MOF-Derived Zirconium Oxide Nanozyme and Its Hydrogel Composite Membrane for Organophosphate Detoxification
Glutathione Peroxidase-Like Activity of Functionalized Tellurides: Insights into the Oxidation Mechanism Through Activation Strain Analysis
Selenium Distribution and Speciation in Tissues from Rats Administered with Non-Native Selenotrisulfides
5
The impact of arsenic exposure on DNA methylation in humans: building an epigenetic biomarker of exposure across three independent cohorts
Threshold and sex-specific associations of prenatal low-level lead exposure with neonatal birth outcomes: a Chinese prospective birth cohort study
Mortality and cancer incidence in a large cohort of lead-exposed workers
Structured tools for assessing quality and risk of bias in Mendelian randomization studies: an updated systematic review
Oral contraceptive use and risk of melanoma in a large cohort of Dutch nurses
6
Detecting drug-related problems following metabolic and bariatric surgery using pharmacovigilance databases
Efficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide on MC4R deficient obesity and their comparison
Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells
Canagliflozin regulates adipocyte lipolysis in vitro via a SGLT2 independent signaling pathway
Maternal monosodium glutamate exposure disrupts leptin and insulin signaling in the hypothalamus, activating NF-κB and mTOR inflammatory pathways, contributing to metabolic dysfunction in male offspring
Gastrointestinal side effects of incretin-based obesity management medications: insights from healthcare professionals and patients’ experiences
11
Deprescribing Intervention and Reduction of Proton Pump Inhibitor Use in Primary Care
Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy
Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults
Benzodiazepine Use in Pregnancy and the Risk of Pregnancy Outcomes
Postmarket Drug Safety−Related Actions Before and After the US Food and Drug Administration Amendments Act
Physical Accessibility of Medicines in Countries Hosting Trials for FDA Approvals
Effectiveness of Colchicine for the Treatment of Long COVID
Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults
FDA Authorization of Therapeutic Devices Under the Breakthrough Devices Program
Diabetes Deprescribing in Older Adults
Physician- and Large Language Model–Generated Hospital Discharge Summaries
4
GH001 vs Placebo in Patients With Treatment-Resistant Depression
Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder
ANK3 as a Novel Genetic Biomarker for Liafensine in Treatment-Resistant Depression
Efficacy and Safety of Seltorexant in Insomnia Disorder
2
MySurgeryRisk Model Predictions of Postoperative Complications and Mortality
Implementing a Patient-Centered Education Bundle to Improve Venous Thromboembolism Prevention
7
Lead-Attributable Cardiovascular Disease Burden
Electronic Health Record Intervention and Deprescribing for Older Adults
Prenatal Exposure to Acid-Suppressive Medications and Risk of Neuropsychiatric Disorders in Children
Gestational Weight Gain and Pregnancy Outcomes After GLP-1 Receptor Agonist Discontinuation
Arsenic Exposure Reduction and Chronic Disease Mortality
Everolimus and Low-Dose Tacrolimus After Heart Transplant in Children
Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder
29
Impact of heme on the therapeutic efficacy of anti-CD20 antibodies
Dynamic Mechanism for Subtype Selectivity of Endocannabinoids
Improvement in binding and function of a monoclonal antibody against Shigella flexneri 3a O-antigen via phage display and whole-cell in-solution panning
Activation dynamics of a water-soluble human mu-opioid receptor
A tandem recruitment site in the pseudokinase scaffold PEAK3 is subject to phosphorylation-dependent regulation and cancer-associated mutations
Co-solute Effects Reveal the Nature of Weak Forces Governing GLP-1 Oligomers Stability
A conserved salt bridge network stabilizes the hepatic organic anion transporters OATP1B1 and OATP1B3
Engineered IgA-Fc fusion protein with bioactive nanobody neutralizes SARS-CoV-2 variants with mucosal delivery potential
The stress-activated kinase p38 mediates non-canonical activation of Src and tyrosine phosphorylation of the adapter protein TAB1
Protein tyrosine kinase Src suppresses hepatitis C virus particle release through regulation of Ndrg1
The divergent roles of tryptophans W354 and W217 in OCT1 transport: similar localization, distinct functions
A humanized transferrin receptor 1-transferrin model supports functional iron homeostasis and therapeutic delivery across the blood–brain barrier
Phylogenetic and structural analyses reveal Cdc2-like kinases (CLKs) as ancient regulators of thermosensitive splicing
Development of a recombinant membrane protein ELISA for analyzing antibody responses against SARS-CoV-2 envelope proteins
Characterization of Mast2 Kinase Defines Structural Features, Regulation, and Substrates
C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases
The organic cation transporters 1 and 2 mediate ethanolamine cellular efflux and control systemic phosphatidylethanolamine level
A new amidohydrolase and β-oxidation–like pathway for piperine catabolism in soil actinomycetes
Enhancing O-linking oligosaccharyltransferase functionality through directed evolution
Dihydroxyacetone decreases the dATP pool, inducing replication stress and genomic instability in BEAS-2B cells
Interaction of cytochrome P450 3A4 with cannabinoids and the drug darifenacin
Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency
Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases
Receptor activity–modifying protein 3 enhances GLP-1-mediated insulin secretion
Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region
Repurposing clofazimine as an antibiotic to treat cholera: Identification of cellular and structural targets
Potential blocker of SARS-CoV entry and a narrow functionality of its spike protein motifs on Qubevirus platform
Selective inhibition of TRPV3 channel by natural rosmarinic acid and its analogs for alleviation of skin lesions through downregulation of NF-κB pathway
Evaluation of AlphaFold modeling for elucidation of nanobody–peptide epitope interactions
1
Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty.
1
ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway
3
A QSAR-machine learning hybrid model for predicting the ecotoxicity of soil organic compounds and deriving thresholds
Biomimetic dual-layer fertilizer: Hydrophilic-hydrophobic synergistic system for enhanced water retention and controlled nutrient release
Novel mechanisms of cadmium detoxification mediated by selenium nanoparticles in selenium hyperaccumulator plants: Discovery of HSP90-1 as a pivotal potential regulatory hub
14
Patterns of TSH test after GLP-1 RAs initiation in patients on levothyroxine: a trial emulation study
The effects of glucose-dependent insulinotropic polypeptide on net splanchnic blood flow in lean humans
Exposure to GLP-1RA and Risk of Structural Progression in Differentiated Thyroid Cancer
Skeletal effect of semaglutide and tirzepatide in patients with increased risk of fractures
Exenatide induces an enhanced endogenous glucagon-like peptide-1 secretory response in patients receiving basal insulin
Diazoxide Choline Extended-release Tablets in Prader-Willi Syndrome: A Randomized, Double-blind, Withdrawal Period Study
GLP-1 receptor agonists in patients with cancer are associated with reduced all-cause mortality and hospitalization
Semaglutide and Taste in Women With Obesity and Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Study
Distribution of Somatostatin and Its Receptors in the Intestinal Tract in Healthy Patients and Patients with Type 2 Diabetes
Increased HSD11β1 Expression in Human Leiomyomatous Uteri: Implication for Enhanced Glucocorticoid Signaling
The separate and combined effects of GIP, GLP-1 and GLP-2 on markers of bone turnover in type 2 diabetes
Effect of Denosumab on Sperm Concentration in Men With Severe Oligospermia: A Randomized Controlled Trial
Qualitative and Quantitative Analyses of Noninvasive Diagnosis of Insulinoma Using [18F]FB(ePEG12) 12-Exendin-4 PET/CT
Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired β Cell Function in Humans
7
Human antibody targeting Crimean-Congo hemorrhagic fever virus glycoprotein 38 protects mice against heterologous virus challenge
Estrogen and obesity synergistically suppress protein S via HIF1α, enhancing thrombosis potential
Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice
Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis
β-cell Gɑs signaling is critical for physiological and pharmacological enhancement of insulin secretion
2
Efficacy and Safety of Ultra-Low-Dose Immunotherapy in Relapsed Refractory Solid Tumors: Phase III Superiority Randomized Trial (DELII).
Investigation of Profile-Related Evidence Determining Individualized Cancer Therapy (I-PREDICT) N-of-1 Precision Oncology Study: Molecular Profiling to Match Individually Dosed, Personalized Drug Combinations.
