New-to-nature photometabolisms are highly intriguing for manufacturing but difficult to achieve. Now, Escherichia coli engineering integrates flavin-based photobiocatalysis with natural enzymatic reactions, achieving efficient semi- and complete photobiosynthesis of diverse unnatural products, demonstrating scalable manufacturing in bioreactors.
- Tengfei Pang
- Yangjinxiu Zhou
- Yuzhou Wu