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Here the authors applied cryogenic time-resolved electron microscopy with rapid UV photolysis of a caged substrate to elucidate the catalytic mechanism of lipid-sugar transfer within the bacterial membrane by the glycosyltransferase GtrB.

The authors introduce a new spectroscopic technique for studying Higgs modes in superconductors and apply it to a cuprate superconductor. The method involves a soft quench of the Mexican-Hat potential, populating Higgs modes of different symmetries, which are then probed by non equilibrium anti-Stokes Raman scattering.

Forest ecotypes of deer mice have longer tails than prairie ecotypes. This study shows that this difference is adaptive and involves changes in six genomic regions, one of which is an allele-specific reduction in Hoxd13 expression that leads to tail elongation.

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

The Ton and Tol systems are bacterial energy-transducing complexes that use the proton motive force at the inner membrane to exert force on outer membrane proteins. Here the authors present the high-resolution cryoEM structures of the inner membrane engine part of these two complexes.

Nitrogen-doped fullerenes and carbon nanotubes have been produced, but the synthesis of nitrogen-doped buckybowls, is an unsolved challenge. Tanet al. report an enantioselective synthesis of triazasumanene, and show that nitrogen doping leads to deeper bowl structures than in all-carbon buckybowls.

Matrix viscoelasticity regulates cell behavior in a stiffness-dependent manner. Here, the authors reveal that the mechanosensitive channel Piezo1 transduces soft matrix viscoelastic cues, through a coordinated interaction with molecular clutch mechanisms.

This study proposes a contact-dominated, field-enhanced design for capacitive sensors, achieving high response, strong linearity, and high sensitivity over a broad range, demonstrating great potential for functionalized flexible electronics and artificial intelligence robotic applications

Bearing capacity, the ability of a surface to support applied loads, is a critical property in planetary exploration to understand a surface’s response to landing or roving. Here, the bearing capacity of the asteroid Didymos is estimated using DART images of suspected boulder tracks on its surface.

Cross-linked polymers with covalent adaptable networks are reprocessed under external stimuli at high temperatures which might deteriorate their performance. Here, the authors introduce carbon dioxide responsive ionic clusters into covalent adaptable polymer networks to facilitate the exchange of dynamic bonds providing materials with a rapid recycling and good mechanical performance.

The roles of extracellular RNAs present in bacterial biofilms are poorly understood. Here, Mugunthan et al. show that specific mRNAs associate with extracellular DNA in the matrix of bacterial biofilms, facilitating the formation of viscoelastic networks.

Different stimuli can induce dynamic changes in blood flow velocity, vessel diameter and permeability. Here the authors develop a multi-photon microscopy-based image analysis tool allowing the identification of vessels and the assessment of rapid changes in large vascular networks.

Europe is rapidly warming but summer days have cooled in North America. Shuman and Stefanescu find parallel patterns during North Atlantic cooling events in the past 8000 years. Similar underlying processes may explain regional differences today.

ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respectively, and both exhibit eQTLs that vary across world populations.

When stars like our Sun die, they expel their outer layers in a dramatic stellar wind. This study of an unusual chemical signature in one particular stellar wind reveals that the signature is due to the presence of a binary system whose components had a close approach around 200 years ago.

SpaceX’s Inspiration4 mission sent an all-civilian crew into orbit to study physiological, neurovestibular and neurocognitive changes in the astronauts and found that short-duration civilian space missions do not pose a major health risk.

Although the trivalent actinides are similar to the lanthanide series in terms of chemistry and bonding, their structures and properties can diverge significantly. Here, the authors report a series of complexes of the trivalent actinides Np(III) through Cf(III) along with their lanthanide counterparts using a polarizable non-innocent, sulfur-donor ligand.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

Species-specific gaze shifts with natural stimuli drive correlated spiking in retinal ganglion cells.

Tergaonkar and colleagues identify a noncanonical interaction between the NF-κB transcription factor family member p52 and the ETS family member ETS1. They find that the p52–ETS1 complex is required for splenic germinal center B cell formation and T cell-dependent antibody responses.

Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic potential of ‘Entotheonella’ symbionts, a talented producer taxon from microbial dark matter.