2
Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling
Decoding the Resistin-CAP1 Pathway in Intermediate Monocytes Mediating Liver Allograft Rejection
14
Population Pharmacokinetic Modeling of Standard- and High-Dose Rifampicin for Tuberculosis Preventive Therapy in the 2R2 Randomized Controlled Trial
<atl>Cefazolin inoculum effect and cefazolin microbiological treatment failure in serious methicillin-susceptible iStaphylococcus aureus/i infections: A multi-center retrospective cohort study</atl>
Daptomycin-Loaded Nanocarriers Facilitate Synergistic Killing of Methicillin-Resistant Staphylococcus aureus via Lipid-Mediated Interactions and Targeting
Pharmacokinetics and Safety of Clofazimine in Women With Rifampicin-resistant Tuberculosis During Pregnancy and the Postpartum Period: Results From IMPAACT P1026s
Ganciclovir Dosing in Premature Infants Receiving Treatment for Congenital Cytomegalovirus Infection: Results of a Prospective Pharmacokinetic Study
Establishing a Practical Approach to Sewer Monitoring for Antimicrobial Resistance Genes and Organisms at Healthcare Facilities
Evaluation of Immunization Route in Induction of Vaccine-Mediated Anti-Gonococcal Immune Responses in a Murine Model of Ascending Infection
Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India
Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies
Fetal Defects in Mice Treated with Integrase Strand Transfer Inhibitors: Comparison of Dolutegravir, Raltegravir, Bictegravir and Cabotegravir
Dolutegravir and Risk of Neuropsychiatric Adverse Events: A Pharmacogenetic Study
Translational Modeling of BTZ-043 to Predict Phase 2A Efficacy and Evaluate Drug-Drug Interactions With Bedaquiline, Pretomanid, and Linezolid in Murine Models
Differences in Neutrophil Counts Between African and Non-African Countries in 2 International Clinical Trials
Pharmacokinetics and Pharmacodynamics of Fosravuconazole, Itraconazole, and Hydroxyitraconazole in Sudanese Patients With Eumycetoma
11
Suppression of In Vitro Epileptiform Activity by GABA Transaminase Inhibition Is Dependent on GABAB Receptors and GABA Transporter Type 1 (GAT1)
The pro-, but not anti-nociceptive effects of Cannabidiol depend on Trpa1b in larval Zebrafish
A Time-Sensitive Plasticity Distinguishes the Rapid and Sustained Synaptic Actions of Ketamine from Its (2R,6R)-Hydroxynorketamine Metabolite
Presynaptic trafficking of Glutamate Decarboxylase isoforms is dispensable for basal GABAergic neurotransmission
Prenatal Downregulation of CB1 Cannabinoid Receptors in the Mouse Prefrontal Cortex Disrupts Cortical Lamination and Induces a Transcriptional Signature Associated with Social Interaction Deficits
Multi-omics Analysis Reveals miR-7220-5p Alleviates N2O Addictive Behaviors via NR2B/ERK/CREB Signaling
Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABAB Receptor Signaling
Phospho-CREB Regulation on NMDA Glutamate Receptor 2B and Mitochondrial Calcium Uniporter in the Ventrolateral Periaqueductal Gray Controls Chronic Morphine Withdrawal in Male Rats
Presynaptic Mu Opioid Receptors Suppress the Functional Connectivity of Ventral Tegmental Area Dopaminergic Neurons with Aversion-Related Brain Regions
Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms
Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex
6
Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice
Abcc1 deficiency protects from corticosterone but not cortisol-induced adiposity and insulin resistance in a sex-specific manner
Fentanyl blockade of K+ channels contributes to wooden chest syndrome
Nicotine influence on cerebrovascular and neurocognitive function with iin utero/i electronic cigarette exposure
Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity
Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation
1
An Artificial Intelligence and Machine Learning model for Personalized Prediction of Long-term Mitral Valve Repair Durability
1
The Price and Quality of Methylphenidate Products
2
Decreased Risk of Cardiovascular Disease in Dermatology Patients Taking Niacinamide: A TriNetX Cohort study
Development and validation of prognostic models using novel inflammatory markers for drug reactions with eosinophilia and systemic symptoms: An international multicenter cohort study
114
Photoswitchable COX-2-Selective Inhibitors as Light-Regulated Anti-Inflammatory Agents
Frozen Interphase Domain and Mechanism of the Snakelike Macroscopic Motion in a Dynamic Crystal Solvate
Regio- and Stereoselective Deprotonation and Functionalization of Strained 1-Aza[n.1.0]bicycles
Fluoro-Wacker Gem-Difluorination of Alkene via Fluoropalladation and Dyotropic Rearrangement
Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Protein Degradation
Biocatalytic Applications and Mechanistic Insights of Deoxypodophyllotoxin Synthase
Programmable DNA Origami-Based Protease Device for Precise and Direct Proteins Degradation
Diastereoselective Synthesis of Housanes via the Carbocupration of Cyclopropenes
Yield Prediction of Organic Reactions in Biased Data Sets via Positive-Unlabeled Learning
Structural Mass-Spectrometric Description of Immune Complexes in Vaccine-Induced Immune Thrombocytopenia and Thrombosis
Discovery of Covalent Ligands with AlphaFold3
Bimetallics Spanned by Linear All-Inorganic Ligands: The Longest Inorganic, All-sp Chains
Supramolecular Polymorphism of an Ir(III) Complex: Kinetic/Thermodynamic Control and Mechano-Responsiveness
Hydrogen–Deuterium Exchange Mass Spectrometry Reveals an Antibody-Induced Allosteric Pathway Driving SARS-CoV-2 Spike Trimer Disassembly
Cancer Cells Degrade the Nanoparticle Protein Corona for Biosynthesis
A Spatially Cued, Sequentially Activated DNA Nanodevice for Atherosclerosis Theranostics via Precise Targeting of Lesional Macrophages
Micron-Scale 2D Antibody Arrays for HER2 Signaling Blockade and Cancer Therapy
A MOF-Lanthanide Theranostic Agent with Bidirectional Near-Infrared Photon Conversion for Tumor-Responsive Therapy and Real-Time Imaging
Unlabeled NMR Approach with Site-Specific Methyl Assignments for Structural Evaluation of the IgG1 Fc Region
Development of Prostate-Specific Lysosome-Targeting Degraders
Chem–Bio Hybrid Synthesis Enables Reengineering of Natural Product-Based Methionine Aminopeptidase 2 Inhibitors for Treating Amebiasis
The Effect of Nonsolvent Post-Processing Induced Structural and Morphological Changes on the Optoelectronic Properties of CsPbBr3 Nanocrystals
Augmenting Large Language Models for Automated Discovery of F-Element Extractants
When Reality Defies Prediction: Polymorphism, Twinning, and Accordion Crystals
Acetylation-Tagging-Assisted Cocrystallization of Stubborn Molecules with Trinuclear Complexes
An Engineered Nanovesicles-Based Lysosome-Targeting Protein Degradation Platform (NV-TACs) for Cancer Immunotherapy
Stability and Degradation-based Proteome Profiling Reveals Cannabidiol as a Promising CDC123-eIF2γ Inhibitor for Colorectal Cancer Therapy
An Alkaloid Biosynthetic Gene Bundle in Animals
In Situ Transformable Photothermal Targeting Chimeras for Spatiotemporally Controllable Protein Degradation and Combination Immunotherapy for Cancer
Polymeric Lysosome-Targeting Chimeras (PolyTACs): Extracellular Targeted Protein Degradation without Co-Opting Lysosome-Targeting Receptors
Discovery of Supra-Bivalent GSK3β Inhibitory Peptides Containing an ATP-Mimetic Amino Acid
Nonclassical Crystallization of Covalent Organic Frameworks Guided by Exogenous Noncovalent Interactions
Spatiotemporal Cascade Targeting from the Cell Membrane to the Endoplasmic Reticulum for Chemoimmunotherapy via the Cyclometalated Iridium-Fatty Acid Scaffold
Receptor-Mediated Shuttling of a D-Amino Acid Peptide Achieves High Nanomolar Cytosolic Concentrations
Identifying Dynamic Metal–Ligand Coordination Modes with Ensemble Learning
Controlled Self-Immolative Release of β-Lapachone via an Optimized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy
Iridium-Catalyzed Enantioselective C(sp3)–H Borylation of Bicyclo[1.1.0]butanes
A Versatile Bioorthogonal Theranostic Platform Enables Relay Activation of Tumor Cell Imaging and Targeted Protein Degradation
Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA)
Fluorocarbyne Insertion into Benzene Skeletons
Oxoaporphine-Metformin Rhodium(III) Mixed Complex Achieving Dual Antidiabetes and Anticancer Effects by Interfering with Glucose Metabolism Reprogramming
Accurately Predicting Solubility Curves via a Thermodynamic Cycle, Machine Learning, and Solvent Ensembles
Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform
Peristaltic Motion in Structurally Adaptive Molecular Crystals Enables Selective Propyne Capture
Luminescent Perhalofluoro Trityl Radicals
Ketoboronate as a Minimal Covalent-Reversible Tag for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins
