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Controlling the hydrothermal reaction kinetics during the fabrication of Sb₂(S,Se)₃ solar cells is challenging. Chen Qian et al. show that sodium sulfide buffers the pH and allows a controlled release of Se, enabling a certified efficiency of 10.7%.

Chromatin profiling methods are often limited by a lack of suitable antibodies. Here, authors present Af-CUT&Tag, a chromatin profiling strategy based on CRISPR-integrated peptide tags which enables sensitive bulk and single-cell mapping of transcriptional regulators.

Aliphatic alcohols usually require pre-activation for successful functionalization of their carbon chain. Here, the authors report a silver-catalyzed δ-selective functionalization of aliphatic alcohols via Csp³-H bond cleavage under mild conditions without the need of substrate pre-activation.

There is an intensive effort in developing grid-scale energy storage means. Here, the authors present a liquid metal battery with a garnet-type solid electrolyte instead of conventional molten salt electrolytes and report promising electrochemical properties at a modest temperature of 240 °C.

How spatial gene expression patterns are orchestrated by enhancers is not fully elucidated. Here the authors present a computational framework called eSpatial revealing a “spatial enhancer code,” where divergent enhancer combinations regulate spatial gene expression during development and diseases.

Flexible reconfigurable transistors are promising for applications in wearable electronics and smart robotics. Here, the authors present intrinsically flexible multimode reconfigurable transistors with dual-gate structure, which can switch among p-type, n-type and ambipolar modes.

The heterogeneity of isoform level m⁶A RNA methylation in single cells is unclear. The authors characterize m⁶A at both single-cell and isoform level through ONT long-read sequencing on single-cell cDNA library with APOBEC1-YTH induced C-to-U mutations. They find the role of m⁶A on surveillance of misprocessed RNAs through CDS-m⁶A decay mechanism.

The power conversion efficiency of wide-bandgap pure-sulfide kesterite is low. Wang et al. propose annealing in a hydrogen-containing atmosphere and report the underlying mechanism that enables a certified efficiency of 11.4%.

Song et al. developed a computational tool to profile binding pairs between tumor-derived antigens and antibodies from high-throughput B cell receptor sequencing data, predicting response to immune-checkpoint inhibitor therapy and risk of adverse events.

Chen, Zhou, Xue et al. show that psychological stress leads to noradrenaline release and Alkbh5 downregulation, causing the transfer of extracellular vesicles containing m⁶A-modified RNAs to neurons to regulate innervation and pancreatic cancer development.

The performance of kesterite solar cells is limited by charge carrier losses, and the underlying mechanisms are unclear. By means of an integrated experimental and modelling framework, Li et al. identify the dominant loss mechanism in charge recombination at grain boundaries.

The emerging kesterite Cu₂ZnSnS₄ solar cell offers a potential low-cost, non-toxic, materially abundant platform for next-generation photovoltaics, yet its efficiency has been mired below 10%. Yan et al. now use post-heat treatment of the heterojunction to show device efficiencies that surpass 10%.

Unimolecular probes detectable via near-infrared fluorescence, magnetic resonance imaging, positron emission tomography and computed tomography allow real-time tracking and quantification of amyloid-β plaques with spatial localization in the living brain of Alzheimer’s disease mouse models and in beagles.

The impact of chromatin structure on gene expression makes it integral to our understanding of developmental and disease processes. Here, the authors introduce a hierarchical hidden Markov model to systematically annotate chromatin states at multiple length scales, and demonstrate its utility for the elucidation of the role of chromatin structure in gene expression.

METTL3-dependent RNA N⁶-methyladenosine (m⁶A) deposition can lead to DNA demethylation. The m⁶A reader FXR1 recruits DNA 5-methylcytosine dioxygenase TET1 to chromatin, which is linked to chromatin accessibility and gene transcription.

In pancreatic duct adenocarcinoma, super-enhancer RNAs (seRNAs) have higher N⁶-methyladenosine (m⁶A) levels than in adjacent normal tissue due to upregulation of the METTL3 cofactor CFL1. Aberrant m⁶A seRNAs promote oncogene expression via the YTHDC2–MLL1 complex.

A molecular interfacial layer optimizes hole transport in tin-based perovskite solar cells, improving energy-level alignment and enhancing hole extraction efficiency.

Antimony chalcogenides are emerging photovoltaic materials, yet difficulties in fabricating high-quality films limit device performance. We show that hydrothermal synthesis affords good morphology and reduced defects in antimony selenosulfide films, enabling solar cells with an efficiency of 10%.

