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Showing 1–50 of 133 results

Advanced filters: Author: Daisuke Sakai Clear advanced filters

NR6A1 is essential for neural crest cell specification, formation and survival

Neural crest cells are migratory cells unique to vertebrates. Here they show that NR6A1 is a key regulator of neural crest cell formation and survival by downregulating pluripotency-associated genes, while upregulating neural crest cell specifier genes and epithelial cell to mesenchyme cell transition.

Emma L. Moore Zajic
William A. Muñoz
Paul A. Trainor
ResearchOpen Access29 Jan 2026
Nature Communications

P: 1-20
Weight optimization of MIMO-UWB distributed beamforming for implant communications

Takumi Kobayashi
Jaakko Hyry
Daisuke Anzai
ResearchOpen Access21 Jan 2026
Scientific Reports

P: 1-13
Heatstroke predictions by machine learning, weather information, and an all-population registry for 12-hour heatstroke alerts

In the context of climate change, heatstroke is expected to become an increasingly relevant public health concern. Here, the authors develop and validate prediction models for the number of all heatstroke cases in different cities in Japan.

Soshiro Ogata
Misa Takegami
Kunihiro Nishimura
ResearchOpen Access28 Jul 2021
Nature Communications

Volume: 12, P: 1-11
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

Back pain and sciatica are often caused by intervertebral disc degeneration. Sakai and colleagues identify a subset of nucleus pulposus progenitor cells from the intervertebral disc and show that loss of these progenitor cells correlates with ageing and intervertebral disc degeneration.

Daisuke Sakai
Yoshihiko Nakamura
Joji Mochida
ResearchOpen Access11 Dec 2012
Nature Communications

Volume: 3, P: 1-11
ABCC6 pathogenic variants are associated with hemorrhagic phenotypes in Japanese patients with severe cerebral small vessel disease

Sho Kitahara
Shoichiro Ando
Osamu Onodera
ResearchOpen Access23 Jan 2026
Scientific Reports

Volume: 16, P: 1-10
Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activities

This study reveals how a cancer-associated mutation in CHD1 leads to the loss of its C-terminal intrinsically disordered region, disrupting condensate formation. This impairment causes improper genome distribution and gene expression, driving cancer development.

Yasuhiro Tsukamoto
Atsuki Kawamura
Katsuya Sakai
ResearchOpen Access30 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

After outlining the rationale for injecting viable cells into the degenerating intervertebral disc (IVD), Sakai and Andersson provide an overview of basic and preclinical studies as well as ongoing clinical trials of cell therapies for IVD degeneration. Consideration is also given to various barriers to the development of these therapies and possible solutions to overcome such obstacles.

Daisuke Sakai
Gunnar B. J. Andersson
Reviews24 Feb 2015
Nature Reviews Rheumatology

Volume: 11, P: 243-256
Zero-field Hall effect emerging from a non-Fermi liquid in a collinear antiferromagnet V_1/3NbS₂

Magnetically intercalated transition metal dichalcogenides provide a platform to study the interplay of magnetism, electronic band structures, and correlations. Here the authors demonstrate a nearly magnetization-free anomalous Hall effect, collinear antiferromagnetism and non-Fermi liquid behavior in V_1/3NbS₂.

Mayukh Kumar Ray
Mingxuan Fu
Satoru Nakatsuji
ResearchOpen Access18 Apr 2025
Nature Communications

Volume: 16, P: 1-11
RNF213 c.14429G > A (p.Arg4810Lys) is associated with non-arteritic retinal artery occlusion

Daisuke Shimada
Satoru Miyawaki
Yoshiaki Shiokawa
ResearchOpen Access10 Oct 2025
Scientific Reports

Volume: 15, P: 1-7
SGLT2 inhibitor requires co-administration with diuretics to effectively reduce interstitial fluid retention: the DAPA-BODY trial