Cell Membrane-Anchored Click Reaction Enhances Porphyrin Uptake for Highly Efficient Photodynamic Therapy of Breast Tumors
Cationic Nano Single Crystals: From In Situ Structural Determination to Synergistic Photoimmunotherapy
A Selenium-for-Oxygen Swapping Reaction Catalyzed by the Radical S-Adenosyl Methionine Enzyme AbmM
Poly(bis(guanidinium)-oxazoline)–Insulin Complex Exerting Long-Acting Glucose-Responsive Insulin Release in Mice and Minipigs
Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation
Fast and Reliable NMR-Based Fragment Scoring for Drug Discovery
In Vivo mRNA Delivery to the Lung Vascular Endothelium by Dicationic Charge-Altering Releasable Transporters
A Sodium Iron Phosphate Nanocatalyst-Regulated High-Mobility Ion Reservoir Enables Tumor-Selective Immunotherapy
In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy
Pretargeted Mitochondrial Delivery of Organoarsenicals for Cancer Immunotherapy
Discovery and Biosynthetic Interrogation of a Cobalt-Containing Terpene-Polyketide-Nonribosomal Peptide Tribrid with Anticoronavirus Activity
Vitrification and Cold Crystallization of a One-Dimensional Perovskite-like Compound Enabled by Reorganizable Coordination Bonds and a Configurationally Restricted Cation
Enantioselective β-C–H Arylation of α-Fluoroalkyl Cyclopropane and Cyclobutane Carboxylic Acids
Cell-Selective Targeting Chimeras (SelecTACB) for Membrane Protein Degradation on B Cells
Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells
Self-Assembly of Artificial Topological Nanostructures for Enhanced Bioorthogonal Activation and Drug Penetration for Cancer Immunotherapy
Trotline-Inspired Mesoporous Carriers for Prolonged Gastrointestinal Retention
Magnetic Sorting of Chiral Pharmaceuticals Using Fe3O4–Cellulose Acetate Phthalate Nanosplitters
Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes
Salt-Induced Polymorphs Observed in Colloidal Single Crystals
Synthesis of Bicyclo[2.1.0]pentanes and Vinylcyclopropanes Using Palladium Carbenes: Ligand-Controlled Carbene Reactivity
Zwitterionic Sulfadiazine-Based Micelle Achieves Effective Drug Delivery to Glioblastoma by Overcoming Multiple Biological Barriers
Triplet Carbene Insertion Enables Modular Access to C2-Substituted Bicyclo[1.1.1]pentanes
Bayesian Optimization for Multicomponent Supramolecular Systems
Defluorinative Coupling of (NH)-Heteroarenes and Unactivated Vinyl Fluorides Enabled by Metal–Organic Frameworks
A Chemo-Enzymatic Platform for Furanolide Synthesis and Functional Exploration
Highly Branched Sulfated Glycopolymers as Mucin Mimetics
Direct Synthesis of Bicyclo[1.1.1]pentanes by Sequential C═C, C–C Functionalization Reactions
The Modulatory Role of Positional Isomerism in Diolein on the Structural Features of pH-Responsive 2-Hydroxyoleic Acid Nanocarriers
Computationally Designed Nanobinders as Affinity Ligands in Diagnostic and Therapeutic Applications
DNA-Templated Spatially Controlled Proteolysis Targeting Chimera for Cyclin D1–CDK4/6 Complex Protein Degradation
Elucidating the Biosynthetic Pathway and Mechanisms of Retrochalcones
Water Dynamics in the Formation of Single-Component-Based Multiphasic Droplets
Probiotic–Drug Conjugates Achieve Synchronized Site-Specific Probiotic Colonization and On-Demand Drug Release against Ulcerative Colitis and Its Complication
An Expedient Synthesis of the Antimitotic Natural Products Sarcodictyin and Eleutherobin, and Carbohydrate Analogues
Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs
N-Heterocyclic Selone-Catalyzed [2σ + 2π] Cycloaddition of Bicyclo[1.1.0]butanes via Photoredox Radical Buffer
Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites
Taming Tautomerism in Organic Crystal Structure Prediction
Monodisperse Giant Unilamellar Niosomes as Minimal Synthetic Cells
NMR Assessment of the High Order Structure of Biological Therapeutics in Erythrocytes Provides a Tool for Drug Delivery Design
Phosphorylation-Inducing Molecules for Regulating Dynamic Cellular Processes
Enzymatic Basis of Stereochemical Control in Reserpine Biosynthesis
Concise Synthesis of Fostriecin and Analogs through Late-Stage Chemoenzymatic Installation of Their Key Pharmacophores
Amorphization-Induced Electronic Modulation of Gd(OH)3 Nanocages with Enhanced Enzymatic Activities for Antitumor Therapy
Engineered Nano-Micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization
Mixed-Chirality Prohibitin Peptide: D-(RLARLAR)2 Enhances Stability and In Vivo Effects on Obesity
Programmable Liposome Organization via DNA Origami Templates
Membrane-Anchored Polyproline Provides Controlled Microdomain Formation and Permeability in Lipid Vesicles
Precursors of Carboximidates Deriving from Thioamide-Trimethyl-Lock System: A General Method for Designing Stable Cascade Acid-Sensitive Prodrugs
Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders
Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition
In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation
Identification of Actionable Targeted Protein Degradation Effector Sites through Site-Specific Ligand Incorporation-Induced Proximity (SLIP)
X-ray-Induced Photodegradation of Hydrogels by the Incorporation of X-ray-Activated Long Persistent Luminescent Nanoparticles
Transformation of Pyridines into 2D and 3D Fused Bicyclic Heterocycles
Phototriggered LYTAC: Photoactive Bispecific Aptamer Chimera Enhances Targeted Degradation of Membrane Protein through Regulating Cell Autophagy
Data-Driven Design of Random Heteropolypeptides as Synthetic Polyclonal Antibodies
Molecular Design of Unimolecular Tetra-Receptor Agonists
The Binding Affinities of Serum Proteins to Nanoparticles
Development of Sclareol- and Sclareolide-Based Chemoenzymatic Approaches to Ring Intact and Seco Limonoids
Developing Pharmaceutically Relevant Pd-Catalyzed C–N Coupling Reactivity Models Leveraging High-Throughput Experimentation
Reactive Oxygen Species-Instructed Supramolecular Assemblies Enable Bioorthogonally Activatable Protein Degradation for Pancreatic Cancer
Engineering Recombinant Chimeric Proteins That Deliver Therapies to the Brain
Glycan-Modified Cellular Nanosponges for Enhanced Treatment of Cholera Toxin-Induced Secretory Diarrhea
Bioactive Assembly Cofactor-Assisted Ursolic Acid Helix for Enhanced Anticancer Efficacy via In Situ Virus-like Transition
Three-Dimensional Atomic-Level Structure of an Amorphous Glucagon-Like Peptide-1 Receptor Agonist
Boosting Cancer Cell Ferroptosis with Carbon Monoxide Poisoned Hemoglobin
4
Extension Reports in Clinical Trials
Effect of Aficamten vs Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy
Sacubitril-Valsartan Versus Enalapril in Heart Failure Due to Chagas Disease: Primary Results of ANSWER-HF Randomized Trial
Electromechanically Optimized Right Ventricular Pacing for Obstructive Hypertrophic Cardiomyopathy (EMORI-HCM)
18
Conducting Medication Reviews: A Comparative Study Between ChatGPT-4 and Healthcare Professionals
Association Between Real‐Time Alerts in Electronic Prescribing Systems and Potentially Inappropriate Prescribing Among Older Adults
Discontinuation of Medications With Limited Benefit at End of Life in Community‐Dwelling Older Veterans
Perspectives of Older Patients on the Complexity of Medication Use
Deprescribing Through the LESS-CHRON Tool: Recruitment Data and Results of Impact on Pharmacological Treatment (LESS-CHRON Validation Project)
Enhancing Medication Adherence in Older Adults: A Systematic Review of Evidence‐Based Strategies
Mail‐Order and Retail Pharmacy Use Among Medicare Beneficiaries With Alzheimer's Disease and Related Dementias
GLP‐1 Receptor Agonist Therapy and Cardiorenal Outcomes in Patients ≥ 80 Years Old With Type 2 Diabetes
Association of Inpatient Prescribing of First‐Generation Antihistamines With Delirium in Older Adults: A Cross‐Sectional Study
Prevalence and Duration of Potential Drug–Drug Interactions Among scpUS/scp Nursing Home Residents, 2018–2020
Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People
Integration of Potentially Inappropriate Medication Screening Into Community Pharmacies: A Pilot Study of Feasibility and Impact
Central Nervous System‐Active Medications and Risk of Hospital Readmission in Older Multimorbid Adults
A Prospective Study on Potentially Inappropriate Drug Use and All‐Cause Mortality in Community‐Dwelling Older Adults
Polypharmacy's Association With Mortality: Confounding From Underlying Morbidity
Increasing Medicare Part D Vaccine Administrations via a Novel Primary Care Clinic‐Pharmacy Collaboration
Facilitators of and Barriers to Deprescribing Diabetes Medications in Older Adults: A Qualitative Study
Effects of Initiating Different Antidepressant Subclasses on Motor Vehicle Crash Risk Among Older Adults With Depression
1
Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial.
