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Previous study showed Zishen Yutai Pill improved pregnancy outcomes in in vitro fertilization. This study showed that Zishen Yutai Pill increased live birth rates in women aged 35–42 undergoing IVF.

A comprehensive single-cell atlas now reveals eosinophil heterogeneity across several mouse tissues, linking distinct cellular states to tissue residency and lifespan, and offering insights into their context-dependent phenotypic and functional adaptations.

Electrochemical CO₂ capture is an emerging field in electrical decarbonization but limiting unwanted side reactivity remains a challenge. Here, authors present an electrochemical capture swing that is decoupled from redox carrier generation, enabling CO₂ capture from O₂-containing gas streams.

Neoadjuvant chemoradiotherapy has become the standard of care in patients with resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). Here, authors present a randomised phase II trial reporting the non-inferiority of neoadjuvant camrelizumab (anti-PD-1) and chemotherapy (nab-paclitaxel and cisplatin) compared to chemoradiation (nab-paclitaxel, cisplatin, and radiotherapy in patients with resectable LA-ESCC.

Hydrogels have some desirable properties, but applications can be limited if they are too fragile. Here, the authors report the development of a freeze-assisted bidirectional ion migration strategy for the fabrication of tough hydrogels.

This study identifies four distinct polycystic ovary syndrome (PCOS) subtypes using unsupervised clustering analysis on data from 11,908 women and validated across five diverse cohorts. The subtypes show unique clinical features and suggest that subtype-specific management could enhance treatment precision for PCOS.

Liu et al. experimentally demonstrate a terahertz chaos source based on a terahertz quantum cascade laser without any external perturbations. It is found that the chaos generation in the terahertz laser is ascribed to the defect-mediated turbulence.

FHIRM-TPM 3.0 is a miniature microscope for multicolor two-photon imaging in freely moving mice. In addition to the multicolor imaging abilities achieved with the help of a specially designed optical fiber, the microscope is also compatible with multiple lenses for a choice of field of view and resolution.

Embryonic stem cells are characterized by self-renewaland pluripotency. Here, the authors show an affordable, efficient, and stable replacement for LIF in mESC cultivation.

Seawater direct electrolysis using renewable energy provides an appealing pathway to harness abundant oceanic hydrogen resources. Here, authors report a redox-mediated decoupled seawater direct electrolysis strategy to suppress the chlorine electro-oxidation side reaction.

As a major source of reactive oxygen species, mitochondria face a challenge to maintain their redox state. Here the authors show that ROMO1 overexpression prevents deleterious oxidation of the mitochondrial cysteinome and exerts beneficial effects on mitochondrial function.

Nimbolide is an inhibitor of poly(ADP)-ribosylation-dependent ubiquitin E3 ligase RNF114. A modular synthesis of nimbolide and its analogues is now reported, using a sulfonyl hydrazone-mediated etherification and a radical cyclization strategy. These analogues give insight into structure–activity relationships and some have superior poly(ADP-ribose) polymerase-1 trapping activity relative to nimbolide.

MAT2A/MAT2B induction is required for hepatic stellate cell activation and FOXM1 is implicated in liver inflammation and fibrosis, but whether they crosstalk in liver disease is unknown. Here, the authors show that upregulation of the FOXM1/MAT2A/MAT2B axis drives liver inflammation and fibrosis.

PinMyMetal (PMM) is an accurate tool for predicting transition metal binding sites in proteins. It integrates geometric and chemical features, outperforms existing methods, and supports large-scale genome analysis and drug design.

This randomized trial assessed the effectiveness and safety of single blastocyst transfer vs single cleavage-stage embryo transfer among women with good prognosis. Here, the authors show improved cumulative live birth rates and relatively unfavorable perinatal outcomes after blastocyst transfer.

Stereoscopic imaging mimics human vision by using two offset cameras to perceive depth. Here, the authors propose time-domain stereoscopy, leveraging space-time duality for high-resolution, real-time 3D imaging via temporally offset optical gating.

Developing fast-responsive NH3 sensors at room temperature is challenging. Here the authors developed robust Hoffmann-type MOF based NH3 sensors with a low detection limit (25 ppb) and quick response (5 s). The sensors exhibit high NH3 selectivity, stability, and easy recovery.

Metabolic disorder significantly contributes to diabetic vascular complications, including diabetic retinopathy (DR). This study reveals that O-GlcNAcylation, a nutrient-sensitive protein modification, drives vascular dysfunction in DR by stabilizing Hippo signaling key components YAP/TAZ. Targeting O-GlcNAc-YAP/TAZ shows therapeutic potential for mitigating DR pathology.

Although urban fire incidents cause enormous casualties due to dense population concentrations, the risks from these incidents under a warming climate remain unknown. This study analyzed a global database of urban fire incidents to quantify and predict changes in the frequency of various urban fire incident types in response to a warming climate, finding general increases in fire frequency.

This study shows that smoking worsens neovascular age-related macular degeneration via the Sema4D-PlexinB1 pathway. Targeting Sema4D reduces choroidal neovascularization and enhances anti-VEGF therapy efficacy, offering a potential therapeutic approach.

The molecular mechanisms underlying acquired chemoresistance to proteasome inhibitors (PIs) in multiple myeloma (MM) remain to be explored. Here, the authors highlight the role of heterochromatin protein 1 gamma as a potential target for overcoming resistance to PIs in MM.

Seawater electrolysis shows promising potential toward sustainable energy generation, but large-scale in-situ demonstrations are still lacking. Here, authors report a floating platform integrating a 1.2 Nm³h⁻¹ seawater direct electrolysis system with wind power for energy input in the Xinghua Bay.

Coptis chinensis represents an early-diverging eudicot lineage with diverse medicinal applications. Here, the authors report its chromosome-scale genome assembly, infer a single ancient whole-genome duplication, and characterize the function of CYP719 in diversification of protoberberine-type alkaloids.

A three-photon miniature microscope with optimized light-collection efficiency facilitates imaging of neuronal activity throughout the cortex, as well as in the hippocampus, in freely moving mice.

The bacterium Lacticaseibacillus paracasei is used in the food industry and as a probiotic. Here, the authors use multi-omics and high-throughput chromosome conformation capture analyses to investigate the roles of a type of DNA methylation (N6-methyladenine modification) in this organism.

Dual blockade therapy is currently being trialled for multiple tumour types, but efficacy is variable. Here, the authors use longitudinal proteomics profiling of 22 patients to develop a predictive model of therapy response.

Aberrant circRNAs expression in repair cells is intricately linked to deficits in wound healing. Here, the authors engineered extracellular vesicles enriched with circCDK13 and demonstrate their ability to facilitate diabetic wound repair.