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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Haptic interfaces for full-body scale requires a balance of high-resolution tactile simulation and breathability. Here, the authors present a breathable, full-body electrical stimulation suit for prolonged use in extended reality applications.

Neuromorphic computing hardware normally makes an unideal trade-off between energy efficiency, scalability and reliability. Kim et al. report a ferroelectric heterostructure based memristor with near-zero nonlinearity, endurance beyond 10E7 cycles, rectifying ratio exceeding 10E6 and sub-pA off-current.

Accumulation of senescent retinal pigment epithelial (RPE) cells is associated with retinal aging and disease. Here, authors identify Bst2 as a membrane-localized marker upregulated in senescent RPE cells and develop an antibody-pluggable drug delivery platform targeting Bst2-expressing cells for targeted senotherapy.

This work demonstrates a biologically inspired ultrathin camera that achieves high-resolution, 140° wide field-of-view imaging through angular sampling on a single planar sensor, thereby advancing compact wide field-of-view imaging systems.

Here the authors report preclinical evidence showing that PG-102, a potency-optimized bispecific Fc fusion protein targeting GLP-1 and GLP-2 receptors, results sustained glycemic control with preserved body weight in mouse models of advanced diabetes. Furthermore, a phase I randomized controlled clinical trial in healthy adults with overweight suggest PG-102 is well tolerated.

As soft electronic waste becomes an urgent concern, biodegradable yet high-performance devices are emerging as a promising solution. Here the authors fabricate durable and multifunctional soft robotic fingers in which both polymers and inorganic electronics are fully compostable.

Researchers developed a light-driven electrochemical system featuring a palladium–titania cathode that generates highly reactive electrons, enabling efficient reductive degradation of “forever chemicals” in contaminated water.

Bio-interfaced applications are limited by the transfer of soft electronic devices onto high curvature and fragile surfaces. Here, the authors develop a stress-responsive transfer fluid that enables distortion-free, adhesion-switchable transfer for conformal integration and stable real-time bioelectronic sensing.

The atomic structure of the electric double layer at practical concentrations remains unsolved. Here, authors elucidate its structure and phase transitions using all-atom simulations, which reproduce the camel-to-bell shape transition in the capacitance curve.

Osteoarthritis is a marked by cartilage loss and limited by the absence of effective disease modifying treatments. Here, the authors show that orphan nuclear receptor small heterodimer partner (SHP) protects cartilage by suppressing IKKβ dependent NF κB signaling, highlighting it as a potential therapeutic target.

This work presents a machine-learning approach that optimizes the learning of atomic interactions across diverse materials. By integrating heterogeneous data, it delivers accurate and transferable predictions beyond its training domain.

Ballistic transport is achieved in nanodevices based on atomically flat, grain-boundary-free single-crystalline Cu(111) thin films. Negative bend resistance below 85 K confirms it, establishing a scalable platform for exploring quantum nature of Cu.

This study describes the synthesis of 3-desoxycollinoketone B, a small molecule that targets amyloid-β and tau aggregates. In mouse models, it crosses the blood-brain barrier, reduces plaques, and ameliorates learning and memory impairments.

An early event after lung injury is extracellular matrix remodelling. Here, the authors show that thrombospondin-1 (TSP1) from megakaryocytes/platelets protects the lung’s extracellular matrix, particularly basement protein COL6. Mice without TSP1 had greater lung damage and neutrophil activity, showing TSP1 reduces injury severity.

The authors show that El Niño’s influence on global sea surface temperatures is projected to intensify in a warming climate due to stronger wind-driven teleconnections and larger air-sea humidity differences.

This study identifies an FDA-approved leukemia drug, Homoharringtonine, that can eliminate aged fat cells, improve metabolic health, reduce inflammation and extend lifespan in mice, revealing a potential approach to treat age- and obesity-related metabolic disease.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

The paper presents a piezoelectric resonator-based DC-DC converter with an embedded flying capacitor and multipath operation. Implemented with an integrated circuit, the design achieves 96.2% efficiency at greater than the optimal 9:1 voltage conversion ratio with enhanced current handling for data center applications.

In this study, the authors identify the role of astrocytic phagocytic receptor MEGF10 in regulating corticostriatal synapse remodeling in the striatum, enabling dopamine- and activity-dependent plasticity in D1 and D2 medium spiny neurons and supporting motor skill acquisition.

Here the authors report that intestinal interleukin-22 promotes GLP-1 production through STAT3 signaling in male mice. This mechanism improves glucose regulation in diet-induced obesity and provides insight into the role of IL-22–GLP-1 signaling in metabolic regulation.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Binding promiscuity is a key property of intrinsically disordered proteins. In this study, the authors reveal the structural mechanism of heterogeneous binding partner exchange pathways using three-color single-molecule FRET.

Solution processing of 2D/3D perovskite structures for solar cells offers limited control over layer formation. Lee et al. propose a dry approach, bringing the 2D and 3D perovskite layers into physical contact, to enhance the quality of the perovskite film.

Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.

Studying brain function requires synchronized recording of the brain and behavior in real time. Jarl Haggerty and colleagues describe Thalamus, an open-source platform that synchronizes multimodal data and enables low-latency closed-loop experiments.

The pathological mechanisms underlying multiple system atrophy (MSA) remain unclear. Here, the authors show in mouse and human MSA models that α-synuclein spreads from neurons to oligodendrocytes via TLR2 leading to myelination defects, and that blocking TLR2 prevents glial cytoplasmic inclusions and myelin damage.

Mitochondrial ROS are thought to be involved in NLRP3 inflammasome activation, but how this occurs is unclear. Here, the authors show that cofilin-1 negatively regulates NLRP3 activity by binding it at baseline, but cofilin-1 oxidation by ROS results in dissociation from the complex, thereby releasing NLRP3 activity.

Researchers identified three distinct white matter hyperintensity progression patterns, validated in both patients and healthy individuals. Each pattern links to different vascular risks and outcomes, improving stroke prediction.

An improved faba bean reference genome and resequencing of winter and spring faba bean accessions identify genetic determinants of winter hardiness.

This study develops photoacoustic computed tomography, which enables real-time, whole-body 3D imaging of cerebrospinal fluid (CSF) pathways in mice and captures anesthesia-dependent CSF flow changes and impaired CSF clearance in an Alzheimer’s disease model.