Search

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

This study shows that tropical cyclone heavy rainfall has extended inland along the coasts of the Northern Hemisphere with a rate of 3.8 km per decade since 1980. Nearshore sea-surface warming drives this expansion, with coastal urbanization further amplifying the effect. These findings highlight increasing flood risk for inland populations as cities grow.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Thermogenic adipocytes are a potential therapy to combat obesity, although the process underlying their activation remains unclear. Here, the authors use epigenetic profiling to demonstrate RUNX1 and RUNX2 inhibit thermogenesis by distinct mechanisms.

2D semiconductors are considered a promising platform to complement silicon in next-generation electronics. Here, the authors report the fabrication of generic logic blocks based on bias-gated 2D MoS₂ transistors, showing the design of logic circuits with transistor count saving of over 60% compared to conventional Si electronics.

The authors mapped the continental-scale fraction of age-dependent leaf area index and revealed a widespread increase in the fraction of photosynthetically efficient young leaves across the majority of Amazon rainforests over the past decades.

A unified optoelectronics platform comprising dual-comb generation, modulation and metasurface-enabled beam steering serves as a transmitter for any standards between 2G and 6G. This architecture reduces power usage and costs, enabling a direct link between edge data-centre devices and the wireless network.

AI models consume growing amounts of energy. Here, the authors introduce a brain-inspired way to prune connections in randomly weighted resistive-memory chips, boosting accuracy while avoiding costly analog tuning to improve general efficiency and reduce power use.

The longevity of leaves determines the overall duration of photosynthesis for plants. This study suggests that climate change drives leaf longevity convergence toward intermediate ranges, which, by altering leaf traits and enhancing photosynthetic capacity, strengthens ecosystem stability and is closely linked to vegetation diversity.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

As an important class of open-shell molecules characterized by triangular nanographenic structures and interesting magnetic properties with high-spin ground states, triangulenes are attractive targets. Here, the authors report a highly stable aza-derivative of [4]triangulene triradical with a quartet ground state.

A recent randomised controlled trial demonstrated effectiveness of a smart pillbox for oral HIV pre-exposure prophylaxis adherence in men who have sex with men in China. Here, the authors show that the intervention is cost effective, with greater benefits for more socially vulnerable groups.

Divalent cation–exchanged zeolites enable complete ambient NO₂ removal with zero NO emission, overcoming a long-standing challenge in air purification and establishing a scalable pathway for zero-emission NO_x filtration.

Diabetic retinopathy is a major cause of blindness, yet ways to predict who will be affected remain limited. Here, the authors show that patterns of blood proteins can reveal disease mechanisms and enable powerful early prediction across diverse populations.

Hydrogen oxidation in alkaline media is limited by slow reaction kinetics. Here, the authors develop a family of bimetallic catalysts by theoretical analysis and reveal that RuIr achieves superior activity and durability through synergistic adsorption of hydrogen and hydroxyl intermediates.

The identification of marine alkenones and anomalously high carbonate carbon isotopic values in sediments suggest the Qaidam Basin in the northern Tibetan Plateau was uplifted from sea level to its present altitude since the Mid-Miocene.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Yao et al. observe and characterize genomic redistribution of the PBAF complexes upon PBRM1 loss, leading to sustained RELA occupancy by SMARCA4, activation of the NF-kB pathway and enhanced kidney tumourigenesis.

The fabrication of two-dimensional covalent organic framework films with uniform thickness, ordered structure and excellent semiconducting performance directly on substrates for applications in electronic devices remains challenging. Here, the authors address the challenge and produce out-of-plane oriented two-dimensional covalent organic frameworks by a Marangoni flow-aided interface synthesis method.

This study presents a scalable and sustainable electro-membrane crystallization-assisted general recycling technology that efficiently recovers high-purity lithium, manganese, nickel, and cobalt from spent lithium-ion batteries.

Smart windows offer more efficient sunlight modulation and heat management. Here, the authors propose a co-assembly strategy to produce smart windows that combine electrochromic and thermochromic functions with tunable components and ordered structures for dynamic solar radiation regulation.

The development of robust catalysts that could work under industrial-scale current densities remains a challenge for chlor-related reactions. Here, the authors report an activation method for designing efficient ruthenium single-atom catalysts that enhance chlor-related production and recycling.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

ENSO teleconnections are usually assumed to be stationary. Here the authors show that volcanic eruptions disrupt ENSO teleconnections with land summer temperatures, with crucial implications for Earth System Models and paleoclimate reconstructions.

Quantum memory — with its unique ability to generate, preserve, and perform nontrivial operations on quantum states — provides powerful quantum-enhanced capabilities and is a promising platform for in-memory computing.