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Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

Reversible-deactivation radical polymerisations are highly sensitive to oxygen and inhibitors, hindering their industrial application. Here, the authors report a heterogeneous phenanthroline-based conjugated hypercrosslinked polymer photocatalyst for photoinduced copper-catalysed atom transfer radical polymerisations, achieving high oxygen and inhibitor tolerance.

Lactate accumulates in intervertebral disc degeneration to promote inflammation storm and nucleus pulposus cells (NPCs) senescence. Here, the authors address these issues by developing a lactate metabolism reprogramming reactor, which converts lactate to the inhibitor of NPCs senescence (alanine) through orthogonal tandem catalysis reaction, guiding the lactate metabolism reprogramming.

Turning lignin oils into nylon ingredients is hard because key bonds resist breaking and products overreact. A light-driven catalyst makes cyclohexanones without added hydrogen and enables tougher, clearer polyamides.

Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation. This study shows that gut microbiota dysbiosis disrupts keratinocyte lipid metabolism via the bile acid–FXR–NQO1 pathway, supporting microbiota-targeted therapeutic approaches.

Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The exchange is needed for testosterone production.

Viral polymerase is essential for the viral replication and transcription. Here, the authors present cryo-EM structures of Ebinur Lake virus polymerase in multiple functional states, elucidating its architecture, inhibitor binding modes, and key regulatory elements of RNA synthesis.

Resistance to targeted therapies in cancer can be induced by metabolic rewiring. Here, the authors show that upregulation of the glucose transporter GLUT6 drives targeted-therapy resistance by diverting glucose metabolism to activate the anti-oxidative stress NRF2 pathway in lung cancer.

Nasopharyngeal carcinoma (NPC) screening in southern China uses EBV serology, but its positive predictive value is low. Here, the authors introduce a swab-based E-CpMQ method in high-risk individuals, achieving better specificity.

Foldamer M4 inhibits Aβ42 aggregation, disrupts existing assemblies, and restores neuronal function. This foldamer reduces oxidative stress, improves mitochondrial integrity, and alleviates pathology and cognitive decline in an Alzheimer’s disease mouse model.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

This study shows that Mg–Fe engineered biochar drives the formation of Mg–Fe layered double hydroxides, immobilizes carbonate, reduces sodicity, and stabilizes soil organic carbon via organo–mineral associations in soda saline–alkaline soils.

Single-cell RNA sequencing reveals cellular diversity, yet existing models often lack regulatory awareness and scalability. Here, the authors develop RegFormer, a GRN-informed foundation model that improves single-cell analysis, genetic perturbation modelling, and drug response prediction.

Anion-mixing strategy is gaining attention for the development of amorphous halide solid electrolytes. Here, authors investigate the structure evolution of nitrochloride amorphous solid electrolyte, Li_3x ZrCl₄ N_x (0.17 ≤ x ≤ 1), demonstrating ionic conductivities of up to 3.21 mS cm⁻¹ at 30 °C, suggesting that the formation of nitrogen-containing frameworks is crucial for enhancing ionic conductivity.

High-performance perovskite tandem solar cells are limited by uneven, disordered self-assembled monolayer (SAM) acting as hole-selective layers. Luo et al. design a SAM that yields uniform, stable interfaces, reducing non-radiative losses and boosting efficiency and durability

Achieving high-density single-neuron recordings in humans is challenging. Here, the authors demonstrate a flexible implantable neural electrode array that enables reliable single-unit recordings in human patients during surgery

This study shows that the EBF2 activates brown fat through biomolecular condensation. Disrupting EBF2 condensates impairs thermogenic gene expression, while small molecules that modulate condensate dynamics improve thermogenic programming.

Reliable quantum computers require error-resistant components like cat-state qubits, along with fast, non-destructive ways to readout them. Here, the authors propose a longitudinal readout protocol for these qubits that achieves faster and higher-fidelity measurements than conventional methods.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Authors reveal symmetry-protected topological phonons and strong phonon interactions in the thermoelectric Mg₃Bi_2-xSb_x family, explaining its low thermal conductivity and offering a strategy to engineer heat flow in thermoelectric materials.

Rodents are frequently used as models of the human immune system, but not all immune functions are shared between the two evolutionary families. Here the authors provide evidence that the immune system of the tree shrew (Tupaia belangeri) is closer to humans than that of rodents and the single cell immune atlas they assemble support the wider employment of the tree shrew as immunological model.

