Nature Search

Natural degradation of RNA polymerase II is essential for oocyte chromatin reorganization and maternal-to-zygotic transition

RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

Jing Wang
Wang Li
Chun So

ResearchOpen Access12 Dec 2025

Nature Communications

Volume: 17, P: 1-21

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.

Siva Kumar Natarajan
Joanna Lum
Sriram Venneti

ResearchOpen Access04 Feb 2026

Nature

P: 1-12

Graph attention-driven relation network for 3D lane detection

Yanji Jiang
Yingyang Zhang
Bowen Fei

ResearchOpen Access19 Nov 2025

Scientific Reports

Volume: 15, P: 1-16

Endothelial RAB5IF is required for pathological and developmental retinal angiogenesis

Endothelial RAB5IF is a critical proangiogenic regulator of both normal and pathological retinal angiogenesis. Here the authors show that RAB5IF-SUMO2-Gαi1/3 signaling axis drives this process, presenting new therapeutic targets for neovascular eye diseases.

Wen Bai
De-pei Yin
Cong Cao

ResearchOpen Access13 Dec 2025

Nature Communications

Volume: 16, P: 1-22

Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases

Anouk Caraux
Qingxian Lu
Claude Roth

Research04 Jun 2006

Nature Immunology

Volume: 7, P: 747-754

Bumping in the Lane Fox Mercurial Pump

D. G.

Research25 Aug 1892

Nature

Volume: 46, P: 394

Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions.

Matthew E. Griffin
John W. Thompson
Linda C. Hsieh-Wilson

ResearchOpen Access03 Feb 2026

Nature Chemical Biology

P: 1-12

Natural products reveal cancer cell dependence on oxysterol-binding proteins

The identification of cellular targets for natural products that potently inhibit the growth of cancer cell lines implicates oxysterol-binding proteins in the growth of cancer cells. These natural products, termed ORPphilins, also affect sphingomyelin biosynthesis.

Anthony W G Burgett
Thomas B Poulsen
Matthew D Shair

Research07 Aug 2011

Nature Chemical Biology

Volume: 7, P: 639-647

Expression of Xist in mouse germ cells correlates with X–chromosome inactivation

John R. McCarrey
Donald D. Dilworth

Research01 Nov 1992

Nature Genetics

Volume: 2, P: 200-203

Light in the fast lane

David F. P. Pile

News & Views06 Jun 2022

Nature Photonics

Volume: 16, P: 409

Policymaker-led scenarios and public dialogue facilitate energy demand analysis for net-zero futures

New research finds that policymakers coleading energy scenario design has the potential both to better align scenarios with policymakers’ priorities and to question current policy, by substantially reducing energy use at half of the cost of technology-focused approaches.

Maria Sharmina
Oliver Broad
Emily White

ResearchOpen Access20 Nov 2025

Nature Energy

Volume: 10, P: 1482-1492

Native top-down proteomics enables discovery in endocrine-resistant breast cancer

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

Fabio P. Gomes
Kenneth R. Durbin
John R. Yates III

Research04 Apr 2025

Nature Chemical Biology

Volume: 21, P: 1205-1213

Multistep receptor binding of the hepatitis B virus preS1 domain

The hepatitis B virus surface protein recognizes host entry receptor via its intrinsically disordered peptide. The authors reveal the dynamic process of the viral surface protein that involves a stepwise binding maturation for establishing high affinity and specific virus-receptor entry complex.

Chisa Kobayashi
Toru Ekimoto
Koichi Watashi

ResearchOpen Access30 Jan 2026

Nature Communications

Volume: 17, P: 1-16

Spatial mechanisms of quality control during chaperone-mediated assembly of the proteasome

Cellular protein degradation requires a molecular machine, the 66-subunit proteasome. Here, the authors show a quality control mechanism during proteasome assembly via its nuclear localization signal, sequestering incorrect subassemblies into the nucleus to antagonize defective proteasome formation.

Eshita Das
Linh Le
Soyeon Park

ResearchOpen Access09 Apr 2025

Nature Communications

Volume: 16, P: 1-17

Pre-assembly of biomolecular condensate seeds drives RSV replication

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Dhanushika Ratnayake
Marie Galloux
Marvin E. Tanenbaum

ResearchOpen Access28 Jan 2026

Nature

P: 1-12

Glucose deprivation drives LIF-dependent lung cancer

Glucose deprivation triggers the secretion of the cytokine LIF, which promotes angiogenesis and immune suppression in lung cancer models.

Fedra Luciano-Mateo
Joaquim Moreno-Caceres
Cristina Muñoz-Pinedo

Research30 Jan 2026

Nature Metabolism

P: 1-21

Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss

Butyrophilin 2A2 is a member of the B7 costimulatory family that is expressed on antigen presenting cells and is linked to the regulation of T cells. Here the authors implicate butyrophilin 2A2 in enhancement of CD45 phosphatase activity within the immunological synapse during T cell activation, leading to expansion of regulatory T cells and reduction of proinflammatory Th17 CD4 T cells.