During early postnatal development in mammals, cardiomyocytes exit the cell cycle, losing their regenerative capacity. Here the authors show that, following myocardial infarction, loss of microRNA-128 promotes cardiomyocyte proliferation and cardiac regeneration in adult mice partly via enhancing the expression of the chromatin modifier SUZ12.

Super-enhancers (SEs) are important regulatory elements for gene expression, but their intrinsic properties remain poorly understood. Here the authors analyse Hi-C and ChIP-seq data and find that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers.

N6-methyladenosine (m6A) modification has important implications in different cancer subtypes. Here, the authors perform transcriptomic m6A profiling to identify two subtypes of pancreatic ductal adenocarcinoma with differential m6A modifications and different clinical outcomes, which is driven by m6A regulator CSTF2.

Controlling the composition and crystal phase of layered heterostructures is important. Here, the authors report the liquid-phase epitaxial growth of Sn_0.5W_0.5S₂ nanosheets with 83% metallic phase on SnS₂ nanoplates, which are used as 100 ppb level chemiresistive gas sensors at room temperature.

The addition of DDT to the spiro-OMeTAD hole transport material enhances the stability of perovskite solar cells to humidity, heat and illumination stress. Fabricated devices exhibit a champion certified power conversion efficiency of 23.1%. Also, the devices could retain 90% of the initial efficiency after 1,000 h of continuous illumination, 97% under moisture stress for 530 h and 91% under 144 h of heat stress.

Manipulating exchange bias is crucial for advancing spintronic devices. Here, the authors demonstrate full electrical switching of perpendicular exchange bias in multilayers featuring an antiferromagnetic layer with anisotropic epitaxial strain.

The implications of long intergenic non-coding RNAs (lincRNAs) on cancer metabolism is unclear. Here, the authors identify that LINC00842 binds to PGC-1α and prevents PGC-1α from deacetylation by SIRT1, resulting in a metabolic reprogramming in pancreatic cancer cells.

METTL3 catalyzes mRNA m⁶A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.

The scalability of quantum information processing applications is generally hindered by loss and inefficient preparation and detection. A minimal loss network based on phonons has now been realized with trapped ions.

Promoter hypermethylation-mediated silencing of the tumor suppressor RASA4 activates Ras signaling in small cell lung cancer, thereby driving tumor proliferation, metastasis, and chemoresistance, and revealing its role as a prognostic biomarker.

Natural killer T cells in the thymus are CD1d-restricted cells that are selected at the CD4⁺CD8⁺ double-positive stage and require a variety of transcription factors for their development. Orkin, Winau and colleagues show that the histone demethylase UTX serves an essential role in the transcriptional control of the thymic maturation of these cells through multiple epigenetic mechanisms.

A recent work introduces a cellular deconvolution method, MeDuSA, of estimating cell-state abundance along a one-dimensional trajectory from bulk RNA-seq data with fine resolution and high accuracy, enabling the characterization of cell-state transition in various biological processes.

Limitations associated with the primary amination of aryl C–H bonds include the poor control of regioselectivity with electron-rich substrates and the challenging nature of the reaction in the case of electron-deficient arenes. Now, site-directed C–C bond primary amination of simple alkylarenes and benzyl alcohols provides a route for the direct and efficient preparation of anilines.

The ETP₂SbCl₅ characterized by the reversible phosphor-glass transition was developed for recyclable luminescent solar concentrators, of which the maximum power conversion and optical efficiencies reached ~5.56% and ~32.5%, respectively.

Transition from one bound state in the continuum to exceptional ring and optical-pump-controlled such exceptional point switching demonstrated in terahertz metasurfaces.

The authors characterize the single-cell chromatin accessibility landscapes of 10 bone marrow samples from AML patients at diagnosis. They introduce a pipeline for the detection of non-coding mutations in cis-regulatory elements using scATAC-seq data.

The interlayer Dzyaloshinskii–Moriya interaction (IL-DMI) in a ferromagnetic/nonmagnetic/ferromagnetic metal multilayer is found to be tuned by the interfaces at the nonmagnetic spacer layer. A controllable IL-DMI can be generated by post-processing in a L1₀-FePt/Pt/Fe multilayer. Then, an apparent field-free magnetization switching with controllable switching polarity is achieved.

A new method and its companion software to study the associational network of lacustrine entombed fauna, or taphocoenosis. The application allows researchers to easily perform exploratory analyses on common abundance profiles from taphocoenosis data.