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Replicating the human brain’s imaginative ability has long been a core AI goal, yet current systems remain limited in speed and efficiency. Yang et al. present a hardware platform based on resistive memory, enabling high-speed, low-power AI content generation while fully preserving output quality.

Electronic skins are capable to monitor stimuli such as temperature and pressure, though they are susceptible to crosstalk diminishing sensitivity. Here the authors report a mechanically and electronically hybrid network using vanadium oxide and liquid metal particles to optimize selectivity and sensitivity.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

ADAR1, an RNA-editing enzyme, can contribute to immunotherapy resistance by suppressing interferon signaling. This study shows that all-trans retinoic acid (ATRA) promotes ADAR1 degradation, supporting ATRA combined with PD-L1 blockade as a potential therapeutic strategy.

This study finds that the most dangerous tick-borne viruses infect many tick and animal species, boosting their chances of reaching humans. Bird migration helps spread them worldwide, and genetic adaptation may increase their ability to infect people.

Researchers develop a swellable polymer platform that immobilizes photocatalysts into flexible films and enables three-dimensional stacking architectures, boosting solar-driven hydrogen production and increasing energy output per unit area.

Triple-negative breast cancer brain metastases present a significant clinical challenge. Here, the authors show that targeting the complex I protein NDUFB9 selectively inhibits tumor growth in the brain.

Post-translational modifications regulate tumorigenesis and cancer therapy sensitivity. Here, the authors show that N-glycosylation defective Interleukin-6 (deNG-IL6) switches downstream signalling pathway from JAK-STAT3 to SRC-YAP axis and lung cancer cells secrete deNG-IL6 to promote metastasis and tyrosine kinase inhibitor resistance.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Photodetectors for aerospace exploration require high temperature and radiation tolerance. Here, the authors report the realization of Au-intercalated potassium niobate ultraviolet photodetectors with stable operation in a wide temperature range (from −263.15 °C to 300 °C) and under γ-ray radiation doses up to 200 kGy.

This work shows that few-layer hybrid-improper multiferroics provide a platform for reversible control of multiple compensated magnetic states and electrically controllable Hall responses without conventional exchange-splitting reversal.

Converting carbon dioxide into useful chemicals needs catalysts that are fast, selective and long-lasting. This study creates nickel–tungsten carbide nano-islands that efficiently make carbon monoxide and stay stable for 100 hours.

This research reveals that platelet infiltration initiated by the platelet HuR-PSPF regulatory process coordinates systemic aging. Targeting platelet HuR may be a promising strategy for anti-aging interventions

cfDNA size is a key feature in fragmentomics for non-invasive cancer detection. Here, the authors present a deconvolution analysis of cfDNA size profiles using the Lorentzian distribution, revealing insights into ctDNA fragmentomic alterations.

Recycling polycarbonate plastics is energy intensive and depends on excess methanol. This work couples plastic breakdown with glycerol conversion to regenerate methanol in situ, reducing energy use while achieving high yields at pilot scale.

Authors develop an autonomous agentic LLM called DxDirector-7B. Its clinical diagnostic accuracy outperforms larger models. Using deep thinking strategies, it significantly reduces physician workload, requesting human assistance only when necessary.

Erythrocyte membrane vesicles (EMVs) are promising for drug delivery but their role in immune-mediated regeneration is unclear. Here the authors show that phosphatidylserine-everted EMVs trigger efferocytosis to enhance endothelialization, reduce calcification, and improve vascular graft patency in animal models.

A global study using 40 years of data from 69 sites shows wetland restoration succeeds when sediment, elevation and tidal creeks align across spatial scales. About 920 km² of lost wetlands worldwide are estimated to be potentially restorable.

Traditional electrolytes are electrochemically unstable on the positive electrode surface. Here, the author designed a solvent locked electrolyte to form a stable boride/fluoride interface. The assembled Na||Na_2.26Fe_1.87(SO₄)₃ battery maintained 88.2% capacity after 16500 cycles at 1 A g^-1.

