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Structural basis for the catalytic mechanism of human lipid phosphate phosphatases

Lipid phosphate phosphatases (LPPs) catalyze the dephosphorylation of bioactive lipid phosphates. In this study, the authors employ structural and biochemical investigations on human LPP1, elucidating its catalytic mechanism and suggesting a potential regulatory role for PIP₂.

Meng Yang
Chunping Sun
Hongwu Qian
Research09 Jan 2026
Nature Chemical Biology

P: 1-9
Dynamic rigidity changes enable rapid cell migration on soft substrates

Cells struggle to migrate on soft substrates, which don’t provide enough traction. Here, the authors show that rapid, cyclic changes in substrate rigidity allow cells to overcome this limitation and move quickly.

Jiapeng Yang
Yu Zhang
Qiang Wei
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Correction: The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy

Bo Yang
Bin Zhang
Quansheng Zhou
Amendments and Corrections06 Apr 2020
Cell Death & Differentiation

Volume: 27, P: 2746
Effects of planting patterns on physicochemical properties, metabolites and microbial community structure of rhizosphere soil in perennial cultivated grassland

Xiaofang Zhang
Chunping Zhang
Quanmin Dong
ResearchOpen Access08 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Acute type A aortic dissection rupture factors prediction using a hybrid ensemble model with feature selection and data augmentation

Lin Junyao
Wang Yichao
Cheng Zhangbo
ResearchOpen Access05 Dec 2025
Scientific Reports

Volume: 16, P: 1-14
Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

A tomato super-pangenome constructed using chromosome-scale genomes of nine wild species and two cultivated accessions highlights genomic diversity and structural variation across wild and cultivated tomatoes.

Ning Li
Qiang He
Qinghui Yu
ResearchOpen Access06 Apr 2023
Nature Genetics

Volume: 55, P: 852-860
Exploiting the CRISPR/Cas9 System for Targeted Genome Mutagenesis in Petunia

Bin Zhang
Xia Yang
Yulong Guo
ResearchOpen Access03 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
Nanoparticles for improving biogas production and effluent biofertilizer

Taha Abdelfattah Mohammed Abdelwahab
Junting Pan
Ahmed Elsayed Mahmoud Fodah
ResearchOpen Access02 Jun 2025
Scientific Reports

Volume: 15, P: 1-11
ROR1 expression correlated with poor clinical outcome in human ovarian cancer

Huilin Zhang
Jinrong Qiu
Jin Zhu
ResearchOpen Access24 Jul 2014
Scientific Reports

Volume: 4, P: 1-7
Effect of alkaline microwaving pretreatment on anaerobic digestion and biogas production of swine manure

Tao Yu
Yihuan Deng
Fumitake Nishimura
ResearchOpen Access10 May 2017
Scientific Reports

Volume: 7, P: 1-8
Effects of Ca²⁺ and fulvic acids on atrazine degradation by nano-TiO₂: Performances and mechanisms

Saiwu Sun
Huijun He
Yongpan Liu
ResearchOpen Access20 Jun 2019
Scientific Reports

Volume: 9, P: 1-11
Species diversity and spatial pattern of heritage trees in Taiyuan

Yang Pan
Shijie Wang
C. Y. Jim
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-16
Analysis of spatial and temporal distribution of grassland yield under grassland ecological subsidy policy

ZhanMing Qiao
Feng Lai
Quan Cao
ResearchOpen Access14 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc

Yunhua Peng
Jing Liu
Jiangang Long
Research25 Feb 2022
Cell Death & Differentiation

Volume: 29, P: 1730-1743
Bacillus as a potential diagnostic marker for yellow tongue coating

Juan Ye
Xueting Cai
Peng Cao
ResearchOpen Access31 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
Therapeutic potential of digitoflavone on diabetic nephropathy: nuclear factor erythroid 2-related factor 2-dependent anti-oxidant and anti-inflammatory effect

Yang Yang
Gang Chen
Peng Cao
ResearchOpen Access24 Jul 2015
Scientific Reports

Volume: 5, P: 1-13
Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis

Ren Liu
Yang Liu
Na Cheng
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
Enhanced biodegradation of n-hexane by Pseudomonas sp. strain NEE2