Shafat Ali
Anders H. Berg
S. Ananth Karumanchi

ResearchOpen Access08 Jan 2026

Nature Communications

Volume: 17, P: 1-20

Light-induced analgesia provides a drug-free optical method for pain relief via activation of TRAAK k⁺ channels

Membrane ion channels can be responsive to a variety of stimuli such as pressure, temperature, or pH. Here, the authors show that simply shining 365 nm light activates a native potassium channel in rodent pain-sensing neurons, delivering powerful analgesia without drugs or genetic manipulations.

Marion Bied
Arnaud Landra-Willm
Guillaume Sandoz

ResearchOpen Access26 Jan 2026

Nature Communications

Volume: 17, P: 1-18

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

Pamela S. Ohashi
Tak W. Mak
Arthur Weiss

Research01 Aug 1985

Nature

Volume: 316, P: 606-609

HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial

There is still a need for effective HIV vaccines. In this phase I clinical trial, the authors show that an HIV-1 vaccine candidate, ConM SOSIP.v7, is well-tolerated in HIV-negative adults and that it elicits a strain-specific neutralising antibody response that differed between female and male participants.

Emma I. M. M. Reiss
Karlijn van der Straten
Godelieve J. de Bree

ResearchOpen Access21 Nov 2025

Nature Communications

Volume: 16, P: 1-16

Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade

Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell responses that complement cellular immunity and contribute to clinical benefit.

Edgar Gonzalez-Kozlova
Robert Sweeney
Sacha Gnjatic

ResearchOpen Access27 Jan 2026

Nature Medicine

P: 1-14

Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway

Schisantherin A (Sin A), a bioactive lignan from Schisandra chinensis, alleviates obesity and liver fat accumulation in mice, but the mechanisms are incompletely understood. Here the authors show that Sin A mitigates obesity and related metabolic disorders by elevating circulating conjugated bile acids, which in turn modulate adipose tissue thermogenesis in mice.

Xunjiang Wang
Xu Wang
Lili Ding

ResearchOpen Access11 Dec 2025

Nature Communications

Volume: 17, P: 1-19

Strain-specific prion-protein conformation determined by metal ions

Jonathan D.F. Wadsworth
Andrew F. Hill
John Collinge

Research01 May 1999

Nature Cell Biology

Volume: 1, P: 55-59

Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex

How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thiodG) targets telomerase to inhibit telomere maintenance in cancer cells and tumors was unclear. Here, the authors show that telomere length and telomerase status determine 6-thio-dG sensitivity and uncover the molecular mechanism by which 6-thio-dG selectively inhibits telomerase synthesis of telomeric DNA.

Samantha L. Sanford
Mareike Badstübner
Patricia L. Opresko

ResearchOpen Access07 Dec 2025

Nature Communications

Volume: 17, P: 1-19

A structure-based designed small molecule depletes hRpn13^Pru and a select group of KEN box proteins

Here, the authors identify a small molecule degrader (XL44) for hRpn13 and solve the XL44-hRpn13 structure. XL44 induces apoptosis in myeloma cells with hRpn13 dependency and also targets KEN box proteins PCLAF and RRM2. Loss of hRpn13 and PCLAF abrogates XL44 restriction of cell viability.

Xiuxiu Lu
Monika Chandravanshi
Kylie J. Walters

ResearchOpen Access20 Mar 2024

Nature Communications

Volume: 15, P: 1-18

Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway

Ye et al. define the structure and mechanisms of a bacterial pathway that performs ubiquitination-like protein conjugation, revealing new insights into the evolution and biological roles of ubiquitination pathways across kingdoms.

Qiaozhen Ye
Minheng Gong
Kevin D. Corbett

Research03 Nov 2025

Nature Structural & Molecular Biology

Volume: 33, P: 71-83

A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

Gunter Meister
Dirk Bühler
Utz Fischer

Research25 Sept 2001

Nature Cell Biology

Volume: 3, P: 945-949

siRNA-directed inhibition of HIV-1 infection

Carl D. Novina
Michael F. Murray
Phillip A. Sharp

Research03 Jun 2002

Nature Medicine

Volume: 8, P: 681-686

Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial

There is a lack of effective therapies for patients with non-V600E BRAF mutant cancer. Here, the authors report limited response in a phase II trial investigating the combination of binimetinib (MEK inhibitor) and encorafenib (BRAF inhibitor) for the treatment of non-V600E BRAF mutant cancer and subsequently investigate resistance mechanisms and combination therapeutic strategies in patient-derived models.

April A. N. Rose
Jennifer Maxwell
Anna Spreafico

ResearchOpen Access03 Jan 2026

Nature Communications

Volume: 17, P: 1-19

Polyamine-dependent metabolic shielding regulates alternative splicing

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Amaia Zabala-Letona
Mikel Pujana-Vaquerizo
Arkaitz Carracedo

ResearchOpen Access14 Jan 2026

Nature

P: 1-10

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

Michael K. Jones
Hongtao Wang
Andrzej S. Tarnawski

Research01 Dec 1999

Nature Medicine

Volume: 5, P: 1418-1423

DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes

DNA computing systems face challenges in switching functions due to complex molecular redesigns. Here, the authors introduce a base Stacking-Mediated Allostery (SMALL) strategy enabling efficient function switching with minimal architecture changes (1-2 nucleotides), implemented across diverse logic operations and cellular gene regulation patterns.