6
Tobacco-related urinary biomarkers and lung cancer risk in women, a case-cohort analysis
Changing standard of care during a randomized trial: examples, considerations and guidelines
Hormonal contraception and lymphoma risk in danish women 15–49 years: a nationwide cohort study
A predictive model for life-threatening fluoropyrimidine toxicity based on DPYD sequencing in colorectal cancer
Antagonistic effect of arsenic exposure and chronic hepatitis viral infection on hepatocellular carcinoma
Association between glucagon-like peptidase 1 receptor agonist and obesity-related cancer in overweight or obese patients with type 2 diabetes: a nationwide cohort study
1
Zigakibart demonstrates clinical safety and efficacy in a Phase 1/2 trial of healthy volunteers and patients with IgA nephropathy
27
Effect of Copolymer Chemistry on the Humidity- and Temperature-Dependent Mechanical Properties and Structure of Polyelectrolyte Complexes
Quantifying Poly(lactide-co-glycolide) Residual Dimer-Alternating Structure and Block-Length Distribution Using Controlled Chemical Degradation and Reverse-Phase Liquid Chromatography–Mass Spectrometry Analysis
Controlled Synthesis of Hydrogen-Bonded Poly[(thio)ester amide]s via Deprotection of Alternating Copolymers from N-tert-Butyloxycarbonyl Aziridine and Cyclic Anhydrides
Polymerization-Induced Self-Assembly versus Nanoprecipitation: A Systematic Comparison of Block Copolymer Micelle Properties
Coupled Thermal–Chemical Stimuli in Hydrogel Swelling: A Multifield Kinetic Model for Dual-Responsive Hydrogel
Entropy-Regulated Swelling as the Mechanistic Driver of Drug Diffusion in a Mechanically Robust Hydroxyapatite/PVA Hybrid Hydrogel
Mixed “Nonsolvents” Induced Phase Separation of Amphiphilic Long-Chain Polyurethanes
pH-Triggered Swelling and Disassembly of Tertiary Amine-Containing Block Copolymer Self-Assemblies: Role of Molecular Weight in Nanocarrier Design
A Hybrid Simulation-Machine Learning Framework for Predicting Thermal Degradation in High-Performance Polyimides
Hexadecylamine Addition Promotes Crystallization-Driven Functionalities in Freezing–Thaw PVA Hydrogels
Hydrogen Bonding Mechanism in Cononsolvency
Translational Dynamics and Structural Enhancement Effect in High-Temperature Supramolecular Systems of Asparaginyl Low-Molecular-Weight Gelators and Propylene Carbonate
Molecular Dynamics Study on the Temperature Response of a Chitosan-Based Graft Polymer with Different Grafting Densities of Oligo(ethylene glycol) Methacrylate Side Chains
Impact of Network Functionalization on the Surface Properties and Behavior of Thermoresponsive Copolymeric Nanogels
High-Throughput Generation of Block Copolymer Libraries via Click Chemistry and Automated Chromatography
The Effect of pH during Fabrication of Platinum-Containing Polymeric Arsenical Hydrogels
Boron-Rich Soft Hydrogels Based on the Coassembly of Cationic A-B-A Triblock Copolymers with Closo-Dodecaborate
Exploring SMILES and BigSMILES: Toward Efficient and Scalable Polymer Representations for Machine Learning
Revisiting the Classical Multicomponent Hantzsch Reaction to Form Fluorescent Dextran Hydrogels with Antibacterial Activity
Dynamic Hydrogels Using Movable Supramolecular Cores to Prepare Multiarm Macromer Analogs
Thermoresponsive Poly(2-Oxazoline)s with pH-Degradable Acetal Side Chains as Potential Drug Delivery Vehicles
The Ester/Amide Exchange Reaction in the Melt Polycondensation of Alternating Poly(Ester Amide)s: Mechanism and Evolution
Facile Synthesis of Trialkylamine Oxide-Modified Platinum Polymer Probes for Mass Cytometry
Constructing Polycarbonate-Based Oxidation-Responsive Polymersome Nanoreactors with Tunable Biocatalysis
Osmotic Pressure-Based Quantification of Network Inhomogeneity in Gels via Free Radical Polymerization
Rheological Properties and Gelation Behavior of Chitosan in a Weakly Alkaline NaHCO3/Urea Aqueous Solution
CO2-Triggered Hydrogelation: Architectural Insights from Random and Graft Polyelectrolytes
1
Reimbursement Policy and Drug Shortages
1
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation
17
Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids
GLP-1 receptor agonists and risk of suicide or suicide attempts – A nationwide cohort and self-controlled case series study
Sterol pathway disruption in pregnancy: a link to autism
Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium
Mechanistic insights into cannabidiol-mediated TrkB activation via FRS2 interaction in attenuating Alzheimer’s disease pathology and cognitive impairment
Pharmacogenomics of antiepileptic drug mood stabilizer treatment response in bipolar disorder: A MoStGen Consortium study
Novel selective morpholine trace amine-associated receptor 1 partial agonists show promising preclinical effects for neuropsychiatric disorders and are well tolerated in healthy volunteers
A five-year risk prediction model of cardiovascular disease in individuals with bipolar disorder: a nationwide register study from Sweden
Brain CB2 receptor: a new target in medication development for treating opioid use disorder in rodents
Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice
Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies
Ketamine reduces microglial activation and brain monocyte infiltration and promotes peripheral regulatory immune cells, relieving lipopolysaccharide (LPS)-induced depressive-like behavior in mice
CB receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice
Dietary caffeine to assess CYP1A2 activity, tailor clozapine doses, and predict treatment response: genetic, epigenetic and clinical analyses
The dietary ligands, omega-3 fatty acid endocannabinoids and short-chain fatty acids prevent cytokine-induced reduction of human hippocampal neurogenesis and alter the expression of genes involved in neuroinflammation and neuroplasticity
DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort
Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant
33
Thermodynamics and Molecule Landscape of Protein Corona
“AND” Logic-Gated Biomimetic Nanoparticles to Activate Macrophage Phagocytosis for Cancer Immunotherapy
A Dicer-Activatable Aptamer-Adamantane/siRNA (AptHyT-siRNA) Chimera Enables Synergistic Targeted Protein Degradation and mRNA Silencing
Overcoming Chemoresistance via an AIEgen-Based Covalent Organic Framework
Machine Learning Prediction of Analyte-Induced Fluorescence Perturbations in DNA-Functionalized Carbon Nanotubes
Hydrophobic/Amphiphilic Prodrug Coassembly Strategy: Exploring the Effect of Oligoethylene Glycol Chains on the Antitumor Efficacy of Nanoassemblies
Label-Free Analysis Reveals In Vivo Premature Drug Release Governed by Diffusion from Polymeric Micelles
Transformable “Bullet Train”-like Nanomotors for Sequentially Overcoming Tumor Delivery Barriers
Bacterial Membrane Coating Potentiates Lipid Nanoparticles for mRNA Delivery
Polymer Blend Controls Nanoparticles’ Surface Charge for Improved Mucus Penetration and Epithelial Cell Adhesion
Carbonic Anhydrase Targeting Polymer with Enhanced Intracellular Protein Delivery and Tumor Penetration for Cancer Therapy
s-Block Atomic Calcium Sites Boost Biomimetic Hydrolysis for Personal Protection
Mineralized Lipid Nanoparticles Containing Gadolinium Enable Integrated X-ray Fluorescence Computed Tomography Imaging and Radiotherapy
Spatiotemporally Orchestrated Microneedle Patch Synergizing Photodynamic Therapy, ROS Scavenging, and Photosynthetic Oxygenation for Chronically Infected Wound Healing
Chemically Designed Functional Nanomicelles for Blood–Brain Barrier Crossing
Synergistic Dual-Targeting Bacterial Extracellular Vesicles Delivering Paclitaxel for Precision Glioblastoma Therapy
Outperforming Biorecognition: Epitope-Imprinted Nanoparticle Enables High-Species-Specificity Purification of Human IgG
Dual-Targeting Nanoplatform to Regulate Metabolic Disorders: From Obesity to Obesity-Related Metabolic Dysfunction-Associated Steatotic Liver Disease
Hydrophobically Modified Paclitaxel Prodrug Enables Ultrahigh Drug Loading Driven by Polarity Redistribution
A Synthetic Liposome Nanoparticle Vaccine Platform for Broad-Spectrum Vaccine Design
Solvent-Directed Self-Assembly of Sorafenib into Spherical Particles for Enhanced Anticancer Efficacy
Polystyrene Nanoplastic Contaminants Denature Human Apolipoprotein A-1
Intersection-Free Fractal-Like Structuring of Recombinant Adhesive Proteins for Surface Functionalization
Inhalable Mucus-Penetrating Engineered Hybrid Nanomedicine for Enhanced Treatment of Idiopathic Pulmonary Fibrosis
Bioinspired Polymeric Nanomedicines with Tumor Extracellular Matrix Anchoring Capability for Prolonged Tumor Retention and Drug Delivery
Targeted Europium Chelation: A Strategy for Intervening Tumor Extracellular Matrix
Impact of Renal-Targeting Ligand Density on Kidney Targeting, Clearance, and Off-Target Effects of Renal-Clearable Nanoparticles
Inhibition of Post-Surgical Tumor Recurrence by 3-Bromopyruvate-Conjugated Gold Nanoclusters via MAPK and PI3K-Akt Pathways
Light-Controlled Small Extracellular Vesicle-Based Spherical Nucleic Acid Nanomotor for Enhanced Transdermal Delivery against Skin Aging
Stabilizing Gold Nanotetrapods via in Situ Polymerization for Superior Photoacoustic and Photothermal Applications
Synthetic Bacterial Membrane Vesicles as Versatile Antigen-Display Platforms against Respiratory Syncytial Virus
Unidirectional Drug Delivery and Responsive Release Guided by Nanofunnel-Shaped Heterojunction
A Hybrid-Targeting Nanoparticle for Penetrable Delivery of Temozolomide to Enhance Glioblastoma Therapy
14
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
Genetic predictors of GLP1 receptor agonist weight loss and side effects
A µ-opioid receptor superagonist analgesic with minimal adverse effects
Pancreatic-targeted lipid nanoparticles based on organ capsule filtration
Collective intelligence for AI-assisted chemical synthesis
Language model-guided anticipation and discovery of mammalian metabolites
Mazdutide versus placebo in Chinese adults with type 2 diabetes