Shanying He
Yaoqi Ni
Chunping Yang
ResearchOpen Access12 Nov 2019
Scientific Reports

Volume: 9, P: 1-9
The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy

Bo Yang
Bin Zhang
Quansheng Zhou
Research06 Mar 2020
Cell Death & Differentiation

Volume: 27, P: 2433-2450
MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents

Bin Yang
Chunping Wang
Yinying Lu
ResearchOpen Access14 Oct 2019
Cell Death & Disease

Volume: 10, P: 1-15
MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS

Fangfang Li
Chen Zhao
Yingwei Li
ResearchOpen Access17 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-13
Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli across China reveals recent endemic plasmid-encoded tet(X4) gene

Sun et al. analyse E. coli strains from pigs and chickens in Chinese farms and slaughterhouses, and reveal that while the tet(X4) gene is not ubiquitous across China, it is highly endemic in northwestern China. Genomic analysis of these strains shows recent and independent acquisitions of plasmids in across regions.

Chengtao Sun
Mingquan Cui
Yang Wang
ResearchOpen Access31 Jul 2020
Communications Biology

Volume: 3, P: 1-10
One-pot synthesis of carbon supported calcined-Mg/Al layered double hydroxides for antibiotic removal by slow pyrolysis of biomass waste

Xiaofei Tan
Shaobo Liu
Bo Chen
ResearchOpen Access21 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Whole-genome sequencing of the endangered bovine species Gayal (Bos frontalis) provides new insights into its genetic features

Chugang Mei
Hongcheng Wang
Linsen Zan
ResearchOpen Access25 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

Dandan Liu
Jinyu Li
Xinggang Yang
ResearchOpen Access28 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q

Jiao Chen
Jie Yang
Peng Cao
ResearchOpen Access28 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer

Zhongwu Li
Yanling Wang
Jie Cheng
Research06 Oct 2014
Laboratory Investigation

Volume: 94, P: 1431-1445
IL-6R blockade by chikusetsusaponin IVa butyl ester inhibits Th17 cell differentiation and ameliorates collagen-induced arthritis

Jie Yang
Yuanyuan Ling
Peng Cao
Correspondence26 Feb 2021
Cellular & Molecular Immunology

Volume: 18, P: 1584-1586

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Structural basis for the catalytic mechanism of human lipid phosphate phosphatases

Dynamic rigidity changes enable rapid cell migration on soft substrates

Correction: The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy

Effects of planting patterns on physicochemical properties, metabolites and microbial community structure of rhizosphere soil in perennial cultivated grassland

Acute type A aortic dissection rupture factors prediction using a hybrid ensemble model with feature selection and data augmentation

Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

Exploiting the CRISPR/Cas9 System for Targeted Genome Mutagenesis in Petunia

Nanoparticles for improving biogas production and effluent biofertilizer

ROR1 expression correlated with poor clinical outcome in human ovarian cancer

Effect of alkaline microwaving pretreatment on anaerobic digestion and biogas production of swine manure

Effects of Ca²⁺ and fulvic acids on atrazine degradation by nano-TiO₂: Performances and mechanisms

Species diversity and spatial pattern of heritage trees in Taiyuan

Analysis of spatial and temporal distribution of grassland yield under grassland ecological subsidy policy

Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc

Bacillus as a potential diagnostic marker for yellow tongue coating

Therapeutic potential of digitoflavone on diabetic nephropathy: nuclear factor erythroid 2-related factor 2-dependent anti-oxidant and anti-inflammatory effect

Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis

Enhanced biodegradation of n-hexane by Pseudomonas sp. strain NEE2

The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy

MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents

MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS

Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli across China reveals recent endemic plasmid-encoded tet(X4) gene

One-pot synthesis of carbon supported calcined-Mg/Al layered double hydroxides for antibiotic removal by slow pyrolysis of biomass waste

Whole-genome sequencing of the endangered bovine species Gayal (Bos frontalis) provides new insights into its genetic features

Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q

Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer

IL-6R blockade by chikusetsusaponin IVa butyl ester inhibits Th17 cell differentiation and ameliorates collagen-induced arthritis

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