An electrothermal co-design strategy can be used to make flexible transistors based on aligned carbon nanotube arrays with current-gain cut-off frequencies of 152 GHz and power-gain cut-off frequencies of 102 GHz.

This study identifies a Rht-A1–TaLA1-D module controlling wheat tiller angle, elucidates its mechanism, and traces the selection trajectory of TaLA1-D during wheat breeding, providing new insights for developing ideotype wheat varieties.

Using RNAi and CRISPR knockouts, the authors measured sex-specific fitness effects of recent and older genes in somatic and germline tissues of Drosophila melanogaster, revealing antagonistic selection between sexes and tissues.

This study identifies NAT10-mediated RNA ac4C modification as a key regulator of colonic epithelial aging. Through N4-acetylation regulation of DYRK1A, NAT10 promotes intestinal senescence, highlighting a potential therapeutic target for elderly-onset colitis.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

The Hippo pathway relies on TEAD transcription factors, but how TEAD4 dynamically engages DNA was unclear. Here, the authors show that TEAD4 multimerisation stabilizes DNA binding and YAP recruitment, with VGLL4 modulating this process in a stoichiometry‑dependent manner.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Inflammatory skin diseases are characterized by immune dysregulation often underpinned by metabolic dysregulation. Here the authors show that in human psoriasis and mouse skin inflammation models, adenosine-mediated crosstalk between fibroblasts and keratinocytes drive mitochondrial dysfunction and pro-inflammatory mediator release in keratinocytes, leading to epidermal inflammation.

Some RNAs carry an NAD⁺ cap that may regulate genes, but current methods miss small RNAs and precise start sites. Here, the authors develop two profiling methods that map NAD-capped RNAs at single-base resolution, uncover many new species in E. coli, and reveal stress-responsive promoter activity.

Tau aggregates disrupt heterochromatin by sequestering H3K9me3, reactivating transposable elements. This generates Z-RNAs, activating ZBP1 to drive neuronal death. ZBP1 haploinsufficiency reverses cognitive decline in aged tau mice, offering a therapeutic target for tauopathies.

Tight regulation of thymic T cell development is critical for immune homeostasis and leukemia prevention. Here, the authors identify USP10 as a MYC-induced deubiquitinase stabilizing SOX4 in early T cell development and T-cell acute lymphoblastic leukemia progression, while USP10 inhibition delays leukemogenesis in mice.

VSIG4 is a co-inhibitory receptor expressed by Kupffer cells. Here, the authors identify a direct binding interaction between VSIG4 and T cell CD5 that can calibrate CD8⁺ T cell responses to liver metastasis. They also design an anti-VSIG4 nanobody to enhance immune checkpoint blockade treatment of mice.

A photolithographic fabrication process can be used to create soft and stretchy organic electrochemical transistor arrays that have a density up to 10,000 devices per square centimetre, and can perform edge computing tasks in wearable devices and soft robots.

The family of oxiranes encompasses a variety of compounds with extensive applications across different fields. Herein, the authors report the photochemical syntheses of a range of highly functionalized strained oxiranes.

In CRISPR/Cas12a systems, small RNA from pre-crRNA maturation is often overlooked. Here, authors show these fragments reconstitute with Cas12a to activate cleavage. They discover a crRNA activating Cas12a in a “delayed-switch” mode, resolving its incompatibility with nucleic acid amplification.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

Azeliragon, a clinically tested RAGE inhibitor, exhibits potent anti-MRSA activity by perturbing membrane phospholipids and interacting with the cell-wall enzyme MurA. This multi-mechanism action supports its repurposing as a promising candidate against MRSA.

Here, the authors establish 1,3-propanediol, a low-cost biomass-derived bulk chemical, as an efficient, green, and sustainable C1 source for the mono-N-methylation of primary amines, via chelation-free C(sp3)−C(sp3) bond cleavage.

Researchers boosted the thermoelectric performance of the ionic-bonded compound MnTe by manipulating chemical bonding, achieving improved TE conversion efficiency and zT values via increased electron delocalization and suppressed phonon transport.

Using data from 96 million mobile phone users across 11 cities in China, this analysis sheds light on the trade-off between spatial proximity and hospital quality in patterns of healthcare utilization, showing that 80.63% of patients bypass their nearest hospital with 211.84% increased travel distance.

Fe-based polyanionic cathodes are promising for Na-ion batteries but are limited by inactive Na sites and irreversible Na loss. Here the authors employ targeted V³⁺ substitution to tune the Na⁺ coordination environment, activate inert sites and stabilize high-voltage redox for high-performance Na-ion batteries.