Inhibitors supercharge kinase turnover through native proteolytic circuits
A skin-permeable polymer for non-invasive transdermal insulin delivery
Atomically accurate de novo design of antibodies with RFdiffusion
Crystal structures of agonist-bound human cannabinoid receptor CB1
Scalable total synthesis of saxitoxin and related natural products
Identification of medication–microbiome interactions that affect gut infection
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III
7
Manufacturing-aware generative models enable petascale synthesis of designed DNA
Pilot phase clinical trial of a wearable, electrochemical aptamer-based patch for continuous drug concentration measurement
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles
Deep-learning-based virtual screening of antibacterial compounds
Folding-mediated secretion of pure bispecific antibodies
A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
Transitive prediction of small-molecule function through alignment of high-content screening resources
7
Charged molecular glue discovery enabled by targeted degron display
A pharmacological modality to sequester homomeric proteins
Navigating condensate micropolarity to enhance small-molecule drug targeting
Enzymatic epimerization of monoterpene indole alkaloids in kratom
Molecular recording of cellular protein kinase activity with chemical labeling
A class of benzofuranoindoline-bearing heptacyclic fungal RiPPs with anticancer activities
Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins
6
Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras
Collective synthesis of 1,2,4-trisubstituted, meta- and ortho-substituted arene bioisosteres from bicyclobutanes
Hetero[3.1.1]propellanes
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3
On-DNA C–H functionalization of electron-rich arenes for DNA-encoded libraries
A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists
174
Effects of different mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance
Generation of mixed-valency, modular multispecific antibodies using disulfide-linked Fc–FcγR complexes
Hidden structural states of proteins revealed by conformer selection
Cryo-EM structures of the CDK11-cyclin L-SAP30BP complex reveal mechanisms of CDK11 regulation
Phosphatidylserine-everted erythrocyte membrane vesicles enhance efferocytosis and remodeling of vascular grafts
Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial
Rational design of a Kappa opioid receptor peptide agonist with attenuated β-arrestin signaling
Enzyme-responsive peptide dendron nanoassemblies for targeting and eliminating intracellular drug-resistant bacteria
Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy
LaMGen: LLM-based 3D molecular generation for multi-target drug design
Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity
Structural optimization of drug molecules with incrementally trained language models
Massive barcode-free chemical screenings enable the discovery of bioactive macrocycles with passive membrane permeability
CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic
Disentangled autoencoding equivariant diffusion model for controlled generation of 3D molecules
Accelerated drug development using a digital formulator and a self-driving tableting data factory
Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader
Bispecific GLP-1/GLP-2 agonism in advanced type 2 diabetes: preclinical characterization and a randomized, double-blind, placebo-controlled phase I trial
In vivo metabolic tagging and targeting of circulating red blood cells
Structural evolution of carbon frameworks realizes in vitro interfacial transport in metabolically reprogrammed senescent cells for senolysis
Surface hydrophobicity and rigidity determines protein corona on orally delivered nanoparticles treating colitis
Candesartan cilexetil disrupts methicillin-resistant Staphylococcus aureus membrane and potentiates gentamicin and polymyxin B activity
Modifying muscle metabolic dysregulation in inclusion body myositis with pioglitazone: a single-arm trial
XA-Novo: high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures
Structural dynamics and immunogenicity of the recombinant and outer membrane vesicle-embedded Meningococcal antigen NadA
A hierarchical theranostic nanoagent for multimodal imaging and targeted foam cell intervention in atherosclerosis
A meta learning and task adaptive approach for drug target affinity prediction
Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis
The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase
The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases
ReactionSeek: LLM-powered literature data mining and knowledge discovery in organic synthesis
Supramolecular coiled-coil peptide platform for site-specific antibody drug conjugate engineering
Visualizing molecular diffusion direction and processes in the solid state via dichromatic fluorescent cocrystalization transformation
Heterobifunctional proteomimetic polymers for targeted degradation of MYC and KRAS
Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1
Deciphering DEL pocket patterns through contrastive learning
Drug-caged drugs enable photocatalytic dual decaging of nitric oxide and anesthetics for antibacterial analgesia
Multi-to-uni modal knowledge transfer pre-training for molecular representation learning
Engineered exosome nanovesicles for delivery of antibodies to treat inflammatory bowel disease
Phosphorescent supramolecular systems for medicine anticounterfeiting
Molecular determinant of low-voltage dependence of human Nav1.7 inactivation revealed by efficacy-based Nav1.7 selective inhibitor
Assessing conformation validity and rationality of deep learning-generated 3D molecules
Counting cells can accurately predict small-molecule bioactivity benchmarks
Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals
Reliable repurposing of the antibody interactome inside the cell
Granzyme B-mimetic nanozyme for nanovesicle targeted anticancer applications
Iterative discovery of potent polymeric antibiotics via multi-stage and multi-task learning against antimicrobial resistance
Injectable hydrogels for osteomyelitis treatment induce metabolic reprogramming for protection against reinfection
Bioresorbable RFID capsule for assessing medication adherence
Phase diagrams of pharmaceutical solvates from mechanochemistry
Comprehensive evaluation of GLP-1 receptor agonists: an umbrella review of clinical outcomes across multiple diseases
Reduction of bacterial colonization on buckling-induced wrinkled surfaces under fluid shear
Photocontrolled trimethoprim PROTACs targeting the eDHFR protein tag
Engineered vesicles enhance oral antibiotic absorption in proximal small intestine and mitigate gut dysbiosis
A brain-to-small intestine circuit mediates morphine-induced constipation in male mice
Neutrophil-mediated delivery of hybrid cross-species nanovesicles for treatment of bacterial infections
A practical method for determining the rate of covalent modification of fragments and leads
Designing an oxidase toolbox for site-directed oxidation of taxanes
Alternative antigen retention by a gp96-fusion approach induces long-lasting and broad immunity in mice
An open-source screening platform accelerates discovery of drug combinations
PhenoProfiler: advancing phenotypic learning for image-based drug discovery
Structural basis for pharmacotherapeutic action of triple reuptake inhibitors
Semi-inductive dataset construction and framework optimization for practical drug target interaction prediction with ScopeDTI
FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra
A randomized phase 2 clinical trial to treat moderate-to-severe plaque psoriasis patients with high-induction dosing of risankizumab
A hardware demonstration of a universal programmable RRAM-based probabilistic computer for molecular docking
De novo design of epitope-specific antibodies via a structure-driven computational workflow
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs
An astrocytic ensemble at vHip-NAc synapses modulates cognitive impairments induced by chronic tetrahydrocannabinol exposure
A resource to empirically establish drug exposure records directly from untargeted metabolomics data
Periodic asymmetric field enhances electrofusion of nanoscale lipid systems
Widespread Fab-arm exchange affects all endogenous serum IgG4
Temporal trends in evidence supporting novel drug target discovery
Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
Temporally resolved and interpretable machine learning model of GPCR conformational transition
NIR-IIb fluorescence ratiometric imaging of tumor-associated neutrophils for immunotherapy efficacy monitoring and strategy optimization
Enhancing kinase-inhibitor activity and selectivity prediction through contrastive learning
TAPB: an interventional debiasing framework for alleviating target prior bias in drug-target interaction prediction
Molecular basis of prostaglandin E reuptake by organic anion transporter PGT
Structural basis for MEKK2 dimerization and substrate recognition
Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation
Kinetically controlled hetero-fusion is a systems-level behaviour of polymer nanoparticle populations
Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion
Molecular Motif Learning as a pretraining objective for molecular property prediction
Highly efficient and long-acting split-and-mix proteolysis targeting chimera based on self-assembled polylactic acid
Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization
State-selective small molecule degraders that preferentially remove aggregates and oligomers
pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis
Bench-stable azidodifluoromethyl imidazolium reagents unlock the synthetic potential of carbonimidic difluorides
Improved analysis of in vivo drug combination experiments with a comprehensive statistical framework and web-tool
Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling
A large-scale human toxicogenomics resource for drug-induced liver injury prediction
Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation
Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance
PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors
Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22
Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis
Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor
Permeation enhancer-induced membrane defects assist the oral absorption of peptide drugs
Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation
Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9
Structural basis of drug recognition by human MATE1 transporter
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
AQuaRef: machine learning accelerated quantum refinement of protein structures
Ring expansion of bicyclo[1.1.0]butyl ketones to bicyclo[2.1.1]hexenes using ketone as both activating and reacting groups
Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A
Development of a genetic priority score to predict drug side effects using human genetic evidence
Extending quantum-mechanical benchmark accuracy to biological ligand-pocket interactions
Molecular mechanisms of SLC30A10-mediated manganese transport
Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes
Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy
Buffer optimization of siRNA-lipid nanoparticles mitigates lipid oxidation and RNA-lipid adduct formation
Chemical knowledge-informed framework for privacy-aware retrosynthesis learning
Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome
Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA
Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID
Organic-inorganic covalent selenium reversing ischemic reperfusion injury
Predictive design of crystallographic chiral separation
Crafting defects in two-dimensional organic platelets via seeded coassembly enables emergent molecular recognition
Harnessing free energy calculations for kinome-wide selectivity in drug discovery campaigns with a Wee1 case study
Target-aware 3D molecular generation based on guided equivariant diffusion
The π-trap approach for obtaining crystal structure data of inherently amorphous cluster compounds
Galloylated liposomes enable targeted drug delivery by overcoming protein corona shielding
Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics
Modular synthesis of CF-containing compounds with PhSOCFH reagent through difluoromethylene radical anion synthon strategy
Data-driven organic solubility prediction at the limit of aleatoric uncertainty
Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates
A retrospective analysis of combination therapy with GLP-1 receptor agonists and SGLT2 inhibitors versus SGLT2 inhibitor monotherapy in patients with MASLD
Chemistry-informed recommender system to predict optimal molecular receptors in SERS nanosensors
Cryo-EM structures of ρ1 GABA receptors with antagonist and agonist drugs
Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord
Simulations and active learning enable efficient identification of an experimentally-validated broad coronavirus inhibitor
Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI
Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor
A self-regulating shuttle for autonomous seek and destroy of microplastics from wastewater
De novo designed protein guiding targeted protein degradation
Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates
Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors
Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury
Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex
ColdstartCPI: Induced-fit theory-guided DTI predictive model with improved generalization performance
Clinical impact of pharmacogenetic risk variants in a large chinese cohort
Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control
Accelerating fragment-based drug discovery using grand canonical nonequilibrium candidate Monte Carlo
Identification of nanomolar adenosine A2A receptor ligands using reinforcement learning and structure-based drug design
A biomimetic multi-component subunit vaccine via ratiometric loading of hierarchical hydrogels
Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy
ToxACoL: an endpoint-aware and task-focused compound representation learning paradigm for acute toxicity assessment
SE(3)-equivariant ternary complex prediction towards target protein degradation
In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation
A genotype-to-drug diffusion model for generation of tailored anti-cancer small molecules
Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication
Boron-chalcogen heterocycles and linear tetraboranes from a cyclic tetra(amino)tetraborane
Optimizing enzyme inhibition analysis: precise estimation with a single inhibitor concentration
Bacterial membrane nanovesicles encapsulating prodrug assemblies combine chemical and immunological therapies for chronic bacterial infection
DeepDTAGen: a multitask deep learning framework for drug-target affinity prediction and target-aware drugs generation
A mild and practical approach to N-CF3 secondary amines via oxidative fluorination of isocyanides
Linker-free PROTACs efficiently induce the degradation of oncoproteins
Comprehensive evaluation of phosphoproteomic-based kinase activity inference
GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice
Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation
Tacrolimus dosing in liver transplant recipients using phenotypic personalized medicine: A phase 2 randomized clinical trial
Building a unified model for drug synergy analysis powered by large language models
Elucidation of the biosynthetic pathway of hydroxysafflor yellow A
Token-Mol 1.0: tokenized drug design with large language models
A self-conformation-aware pre-training framework for molecular property prediction with substructure interpretability
Time since last intravenous bisphosphonate and risk of osteonecrosis of the jaw in osteoporotic patients
BiDAC-dependent degradation of plasma membrane proteins by the endolysosomal system
Development and external validation of prediction algorithms to improve early diagnosis of cancer
Labels as a feature: Network homophily for systematically annotating human GPCR drug-target interactions
1
Real-time dynamic polygenic prediction for streaming data
7
Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes
Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial
Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide
Lifetime Benefits of Comprehensive Medical Therapy in Heart Failure with Mildly Reduced or Preserved Ejection Fraction
Clinical implementation of an AI-based prediction model for decision support for patients undergoing colorectal cancer surgery
Macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity
Effect of naltrexone pretreatment on ketamine-induced glutamatergic activity and symptoms of depression: a randomized crossover study
3
Cell-free immuno-profiling on a genetically programmed biochip
Nanofibrous supramolecular peptide hydrogels for controlled release of small-molecule drugs and biologics
A modular mRNA vaccine platform encoding antigen-presenting capsid virus-like particles enhances the immunogenicity of the malaria antigen Pfs25
1
Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus
1
Hypervariable loop profiling decodes sequence determinants of antibody stability
2
A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo
Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal
2
Ophthalmic Drug Shortages in the United States: Survey of the University of Utah Drug Information Service Drug Shortage Database
Special Report: Recommendations on Screening for Hydroxychloroquine Retinopathy (2026 Revision)
59
Fluorinative Cyclization of ortho-Diisocyanoarenes: One-Pot Synthesis of N-CF3 and N-CF2H Benzimidazoles
Exploring the Construction of a Fused-Ring Triazolopyrimidine Energetic Molecule
Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases
Modular Defluorinative Annulation Enabled by a Dearomative Rearrangement: Diversified Synthesis of Azaheterocycles
Base-Promoted Cascade Multicomponent Access to Azatrithiathiophthenes from Cinnamonitriles, Sulfur and Active Methylhetarenes
Denitrogenative Annulation of Benzotriazoyl Porphyrins: Synthesis of Diverse N-Heterocycle-Fused Porphyrinoids with Enhanced NIR Absorption
C(sp3)–F Bond Functionalization of Isoflurane with Complex Phenols for the Synthesis of CF2-Based (Deuterated) Aryl Ethers
Difluorocarbene-Promoted Regioselective Ring-Opening of Benzimidazoles
Chemistry for the Incorporation of S-Aryl Dithiocarbamates into a DNA-Encoded Library
Dual Strain-Release Cascade for Accessing sp3-Rich Azetidine–Bicyclopentane Frameworks Bearing Multiple Quaternary Carbon Centers
Truce–Smiles Rearrangement Cascade Enables Synthesis of Pyrazoline Derivatives
Denitrogenative C–C and C–X Coupling Reactions of a Carbohydrate Tethered [1,2,3]Triazolo[1,5-a]pyrazine: Access to Chiral 2,5-Disubstituted Pyrazines as Potential Hypoglycemic Agents
PPh3-Catalyzed Remote Aminofluorination Reactions: Regioselective Access to γ- and ε-Fluoroamines Containing Oxindole
Studies toward Pestalachloride B: Synthesis of the 6/7/6 Tricyclic Scaffold
One-Pot Synthesis of Isoindolinones Mediated by LiN(SiMe3)2/CsF
Construction of Heterocyclic-Triazolopyrimidine Framework for Energetic Compounds: High-Energy, Low-Sensitivity Explosives
Chromone–Thiocoumarin Transmutation Enabled by Lawesson’s Reagent
Stereodefined Synthesis of 3-Difluoromethyl-Benzoxaboroles: Novel Antimicrobials with Unlocked H-Bonding
Pyridine-Fused C25 abeo-Steroid Alkaloids from a Fungus: Biomimetic Semisynthesis and Anti-HIV Mechanistic Study
Synergistic Fluoroalkyl and Electron-Rich Vinyl Units for Ionizing Radiation-Induced Cross-Linking
HFIP-Mediated (3+2) Annulation of Bicyclobutanes with Indolyl Alcohols for Diastereoselective Access to Tetracyclic Spiroindolenines
Accessing α-Ketoamides on DNA through a Coupling–Oxidation Strategy
Base-Promoted [4 + 3] Cycloadditions Enabling the Construction of Polycycle-Fused Uracils from N-Aminoisoquinolinium Derivatives
