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A microwave-assisted process is developed for the rapid and scalable manufacture of pure-phase metallic MoS₂ nanosheets, enabling practical electrochemical devices for energy applications.

Nanocrystal assembly is key to creating complex architectures. Here, the authors show that tuning competitive ion adsorption alters anisotropic surface potentials and electrostatic torques, directing facet attachment to enable alternative mesoscale designs.

Human antibodies DENV-290 and DENV-115 are ultrapotent against dengue virus 3 strains with differing particle morphologies. CryoEM shows both bind across two protomers at the center of the envelope protein dimer, defining a new class of epitope.

The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes. Here the authors present the structure of a soluble pore-like form of the C9 component that reveals details of the oligomerization interfaces.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.

A nanoporous photocatalyst producing low levels of hydrogen peroxide is shown to modulate intracellular stress granules, enhancing resilience against oxidative stress and providing cardioprotection in an ex vivo rodent model of myocardial ischaemia–reperfusion injury.

Structural analyses of antibody-virus complexes offer critical insights into immune recognition mechanisms. In this report, we present how a patient-derived IgG recognizes a quaternary epitope on EEEV particles through strictly bivalent interactions.

The human monoclonal antibody ZIKV-117 has demonstrated therapeutic potential against Zika while showing no cross-reactivity to other flaviviruses. Here the authors present a cryo-EM structure of the ZIKV strain H/PF/2013 in complex with the ZIKV-117 Fab, shedding light on its neutralization mechanism.

Activated carbon has been widely used for PFAS adsorption, but this method generates secondary solid wastes. The flash Joule heating approach realizes mineralization of PFAS and generation of useful flash graphene in waste granular activated carbon.

The presynaptic protein Munc13 forms nanoclusters at synaptic release sites, but its internal organization is unclear. Here, the authors show that two distinct ordered Munc13 oligomers couple synaptic vesicle docking and SNARE assembly to regulate neurotransmission

The simplicity of particle suspension reactors and the precise synthetic control afforded by silicon nanowire growth are used to develop a system that can produce hydrogen fuel by splitting water with sunlight.

The scalable, energy-efficient and environmentally friendly production of solid-state materials is crucial for next-generation material synthesis. Now an efficient and gram-scale synthesis of transition metal dichalcogenides, group XIV dichalcogenides and non-transition metal dichalcogenides has been achieved using the flash-within-flash heating technique, a non-equilibrium, ultrafast heat conduction method.

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

The layer stacking order in 2D materials can be used to control functional properties. Here, the authors find a thickness effect, where thin flakes of MoTe₂ display stacking arrangements different from bulk crystals.

Most proteins mediating biomineralization in nature are not well structured, and the structures of the relevant protein-mineral interfaces regulating mineralization are elusive. Here, the authors computationally design proteins that modulate calcium carbonate mineralization to generate hybrid materials and elucidate the roles of designed proteins in controlling mineralization.

Intracellular, intercellular and extracellular silicon interfaces enable light-controlled non-genetic modulation of intracellular calcium dynamics, of cellular excitability, of neurotransmitter release from brain slices, and of brain activity in vivo.

Cerebrospinal fluid (CSF) is essential for brain development. Here, the authors use gold nanoparticle enhanced X-ray microtomography to map CSF distribution in post-natal rodents and describe particle size-dependent CSF pathways that transport CSF into the brain parenchyma of rodents.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

In situ and computational methods are used to investigate the nature of the dense liquid phase of calcium carbonate and its transformation to the amorphous phase that is common in biomineralization processes.

Graphite spontaneously exfoliates into single layers of graphene in chlorosulphonic acid, resulting in a solution that is an order of magnitude more concentrated than any previously reported, and forms a liquid-crystalline phase at high concentrations.

Giant viruses are large DNA viruses with capsid diameters up to 500 nm. Given technical challenges only few high-resolution structures of viral capsids exist. Here, Shao et al. provide a nearatomic structure of giant virus PBCV-1 capsid and resolve the previously unknown asymmetric capsid components. The local capsid microenvironments created by these components provide insights into the mechanism of capsid assembly of giant viruses.

CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.

Microfabrication has an essential role in device fabrication but is accompanied by unfavourable environmental footprint. This study presents a bioinspired permeable junction approach for sustainable microfabrication, which eliminates the use of hazardous chemicals and minimizes energy consumption.