The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.

By carefully structuring and patterning a material, it is possible to introduce emergent properties that would otherwise not exist. These metamaterials have allowed the development of a wide variety of new optical properties. Here, Matsubara et al present a magnetic metamaterial, where spin-currents can be directed by tuning the polarization of the incident light.

Stereo images of gold nanoparticles in a pyramid shape are reconstructed from X-ray coherent diffraction patterns. Depth information is retrieved by computing disparity maps without a priori knowledge of the sample shape.

Rising demand for ruminant meat and dairy products in developing nations drives increasing GHG and ammonia emissions from livestock. Authors show here that only long-term adoption of global best-practice in sustainable intensification buffered by a short-term coping strategy of green-source trading can offer a way forward.

3D printing has potential in designing personalised scaffolds, but minimally invasive implantation is still challenging. Here, the authors report the development of a polyurethane material with temperature triggered shape memory and water triggered deformation that allows for transcatheter delivery.

Diabetic retinopathy is a major cause of blindness, yet ways to predict who will be affected remain limited. Here, the authors show that patterns of blood proteins can reveal disease mechanisms and enable powerful early prediction across diverse populations.

Standard approaches for identifying pleiotropic genetic variants may lead to spurious results. Here the authors present a new statistical method and show that it uncovers five genes linked to metabolites in METSIM participants, which were previously undetected by existing methods.

In Drosophila, the physical structure of the eye has a key role in the directional tuning of motion-sensitive neurons, showing how navigational behaviour is tightly associated with anatomy.

Tropical cyclones can occur concurrently in the same basins in clusters, potentially resulting in greater damage. Here the authors show that global warming causes a shift in hotspots of such clusters towards the North Atlantic.

The XPD/Rad3 helicase, YoaA-χ, helps resolve DNA damage in E. coli. Here, the authors show that single-stranded DNA binding protein (SSB) affects helicase activity in a substrate specific manner. Single molecule experiments show YoaA- χ can pull SSB along DNA while translocating

Multidrug-resistant (MDR) bacteria are a global health problem. In this work, the authors report an antimicrobial polymer that crosses the bacterial membrane and phase separates with intracellular nucleic acids, demonstrating efficacy against MDR bacteria in various murine models.

The transport behavior of the carriers residing in the lowest Landau level is hard to observe in most topological materials. Here, Liu et al. report a surprising angular dependence of the interlayer magnetoresistivity and Hall conductivity arising from the lowest Landau level under high magnetic field in type II Weyl semimetal YbMnBi₂.

Liccione et al. report the isolation and characterization of neutralizing antibodies targeting the spike protein of the endemic Alphacoronavirus HCoV-229E.

MetaSTAAR enables functionally informed rare variant association analysis in biobank-scale cohorts using an efficient, sparse matrix approach for summary statistic storage.

Here, the authors find that relative abundances of stress-sensitive gastrointestinal microbes at age 2 years predicts internalizing symptoms in middle childhood through altered emotion-related brain network connectivity.

A challenge of magnetically-actuated devices is to obtain different behaviours from each component under the same driving field. Here the authors tune the dipolar interactions between rotors to obtain different rotational behaviours when actuated by a magnetic field leading to complex collective dynamics.

This study reveals that over half of China’s steel units lack sufficient renewable energy for hydrogen-based direct reduced iron technology. Aggressive deployment would increase carbon emissions, economic costs, and water usage in the steel sector.

IP6 is a critical host cofactor for HIV-1 assembly and infectivity. In this study, the authors uncover the structural basis by which HIV-1 adapts to a deficiency in IP6 packaging through a G225R mutation at the C-terminus of the capsid protein.

Observations of the Faraday rotation towards pulsars in the halo globular cluster 47 Tucanae have been used to constrain the magnetic field strength in the Galactic halo, finding that it is unexpectedly strong.

Piezoelectric materials are used as sensors or actuators in many devices. Here, the authors demonstrate that semiconducting ZnO particles embedded into a Bi_0.5Na_0.5TiO₃-based matrix improve its piezoelectric properties, promising an alternative to presently used lead-based materials.