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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

In conventional s-wave superconductors, ferromagnetism is strongly suppressed, due to the singlet pairing of the electrons. Here, Xiang, He, Lin, and coauthors find a long-range ferromagnetic order among impurity sites in the spin-orbit coupled Fe(Se,Te) using scanning superconducting quantum interference device microscopy.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

The function of metal-organic frameworks is governed by their synthesis precision. Here, the authors report a light-driven strategy enabling ambient-temperature synthesis for cobalt-porphyrin frameworks, overcoming traditional thermal constraints.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Ribosomal Protein S15 (RPS15) is recurrently mutated in B-cell leukemia but its leukemogenic role remains unclear. Here, the authors establish mutant RPS15 as a cancer driver and reveal mechanisms by which these mutations induce translational defects, DNA damage and genomic instability that together promote leukemogenesis.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

Pancreatic ductal adenocarcinoma carries a poor prognosis, with pancreatectomy as the only potentially curative option. This Phase II trial assessed distant metastasis-free survival in locally advanced disease using GVAX vaccine, pembrolizumab, and SBRT following chemotherapy.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Climate warming alters plant lifecycles, but the extent of these shifts is also determined by plants’ inherent traits, not just climate.

IMiD-based PROTACs may degrade IKZF1/3 with hematologic effects. This study profiles these liabilities using hematopoietic assays showing stem cell rewiring and interferon activation and introduces a CRBN ligand that reduces them.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

Structural complexity often hinders the efficient conversion of lignin into sustainable high-value products. This bifunctional core–shell catalyst enables a relay reaction that transforms lignin into jet-fuel range cycloalkanes with high yields.

In this study, the authors report the structure of a human astrovirus spike protein bound to the FcRn receptor and show that clinically approved FcRn inhibitors potently inhibit virus infection via competing with viral spike proteins for receptor binding.

Ynimines are structurally versatile chemical motifs yet remain largely underexplored in organic synthesis compared with the extensively studied ynamides. Here, the authors report a three-component synthesis of 1- imido-3,4-trans-disubstituted cyclohex-1- enes via in situ generation of 2-imido-1,3-dienes from ynimines and carboxylic acids.

An early event after lung injury is extracellular matrix remodelling. Here, the authors show that thrombospondin-1 (TSP1) from megakaryocytes/platelets protects the lung’s extracellular matrix, particularly basement protein COL6. Mice without TSP1 had greater lung damage and neutrophil activity, showing TSP1 reduces injury severity.

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Global cropland subsoil hides a “biogeochemical engine” where crop roots, soil texture, nitrifier communities, and hydrological conditions interact to fuel nitrification, silently driving soil acidification and groundwater nitrate pollution.

‘Desalination of hypersaline waters is challenging for conventional methods. Here, authors enhance MOF-801 membranes by regulating missing linkers, improving water transport and achieving high salt rejection, offering an efficient solution for water purification.’

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

While atomic disorder normally promotes glassy states, in some rare cases long-range magnetic order can persist. However, the mechanism, and microscopic characters, remain elusive. Here, Shen et al combine neutron diffraction and resonant X-ray scattering to shed light on the formation of long-range magnetic order in a high-entropy honeycomb van der Waals magnet.

Recently, superconductivity was achieved in La3Ni2O7 and (La,Pr)3Ni2O7 thin films at ambient pressure due to in-plane compressive strain. Here, the authors report the enhancement of the superconducting onset from about 30 K to over 48 K by applying hydrostatic pressure to the films.

Using an integrative spatial Bayesian framework that merges high-resolution environmental pesticide risk modelling with comprehensive cancer registry data, this analysis reveals spatial patterns of pesticide exposure and liver tissue-derived molecular signatures across Peru, establishing links between pesticide usage and cancer insurgence at the national scale.

A global study of 1602 soil samples identifies dominant bacterial plant pathogens and reveals microbial traits, soil carbon and climate that promote natural suppression, while climate change may increase disease risks in many regional hotspots.

Lin and colleagues present high-affinity split-HaloTag pairs for protein tagging and multiplexed labelling. This versatile system allows protein visualisation with diverse imaging modalities, including live-cell super-resolution microscopy.

Immune imprinting narrows the vaccine recall response towards dominant epitopes but protection against rapidly evolving viruses is enhanced if the breadth of responses is preserved. Here authors show in a ferret model that introducing optimized antigenic variation between prime and boost vaccines diversify the targeted epitopes and thus broadens immunity in a ferret model of influenza vaccination.

The response of Mars’ ionosphere to major solar energetic events has been known, but such observations are challenging. Here, the authors show mutual radio occultation observations revealing that a solar flare in May 2024 enhanced the lowest ionospheric layer of Mars by 278% of its typical size.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Recent work has identified long-lived two-level systems in fluxonium qubits, prompting the development of techniques that capture environmental memory effects. Here, using two-timescale relaxometry, the authors show that the relaxation dynamics of fluxonium qubits are dominated by a discrete set of two-level systems with millisecond relaxation and sub-microsecond coherence times.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Single-variant and ultrarare variant burden analyses leveraging exome sequencing data from 22 cohorts identify new risk genes for amyotrophic lateral sclerosis and show cumulative effects of several rare variants on disease risk.

Plasma ctDNA testing for FGFR alterations in metastatic urothelial carcinoma shows high concordance with tissue testing and identifies additional patients with actionable alterations. Here, the authors show that clinical uptake of ctDNA FGFR testing can be combined with tissue-based approaches.

Extreme thermal transport in 2D materials challenges classical models. Here the authors combine microheater-based thermal control and Raman thermometry to reveal high in-plane thermal conductivity and non-diffusive phonon transport in suspended monoisotopic hBN.

Cyclic di-GMP, a bacterial second messenger, governs many cellular processes including bacterial lifestyle transitions. Here, authors develop a set of FRET-based biosensors that enables them to monitor real-time cellular dynamics of c-di-GMP and to perform a genome-wide analysis that reveals complex interplay between motility and c-di-GMP regulation.

Arsenic’s dual nature—both beneficial and toxic—has long challenged its practical use in chemistry. Now it has been shown that photoredox catalysis can directly convert arsenic sulfide minerals into diverse organoarsenicals, bypassing hazardous intermediates and offering a safe, sustainable and scalable route to functionalized arsenicals.

Improving crop yield very often comes at the cost of crop quality and stress resistance. Here, the authors report that gene editing of the thiamine pyrophosphate riboswitch in rice leads to elevated levels of various vitamins and phytonutrients, as well as resistance to cold and blast disease without penalty on grain yield.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

A computational ‘information co-evolution’ framework is developed for the discovery of covalent organic frameworks (COFs) for hydrogen peroxide photosynthesis. By integrating cross-level feature fusion with data augmentation and ensemble modelling, this strategy overcomes challenges in structural representation and data limitations, enabling the identification of high-performance COF candidates and the discovery of important structural motifs.

Synthetic cells mirror fundamental biological behaviors, like growth, metabolism, and mobility, but have lacked genotype-driven selection, which is essential for Darwinian evolution. Here, the authors introduce libraries of short DNA sequences as genotypes into fuel-dependent peptide-RNA-based coacervate droplets, identify sequences that partition on the droplets, and show they differentially affect the droplet phenotype.

Bimerons are magnetic solitons that are topologically equivalent to skyrmions in in-plane magnetized systems. This study demonstrates the room-temperature creation of bimerons in Co₈Zn₈Mn₄ via femtosecond laser pulse excitation, revealing dynamic topological control and morphological transitions of these solitons.