AFM measurements of peptoids assembling into sheets and networks show that the crystallization mechanism is determined by the molecular structure, where the addition of a hydrophobic segment alters the crystal formation process into a two-step pathway.

Manufacturing perovskite solar cells in dust-free environments is expensive and not practical in some settings. Here, the effect of non-conductive dust settling on small-area devices during manufacture is assessed, finding only minor drop-off in some performance metrics

Host proteins CPSF6, NUP153, and SEC24C are vital for HIV-1 infection. They bind to the viral capsid protein and contribute to shuttling of virions through the cytoplasm (SEC24C), import into the nucleus (NUP153 and CPSF6) and subsequent trafficking to preferred integration sites (CPSF6). Here, Wei et al. combine structural, biochemical and virological assays to emphasize the importance of prion-like low complexity domains surrounding short phenylalanine-glycine regions in binding and increasing the avidity when interacting with viral capsid.

The wireless and photoelectrochemical stimulation of primary rat dorsal root ganglion neurons is demonstrated by shining laser light onto coaxially doped silicon nanowires deposited on the neuronal membrane.

A multi-ancestry genome-wide association study for age at menarche followed by fine mapping and downstream analysis implicates 665 pubertal timing genes, such as the G-protein-coupled receptor 83 (GPR83) and other genes expressed in the ovaries involved in the DNA damage response.

Here, Zhouyan et al. present the structure of yeast SIN3–HDAC complex Rpd3L, revealing a distinctive organization mechanism compared with other class I HDAC complexes. The authors observe that two distinct arms hang on a T-shaped scaffold formed by two coiled-coil domains.

There is no licensed vaccine or therapeutic for dengue virus (DENV) infection. Here, the authors show that a highly potent human monoclonal antibody binds to DENV particles in an unusual and very effective way by interacting with three viral envelope proteins.

Caveolae are spherical nanodomains of the plasma membrane generated by assembly of caveolin and cavin proteins. Here, the authors show that fuzzy electrostatic interactions between caveolin-1 and Cavin1 proteins, combined with membrane lipid interactions, are required to generate membrane curvature and a metastable caveola coat.

With the growing threat of antibiotic resistance, unconventional approaches to antimicrobial discovery are needed. Here, the authors present a peptide topology that mimics virus architecture and assembles into antimicrobial capsids that disrupt bacterial membranes upon contact.

Creating hierarchical synthetic materials that can modulate microbial communities remains a great challenge due to the complex interactions between microbiota and their colonized environments. Now, a soil-inspired chemical system that responds to chemical, optical and mechanical stimuli has been developed. The soil-inspired chemical system can enhance microbial cultures and biofuel production, enrich gut bacterial diversity and alleviate ulcerative colitis symptoms.

Here the authors design an electrolysis reactor to generate H₂O₂ which could be further catalytically activated by Cu single atoms to yield hydroxyl radicals. Combining the two reactions enables a system that could treat organic wastewater, providing a path toward sustainable advanced oxidation processes.

Nucleocytoplasmic large DNA viruses are a group of viruses that infect many eukaryotic hosts. Here, the authors provide a 3.5 Å resolution icosahedrally-averaged capsid structure of Paramecium bursaria chlorella virus 1 and show how 1800 minor capsid proteins form a hexagonal network below the outer capsid shell.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

There is ongoing interest in the development of non-precious metal catalysts for hydrogen evolution. Here, the authors fabricate a cobalt catalyst in which the cobalt is dispersed as single atoms on nitrogen-doped graphene, and report its high activity and stability for water reduction in acidic media.

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Ultrasmall metallic clusters receive great attention for atom-efficient catalysts. Here a metallic cluster–organic framework is synthesized and characterized; authors demonstrate its stability and catalytic proficiency, paving the way for molecular-scale metal nanoparticle interlocking.

Pentameric ligand-gated ion channels are modulated by anionic phospholipids. Here, by capturing an open-channel conformation of ELIC, the authors demonstrate the structural details of channel activation and a leaflet-specific mechanism for modulation by phosphatidylglycerol.

Bone tissue is a complex organic-inorganic nanocomposite and strategies that replicate the characteristics of bone tissue are scarce. Here the authors demonstrate the deposition of nanoscale apatite in collagen embedded with mesenchymal, vascular and nerve cells, using a protein-guided biomineralization approach.