Coordination materials play a pivotal role in advancing multidisciplinary fields within contemporary science. Here, the authors present a heterogeneous in situ approach that employs zero-valent metal as a cation source in aqueous media, coupled with linker supersaturation, as a scalable synthesis process for the discovery of crystalline coordination materials.

Portal fibrosis, a hallmark of progression in chronic liver diseases, typically develops following biliary injury. This study identifies Clec3b⁺ fibroblasts as key drivers of liver portal fibrosis and demonstrates that a KLF4/periostin signaling axis controls their activation, highlighting potential therapeutic targets for inhibiting fibrosis in biliary diseases.

Optical frequency comb generation usually relies on Kerr or Pockels nonlinearities. Here, the authors create a Floquet cavity by periodically modulating the resonance, achieving phase-locked Floquet sideband generation under nanowatt power consumption. The produced combs is independent of a pumping threshold and insensitive to pump detuning.

Here, the authors identify ten morphogroups of dermal denticles across extant shark species and quantify their mechanical properties and material composition alongside swimming performance, linking these traits to distinct ecological niches.

CNS injury disrupts neural circuits, with poor regeneration due to HDAC retention and hostile environments. Here, the authors show a nanosystem with LMK-235 that forms electroactive scaffolds and promotes regeneration and enhances synaptic reconnection

PI3K has emerged as a potential therapeutic target for serious endometrial cancer but efficacy and duration of response is limited. Here, the authors develop a serous endometrial cancer murine model driven by PIK3CA mutation, TP53 loss and MYC overexpression, identifying FGFR pathway activation as a driver of PI3K-targeted therapeutic resistance and immune suppression.

In this study, the authors find that the perirhinal cortex controls hippocampal seizures in male mice via multiple downstream circuits that arise from distinct neuronal subpopulations, including projections to the fasciola cinerea, highlighting it as a promising therapeutic target.

Kinetic resolution is a privileged strategy in enantioselective synthesis, yet its extension to radical chemistry has remained challenging. Here, the authors report the kinetic resolution in Minisci radical additions, affording enantioenriched products and recovered starting materials under chiral Brønsted acid catalysis.

An electrothermal fluorination methodology has been developed to transform granular activated carbon-sorbed aqueous film-forming foam waste into graphene and a fluorinating reagent, subsequently enabling lithium recovery from brine sources.

The crystal phase of metal nanocatalysts critically influences their catalytic performance, yet the atomic-scale mechanisms underlying their phase-dependent reactivity remain poorly understood. Using operando gas-cell transmission electron microscopy, here the authors directly correlate the crystal structure of Ru nanoparticles with their catalytic behavior during CO oxidation.

Tracing the origins of lithium dendrite growth remains a critical challenge for lithium metal batteries. Here, the authors introduce an interfacial excess charge distribution factor to understand lithium dendrite growth, guiding the design of an electrolyte that suppresses Li dendrites in practical pouch cells.

The Small Auxin Up RNA (SAUR) protein ZmSAUR72 in maize (Zea mays) promotes silk growth via regulation of H⁺-ATPase activity, and is a key determinant of the anthesis-silking interval and thus resilience to drought.

Vascular smooth muscle cells undergo complex transitions to multiple disease-related phenotypes in coronary artery disease. Using vascular smooth muscle lineage-traced single-cell RNA and ATAC sequencing, the authors map molecular spatiotemporal patterns of murine atherosclerosis and discover molecular mechanisms of TCF21-mediated coronary artery disease risk.

Surface acoustic waves (SAWs) are commonly generated with interdigital transducers (IDTs) on a piezoelectric substrate, lacking dynamic reconfigurability. Here, authors develop a programmable IDT array architecture enabling spatial and spectral control over SAW generation, demonstrating non-diffracting Airy SAWs and dynamically focused SAWs.

Conventional Si-based physical unclonable functions (PUFs) are normally limited by limited entropy and lack of reconfigurability, exposing them to machine learning attacks. Here, the authors report optically reconfigurable PUFs based on 2D MoS₂ ring-oscillator arrays, demonstrating machine-learning-attack-resistant image encryption.

The authors report associations of social isolations and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioral phenotypes among UK Biobank participants.