Search

In thin film spintronic devices, heavy metals with strong spin-orbit coupling are required to achieve a sizeable spin Hall effect. Here, the authors demonstrate an enhancement of the spin Hall effect in Cu, a material with weak spin-orbit coupling, via natural oxidation.

A size-controlled composite powder feedstock design effectively enhanced the cryogenic strength and ductility of additively manufactured medium-entropy alloys through in-situ formation of hard and stiff reprecipitates.

The need to use blue or high-energy near-UV light limit the synthetic applications of the combination of photocatalysis and transition-metal catalysis. Here, the authors report a method for red-light-driven nickel catalyzed cross-coupling reactions of aryl halides with 11 different types of nucleophiles using a polymeric carbon nitride as photocatalyst.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

Classical metalation reactions in organic synthesis typically involve metal-halogen exchange. Here, the authors introduce a metal-carbon exchange strategy that enables the skeletal editing of biologically relevant lactams by a Ni(0) compound.

Stereoselective synthesis of tri-and tetrasubstituted olefins is challenging due to the usually low energy difference between their E/Z isomers. Now, access to these molecules in high E:Z ratios from monosubstituted olefins is achieved through a sequential nickel-catalysed Heck reaction and alkene migration.

Converting plastic waste into single-atom catalysts (SACs) provides both a sustainable approach to waste management and a source of valuable catalytic materials. Here, the authors present a straightforward, scalable method to upcycle plastic waste into diverse porous SACs and showcase their outstanding performance across multiple catalytic reactions.

The CorA-associated type III-B CRISPR–Cas system synthesizes S-adenosyl methionine (SAM)-AMP, triggering immune responses. Through structural characterization and biochemical validation, Duan and Jin et al. unveil unique mechanisms for SAM-AMP synthesis and degradation and provide insights into the molecular basis of type III CRISPR–Cas signaling.

Efficient catalysts are key to advancing the hydrogen economy, particularly for the hydrogen evolution reaction. Here, the authors report that ultra-low coordinated hollow PtRuNi-Ox nanocages offer comparable catalytic performance and stability in both freshwater and wastewater conditions.

The oxygen evolution reaction is crucial for energy conversion but faces challenges in catalyst optimization. Here, the authors present a dual-modulated NiFe oxyhydroxide (R-NiFeOOH@SO4) that enhances OER performance through optimized metal and lattice oxygen sites, achieving a compatible multi-mechanism.

Many proposed spintronic devices, where spin, rather than charge is used for information processing, rely on the combination of multiple materials, for example, heavy metals and magnetic materials in spin-orbit torque devices. Here, Gao et al. show how the interface between a ferromagnet and a semimetal, Ni81Fe19/Bi0.1Sb0.9, can result in a barrier-mediated spin-orbit torques

Layered double hydroxides are promising candidates for electrocatalytic oxygen evolution reaction yet their catalytic stability needs to be further improved. Here, the authors use trimesic acid anchoring to stabilize nickel-iron layered hydroxides for water oxidation with enhanced stability.

The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

Mycobacterium tuberculosis produces linoleic acid, which is released from macrophages during infection and upregulates regulatory T cell activity, to suppress macrophage control of intracellular bacteria in mice.

Without directing auxiliaries, the addition of carbogenic groups to unactivated alkenes is typically inefficient and suffers from poor regioselectivity. Now, a directing-group-free, nickel catalyst-controlled strategy has been developed, enabling the site-selective dicarbofunctionalization of a broad array of activated and unactivated alkenes.

RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism. Here the authors introduce a method named HARD-AP that effectively isolates RBPs and their closely associated RNA regulatory complexes from both cultured cells and fresh tissues.

The partial hydrogenation of multi-substituted allenes is a highly useful reaction but impeded by difficult selectivity control. Now, pincer cobalt catalysts enable this transformation through metal–ligand cooperative interactions, achieving ligand-controlled selective allene semihydrogenation in a divergent manner.

How metabolic signals are sensed by the cell cycle machinery remains unclear. Here, the authors demonstrate that the glycolytic enzyme PFKM acts as a citrate sensor to promote mitosis, coupling metabolic activity to cell cycle regulation.

R2 retrotransposons are natural RNA guided gene insertion systems. Here, Edmonds et al. characterize the structure and biochemistry of an avian R2 and engineer a compact, all-RNA system to integrate DNA in mammalian cells, aiding the development of future retrotransposon-based gene editors.

Cryo-electron microscopy structures of GPR56 and latrophilin 3 show how the released tethered agonist peptide interacts with the transmembrane domain, suggesting a model for the activation mechanism of adhesion G-protein-coupled receptors.

Glass-to-glass transitions can help understanding the glass nature, but it remains difficult to tune metallic glasses into significantly different glass states. Here the authors demonstrate the high-entropy effects in glass-to-glass transitions of high-entropy metallic glasses.

Li and coworkers quantitatively evaluate the tendency and direction of electron transfer in the deep Earth using a machine learning method to predict the electronegativity of atoms and work function of minerals under pressure.

Efficient and selective gold recovery from electronic waste is highly demanded. Here, authors demonstrate the application of a porous organic polycarbene adsorbent with up to 2.09 g/g gold-capturing capability.

By embedding superparamagnetic nanoparticles in a thermoelectric matrix, phonon and electron transport within the material can be controlled simultaneously at nanometre and mesoscopic length scales, thereby improving the thermoelectric performance of the material.