Rhodium(III)-Catalyzed Three-Component Diamination of Bicyclo[1.1.0]butanes via Nitrene Transfer
B(C6F5)3-Catalyzed Dearomative [2π+2σ] Cycloaddition of 1-Naphthols with Bicyclo[1.1.0]butanes
Synthesis of Fused Azole-Pyridazine/Pyrimidine and Imino-Bridged Pyrazole-Based Energetic Materials via Property Tuning and Skeletal Editing
Construction of Benzothiophene-Fused 1,2,4-Triazocines via a Skeletal Editing Strategy and DFT Study on the Reaction Mechanism
Mechanistic Insights into the Regioselective Defluorofunctionalization of Trifluoromethylanilines via Photocatalytic SET: A Combined Experimental and Computational Study
Modular Synthesis of Diverse gem-Difluoroalkenes from Trifluoroacetic Anhydride via Phosphorus-Assisted Fluoride Elimination
On-DNA Synthesis of β-Sulfonyl-α,β-Unsaturated Carbonyl Scaffolds via Hydrosulfonation of Alkynylcarbonyl Compounds
On-DNA Synthesis of 2-Hydroxy Dithiocarbamates
Difluorocarbene as a Dual C1/CF2 Source for HCF2S Heterocycle Synthesis
Metal-Free, Photoinduced On-DNA Synthesis of β-Hydroxy Sulfides
Visible-Light-Induced Monofluoromethylation of Styrenes
Scalable Transannular Bromocyclization Approach to Functionalized Bis-Heterobicyclo[3.n.1]anes
SN2′-Type Difluoro- and Perfluoroalkylation of gem-Dichlorocyclobutenones Mediated by (DMPU)2Zn(Rf)2
On-DNA Deoxygenative C(sp2)–C(sp3) Coupling Facilitated by Surfactant–DNA (Surf-DNA) Workflow
Generation [via Tetradehydro-Diels–Alder Reactions] and Reactivity of 6-Fluorocyclohexa-1,2,4-triene Intermediates
Palladium-Catalyzed [4+1] Cycloaddition of 3,3-Difluoropent-4-en-2-ones with Amines: A Modular Approach to 3-Fluoropyrroles
Palladium-Catalyzed Cascade Transformations of 1,4-Diyn-3-yl Carbonates to Construct Cyclobutane-Embedded Frameworks
Enantioselective Synthesis of α-Aryl-α-fluoroketones by CPA-Catalyzed Desymmetrization of 1,3-Indanediones
Lanosdracaenin A and (±)-Neodracaflavonoids A, Triterpenoid and Flavonoids with Anti-Inflammatory Activities from Dracaena cochinchinensis
Surf–DNA-Enabled DNA-Encoded Library-Compatible Amino Radical Transfer C(spsup2/sup)–C(spsup3/sup) Coupling
Subtle Strain-Release-Driven Aroylation of Four-Membered Rings via Decarboxylative Giese-Type Reactions
Light-Induced and Strain-Releasing Reactions of Bicyclo[1.1.0]butanes with Alkenes as a Route to Spirocyclobutanes
Sappanumols A−C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum
Controllable Defluorinative Cyclization for Divergent Synthesis of Pyrrolo[2,3-d]pyrimidines and Fluorinated Pyrimidines from β-CF3-1,3-Enynes and Amidine Hydrochlorides
Precise Modulation of BCB Reactive Sites via Lewis/Brønsted Acid Switching for the Synthesis of Spirocycles and Bridged Frameworks
General Approach To Access Aldehyde Oxidase Metabolites of Drug Molecules via N-Oxidation/Reissert–Henze-Type Reaction
Biosynthesis of Circumdatins Employs an Anthranilate Tailoring Pathway for NRPS Substrate Supplies
One-Pot Three-Component Cascade Strategy for the Site-Selective Synthesis of 5-Sulfenylated/Selenylated 2,4-Disubstituted Pyrimidines
Energy Transfer Mediated [2π + 2σ] Photocycloaddition of Bicyclo[1.1.0]butanes with Maleimides: Formation of Potential Bioisotere of Phthalimide
Visible-Light-Mediated Perfluoroalkylation/Thioetherification of [1.1.1]Propellane under Photocatalyst-Free Conditions
Synthesis of a 2,4,6,8-Tetraoxaadamantane-Based 3D Energetic Biocidal Agent via Stepwise Cyclization Strategy
Copper-Catalyzed Regio- and Enantioselective Hydroamination of igem/i-Difluoroalkenes to Access Chiral Difluoromethyl Amines
Metal-Catalyzed Fluoroacetyl Carbene Transfer from Sulfonium Salts
Initial Investigation of the Direct Incorporation of the 1,1,2-Trifluoroethyl Substituent into Organic Compounds
A General Medium-to-Large Sized Ring Synthesis Enabled by Copper-Catalyzed Difluoroalkylamidation Cyclization of Alkynes
Photoexcited Copper-Catalyzed Intramolecular [2+2] Cycloaddition To Construct Bicyclo[3.2.0]heptanes
1
Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
1
Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans.
6
SGLT2 inhibitors, GLP-1 RAs, and DPP4 inhibitors and the risk of hypomagnesemia in type 2 diabetes: A target trial emulation
Leukemia in users of contemporary hormonal contraception: A nationwide registry-based cohort study among premenopausal women in Denmark
The benefits and risks of maternal RSV vaccination on mortality in South Africa: A modeling study
Association between proton pump inhibitor use and upper gastrointestinal cancer: A matched case-control study accounting for reverse causation and confounding by indication
Pediatric studies and labeling additions required by the U.S. FDA for novel drugs approved from 2011 to 2023: A retrospective cohort study
The comparative effectiveness and safety of fluticasone-salmeterol via metered-dose versus dry powder inhalers for COPD: A new user cohort study
7
Salvia miltiorrhiza-Derived Vesicle-Like Nanoparticles Functionalised Hydrogel With Excellent Ability of Oxidative Stress Modulation and Anti-Cardiomyocyte Apoptosis for Sepsis-Induced Myocardial Injury
Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum
<atl>A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in iArtemisia capillaris/i</atl>
Resurrected Ancestral Cannabis Enzymes Unveil the Origin and Functional Evolution of Cannabinoid Synthases
Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum
Characterisation of Early Biosynthetic Steps of Atractylon via an Integrative Strategy
N6-methyladenosine RNA modification regulates light intensity-dependent terpenoid biosynthesis in Schizonepeta tenuifolia
49
The identification of potent nonopioid analgesics and their potential for perioperative use
Energetics of biomolecular shells in core–shell nanocomplexes
Targeted degradation of c-Myc through the midnolin–proteasome pathway
AI-derived therapeutic development of a serotonin receptor–targeting drug for the treatment of opioid use disorder
Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapies
Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases
Fab–Fc and Fab–Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG1 antibodies
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models
DeepDegradome: A structure-aware deep learning framework for PROTAC and ligand generation against protein targets
Opioid-specific brain connectivity dynamics distinguish analgesia from secondary effects: Studies in male mice
Mechanical performance of hybrid polymer–lipid vesicles with leaflet asymmetry engineered using microfluidics
Med14 phosphorylation shapes genomic response to GLP-1 agonists
Neutralization of acyl-CoA-binding protein attenuates glucocorticoid-mediated suppression of cancer immunosurveillance
Extended local anesthesia enabled by flavonoid permeation enhancers
Lipoprotein diffusion in dense yolk plasma is governed by softness, hydrodynamics, and caging: Insights from MHz-XPCS
Enhanced screening via a pure DNA-encoded peptide library enabled by an Fmoc modification
Molecular assemblies and pharmacology of cerebellar GABAA receptors
Neuron-specific modulation of SLC30A10 identifies dopaminergic and glutamatergic neurons as targets of manganese-induced motor disease
A cytokine receptor–targeting chimera toolbox for expanding extracellular targeted protein degradation
Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium
Cannabis produces acute hyperphagia in humans and rodents via increased reward valuation for, and motivation to, acquire food
Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection
Therapeutic hypothermia reprograms nanocarrier protein corona via apolipoprotein C1 enrichment for precision cardiovascular therapy
Modulating antigen processing through metal–organic frameworks to bias adaptive immunity
Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy
From sequence to scaffold: Computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks
A multivalent nanobody–drug conjugate to prevent and treat influenza virus infections
Dibromocarbene addition to bicyclo[1.1.0]butanes: A facile route to substituted bicyclo[1.1.1]pentanes
Accessing robust vaccine coformulation stability by single adjuvant detection on a microelectrode
A generalizable deep learning framework for structure-based protein–ligand affinity ranking
BTK autoinhibition analyzed by high-throughput swaps of SH2 domains
Manifold-constrained nucleus-level denoising diffusion model for structure-based drug design
Graph neural networks for predicting metal–ligand coordination of transition metal complexes
Ultrasmall inorganic nanoparticles repair damaged meningeal lymphatic vessels to boost Parkinson’s disease therapy
Influence of the protein corona on hematopoietic stem and progenitor cell uptake and macrophage clearance of membrane-wrapped nanoparticles
Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus
Φ value analysis underscores strong functional and structural compactness of the GABAA receptor
Topology and kinetic pathways of colloidosome assembly and disassembly
Manipulating anthracyclines for deeper tissue penetration and implications for glycolytic tissues
Discovery and development of an oral analgesic targeting the α2B adrenoceptor
Accelerating countermeasure candidate discovery for A-series chemical warfare agent exposure
Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants
Optimization of a sarbecovirus llama nanobody–antigen binding interface via a combined computational and phage display protein engineering approach
Total synthesis and biological activity of “carbamorphine”: O-to-CH2 replacement in the E-ring of the morphine core structure
Testicular somatic and germ cell maturation during rhesus macaque development
Sequential drug release system: Targeting the tumor ECM for enhanced chemotherapy efficacy
Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling
Framework to identify innovative sources of value creation from platform technologies
Shared host genetic landscape of respiratory viral infection
2
Assessing Drug-mediated Inhibition of Liver Transporter Function with MRI: A First-in-Human Study.