Takahiro Masuda
Maki Asakura-Kinoshita
Yoshiyuki Morishita
Research01 Oct 2025
Hypertension Research

Volume: 49, P: 499-507
Selective Inhibition of Acyl-CoA:cholesterol Acyltransferase 2 Isozyme by Flavasperone and Sterigmatocystin from Aspergillus Species

Kent Sakai
Satoshi Ohte
Hiroshi Tomoda
Research01 Sept 2008
The Journal of Antibiotics

Volume: 61, P: 568-572
The crystal structure of multidrug-resistance regulator RamR with multiple drugs

RamR is an important multidrug-resistance factor, however, its structure and the molecules to which it responds are hitherto unknown. Here, the authors report the crystal structures of RamR complexed with multiple drugs, revealing significant flexibility in its substrate-recognition region.

Suguru Yamasaki
Eiji Nikaido
Kunihiko Nishino
ResearchOpen Access26 Jun 2013
Nature Communications

Volume: 4, P: 1-7
Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

Homeobox protein Mohwak (Mkx) is involved in tendon and ligament development. Here the authors show that Mkx in the outer annulus fibrosus of the intervertebral disc plays a role in maintenance of the IVD, showing that stem cells overexpressing Mkx enhance therapeutic IVD regeneration in mice.

Ryo Nakamichi
Yoshiaki Ito
Hiroshi Asahara
ResearchOpen Access16 Aug 2016
Nature Communications

Volume: 7, P: 1-14
Selective Deposition of SiO₂ on Ion Conductive Area of Soda-lime Glass Surface

Daisuke Sakai
Kenji Harada
Junji Nishii
ResearchOpen Access13 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Author Correction: Iron-based binary ferromagnets for transverse thermoelectric conversion

Akito Sakai
Susumu Minami
Satoru Nakatsuji
Amendments and Corrections12 Aug 2020
Nature

Volume: 584, P: E37
Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans

Vertically oscillating head motions mimicking mechanical accelerations experienced during light jogging or treadmill running at moderate velocity reduce blood pressure in rats and human adults with hypertension.

Shuhei Murase
Naoyoshi Sakitani
Yasuhiro Sawada
ResearchOpen Access06 Jul 2023
Nature Biomedical Engineering

Volume: 7, P: 1350-1373
Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation

The TCOF1 gene is mutated in Treacher Collin's syndrome, a congenital craniofacial syndrome. Here, the authors show that Tcof1loss-of-function results in oxidative stress induced DNA damage and neuroepithelial cell death, and addition of antioxidants to pregnant mutant mice protected against these defects.

Daisuke Sakai
Jill Dixon
Paul A. Trainor
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-13
Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction

This study identified a subset of osteoclastogenic fibroblasts expressing INHBA/activin A in human cholesteatoma. It further elucidated the mechanism behind the induction of inflammatory bone destruction, suggesting a potential therapeutic target.

Kotaro Shimizu
Junichi Kikuta
Masaru Ishii
ResearchOpen Access03 Aug 2023
Nature Communications

Volume: 14, P: 1-12
Periportal macrophages protect against commensal-driven liver inflammation

A subset of Macro-positive macrophages is identified to have immunosuppressive functions in the periportal vein zones of the liver to mediate excessive inflammation, and their effects depend on commensal gut bacteria.

Yu Miyamoto
Junichi Kikuta
Masaru Ishii
Research24 Apr 2024
Nature

Volume: 629, P: 901-909
Direct entry of cell-penetrating peptide can be controlled by maneuvering the membrane curvature

Kazutami Sakamoto
Taku Morishita
Hideki Sakai
ResearchOpen Access08 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
Trastuzumab deruxtecan in HER2-positive advanced gastric cancer: exploratory biomarker analysis of the randomized, phase 2 DESTINY-Gastric01 trial

Exploratory analyses of the DESTINY-Gastric01 trial show that baseline HER2-associated biomarkers in circulating tumor DNA or tissue samples were associated with therapeutic response in patients with HER2-positive tumors, and these analyses identify potential drivers of resistance.