Yongpeng Zhang
Bozhao Li
Cheng Zhang

ResearchOpen Access23 Oct 2025

Nature Communications

Volume: 16, P: 1-14

Enhancing lane detection in autonomous vehicles with multi-armed bandit ensemble learning

J. Arun Pandian
Ramkumar Thirunavukarasu
L. Thanga Mariappan

ResearchOpen Access25 Jan 2025

Scientific Reports

Volume: 15, P: 1-15

ATP joins the fast lane

C. D. Benham

News & Views10 Sept 1992

Nature

Volume: 359, P: 103-104

PEX39 facilitates the peroxisomal import of PTS2-containing proteins

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins.

Walter W. Chen
Tony A. Rodrigues
Bettina Warscheid

ResearchOpen Access30 Jul 2025

Nature Cell Biology

Volume: 27, P: 1256-1271

Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci

Here, the authors identify mechanisms of glycosylation of intrinsically disordered regions present in streptococci membrane proteins, uncovering a functional role for glycosylation in Streptococcus mutans chaperone PrsA.

Mohammad M. Rahman
Svetlana Zamakhaeva
Natalia Korotkova

ResearchOpen Access29 Apr 2025

Nature Communications

Volume: 16, P: 1-20

Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins

Using cryo-EM, the authors identified 42 MIPs, including outer junction protein CFAP77 and outer dense fibers, in native doublet microtubules of Tetrahymena thermophila. Knockout of CFAP77 reduced ciliary beat frequency and led to outer junction damage.

Shintaroh Kubo
Corbin S. Black
Khanh Huy Bui

ResearchOpen Access15 Apr 2023

Nature Communications

Volume: 14, P: 1-16

SeqControl: process control for DNA sequencing

SeqControl uses 15 quality metrics of high-throughput sequencing experiments to predict how much sequencing is needed to reach a desired depth of coverage.

Lauren C Chong
Marco A Albuquerque
Paul C Boutros

Research31 Aug 2014

Nature Methods

Volume: 11, P: 1071-1075

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

C. Ruwende
S. C. Khoo
A. V. S. Hill

Research20 Jul 1995

Nature

Volume: 376, P: 246-249

Effective lane detection on complex roads with convolutional attention mechanism in autonomous vehicles

Vinay Maddiralla
Sumathy Subramanian

ResearchOpen Access19 Aug 2024

Scientific Reports

Volume: 14, P: 1-14

Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

Esha Madan
António M. Palma
Rajan Gogna

Research09 Dec 2024

Nature Biotechnology

Volume: 43, P: 1833-1847

Reply to: a quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy

Lincoln M. P. Shade
Qi Qiao
David W. Fardo

Research26 Jan 2026

Nature Genetics

P: 1-2

BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect

Andrew R Hallahan
Joel I Pritchard
James M Olson

Research20 Jul 2003

Nature Medicine

Volume: 9, P: 1033-1038

RRT-guided experience generation for reinforcement learning in autonomous lane keeping

Tamás Bécsi

ResearchOpen Access14 Oct 2024

Scientific Reports

Volume: 14, P: 1-10

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

Wayne A. Border
Nancy A. Noble
Erkki Ruoslahti

Research26 Nov 1992

Nature

Volume: 360, P: 361-364

Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM

High-speed AFM reveals CaMKIIα/β subunits are mixed within 12-unit rings, with βs frequently neighboring. Activated heterooligomers form stable kinase complexes, shedding light on their structural function in neuroplasticity.

Keisuke Matsushima
Takashi Sumikama
Mikihiro Shibata

ResearchOpen Access24 Dec 2025

Nature Communications

Volume: 16, P: 1-14

The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis

Robert Meineke
Ayse Agac
Guus F. Rimmelzwaan

ResearchOpen Access27 Jan 2026

npj Viruses

Volume: 4, P: 1-20

Pertpy: an end-to-end framework for perturbation analysis

Pertpy serves as a one-stop and performant framework for single-cell perturbation data analysis.

Lukas Heumos
Yuge Ji
Fabian J. Theis

ResearchOpen Access31 Dec 2025

Nature Methods

P: 1-10

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial

In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficient tumors is safe and elicits neoantigen-specific T cells in individuals with Lynch syndrome.

Anna Morena D’Alise
Jason Willis
Eduardo Vilar

ResearchOpen Access16 Jan 2026

Nature Medicine

P: 1-10

Secretory protein translocation across membranes—the role of the ‘docking protein’

David I. Meyer
Elke Krause
Bernhard Dobberstein

Research24 Jun 1982

Nature

Volume: 297, P: 647-650

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