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Cells struggle to migrate on soft substrates, which don’t provide enough traction. Here, the authors show that rapid, cyclic changes in substrate rigidity allow cells to overcome this limitation and move quickly.

Treatment selection for recurrent hepatocellular carcinoma (rHCC) after hepatectomy remains challenging. Here, the authors develop HEROVision, a Vision Transformer-based model for personalised prognosis prediction and treatment optimisation in rHCC based on clinical and imaging data, outperforming other guideline staging systems and revealing patients who would benefit from changing treatments.

Wan et al. report a T-shaped PbSe photothermoelectric detector in which spatial confinement induced local phonon scattering suppresses the hot carrier relaxation, leading to an external quantum efficiency over unity. Focal plane array with 32x32 pixels is fabricated with a non-uniformity of 5.6E-6%.

Three-dimensional representation learning is efficient in material science. Here, authors proposed a transformer-based framework for multi-purpose gas adsorption prediction. Predicted values correspond with the outcomes of adsorption experiments.

It is still challenging to engineer single-atom catalysts for electrocatalytic methanol oxidation. Here, the authors design Pt single atom supported on RuO2 for highly active methanol oxidation in contrast to the inert Pt single atom supported on carbon.

A key challenge in robotics is leveraging pre-training as a form of knowledge to generate movements. The authors propose a general learning framework for reusing pre-trained knowledge across different perception and task levels. The deployed robots exhibit lifelike agility and sophisticated game-playing strategies.

OLEDs that emit circularly polarized light are essential for many technologies. Here, the authors develop OLEDs based on chiral nanoparticles that have large emission dissymmetry factors and high external quantum efficiencies.

Achieving high-dexterity, multimodal perception at low cost remains a challenge for anthropomorphic hands. Here, authors present an 18-DOF dexterous hand that relies solely on a monocular camera to sense joint angles, contact forces, and object properties without the need for additional sensors.

Expanding the library of chiral plasmonic nanoparticles will foster the development of chiroptical applications. Here, the authors apply halide-assisted differential growth to convert Au nanodisks into triskelion-shaped chiral nanoparticles with threefold rotational symmetry.

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Purifying C₂H₂ by removing trace CO₂ is needed but challenging due to their analogous physical properties. Herein, the authors report the pilot-scale production of a commercial resin adsorbent loaded with polyethyleneimine for the selective capture of CO₂ traces and exclusion of C₂H₂.

Aguirre-Ghiso and colleagues report that bone-marrow-resident mesenchymal stem cells promote cancer dormancy through TGF-β family members.

The successful deployment of protonic ceramic fuel cells requires the discovery of high-performance and low-cost cathode catalysts. Now, theoretical insights guide the rational design of a Ba_0.875Fe_0.875Zr_0.125O_3−δ material that achieves excellent oxygen reduction performance.

A dissipative self-assembly system was developed by re-engineering a naturally hexameric adenosine 5′-triphosphatase (ATPase) enzyme (filamentous temperature-sensitive protease H) to form transient one-dimensional tubular structures in an ATP-dependent fashion. These tubular structures in turn exert negative feedback on the ATP-dependent activation of the protein building blocks.

Liquid-infused porous membranes with rich interfacial properties have been developed and demonstrate potential across diverse applications. The in situ infusion of selected liquids into aerogel membranes enables on-demand emulsification and demulsification, conserving energy and exhibiting anti-fouling characteristics.

Flexible laminated polymer nanocomposites with the polymer layer confined are found to exhibit enhanced thermal stability and improved high-temperature energy storage capabilities.

TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.

The codling moth, Cydia pomonella, is one of the major pests of pome fruit (apples and pears) and walnuts. Here, the authors sequence and analyze its genome, providing insights on olfactory and detoxification processes that may underlie its worldwide expansion.

An analysis of POLE and POLD1 mutations distinguishes driver mutations from passengers and explores their functionality. Driver mutations are associated with specific mutational signatures and correlate with immune checkpoint blockage response.

Mammalian respiratory supercomplexes are imaged in their native membrane environment by in situ cryo-electron microscopy, providing insight into their reactive intermediates and conformational dynamics.

In this Review the authors describe current knowledge on cellular plasticity in the bladder urothelium, emphasizing its role in bladder repair and tumorigenesis, and explore the molecular mechanisms of urothelial plasticity and discuss its potential as a novel therapeutic target for bladder-related diseases.

Rationally manipulating the in-situ-formed catalytically active surface of catalysts is a challenging but promising endeavour. Now, the surface of LiCoO₂ during water oxidation is engineered by Cl doping via a cationic redox-tuning method that modulates in situ leaching and redirects the dynamic surface restructuring.

Enzymatic catalysis of pericyclic [6+4] cycloaddition reactions to form ten-membered rings is observed during biosynthesis of the macrocyclic antibiotic streptoseomycin, and the mechanism of these transformations is established.

We introduce an innovative quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy technique that utilizes a quartz tuning fork to achieve resonant detection of a dual comb based on the photoacoustic effect.

Mepiquat chloride is a growth retardant used in cotton farming to optimize growth by inhibiting gibberellin metabolism, but it is not effective in other crops. Now, its molecular target is found, enabling selective agrochemical inhibition of growth in cereals.

Association between antihypertensive drug classes and intensity with NT-proBNP improvement and long-term clinical outcome.

Electrically creating bi-layer ferroelectric domains in a thin-film lithium niobate waveguide enables high-efficiency second-harmonic generation and photon-pair generation.