The application of single atom catalysts (SACs) is hindered by the lack of versatile and scalable preparation approaches. Here the authors report a precursor-atomization strategy that can be scaled up with productivity over 1 kg/day for the synthesis of a series of SACs and derivatives.

Adipose tissue macrophage (ATM) has been implicated in inflammation and obesity, but the underlying mechanisms are still unclear. Here the authors show that AMPK is suppressed in ATMs from mice fed with high fat diet, leading to subsequent activation of SUCLA2, over-production of succinate and IL-1β, and ultimately inflammation and obesity.

This study reports oxygen functional group-coordinated p-block metal catalysts that optimize the adsorption strength of key H₂O₂ intermediates for the oxygen reduction reaction. An electrolyser based on electron-deficient Sn active sites achieves an energy efficiency of 43% for the electrosynthesis of H₂O₂ and is stable for over 200 h.

A study reports a dual quantum spin Hall insulator in monolayer TaIrTe₄, arising from the interplay of its single-particle topology and density-tuned electron correlations.

The general synthesis of single atom catalysts (SACs) is of broad interest to chemists but remains a formidable challenge. Here, with the precursor-dilution strategy, the authors successfully prepare 24 different SACs and the Pt SACs exhibit superior chemo- and regio-selectivity in hydrogenation.

Sarbecovirus ORF6 binds to the Rae1-Nup98 complex, a component of the cytoplasmic face of the nuclear pore complex, and has been shown to suppress interferon responses. Here, the authors provide structures of Rae1-Nup98 in complex with the C-terminal tails of SARS-CoV-2 and SARS-CoV ORF6 and provide insights into ORF6-mediated blockade of mRNA and STAT1 nucleocytoplasmic transport.

The tomato spotted wilt orthotospovirus nonstructural protein NSs interferes with phytohormone signalling in plants to compromise plant defences by interacting with plant TCP21—this effect of the viral protein is counteracted by the plant NLR immune receptor protein Tsw.

Multi-omics analysis of mouse livers shows that protein β-hydroxybutyrylation (Kbhb) is strongly affected by the ketogenic diet. Combining bioinformatics with experimental validation, a role of Kbhb sites in modulating mammalian target of rapamycin signalling and cancer cell metabolism is identified.

Here, the authors provide evidence that SARS-CoV-2 N protein leads to autophagic degradation of Dicer, XPO5, SRSF3, and hnRNPA3, inducing DNA damage and proteotoxic stress, eventually causing pneumonia. The small-molecule drug PJ34 or anastrozole alleviates N protein-induced pneumonia.

Formalin-fixed paraffin-embedded (FFPE) tissues constitute a vast and valuable patient material bank, but single nucleus RNAseq using such tissues is challenging. Here the authors develop a droplet-based method called snRandom-seq for high-throughput and sensitive single nucleus RNA-seq of FFPE samples.

Phosphorus is one of the essential nutrients for all living organisms. Plants and fungi store phosphate in their vacuoles. Multiple plant influx transporters have been reported to import phosphate to the vacuoles. Now, two new phosphate efflux transporters are shown to be important for phosphate export from the vacuole in rice and probably other land plants.

The anisotropic electrical and optical response of materials has allowed for the development of variety of sensors, memories and other interesting devices. Here, Qi et al turn their attention to the van der Waals antiferromagnetic insulator CrPS₄, and demonstrate a very large, electrically tunable anisotropy in magnon transport, and present a multibit read-only memory based on this anisotropy.

Engineering 2D heterostructures with unique physiochemical properties and molecular sieving channels is one approach for designing membranes selective gas molecule transport. Here authors arrange graphene and boron nitride nanosheets in an alternating pattern, resulting in narrow porous nanochannels and excellent hydrogen separation properties.

Crystal structures of human vasohibin 1 and 2 in complex with small vasohibin-binding protein (SVBP) in the absence and presence of different inhibitors and a C-terminal α-tubulin peptide define the structural basis of tubulin detyrosination.

While noble metal usage in catalysis is ubiquitous, the metals’ scarcity necessitates new materials designs for efficient utilization. Here, authors report a general strategy to prepare amorphous noble metal nanosheets and find the nanomaterials to act as efficient water-splitting electrocatalysts.

Wang et al. show that Akt methylation by SETDB1 is recognized by demethylase JMJD2A, which then recruits E3 ligases to induce K63-linked Akt ubiquitination, leading to Akt activation and tumorigenesis.

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mouse models of osteoporosis.

Potent pan-Atg8 or GABARAP-selective inhibitory peptides derived from giant neuronal ankyrin-B and -G effectively block autophagy in cell cultures and in C. elegans spatiotemporally.

The interplay between fungal pathogens and the innate immune system remains incompletely understood. Here, Wang et al. show that a small protein secreted by Candida albicans induces a TLR2- and TLR4-mediated inflammatory response in a mouse infection model.

By combining vector magnetometry and magneto-transport measurements of epitaxial films with different crystallographic orientations, an anomalous Hall effect can be measured in collinear altermagnetic ruthenium dioxide with an anomalous Hall conductivity exceeding 1,000 Ω^–1 cm^–1.

Attempts to treat Alzheimer's disease by targeting γ-secretase cleavage of APP into Aß have been unsuccessful, partially due to off-target effects. Here, the authors identify TRPC6 as a novel γ-secretase modulator, showing that it interacts with APP to regulate Aß levels while sparing Notch cleavage.