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The substrate surface engineering approach prevents the formation of twin structures, while the elimination of twins greatly enhances carrier mobility and suppresses bipolar conduction, leading to optimized power factor in twin-free Bi₂Te₃ films.

Helitrons are a recently identified category of transposons. This study reveals that heat stress combined with reduced DNA methylation can mobilize a Helitron family in wheat. Its mobilization is genetically linked to a specific full-length member catalysing the full Helitron life cycle.

Prostate cancer heterogeneity limits the efficacy of current therapeutic approaches. Here, the authors develop two methods, snFLARE-seq and mxFRIZNGRND, using formalin-fixed paraffin embedded samples for analysing the transcriptomic and metabolomic landscape of different anatomical origins.

Cross coupling via the activation of two carbon-hydrogen bonds avoids the need for organometallic coupling partners and associated waste. Here, the authors report a radical process that allows selective coupling between alkynes and non-activated C(sp³)-H groups via a multimetallic catalytic system.

An n-type conducting polymer with excellent mixed ionic and electronic transport enables a practical lithium–organic battery that exhibits a wide operating temperature range and excellent safety.

Distinguishing surface rain from snow in real time is crucial for winter storm warnings. This study presents “RePPIC-Net”, a hybrid AI model that fuses satellite data with AI weather forecasts to decipher snow from rain with rapid speed and accuracy, paving the way for improved global hazard alerts.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Silicon solar cells with hybrid interdigitated back contacts have a power conversion efficiency approaching 95% of the theoretical limit and a fill factor approaching 98% of the theoretical limit.

“Understanding the structure-property relationship of organic molecules which exhibit different properties upon aggregation is important for the field of material science. Here, the authors prepare nonconjugated rhodamine-based molecules without aggregation-induced emission building blocks yet displaying typical aggregation-induced emission behavior.”

Oxidative carbonylation using CO/O₂ is an attractive strategy to construct carbonyl compounds, but the explosive limit of the gas mixture hampers its application. Now, this safety issue is overcome in the aminocarbonylation of alkynes by replacing the external oxidant O₂ by electrochemistry facilitating a mild and safe reaction.

Electrochromic devices offer dynamic modulation of light and heat but suffer from limited color tunability, sluggish switching speeds, and low coloration efficiency, especially in inorganic electrochromic materials, which impede their widespread adoption. Here, the authors show a complementary organic electrochromic device that employs dual conductive polymers and overcomes these limitations.

We fabricated silicon heterojunction back-contact solar cells using laser patterning, producing cells that exceeded 27% power-conversion efficiency.

Solid waste disposal is a major source of anthropogenic methane, yet estimating these emissions is difficult. Here the authors use satellite data to assess emissions from high-emitting landfills and find that transforming open sites to sanitary landfills could offer a large mitigation potential.

Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent signalling activation and tumour progression.

Current mesenchymal stem cell (MSC) transplantation practices are limited by the loss or reduced performance of MSCs. Here the authors develop a bead-jet printer for intraoperative formulation and printing of MSCs-laden Matrigel beads to improve skeletal muscle and hair follicle regeneration.

A high-quality autopolyploid genome of Saccharum spontaneum accession Np-X and resequencing of 102 accessions provide insights into the recent chromosome reduction and polyploidization in Saccharum.

The haplotype-resolved genome of tetraploid modern rose, along with a variation map of 233 wild and cultivated Rosa accessions, reveals the complex genome composition of modern roses and elucidates the genomic bases of their origin and breeding.

A haplotype-resolved genome of hybrid sugarcane cultivar XTT22 and population analyses of Saccharum accessions highlight the genome evolution of allopolyploids and provide opportunities for sugarcane breeding.

Achieving both high efficiency and stability in organic solar cells is challenging. Now, Liang et al. show that oligomer acceptors improve the molecular packing and morphology of the active layer, affording a 15% efficiency and enhanced stability.

The sugarcane relative, Erianthus rufipilus, is one of the rare diploid species within the Saccharum complex. Its gap-free genome reveals centromere diversification, epigenetics of a palaeo-duplicated chromosome and evolution of Saccharum.

Immunosuppression as a result of severe infection impairs pathogen clearance and can increase susceptibility to secondary infection. Here, the authors dissect how T cell aging and the thymic involution that occurs during this process contribute to immunosuppression and find a key role for IL-33.

Osteosarcoma survival rates have been largely unchanged for several decades, and treatment response is variable. Here, the authors analyzed genomic, transcriptomic and epigenomic data from 121 osteosarcoma patients and identify subtypes related to treatment outcome.

Glucose metabolism is crucial for cellular energy regulation and affects the immune response. Here the authors show that nutritional supplementation of mannose may be beneficial during virus infections by rewiring glucose metabolic dysregulation and alleviating inflammatory tissue damage.

Controlling the kinetics and thermodynamics of electrochemical processes is essential to achieve high-performance multielectron reduction. Here, the authors report laser-induced copper bipyramids with abundant nanograins and controlled tip angles for enhanced multielectron CO₂ and nitrate reduction.

While strain engineering via support modification is a powerful strategy to tune catalytic properties, it is complex to control for immobilized molecular complexes. Now the curvature of carbon nanotubes is leveraged to induce strain to metal phthalocyanine complexes and boost their electrocatalytic activity

A reaction is described combining oxidative polymerization and in situ reductive n-doping to yield poly(benzodifurandione), a facilely synthesized stable n-type conducting polymer with ultrahigh conductivity, with applications in organic electronics.

Mercury (Hg) is a global neurotoxic pollutant and has a long chain from economic activities to human health risks. Here the authors presented a map of Hg-related health risks in China and found significant impacts of interprovincial trade on health risks, such as the prevention of deaths from fatal heart attacks by the trade induced by final consumption.

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

The termination of the Marinoan snowball Earth event marks one of the most drastic transitions in Earth history, but the oceanic response remains unclear. Here, the authors’ integrated analysis demonstrates that the ocean experienced transient but widespread euxinia following this Snowball Earth event.

This Registered Report presents the results of the Long-read RNA-Seq Genome Annotation Assessment Project, which is a community effort for benchmarking long-read methods for transcriptome analyses, including transcript isoform detection, quantification and de novo transcript detection.

The deglaciation of Marinoan snowball Earth (~635 Myr ago) has been associated with potentially extensive CH₄ emissions in relation to transient marine euxinia. Here, the authors find that active methanogenesis occurred during the termination of Marinoan snowball Earth, fueled by methyl sulfide production in sulfidic seawater.

A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.