Search

Immunosuppressive tumor-associated macrophages (TAM) contribute to resistance to immune checkpoint blockade. Here, the authors propose BCAT1 to inhibit crotonate-mediated epigenetic reprogramming of tumor-associated macrophages, with BCAT1 loss promoting immune escape in hepatocellular carcinoma mouse models.

Tree cover gains in the moist tropics (1982–2015) were 56% naturally regenerated forests and 27% managed tree systems, with forest type influencing carbon recovery. Effective forest restoration requires robust tracking of forest types established by restoration efforts.

When a femtosecond laser is focused onto a tungsten tip, excited surface plasmon polaritons form a relativistic terahertz soliton at the tip apex in a supersonic argon jet. It exhibits sustained stability over 100-ns durations and 400-μm spatial dimensions and resembles ball lightning.

This systematic analysis of electroactive cardiac patches with different conductivities challenges the widely accepted hypothesis that an implant conductivity similar to normal myocardium is optimal for therapeutic and clinical outcomes, and supports the claim using animal models and patient-specific theoretical modelling.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

One of the challenges in the development of photoresist materials is the trade-off between resolution, line roughness and sensitivity, however, the underlying dynamics remain underexplored. Here, the authors combine Fermi’s Golden Rule for photoionization, natural orbital branching real-time TDDFT (NOB-rt-TDDFT) for excited-state dynamics, and ab initio molecular dynamics (AIMD) for fragment evolution to study EUV-induced photolysis in phenyl triflate, proposing a photodissociation mechanism based on non-adiabatic energy transfer.

Manipulating cellular mechanotransduction is important for research and therapeutics. Here, the authors report on magnetically controlled gear-like MOFbots to stimulate microvilli, triggering intracellular signal and delivering therapeutics into cells via mechanotransduction controlled membrane permeability.

This study reports DLFea4AMPGen, a peptide design strategy that leverages deep learning to identify and extract key features for the generation of new antimicrobial peptides (AMPs), which allowed for the identification of 12 AMPs with bioactivity.

In this study, authors reveal an evolutionary strategy in bacteria, where multidrug resistance are stably maintained through multicopy heterogeneous genes on a single plasmid, conferring an adaptive advantage under fluctuating clinical drug pressures.

Organic light-emitting materials with narrow emission bands still struggle with difficult synthesis and performance losses from aggregation and slow spin conversion. The authors design a boron–nitrogen–boron molecular framework that improves spin interactions, limits aggregation, and yields efficient, narrow emission.

Assessing the hepatotoxicity of a drug is critical in drug development. Here, the authors develop human multi-lineage liver organoids and identify imipramine as an inducer of indirect hepatotoxicity from a drug screen. The study offers insight into indirect hepatotoxicity and an in vitro platform for drug safety testing.

Here, Zhang et al. succeed in creating a heavily distorted oxygen deficient film of lanthanum cobaltite. The new phase of LaCoO_2.5 has several unique properties, most notably, a Curie temperature of 284 K, significantly larger than the films from which it was derived.

High-speed electrostatic micromotors with low energy consumption are attractive for small-scale electromechanical systems, but applications are limited by power supplies. Here the authors use a triboelectric nanogenerator for actuation of a high-speed micromotor by low-frequency mechanical stimuli.

Prussian blue has been used as a photothermal agent for cancer therapy. Here the authors describe the production of Prussian blue nanoparticles from S. oneidensis MR-1 bacteria and show that a Prussian blue-based mitochondria-targeting nanoplatform potentiates response to immune checkpoint blockade.

How the conditions in soil layers below the surface change is not well understood. Here the authors assess changes in subsurface soil moisture, finding that these droughts also become more persistent and intense than surface droughts.

The magnitude of the increase in global river flow between 1980 and 2014 is 13.6% lower than Earth system models estimate and is expected to be 9.3% lower in the future, according to an analysis of emerging constraints on the components of the water cycle.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Synovitis is a key early driver of osteoarthritis (OA), and RANKL contributes to cartilage degradation in OA. Here the authors show that denosumab, an anti-RNKL antibody, reduces synovitis and delays OA progression in animal models and patients.

Macrophage TP53-induced glycolysis and apoptosis regulator (TIGAR) is implicated in a range of immunopathology. Here the authors show TIGAR drives inflammation and sepsis via activation of TAK1 and that disruption of TIGAR-TAK1 interaction in a murine model of sepsis reduces immunopathology.

Enhancing the toughness of hydrogels while maintaining biocompatibility is desirable for many biomedical applications. Here, Zhu et al. reports a strategy using peptide-based rigid nanorods for increased hydrogel toughness and compressive strength while preserving biocompatibility, demonstrating enhanced osteochondral repair and compatibility with additive manufacturing.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

Using time-resolved Coulomb-explosion imaging, the authors capture a 600 fs pseudorotation in the benzene cation, revealing coherent vibronic dynamics around a conical intersection and visualizing transient structural variations.

Here the authors reveal that phase‐separated nuclear CCER1 condensates are required for male fertility by mediating chromatin condensation and histone epigenetic modification, while loss‐of‐function variants of human CCER1 are pathogenic in patients with nonobstructive azoospermia (NOA).

Pancreatic cancer detection can be challenging, and is often diagnosed at a late stage. Here, the authors present a cfDNA-based liquid biopsy model that enables early detection and prognosis prediction of pancreatic cancer.

Aqueous zinc metal batteries often face performance decay under thermal environments, originating from side reactions caused by aqueous electrolytes. Here, authors report an organic-inorganic-H₂O multiphase aqueous soggy-sand electrolyte that reconstructs hydrogen-bond networks, eliminates parasitic reactions, and promotes uniform Zn deposition at elevated temperature (140 ^oC).

Researchers employ machine learning-driven simulations to investigate the behavior of oxygen under extreme pressures up to 1,000 TPa. They identify stable phases and obtain information on the melting line and thermal properties of oxygen, improving our understanding of the structure and evolution of white dwarfs.

Base editors lacking a deaminase improve thymine and cytosine conversion.

The suboptimal performance of perovskite solar cells based on non-fullerene acceptor as the electron-transporting layer underscores the need for their molecular engineering. Here, authors substitute the core of Y6 with phenanthroline and crown ether, achieving a certified efficiency of 25.59%.

The authors introduce an exciting paradigm for achieving perfect anomalous refraction using an all-dielectric quasi–three-dimensional subwavelength structure and demonstrate half-space beam scanning.

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

The systematic ferroelectric domain control in ferroelectric CuInP₂S₆ systems has remained elusive. Herein, the authors report the efficient ferroelectric domain engineering under a unipolar electric field in CuIn₂S₆ system.

Semi-aquatic robots rely on surface tension for propulsion, which implies that breaking the water surface is a limitation. Here, the authors developed a soft robot with a superhydrophobic body, achieving high jumping height and take-off velocity.

Orbital torque, arising from the orbital Hall effect, allows for the manipulation of magnetic order. Crucially, many light elements have large orbital Hall effects and therefore large orbital torques. Here, Zhang, Wei, Duan, Chen, and coauthors demonstrate efficient magnetization switching of Fe3GaTe2 using orbital torque.

Base editing technology has great potential in treating pathogenic single-nucleotide variations. Using a dual-AAV base editing system, Wu et al. restored visual functions in a mouse model of retinitis pigmentosa.