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The role of ion coordination environments in influencing metal-ion redox potentials has remained elusive for electrochemical systems. Now it has been shown that the hard/soft character of coordinating ions shapes the electrostatic potential of metal ions, enabling substantial shifts in redox potential and offering a handle for rational electrolyte design.

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non-canonical nuclear metabolic roles in cancer.

Neogene lithium isotope records from the Tibetan Plateau suggest that silicate weathering in mountain ranges may not persistently contribute sufficient lithium into the ocean to regulate seawater lithium isotope evolution

Breast cancer (BC) is the most common malignancy in female patients with Li-Fraumeni Syndrome (LFS). Here, the authors perform a multimodal analysis of LFS breast cancer (LFS-BC) compared to sporadic premenopausal BC, finding important differences in genomic alterations and instability, gene regulation, and the immune microenvironment.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Immune checkpoint inhibitors combined with chemotherapy have demonstrated significant benefits in treating triple-negative breast cancer (TNBC). In this study, the authors present results from a randomized phase II trial evaluating the platinum-based and DNA-damaging agent carboplatin in combination with nivolumab in patients with metastatic TNBC.

The authors compare standard and personalized genome references across multiple assays and find that genome choice has modest effects but can reveal biology missed by standard references, including hidden DNA methylation at non-reference elements.

PDS5B, a cohesin regulatory protein, is shown to bind DNA and enhance the RAD51 recombinase in the promotion of DNA strand exchange and protection of DNA from MRE11 RAD50-NBS1. Here the authors use biochemical and cellular analyses to reveal that DNA binding by PDS5B is essential for DNA damage repair and the preservation of stressed DNA replication forks.

Programmed cell death receptor-1 (PD-1) has been implicated in thymic regulation of T cell development and function. Here, the authors characterize CD8⁺ T cell development in PD-1–deficient mice and show that PD-1 constrains the emergence of an effector-like program during thymic development, thereby shaping peripheral T cell responses and exhaustion in tumours.

Results from integrative population-based investigations indicate co-occurring types of clonal hematopoiesis are highly enriched and markedly increase blood cancer risk, highlighting new opportunities for early detection and targeted surveillance of high-risk individuals.

Chemically induced dimerization (CID) systems allow control over cellular processes. Here, the authors present a proof-of-principle demonstration that a complete CID system can be de novo designed, reporting a designed ligand and protein pair where a protein homodimer is induced by a macrocyclic peptide.

Accurately measuring the chirality of carbon nanotubes is a challenge in the absence of pure reference samples. Here, the authors combine hyperspectral imaging and chiroptical spectroscopy to quantify enantiomeric purity without having to rely on such standards.

Alexis Maurel and colleagues report 3D printable gel polymer electrolytes for Li-ion batteries using vat photopolymerization. The 3D printed materials show high ionic conductivity, stable cycling, and can be fabricated into complex geometries.

In drug-resistant temporal lobe epilepsy, thalamo–cortical synchrony in the first 20 seconds after seizure onset is stronger in clinical than electrographic seizures, highlighting network engagement as a key driver of seizure symptoms.

Advancing Li-CO₂ systems as a sustainable alternative technology requires a deep understanding of the reaction mechanisms. Here, authors establish a controlled supply of O₂ in Li-CO₂ batteries as a strategy to increase performance and reveal the distinct reaction pathways under CO₂ and CO₂/O₂ gas.

Molecular precursors containing V, Bi and Zn are thermally transformed into oxide materials. Detailed studies reveal and characterise the formation of amorphous intermediates, a new kinetic polymorph of BiVO₄, and incorporation of Zn dopants.

Stainless steel dissolution limits the use of lithium bis(fluorosulfonyl)imide in battery electrolytes. Here, authors reveal a Cl- and FSI- anion-driven dissolution mechanism and introduce lithium difluoro(oxalato) borate, resulting in stable long-term cycling in the considered cells.

SUCCEED is a supervised multi-task DNA foundation model pretrained on 6,389 ENCODE tracks. It integrates CNN and Transformer architectures to model local motifs and long-range dependencies, enabling prediction of genomic regulatory features across tasks and cell types.

Lithium||sulfur batteries are limited by sluggish solid-state sulfur conversion. Here, authors investigate spin-state transitions as a key kinetic barrier and design a spin-regulated catalyst that accelerates sulfur conversion, suppresses polysulfide shuttling, and enables high-capacity pouch cells.

Second-line CAR T cell therapies have become standard-of-care treatments for relapsed or refractory large B-cell lymphomas (LBCL). However, real-world evidence on the efficacy and immunological phenotypes is limited. Here, the authors present a retrospective single-center study of 64 patients treated with axi-cel or liso-cel and report efficacy and safety readouts. By performing immunophenotypic analysis on samples from apheresis and post CAR T cell infusion, the authors also investigate how the magnitude of CAR T expansion and early phenotypic features influence persistence and therapeutic outcomes.

Triticum urartu is the diploid progenitor of polyploid wheat A subgenome. Here, the authors report an improved genome assembly of T. urartu and uncover a lipoxygenase gene that shapes T. urartu gene pools and their contributions to polyploid wheat A subgenome by regulating growth-defense trade offs.

Nanofluidic technologies require precise control of ion and molecular transport at the nanoscale, yet existing fabrication methods face limitations in cost, scalability, and programmability. Authors demonstrate the use of self-grown fungal mycelium to create adaptable nanofluidic devices that exhibit significant ion transport capabilities.

