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Zero-field mobility has been an unreliable indicator to predict thick-film organic solar cell performance. Here, authors reveal that critical length is a decisive factor governing thick-film device performance and achieve maximum efficiency of 19.0% in 300-nm thick-film D18:L8-BO:BTP-eC9 devices.

Defect formation and phase instability remain critical challenges for perovskite/organic tandem solar cells. Jiang et al. address this by designing an additive to modulate the crystallization thermodynamics of wide-bandgap perovskite, achieving a record efficiency of 22.1% in a flexible cell.

How high-fat diet disrupts brain circuits that regulate food intake is unclear. Here, the authors show such a diet downregulates Hcn1 and Gad2 in lateral septum, which in turn disrupts circuit activity and promotes overeating and obesity in mice.

AI models consume growing amounts of energy. Here, the authors introduce a brain-inspired way to prune connections in randomly weighted resistive-memory chips, boosting accuracy while avoiding costly analog tuning to improve general efficiency and reduce power use.

Researchers report a spontaneous method that produces chlorine directly from chloride-containing brines by harnessing their inherent osmotic energy and chloride ions, without any external energy input.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Cryo-electron microscopy structures of the bile acid transporter OSTα–OSTβ, which has a key role in bile acid homeostasis, provide insight into its distinct architecture and mechanism of substrate translocation.

China’s crowded coasts must balance seafood demand with conserving migratory shorebirds that rely on tidal flats along the East Asian–Australasian Flyway. This study suggests that well-managed mariculture feeds shorebirds and limits overharvest, benefiting seafood production and biodiversity.

A chromosome-level Bactrian camel genome and multi-omics comparisons reveal adaptive evolution and convergent selection in desert ungulates, highlighting lipid/sterol metabolism—especially INSIG1—as a key driver of metabolic flexibility for desert survival.

Wang, Chu, Chen, Wei and colleagues discover a subset of tumour-associated macrophages expressing SLC2A1 whose spatial proximity to CD8⁺ T cells drives resistance to anti-PD-L1 treatment in non-small-cell lung cancer.

A heat-shrinking method—in which semi-liquid metal-based circuits are printed on thermoplastic films that subsequently shrink and wrap around a target object when mildly heated—can be used to create conformal electronics on various substrates, including plants and skin.

This study investigates the mechanisms underlying the operation of graphene-based potassium ion-filled-channel transistors by ab initio molecular dynamics simulations. Graphene electrons are found to enable long-range correlation of confined ions, which provides a basis for the sensitive response of transistors to the channel ion density.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

An analogue memory built from a two-dimensional material with antimony contacts enables very high, energy-efficient in-memory searches and k-nearest-neighbour classification, offering a scalable, low-power hardware platform for real-time edge artificial intelligence applications.

Symmetry breaking is key to numerous notable effects, for instance, the emergence of a Rashba interaction at interfaces between two materials. Here, Zhang, Ding, and coauthors succeed in breaking in-plane mirror symmetries via crystallographic engineering, and observe a giant non-linear Hall effect and current induced magnetization at room temperature.

A strategy based on the design of a composite coating that enables slip-enhanced close-contact melting inside sealed phase-change thermal batteries to improve charging rates enables high-performance thermal energy storage over a wide range of temperatures.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Field data reveal that thaw slumps on the Tibetan Plateau initially turn alpine grasslands from CO₂ sinks into sources by exposing bare ground; as slumps stabilize and vegetation returns, CO₂ exchange recovers toward a sink.

Monocytes/macrophages exert pro-atherogenic functions depending on their metabolic programming. Here, the authors show the pivotal role of methionine metabolism in the proinflammatory and migratory functions of monocytes/macrophages and identify MAT2A as a potential target for the management of atherosclerosis.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

Using size-specific infrared spectroscopy and quantum-chemical calculations, structural motifs of interference-free neutral water undecamer (H₂O)₁₁ were characterized, revealing three isomer families and insights into hydrogen-bonding networks essential for understanding solvation processes.

Elevated succinate in aging drives cardiac fibrosis by inducing PKM2 succinylation, dimerization, and nuclear translocation, activating fibroblasts. Targeting this axis may slow cardiac aging

The study finds elevated CO₂ reduces methylmercury production across 45 freshwater lakes spanning 1200 longitudinal kilometers, specifically 54–96% in eutrophic ones, by shifting methanogenic pathways, highlighting the need to integrate climate drivers for methylmercury risk predictions.

The reactivity and ligandability of arginine within the human proteome have been largely unexplored despite it being involved in various biological functions. Now, arginine reactivity and ligandability have been mapped across the proteome, revealing hyper-reactive sites and identifying residues that control liquid–liquid phase separation, protein activity and protein–protein interactions.

This work introduces GLORI 2.0 and 3.0, enabling sensitive m⁶A quantification from RNA inputs as low as a few hundred cells.

Here, the authors characterize the gut virome of 647 one-year-old children in the COPSAC2010 cohort, finding that anelloviruses are highly prevalent and associated with daycare attendance, gestational age, and FUT2 secretor status.

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Metabolic compartmentalization changes are common in cancer, but their mechanisms remain unclear. Here, the authors show that low expression of the integral membrane protein SMIM4 in pancreatic cancer reshapes malate metabolism and promotes survival under glucose deprivation and RSL3-induced toxicity.

Nociceptive sensory nerves infiltrate the peripheral trauma area, mediating the biased repair response due to the formation of fibrotic mesenchymal stromal cells (MSCs) neurogenic niche. Nociceptive sensory neuron-derived nerve growth factor activates the TrkA receptors in MSCs and triggers the Hif1α-Twist1 pathway, driving the differentiation of MSCs into myofibroblasts to mediate fibrosis. TPX-0005 exerts therapeutic effects by inhibiting TrkA to reverse fibrosis.

In this study, the authors present an fMRI‑based signature of corticospinal connections, which predicts individual pain sensitivity, generalizes to patient cohorts, and tracks changes after brain stimulation, suggesting a biomarker to guide personalized pain care.

A flexible perovskite/silicon tandem solar cell making use of a dual-buffer layer comprising a compact SnO_x layer deposited first followed by a loose SnO_x layer is described, showing efficiencies rivalling rigid counterparts and good durability.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Metal–organic frameworks are typically assembled using discrete organic linkers and inorganic nodes. Now it has been shown that combining covalent organic chains and layers as infinite building units with metal clusters results in compartmentalized frameworks with well-defined pores.

Catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a challenge, due to the limited catalytic systems and substrate scope. Herein, the authors report the enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides via copper catalysis, affording a variety of chiral 1,2,3-triazoles.

Anti-TSLP biologics have shown promise for the clinical treatment of type 2 respiratory disease. Here the authors present a clinical trial of CM326, a monoclonal antibody against TSLP, and show the clinical effects in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), who present with type 2-dominant inflammation.

Edge devices require real-time processing of high-throughput analog signals. Here, authors present a photonic intelligence chip that fuses multiple analog signal types into optical spectra for ultra-fast, energy-efficient on-chip AI computation, enabling diverse edge intelligence applications.