Multiparametric MRI Evaluation of Liver Fat and Iron after Glucagon-like Peptide-1 Receptor and Glucagon Receptor Dual-Agonist Treatment in a High-Fat Diet-induced Mouse Model.
7
A high-throughput selection system for fast-acting covalent protein drugs
A unified platform for nucleoside analog synthesis
Deep contrastive learning enables genome-wide virtual screening
Conformational landscape adaptations enable processive phosphorylation by Src family kinases
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
47
Pulmonary neuroendocrine cell–derived exosomes regulate iron homeostasis and oxidative stress in lung neurons
Mechanistic insights into the therapeutic properties of delta opioid receptor
Transforming cisplatin into targeted photothermal chemotherapeutics through the platinum-phosphate coordination within a hyaluronan nanogel
Universal progression of structure and dynamics in colloidal nanocrystal gels during salt-accelerated aging
Preclinical development of a well-defined semisynthetic glycoconjugate vaccine against Haemophilus influenzae type b
Assessing the health risks of rice cadmium content standards in China
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia
The allosteric landscape of the Src kinase
Single-molecule localization microscopy reveals the molecular organization of endogenous membrane receptors
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
Oxidation-activated nanotherapy boosts tumor immunity and disrupts tumor-nerve crosstalk to combat bone metastases and cancer pain
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers
AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications
Nickel-catalyzed radical relay enabled chemoselective fluoroalkyl-borylation of [1.1.1]propellane under kinetic control
A softness zwitterionic micelles efficiently deliver inhaled nintedanib by enhancing airway mucus penetration
Scalable manufacturing of multifunctional insect wing membrane via interfacial lase-and-peel strategy
Fluidic microgel assemblies with enhanced oral delivery of biologics alleviate colonic inflammation in murine and canine models
Tumor microenvironment–targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors
Activating PEG host to enable spatially controlled surface functionalization of nanocarriers for biomedical applications
A gastric retentive robotic capsule enables emergency-prepared and responsive oral drug delivery in canine models
A unique mechanism involving cocatalysis of enzyme and nonenzyme to form β-carboline and spirotryprostatins in Aspergillus fumigatus
Padlock-designed MOFs triggers an “avalanche effect” to enhance apoptosis and suppress metastasis in central nervous system lymphoma
Site-specific adaptive nanovesicles for oral insulin delivery
A microneedle device for rapid dermal interstitial fluid sampling
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion
Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines
Lipid nanoparticles for mRNA delivery in brain via systemic administration
Insights into angiosperm evolution and lineage-specialized lignan biosynthesis from the early-diverging Schisandra genome
Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance
A closed-loop bioelectronic patch for intelligent blood pressure management
Machine learning-assisted exploration of multidrug-drug administration regimens for organoid arrays
Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption
Dual-phoretic wireless device for directionally oriented and carrier-free targeted drug delivery
Developmental Pb exposure increases rate of forgetting on a delayed matching-to-sample task among Mexican children
Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy
Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models
Negative chemical data boosts language models in reaction outcome prediction
Lipid droplet–enriched luminogens enable adoptive macrophage transfer for treatment of bacterial sepsis
Precision-controlled sequential drug release via electrochemical corrosion of liquid metal nanoparticles
Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning
Development of a targeted oral pharmacologic duodenal exclusion therapy for the treatment of metabolic diseases
Intestinal L-cell mechanoreception regulates hepatic lipid metabolism through GLP-1
Macrophage hitchhiking nanomedicine for enhanced β-elemene delivery and tumor therapy
Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis
Cellular determinants influence the red blood cell adsorption efficiency of poly(amine-co-ester) nanoparticles
12
Neutrophil-mediated delivery of antibiotics across the tympanic membrane for otitis media treatment in a preclinical model
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective
Single–amino acid variants in target epitopes can confer resistance to antibody-based therapies
Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs
S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models
Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient
Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis
Core-shell microcapsules compatible with routine injection enable prime/boost immunization against malaria with a single shot
Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion
Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models
Anti-inflammatory, but not lipid-lowering, activity of hepatocyte PPARα improves atherosclerosis in Ldlr-deficient mice
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry
5
Benzodiazepine or Z-hypnotic use during pregnancy and risk of psychiatric disorders in children: population based cohort study
Adherence to legislation and recommendations to publicly post protocols and results of post-authorisation studies registered with European Medicines Agency: cross sectional study
Long term use of proton pump inhibitors and risk of stomach cancer: population based case-control study in five Nordic countries
Oral contraceptives with progestogens desogestrel or levonorgestrel and risk of intracranial meningioma: national case-control study
Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial
2
Molecular requirements for PLK1 activation by T-loop phosphorylation
Structural insights into selective and dual antagonism of EP2 and EP4 prostaglandin receptors
1
Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation
12
Enantiomer-Specific Nucleation Phase Selection under Nonequilibrium Optical Trapping
Coupled Orientational Disorder and Hydrogen-Bond Destabilization Drive Anisotropic Surface Melting in Curcumin Polymorphs
META-Tox: Multiview Ensemble with Topological Aggregation for Robust In Vivo Toxicity Prediction
Molecular Representation Matters: Comparative Evaluation of Fingerprints, RDKit Descriptors, and Hashing Effects
Dual-Path Global Awareness Transformer for Optical Chemical Structure Recognition
Machine Learning Accelerates Discovery of High-Performance Corrole Photosensitizers for Optical Imaging Diagnosis and Photodynamic Therapeutics of Nasopharyngeal Carcinoma
Multimodal Machine Learning for Molecular Identification Based on IR, Raman, and NMR Spectra
Biophysical Descriptors of Nanoparticle Protein Coronas
Manipulating the Aggregation of Phenoxazine-Modified Helical Boron-Dipyrromethene to Enhance Singlet Oxygen Generation for Efficient Tumor Therapy
LumiCharge: Spherical Harmonic Convolutional Networks for Atomic Charge Prediction in Drug Discovery
Multiple Molecule λ-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations
Interpretable Multimodal Deep Ensemble Framework Dissecting Bloodbrain Barrier Permeability with Molecular Features
6
Efficacy and safety of rocatinlimab for the treatment of moderate-to-severe atopic dermatitis in ROCKET-IGNITE and ROCKET-HORIZON: two global, double-blind, placebo-controlled, randomised phase 3 clinical trials
Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study
Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis
Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial
2
Efficacy and safety of cAMP-biased GLP-1 receptor agonist ecnoglutide versus dulaglutide in patients with type 2 diabetes and elevated glucose concentrations on metformin monotherapy (EECOH-2): a 52-week, multicentre, open-label, non-inferiority, randomised, phase 3 trial
Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial
2
Adverse drug reaction reporting with the Med Safety app in Uganda: a cluster-randomised, controlled trial
Development, launch, and scale-up of health products in low-income and middle-income countries: a retrospective analysis on 59 health products
2
Candesartan versus placebo for migraine prevention in patients with episodic migraine: a randomised, triple-blind, placebo-controlled, phase 2 trial
Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study
1
Oral contraceptive use and risk of liver cancer: a population-based study, systematic review, and meta-analysis
4
Association between GLP-1 receptor agonist use and worsening mental illness in people with depression and anxiety in Sweden: a national cohort study
The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis
Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK
Pharmacological treatment of anxiety in older adults: a systematic review and meta-analysis
7
A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide
Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis
Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague
Ivermectin to Control Malaria — A Cluster-Randomized Trial
Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight
4
Assessment of macrolide resistance in the respiratory tract of preterm-born infants during treatment with azithromycin in the AZTEC clinical trial
Cardiopulmonary exercise testing before lung resection surgery: still indicated? Evaluating predictive utility using machine learning
Identifying azithromycin responders with an individual treatment effect model in COPD
Effect of viloxazine and trazodone in obstructive sleep apnoea: a randomised, placebo-controlled, cross-over study
5
Graph neural network-based prediction and interpretation of Daphnia toxicity using distinct scale molecular representations
Cross-modal attention deep learning reveals how transformation products inherit life-cycle risks from parent antibiotics: Insights for environmental, ecological, health, and AMR risks
Screening toxic transformation products of emerging pollutants in advanced oxidation processes with 3D deep learning and in vitro assays
Insights into the effect of sertraline on anaerobic digestion: stimulating CH4 and CO2 production
Evaluating dextrorphan as a wastewater biomarker for cough suppressant use:A longitudinal study in China

Numerical information only (in the tables above) is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International.