Retroelement transcripts-derived double-stranded RNAs (dsRNAs) can trigger innate immune responses in cancer through a process known as viral mimicry. Here the authors show that METTL3, the writer of m6A modification, regulates the abundance of steady-state dsRNAs and it could be targeted together with DNA methyltransferases to enhance viral mimicry in colorectal cancer therapy.

The role of lumen acidification during endosome maturation has been unclear. Here, the authors show that proton efflux via a Na+/H+ exchanger is detected by a pH-sensitive Rab GAP, which promotes endosome maturation, supporting inside-out proton signaling and linking efflux to neural diseases.

One bacterium can produce many ribosomally synthesized and post-translationally modified peptides (RiPPs) from different families. Here, the authors show how two closely related RiPP families in Bacillota co-evolved to exclude non-cognate precursor peptides, preventing biosynthetic pathway interference.

Cation identity and concentration influence electrocatalytic reactions, yet the origin remains debated. Here, the authors report a theoretical framework showing how cations modulate interfacial electrostatics and water dissociation kinetics, explaining multiple inversions of cation-dependent activity trends in alkaline hydrogen evolution reaction.

Although lithium–sulfur batteries are prized for their sustainability, practical energy densities are often limited by heavy host materials. The authors report a graphdiyne architecture that integrates anchoring and catalytic functions, enabling ultrahigh sulfur loading and exceptional energy densities, even in pouch-cell configuration.

Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of HSC lineage bias.

Immune dysfunction is implicated in bipolar disorder, but mechanisms are unclear. Here, the authors map epigenomic changes in peripheral blood from patients with bipolar disorder and link them to genetic risk and regulatory networks, revealing new disease mechanisms, patient subtypes, and potential therapeutic targets.

Fast-charging and slow-discharging operation of lithium metal batteries is limited by ion depletion and uneven charge transfer. Here, authors present a (difluoromethyl)trimethylsilane diluent with a large electrostatic potential difference to stabilize long cycling under 6 min fast charging.

In this work, the luminescence performance of oxide phosphors was significantly improved and tuned through a vitrification followed by crystallization protocol. This enabled the fabrication of a high-power solid-state lighting device.

The spread of carbon neutrality pledges calls for robust estimates of their agricultural and economic impacts. Using an integrated assessment framework that links climate, atmospheric chemistry, agriculture and economic modules, this study shows that accounting for ozone increases the estimated crop and economic benefits of these pledges.

In Li-mediated electrochemical N₂ reduction to ammonia, selectivity and activity are governed by the solid electrolyte interphase (SEI). This study reveals how the applied potential shapes the SEI properties and composition, thereby influencing reaction performance.

This study reports a paralog-selective p300 degrader with potent anti-cancer activity in hematological malignancies, demonstrating a strategy to selectively target transcriptional coactivators through protein degradation.

This study reconstructs Earth’s temperature over the past 539 million years by integrating rock chemistry and climate models, showing that global temperatures remained within ~10–30 °C, challenging ideas of anomalously high early Paleozoic climates.

Using pear as a study system, the biosynthetic pathway of acetophenones has been elucidated: naturally impaired side-chain shortening of aromatic 3-ketoacyl-CoAs leads them to undergo hydrolysis, followed by decarboxylation, to yield acetophenones.

A photolithographic fabrication process can be used to create soft and stretchy organic electrochemical transistor arrays that have a density up to 10,000 devices per square centimetre, and can perform edge computing tasks in wearable devices and soft robots.

Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

Using an industry-compatible and tunable oxygen-incorporated technique to heal defect states, p-type monolayer tungsten diselenide transistors can be created with a hole mobility of 137 cm²V⁻¹ s⁻¹ and a contact resistance of approximately 560 Ω µm at room temperature.

The gut microbial-derived metabolite HMB induces hepatic SNHG9, which suppresses MYC translation via IMP2, thereby derepressing MAS expression. MAS promotes protective autophagy, and HMB supplementation mitigates acetaminophen-induced liver injury.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

High-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe identifies SNOR protein, which binds to ribosomes during dormancy induced by glucose depletion, priming them for rapid reactivation of protein synthesis upon glucose repletion.

Autophagic activity has a protective role in Alzheimer’s disease in mice. Here the authors investigate the role of autophagy-initiating protein ULK1 and report that its overexpression stimulates autophagic flux, reduces amyloid and tau pathology and delays cognitive decline.

Here they show that NELFA is critical for human naïve pluripotency and can drive cells into an 8C-like state that expresses zygotic genome activation genes, offering valuable insights into early human embryogenesis.

Lithium sulfides have been previously investigated as 1 V anodes for Li-ion batteries, but suffered from significant performance issues. Here, the authors report on a 1 V lithium sulfide electrode with noteworthy performance, demonstrating that sulfide-based electrodes may merit further exploration.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

The authors present measurements of magnetotropic susceptibility in UTe2, a quantity that is sensitive to magnetic susceptibility in a direction transverse to the applied magnetic field. At high magnetic fields, they observe a large increase in the transverse magnetic susceptibility, likely arising from ferromagnetic spin fluctuations

CD19-specific chimaeric antigen receptor (CAR) T cell therapy has recently been evaluated for the treatment of systemic sclerosis (SSc). Here, the authors use multiomic analyses to demonstrate that CD19 CAR T cell treatment promotes skin tissue remodeling in patients with SSc.

The properties of metal–organic framework glasses can be modulated by additives, but understanding how they modify the glass network is challenging. Now, alkali-modifier sites in MOF glasses have been identified, and the impact of both modifier content and identity on the processing temperatures and hierarchical porosity has been examined.