Kohei Shitara
Yung-Jue Bang
Kensei Yamaguchi
ResearchOpen Access14 May 2024
Nature Medicine

Volume: 30, P: 1933-1942
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Interplay between multipolar order and multipole-induced superconductivity in PrTi₂Al₂₀

The rare-earth superconductor PrTr₂Al₂₀ (Tr = Ti, V) possesses quadrupolar and octupolar but no magnetic dipolar moments. Here, the authors suggest an intimate link between the quadrupolar order parameter and the superconducting pairing in this material.

Akito Sakai
Yosuke Matsumoto
Satoru Nakatsuji
ResearchOpen Access03 Mar 2025
Nature Communications

Volume: 16, P: 1-8
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2

Hoshino et al., engineer a human virus receptor, hACE2, and demonstrate its potential for overcoming SARS-CoV-2 mutations that otherwise hinder therapeutic interventions. Overall, the data provide insights in to the therapeutic potential of engineered receptors.

Yusuke Higuchi
Tatsuya Suzuki
Atsushi Hoshino
ResearchOpen Access21 Jun 2021
Nature Communications

Volume: 12, P: 1-13
Multiancestry genomic and transcriptomic analysis of gastric cancer

A cross-ancestry genomic and transcriptomic cohort of gastric cancer highlights significantly mutated genes and mutational signatures, some of which are ancestry-specific.

Yasushi Totoki
Mihoko Saito-Adachi
Tatsuhiro Shibata
Research13 Mar 2023
Nature Genetics

Volume: 55, P: 581-594
Effects of Molecular Weight Distribution on Zero-Shear Viscosity of Linear Polymers in Dilute and Semidilute Regions

Yoshiaki Takahashi
Daisuke Sakakura
Ichiro Noda
Research01 Sept 1992
Polymer Journal

Volume: 24, P: 987-990
The influence of bone marrow edema for the assessment of the boundaries of necrotic lesions in patients with osteonecrosis of the femoral head

Satoshi Ikemura
Goro Motomura
Yasuharu Nakashima
ResearchOpen Access04 Nov 2022
Scientific Reports

Volume: 12, P: 1-9
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Predicting proximal junctional failure in adult spinal deformity patients using machine learning models based on spinal alignment parameters

Akihiko Hiyama
Daisuke Sakai
Masahiko Watanabe
ResearchOpen Access20 Nov 2025
Scientific Reports

Volume: 15, P: 1-14
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Breunnerite grain and magnesium isotope chemistry reveal cation partitioning during aqueous alteration of asteroid Ryugu

Returned samples from the carbonaceous asteroid Ryugu provide pristine information on the original aqueous alteration history of the Solar System. Here, the authors utilize Breunnerite grain and magnesium isotope chemistry to reveal cation partitioning during aqueous alteration of asteroid Ryugu.

Toshihiro Yoshimura
Daisuke Araoka
Yoshinori Takano
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus

Mya Myat Ngwe Tun
Kotaro Aoki
Daisuke Hayasaka
ResearchOpen Access18 Jun 2014
Scientific Reports

Volume: 4, P: 1-9
Humanization of autoantigen

Wataru Nishie
Daisuke Sawamura
Hiroshi Shimizu
Research25 Feb 2007
Nature Medicine

Volume: 13, P: 378-383
Iron-based binary ferromagnets for transverse thermoelectric conversion

Aluminium- and gallium-doped iron compounds show a large anomalous Nernst effect owing to a topological electronic structure, and their films are potentially suitable for designing low-cost, flexible microelectronic thermoelectric generators.

