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Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

The weak contact between the oxide electrode and molecular layer in inverted perovskite solar cells is prone to deformation, limiting long-term device stability. A bulk nano-heterointerface is designed to strengthen the binding force between molecules and spherical silicon oxide nanoparticles, increasing the interfacial contact area and improving the operational stability of perovskite solar cells.

Japonica subspecies has a lower nitrogen use efficiency (NUE) than that of indica rice. Here, the authors show that natural variations in the NIN-like protein 4 (OsNLP4) encoding gene are responsible for the divergence and introgression of the indica OsNLP4 allele into elite japonica cultivar can increase NUE and grain yield.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Conventional spin-orbit torques are limited by symmetry. Here, the ferroelectric domain structure of multiferroic bismuth ferrite is engineered to manipulate the orientation of magnon spin current, enabling field-free type-x magnetic switching.

AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly novel interactions compared to experimental screens, exposing open challenges in interaction prediction.

Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and their temporal effects.

Photonic components fabricated from van der Waals materials and patterned using focused ion beam lithography with aluminium passivation demonstrate quality factors exceeding 10⁶ and an efficient nonlinear optical response.

Emerging multidrug-resistant Neisseria gonorrhoeae is a global health threat in the treatment of gonorrhoea. This study reports the discovery and characterization of a promising antigonorrhoea agent that addresses antibiotic resistance.

Magnetic systems can exhibit flat bands where the magnon bands have little to no energy dispersion. Here, Luo, Chen, and coauthors show the nearly flat bands of the van der Waals antiferromagnet, CrOCl, and demonstrate quasi one-dimensional magnon transport.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Microbially derived 10-oxostearic acid (10-oxoSA) interacts with PPARα in the colon to alleviate gut inflammation in acute and chronic mice models.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

A single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.

Cyclic di-GMP, a bacterial second messenger, governs many cellular processes including bacterial lifestyle transitions. Here, authors develop a set of FRET-based biosensors that enables them to monitor real-time cellular dynamics of c-di-GMP and to perform a genome-wide analysis that reveals complex interplay between motility and c-di-GMP regulation.

The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific transcription factor binding and chromatin accessibility during human development.

The response of Mars’ ionosphere to major solar energetic events has been known, but such observations are challenging. Here, the authors show mutual radio occultation observations revealing that a solar flare in May 2024 enhanced the lowest ionospheric layer of Mars by 278% of its typical size.

He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO₂-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain pyrenoid size and number through the cell cycle.

IMiD-based PROTACs may degrade IKZF1/3 with hematologic effects. This study profiles these liabilities using hematopoietic assays showing stem cell rewiring and interferon activation and introduces a CRBN ligand that reduces them.

Zinc isotopes in basalts along a 1,100-km transect of the Gakkel Ridge record widespread mantle recycling of surface carbonates via ancient oceanic subduction, explaining the unusually carbon-rich nature of the Arctic asthenosphere.

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Developing strategies for reducing carbon emissions in municipal solid waste management is essential to achieve the net-zero target. Here the authors systematically assess strategy options of different countries for achieving net-zero municipal solid waste management.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Development of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.

Wang et al. introduce MicroSyn-X, a synthetic X-ray data generation framework that overcomes data scarcity in miniature medical devices, enabling robust deep learning-based tracking and real-time robotic navigation in challenging surgical settings.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

Aspartate transcarbamylase has been studied as a textbook example of allostery for decades. Here, the authors show that the enzyme breathes like a flexible balloon, with symmetric nucleotide binding compressing or expanding it to regulate activity.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Adsorption of trace transition-metal cations endows common Ca/Mg-carbonates and phyllosilicates with catalytic activity for electrochemical CO2 reduction under planetary conditions, potentially promoting prebiotic chemistry and the origin of life.

Particle processing plays a critical role in advancing solid state batteries. Here, authors show how solvent-free mechanofusion enables mixed conducting matrix coatings on cathode particles and relate coating quality to macroscopic mixing stresses for scalable solid state battery manufacturing.

Bistable superlattice switching between two lattice configurations with sharply contrasting periodicities has been observed in monolayer TaIrTe₄, a dual quantum spin Hall insulator.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Strong optical anisotropy is commonly achieved by complex engineered materials. Here, authors synthesize elemental crystals of type-II red phosphorus made of wavy tubular structures, exhibiting strong birefringence in the visible and near-infrared spectral region. They demonstrate anisotropic photoluminescence, Raman scattering and second-harmonic generation.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Machine learning was used to screen a library of diverse lipids on the basis of their spatial conformation and identify an LNP formulation that enabled organ-targeted mRNA delivery and tumour suppression. The work highlights the critical role of ionizable lipid conformation in LNP engineering.

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

Researchers created a moiré superlattice in Sb₂Te₃/FeTe bilayers, producing spatially modulated superconducting gaps directly imaged with Josephson scanning tunnelling microscopy and spectroscopy, tunable by replacing Sb₂Te₃ with Bi₂Te₃.

An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing an experimental framework for the exploration of antigen diversification in Trypanosoma brucei and in other pathogenic microorganisms.

This study uses the inception loop framework to map neuronal invariances in mouse V1, revealing a bipartite receptive-field organization linked to segmentation and a synaptic-level hierarchy of increasing invariance supported by the MICrONS dataset.

Topological interfacial coupling enhances PMA in 2D Fe₄GeTe₂, yielding coexisting IMA/PMA components enabling field-free SOT switching at low current density with polarity control, demonstrating reconfigurable logic for low-power spintronics.

A deep learning framework integrates protein language models, protein interactions and domains, medical knowledge graphs and electronic health records to map variants to phenotypes.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.