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Signalosomes amplify cellular responses, but how they avoid uncontrolled activation is unclear. The authors use quantitative super-resolution imaging and mathematical modeling to reveal optimal RIP3:RIP1 ratios that ensure precise cell death signaling.

The catalytic enantioselective synthesis of sulfinimidate esters remains a formidable challenge in organic chemistry. Here the authors report an enantioselective oxidative esterification of sulfenamides to form sulfinimidate esters by using anionic stereogenic-at-Co(III) complexes as catalysts.

Even though chiroptical luminophores have high potential for optoelectronic innovation and precision bioimaging, their rational engineering remains constrained by synthetic limitations. Here, the authors report a streamlined and programmable asymmetric synthesis platform enabling systematic construction of boron-stereogenic boron dipyrromethenes (BODIPYs) with near-infrared chiroptical activity.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

A radical-mediated dynamic remedial strategy based on bio-inspired disulfide metathesis has been developed to construct metal–organic frameworks with crystalline dynamicity. The disulfide exchange-based crystal dynamics of the metal–organic frameworks allows for sustained gas separation.

Traditional electrorefining process is limited by deposition potential of the metal itself. Here, the authors explore an in-situ anodic precipitation process based on different solubility of target metal chlorides that can efficiently separate components of aluminum alloys.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

In this prespecified analysis of the ongoing TORCHLIGHT phase 3 trial, first-line treatment with toripalimab and nab-paclitaxel in patients with advanced triple-negative breast cancer led to significantly longer progression-free survival in the PD-L1-positive population compared to nab-paclitaxel alone.

IleRS knockdown in Mycobacterium abscessus and Mycobacterium marinum disrupts branched-chain and pantothenate metabolism, weakens persistence in host models, and effectively increases pyrazinamide sensitivity.

The Authors present a universal framework that utilizes photonic integrated circuits (PIC) to enhance the efficiency of reinforcement learning (RL). Leveraging the advantages of the hybrid architecture PIC (HyArch PIC), the PIC-RL experiment demonstrates a remarkable 56% improvement in efficiency for synthesizing perovskite materials.

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

The gut microbiome plays an important role in colorectal carcinogenesis and predictive microbiome signatures have been proposed for colorectal cancer (CRC) diagnosis. Here the authors perform a meta-analysis of 16S rRNA-based profiles to identify microbial markers able to discriminate patients with adenoma from control and CRC, building a model that can be applied for the early detection of CRC.

N⁶-methyladenosine is mapped at single-base resolution in as few as ten cells.

ZCCHC4 was identified as a mammalian ribosome RNA (rRNA) N⁶-methyladenosine (m⁶A) writer protein that installs m⁶A 4220 in 28S rRNA. 28S rRNA methylation affects global translation and cell growth and contributes to tumorigenesis in cancer cells.

Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-gate in an open conformation and discuss mechanistic implications.

The acetyltransferase cysE is involved in mitigating oxidative stress, which modulates the virulence and drug resistance of M. tuberculosis.

Multi-omic profiling of brain tissue from patients with Alzheimer’s disease (AD) identifies gains in H3K27ac and H3K9ac linked to transcription and disease pathways. Increasing H3K27ac and H3K9ac in a fly model of AD exacerbates neurodegeneration.

The separation of xylene isomers remains a great challenge in industry due to their similar molecular structure and physical properties. Here the authors demonstrate adaptively molecular discrimination of xylene isomers by employing a NbOF₅²⁻-pillared metal–organic framework with rotational anionic sites.

Wang et al. show that Akt methylation by SETDB1 is recognized by demethylase JMJD2A, which then recruits E3 ligases to induce K63-linked Akt ubiquitination, leading to Akt activation and tumorigenesis.

Zhang et al. report the role of CaMKII-δ9, a previously less-studied isoform, in driving cardiomyopathy. Mechanistically, CaMKII-δ9 phosphorylates UBE2T, resulting in its degradation and impairing DNA repair.

Enantioselective dicarbofunctionalization of tethered alkenes typically relies on facially selective arylmetalation as a key step. Here, a nickel-catalyzed reductive carboacylation of alkenes and alkyl iodides which features acylnickelation as the enantiodetermining step is reported.

Locusts are destructive agricultural pests and serve as a model organism for studies of insects. Here, the authors report a draft genome sequence of the migratory locust, Locusta migratoria, and provide insight into genes associated with key survival traits such as phase-change, long-distance migration and feeding.

Direct observation of liquid–liquid phase separation (LLPS) and resulting protein aggregation plays a crucial role in understanding the associated mechanisms and progression. Here, the authors review advanced imaging techniques for visualizing LLPS and protein aggregates, offering insights into real-time monitoring of phase-separated processes.

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Neuronal stimulation induces protein translation of m⁶A-methylated neuronal mRNAs facilitated by YTHDF1, and this process contributes to learning and memory.

The extraction of uranium from seawater is limited by the high concentrations of carbonate and competing metal ions. Now, a highly selective uranyl-binding protein with femtomolar affinity has been developed. This protein can extract up to 60% uranium from synthetic seawater when immobilized on bacterial cell surfaces or amylose resin.

Jones et al. examine the generalizability of the valence–dominance model of social judgements of faces in 41 countries across 11 world regions. They find evidence of both generalizability and variation, depending on the analytical method.