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Current tactile sensing solutions face challenges in excessive wiring, high energy demands of AI computing, and limitations in scalability and parallel processing. Here, the authors present a neuromorphic tactile system combining artificial skin and spiking hardware encodes touch with high accuracy at low power.

The relationship between physical activity and mortality has not clearly emerged from lifestyle intervention trials. In this post hoc trial analysis, the authors show that a three-year physical activity-based counseling intervention in people with type 2 diabetes was associated with a ~ 50% reduction in long-term mortality.

Plasma extracellular vesicles contain quantifiable amounts of TDP-43 and full-length tau, allowing the accurate assessment of pathology in frontotemporal dementia, frontotemporal dementia spectrum disorders and amyotrophic lateral sclerosis.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Human serum transferrin plays a crucial role in iron homeostasis, but its interaction with potential metallodrugs remains underexplored. Here, the authors solve the X-ray structure of an adduct between transferrin (Fe_C-hTF) and [V^V₂O₆]^2–, generated from a vanadium-based drug [V^IVO(acac)₂], showing that binding preserves the overall conformation of Fe_C-hTF.

Stress resilience is the maintenance of mental health despite adversity. Here, the authors show that how we typically evaluate adverse events is a key resilience factor and that improving it goes along with improved resilience.

UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

In the proof-of-concept phase 2 ROME trial, comprehensive genomic profiling followed by molecular tumor board evaluation and randomization of patients with metastatic solid cancer to receive personalized therapy or standard of care led to a significantly higher objective response rate and longer progression-free survival in patients who received personalized therapy.

Clinical studies have suggested that the therapeutic potential of polyclonal convalescent plasma is highest in the first days of symptoms. Here, the authors present results from a pooled analysis of two clinical trials in COVID-19 outpatients that did not provide conclusive evidence in favor of convalescent plasma.

Maldonado, Lopez-Hernandez, et al. use a matched case-control study to compare E. coli-infected patients with or without sepsis. Their analysis shows that the ST69 clone is associated with risk of sepsis development, and certain genetic factors such as adhesion genes papC and fdeC were associated with a protective effect.

In this longitudinal study, Bernasconi and colleagues explore the association of minor hallucinations and theta oscillations with the future occurrence of cognitive decline in patients with early Parkinson’s disease.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Unstable and harsh climates have been implicated as partial causes of Neanderthal demise. Here a speleothem palaeoenvironmental record spanning the Middle to Upper Palaeolithic transition attests to stable and moderate conditions in the Mediterranean during this time suggesting a more complicated picture than previously thought.

DOPA decarboxylase (DDC) in cerebrospinal fluid has great diagnostic potential for Lewy body disorders. Here, the authors report limited diagnostic potential of plasma DDC and a strong association with dopaminergic treatment.

Guidance on how to decarbonize the economy while limiting impacts on jobs and ensuring stability is scarce. Now a study finds that relying on a carbon tax alone falls short, whereas combining industrial regulations, subsidies and a modest tax is the most promising approach to achieve sustainable growth with green jobs.

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiation complex, revealing its dual polymerase interaction mechanism.

RNA repair helps bacteria survive antibiotic stress. Here, authors show that Rtc-driven repair causes cell-to-cell variation in resistance levels, revealing a potential form of heteroresistance, and identify key Rtc targets to enhance antibiotic effectiveness.

An ensemble of green industrial policies and targeted subsidies, coupled with a mild carbon tax, is the most promising strategy to support an orderly transition towards achieving the Paris Agreement targets. Such a policy package can be designed to have a neutral effect on public finances and boost job creation, while preserving economic stability and income growth.

Kidney involvement can be a serious complication of hematopoietic stem cell transplantation. In this Case Study, Fofi and colleagues describe a rare case of focal segmental glomerulosclerosis occurring as a complication of chronic graft-versus-host disease following peripheral blood stem cell transplantation.

Sediment supply to the Venice Lagoon is substantially reduced by flood barriers inhibiting storm-related sediment reworking and transport, according to observations through multiple storm events before and after barrier installation.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

X-ray crystal structures and mutational analysis of the Arp8 module of the yeast chromatin remodeler INO80 reveal its function as a linker DNA sensor required for nucleosome positioning.

In this work, the authors apply polymer models to reconstruct the 3D structure of the genome during SARS-CoV-2 infection and examine how the virus impacts key mechanisms of chromatin organization.