Search

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?

New research shows that an extended autoantibody repertoire is associated with adverse clinical outcomes in patients with rheumatoid arthritis. Testing for rheumatoid factor and antibodies against citrullinated proteins is now routine in the evaluation of patients with rheumatoid arthritis; should this testing be extended to include other classes of autoantibody?

Pilcher et al. present a single-cell transcriptomics-based immune atlas of participants with newly diagnosed multiple myeloma, reporting on the association of cell types, gene expression and intercellular interactions with disease progression phenotypes.

Despite improving therapeutic options, the prognosis for patients with metastatic castration-resistance prostate cancer (mCRPC) remains poor. Here, the authors identify MCL1 copy number alterations as a prognostic and predictive biomarker, demonstrating its therapeutic potential as a drug target, either alone or in combination, in patients with mCRPC.

Only 9.5% of the country’s engineering graduate programmes have voluntarily adopted minority-inclusion initiatives over the past few decades.

Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to peripheral receptor changes.

The authors develop a high-resolution model of coral larval dispersal for the southern Great Barrier Reef. They show that 2 °C of warming decreases larval dispersal distance and connectivity of reefs, hampering post-disturbance recovery and the potential spread of warm-adapted genes.

The co-crystal structure of VSGsur with the trypanocidal compound suramin directly links the binding of the drug to the resistance phenotype displayed by strains of Trypanosoma brucei expressing VSGsur. Therefore, VSGs can have a function beyond that of antigenic variation.

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

The presentation of viral antigens to T cells via the MHC molecules is a critical component of the host response to viral infection. Here the authors suggest SARS-CoV-2 possesses the immune evasion strategy against the MHC class I pathway by targeting key transcriptional regulators.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Double fertilization in flowering plants produces both the embryo and the endosperm that is going to nourish it, forming a seed. Development of the endosperm is triggered by auxin production, derepressed by an epigenetic pathway after fertilization.

An assay-based laboratory study that defines precompetency durations of 2 – 6 days and compares settlement preference amongst common inducers, for 25 Scleractinian Indo-Pacific coral species.

Long-term characterisation of SARS-CoV-2 antibody kinetics is needed to understand the protective role of the immune response. Here the authors describe antibody levels and neutralisation activity in healthcare workers over seven months and investigate the role of immunity to endemic human coronaviruses.

Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

In this work, authors utilise comparative transcriptomics to reveal lncRNAs that distinguish pathogen-specific from core macrophage responses. They identify a Q fever-specific AHR-regulated CYP1B1-AS1/CYP1B1 axis that modulates mitochondrial homeostasis and survival of Coxiella burnetii.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Analysis of the conidial surface proteome of the fungal pathogen Aspergillus fumigatus and three closely related species reveals factors important for evasion and modulation of host immunity

Human-induced pressure may alter the size structure of animal communities. Here, the authors investigate the impact of land use, non-native species and climatic variables on the body size structure of fish communities and fishery-associated ecosystem services in the Upper Paraná Floodplain.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

Wood density is a key control on tree biomass, and understanding its spatial variation improves estimates of forest carbon stock. Sullivan et al. measure >900 forest plots to quantify wood density and produce high resolution maps of its variation across South American tropical forests.

Transcriptome-wide association studies (TWAS) have identified colorectal cancer (CRC) susceptibility genes. Here, the authors combine two multi-tissue TWAS methods, Mendelian randomisation, and genetic colocalization to identify 37 likely causal CRC susceptibility genes.

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capillary–venous networks contribute to age-related hypoperfusion and white matter damage in mice.

The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting in regeneration.

Characterization of clinical isolates of the cryptic fungal pathogen Aspergillus latus revealed traits that distinguish it from other species. Steenwyck et al show that A. latus originated via allodiploid hybridization with both parental subgenomes actively expressed.

N⁶-methyladenosine is enriched in poly(A) tails of VSG transcripts in Trypanosoma brucei, and when lacking result in mRNA degradation.

Droplet microfluidic tools with single-cell resolution and high-throughput screening capacities remain scarce. Here, the authors propose NOVAsort, a next-generation droplet sorter that can discern droplets based on both size and fluorescence, which can overcome common problems with conventional sorters.

Genomic and epidemiologic analyses revealed that a novel reassortant viral lineage of the Oropouche virus, which has been circulating in the western Amazon region of Brazil for about a decade, is associated with the recent human outbreaks between 2022 and 2024.

Data from a variety of sources—including satellite, climate and soil data, as well as field-collected information on plant traits—are pooled and analysed to map the functional diversity of tropical forest canopies globally.

Most genetic studies have been done on European cohorts, which affects the efficacy of polygenic risk scores in non-European populations. Here, the authors demonstrate that a colorectal cancer PRS including Asian and European ancestries has improved performance over the European-centric PRS across racial and ethnic groups.

In patients with AIDS, urogenital tuberculosis presents both diagnostic and therapeutic challenges. In this Case Study, Figueiredo et al. present a 38-year-old man who was initially misdiagnosed as having a usual urinary tract infection. The authors use the patient to illustrate the unusual presentation and special treatment requirements of immunosuppressed patients with urogenital tuberculosis.

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences.

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Malnutrition is an increasingly recognized complication of chronic liver disease. In patients with cirrhosis, malnutrition increases morbidity and mortality, and patients who are severely malnourished before transplantation have a higher rate of complications and higher post-operative mortality. The authors of this Review consider the etiologies of malnutrition, methods used to assess nutritional status, and appropriate treatment strategies.