Search

Protein language models capture single proteins but struggle with interactions. Here, authors present MINT, trained on large PPI datasets, which outperforms existing PLMs in predicting binding, mutations, and immune interactions, advancing biomedical discovery.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Metabolic syndrome (MS) is associated with enhanced risk to develop endometrial cancer (EC). Here, the authors show that oleic acid, increased in MS, promotes endometrial cancer by supporting the stability of the rate-limiting enzyme in polyamine metabolism ODC1 and polyamine accumulation.

The development of novel two-dimensional antiferromagnets is crucial for enhancing the performance of spintronic devices. Here, authors realize the synthesis of CrOCl monolayer films and nanosheets that exhibit excellent performance.

The taurine transporter TauT regulates taurine-mediated physiological and pathological functions by facilitating taurine uptake in a sodium- and chloride-dependent manner. Here, the authors use cryo-EM to elucidate the substrate coordination and inhibitor recognition mechanisms of TauT.

This work presents SCIGEN, a machine learning framework integrating geometric constraints into material generation. The framework enables the discovery of stable quantum material candidates, and the authors synthesize two predicted magnetic materials.

Atomic disorder limits the performance of kesterite solar cells. Jinlin Wang et al. introduce surface vacancy defects via magnesium doping, which reduces cation disorder and charge losses, enabling a certified efficiency of 14.9%.

Vapour-phase methods are promising for nanomaterial synthesis but the vaporization of different precursors for the synthesis of a broad nanomaterial space is challenging. Here electrified vapour deposition generates ultrahigh-temperature, high-flux atomic vapour at atmospheric pressure to rapidly vaporize diverse precursors, enabling the synthesis of multi-elemental nanomaterials with uniform compositions and tunable structures.

Sustainable end-of-life management strategies for fibre-reinforced plastics are urgently needed from a sustainability perspective. Here the authors develop a solvent-free flash upcycling method, enabling ultrafast and efficient upcycling of fibre-reinforced plastics to fulfil such a need.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Biotic-abiotic hybrid systems are promising for solar-to-chemical conversion, but it remains challenging to achieve atomically precise interface contact. Here, the authors report a general strategy of facilitating direct electron uptake via building single-atom bridges across biotic-abiotic interfaces to enhance solar-driven hydrogen production.

The heterogeneity of HSPCs in response to IR stress remains poorly characterized. Here, the authors provide insights into the molecular intricacies of IR-induced BM injury and reveal the roles of BMP4-BMPR2 signaling in radiation resistance of HSCs.

An approach combining machine learning and combinatorial chemistry enables the creation and evaluation of ionizable lipid libraries for lipid nanoparticle formulation to effectively deliver messenger RNA to several cells and tissues.

Defect engineering has emerged as a promising approach to enhancing the carrier concentration of piezocatalytic materials, however, introducing defects can negatively affect piezoelectric performance by increasing charge screening and reducing domain wall mobility. Here, the authors show that using an external electric field to rearrange oxygen defect dipoles leads to a high carrier concentration while simultaneously improving both piezoelectric and piezocatalytic properties.

A light-inducible RNA base editor fine-tunes gene expression for therapeutics.

Inhalable nanozymes aggregate and become active in inflamed sites in the lungs, decreasing reactive oxygen species and inflammatory cytokines, and promoting macrophage polarization to alleviate viral pneumonia and secondary bacterial infection.

Microneedles offer a minimally invasive transdermal drug delivery method with advantages like painless administration. Here, the authors developed a pneumatic microneedle patch powered by live Enterobacter aerogenes to enhance and control drug delivery, significantly improving treatment outcomes in a psoriasis model.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.

A graph-based pan-genome constructed from 30 genome assemblies covering Malus domestica ‘Golden Delicious’ and 29 wild diploid or polyploid Malus species highlights structural variation and genome evolution in the Malus genus.

Comparative analysis of whole-genome sequencing of six zokor species that live at different altitudes show the contribution of deletions and inversions to adaptation to high altitude in these subterranean rodents.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Solid polymer electrolytes are commonly used in lithium-metal batteries, but their capacity and energy density cannot be easily increased beyond a charging cut-off voltage of 4.5 V due to the presence of easily oxidized oxygen-bearing polar groups. Here, authors apply a polyfluorinated crosslinker to enhance the oxidation resistance to solve this issue

COMPACT allows imaging of large volumes in the brain through a periscope-like probe inside a glass capillary.

New alkenone results and existing temperature records together show contrasting Holocene temperature trends and thus display spatial patterns over mid-latitude Eurasia, with implications for the Holocene temperature conundrum.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

The delta opioid receptor (δOR) is key in modulating sensation and emotion with a lower risk of drug dependence. Here, authors report cryo-EM structure of δOR and design probes to explore its signaling bias, with insights for drug discovery.

Twisted 2D magnets provide a rich playground for potential spintronic device architectures. Here, the authors use tunneling magnetoresistance measurements to investigate the collective spin states of twisted double bilayer CrI₃ in various configurations, providing evidence of non-volatile spin textures.

Developing iontronic pressure sensors with high sensitivity in a wide linear range can be challenging due to a trade-off between sensitivity and linear range. Here, authors bypass this limitation by using laser-assisted gradient micro-pyramids and insights from multiphysics simulations.

This work proposes a cracking control strategy using MXene and silver nanowire composite films to achieve a stretchable strain sensor system with high resolution, range, sensitivity, speed, and stability

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.