Akito Sakai
Susumu Minami
Satoru Nakatsuji
Research27 Apr 2020
Nature

Volume: 581, P: 53-57
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Masaharu Masuda
Akihiro Sunaga
Takuya Ohashi
ResearchOpen Access30 Apr 2025
Nature Medicine

Volume: 31, P: 1661-1667
Chemical evolution of primordial salts and organic sulfur molecules in the asteroid 162173 Ryugu

The asteroid Ryugu samples are by far the freshest extraterrestrial carbonaceous material. The authors report soluble ions and organic sulfur molecules linked with primordial brine and prebiotic organic evolution of the primitive asteroid.

Toshihiro Yoshimura
Yoshinori Takano
Yuki Kimura
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-11
Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans

Shuhei Murase
Naoyoshi Sakitani
Yasuhiro Sawada
Amendments and CorrectionsOpen Access07 Nov 2023
Nature Biomedical Engineering

Volume: 7, P: 1530
Sound velocity of hexagonal close-packed iron to the Earth’s inner core pressure

New constraints on the composition of Earth’s inner core are provided by experimental verification of Birch’s law for hexagonal close-packed iron to pressure above 300 gigapascals, about double the pressure achieved in previous investigations

Daijo Ikuta
Eiji Ohtani
Alfred Q. R. Baron
ResearchOpen Access25 Nov 2022
Nature Communications

Volume: 13, P: 1-8
Insights into IVDD pathogenesis in 2024

Emerging research in intervertebral disc degeneration in 2024 highlights microbial, immune and inflammatory mechanisms that drive chronic low back pain. These insights pave the way for potential transformative therapies that address the root causes of intervertebral disc degeneration and could improve patient outcomes.

Daisuke Sakai
News & Views20 Dec 2024
Nature Reviews Rheumatology

Volume: 21, P: 71-72
Short-term comparison of preoperative and postoperative pain after indirect decompression surgery and direct decompression surgery in patients with degenerative spondylolisthesis

Akihiko Hiyama
Hiroyuki Katoh
Masahiko Watanabe
ResearchOpen Access03 Nov 2020
Scientific Reports

Volume: 10, P: 1-7
Cosyntropin stimulation in adrenal vein sampling improves the judgment of successful adrenal vein catheterization and outcome prediction for primary aldosteronism

Midori Yatabe
Kanako Bokuda
Atsuhiro Ichihara
Research30 Apr 2020
Hypertension Research

Volume: 43, P: 1105-1112
A nationwide survey on the incidence and characteristics of traumatic spinal cord injury in Japan in 2018

Naohisa Miyakoshi
Kota Suda
Yoichi Shimada
Research11 Aug 2020
Spinal Cord

Volume: 59, P: 626-634
Changes in Spinal Alignment following eXtreme Lateral Interbody Fusion Alone in Patients with Adult Spinal Deformity using Computed Tomography

Akihiko Hiyama
Hiroyuki Katoh
Masahiko Watanabe
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia

Hajime Senjo
Masahiro Onozawa
Takanori Teshima
ResearchOpen Access10 Nov 2020
Scientific Reports

Volume: 10, P: 1-7
Correlation analysis of sagittal alignment and skeletal muscle mass in patients with spinal degenerative disease

Akihiko Hiyama
Hiroyuki Katoh
Masahiko Watanabe
ResearchOpen Access19 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells

Masamitsu Konno
Hidetoshi Matsui
Hideshi Ishii
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-9
Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis

Jun Koseki
Masamitsu Konno
Hideshi Ishii
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-7
A Palindromic Motif in the −2084 to −2078 Upstream Region is Essential for ABCA12 Promoter Function in Cultured Human Keratinocytes

Yoshitaka Shimizu
Yasushi Ogawa
Masashi Akiyama
ResearchOpen Access23 Oct 2014
Scientific Reports

Volume: 4, P: 1-5
Effects of Citrin Deficiency in the Perinatal Period: Feasibility of Newborn Mass Screening for Citrin Deficiency

Akiko Tamamori
Akie Fujimoto
Tsunekazu Yamano
Research01 Oct 2004
Pediatric Research

Volume: 56, P: 608-614

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