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A dual-action force dynamics strategy using a hard silicon template as a nanoimprinting stamp combined with inverted transfer printing is described for the manufacture of high-performance full-colour ultrahigh-resolution quantum dot light-emitting diodes (LEDs) for active-matrix displays, while revealing electric-field reconstruction in nanoscale arrays and introducing dielectric matching to mitigate field concentration and performance degradation.

Repeated rapid structural MRI scans substantially improve the precision of individual differences in brain change. This allowed for individualized insight into subtle differences in the detected rates of brain aging and neurodegeneration to be detected.

Targeting delivery of antibiotics and antibacterial agents can increase efficacy. Here, the authors develop antibiotic loaded inflammation-targeted fusion vesicles which hitchhike on neutrophils for targeted delivery to treatment bacterial-induced sepsis and pneumonia.

A donor–π–acceptor carbon nitride photocatalyst with enhanced charge separation enables efficient hydrogen production from natural seawater under ambient pressure and sunlight, advancing scalable green hydrogen generation.

Type 2 diabetes is an established risk factor for dementia. Here, the authors use data from 33,136 older Chinese adults to show that polygenic risk for type 2 diabetes was associated with vascular dementia but not Alzheimer’s disease.

Practical implementation of all-perovskite tandem solar cells faces challenges due to the self-reinforcing photothermal-mechanical degradation mechanism. Here, authors employ a polyamine ligand to establish I-Sn-N coordination for stabilizing lattice framework, achieving device efficiency of 29.6%.

The suboptimal interfacial contacts between nickel oxide and self-assembled monolayers in wide bandgap subcells limit the photovoltaic efficiency and stability. Here, authors employ boric acid as an anchoring group for chemisorption, achieving efficiency of 28.5% for two-terminal tandem solar cells.

Increasing post harvest consumption of fish to 74% of total catch would deliver an additional 850 million portions of fish per day globally, according to mathematical modelling of fish utilization

YAP is a key oncogenic driver that has long been considered undruggable. Here, the authors present the development of a nanobody-based bioPROTAC that efficiently degrades endogenous YAP, demonstrating potent anticancer activity and providing a promising therapeutic strategy for YAP-dependent tumors.

Propane oxidative dehydrogenation offers a promising path for propylene production, but selective propylene formation with minimal COx remains challenging. Here, the authors introduce dual-atom catalysts achieving just 5.2% COx selectivity at 46.1% propane conversion (520 °C) with stable performance for over 1000 hours.

In the NATION-1907 trial, treatment of patients with resectable esophageal squamous cell carcinoma with the anti-PD-L1 agent adebrelimab was safe and showed preliminary overall survival efficacy, with responders exhibiting an immune-enriched tumor microenvironment phenotype at baseline.

The magnetic field effect of ferromagnetic spin electrocatalysts to enhance catalytic activity under external magnetic fields brings promises and challenges. Here, the authors report the ferromagnetic Fe-TiO₂ to investigate magnetic field effect on electrocatalytic reduction of nitrate for ammonia.

Brain iron accumulation has been associated with multiple brain disorders, but the mechanism is not well understood. Here, the authors investigate the genetic determinants of brain iron accumulation and their implications for neuropsychiatric disorders.

Cao and colleagues show that the RNA-binding E3 ligase MKRN2 selectively inhibits the translation of Il6 messenger RNA in activated macrophages.

The efficiency of narrow bandgap subcells is hindered by structural instability and strain accumulation. The authors introduce a rigid sulfonate molecule that suppresses light-induced lattice distortions, enabling certified 29.2% efficiency in all-perovskite tandem solar cells.

Wannier excitons exhibit a relatively large Bohr radius, and this limits the strength of coupling to magnetic ions, in exciton hosting material. Here, Huang et al. overcome this limitation by using self-trapped excitons in Cs₃Cu₂I₅, with a resulting large exciton Zeeman splitting.

Wei et al. identify that cytoplasmic METTL3 interacts with PABPC1 to facilitate translation of epigenetic factor mRNAs without m⁶A modification to promote tumour progression, suggesting an m⁶A-independent mechanism for this methyltransferase.

Child behavior has been associated with parenting behavior. Here, the authors investigate associations between child behavior, parental behavior, and structural MRI using the Adolescent Brain Cognitive Developmental (ABCD) study dataset.

Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complementary targets mediated miRNA decay.

Hexagonal boron nitride (h-BN) encapsulation is important to improve the performance of graphene devices, but it is normally restricted by exfoliation and transfer methods. Here, the authors report the conformal h-BN encapsulation for the hierarchical configuration of large-scale graphene-skinned glass fiber fabrics via chemical vapor deposition, leading to improved electrical and thermal stability.

Twisted photonic crystals enable a strong light-matter interaction due to the flatband and high Q factor. Here, authors demonstrate Purcell enhancement between single quantum dots and Moiré nanocavities, with a PL intensity enhancement of about 8.4 times and a Purcell factor around 3.0.

Immune checkpoint blockade therapy such as anti-PD-L1 is efficient for treating specific cancer types, but poor response rates remain a caveat. Here the authors generate a peptide-based, self-assembly nanomaterial that binds and aggregates PD-L1 as a fibrillar networks to enhance the anti-tumour efficacy of anti-PD-L1 in multiple mouse tumour models.

Giant cell tumor of bone (GCTB) is a rare primary osteolytic bone tumor with high local recurrence rate after surgical resection. Here the authors conduct a phase Ib/II trial, evaluating the efficacy and safety of JMT103 (RANK-RANKL inhibitor) in patients with unresectable or surgically-challenging GCTB.

Understanding the mutation landscape of cancer may enable the development of more targeted therapies. Here, the authors sequence a panel of genes in a large Asian cohort and compare to American cohorts and find 64% of the Asian patients have actionable mutations.

Physiologically, the host suppresses intestinal epithelial cell death to prevent intestinal inflammation. Here, the authors show that EF-hand domain-containing protein D2 (EFHD2) endogenously suppresses intestinal epithelial cell death by blocking TNFR1 internalization and protects the intestine from excessive inflammation.

Full polarization control of photons is achieved using coupled nanobeam cavities, in which the ultra-subwavelength gap results in the evanescent wave coupling and introduces non-Hermitian effects.

Discovery of a biochemical mechanism through which lactate binds and inhibits the SUMO protease SENP1, stimulating timed degradation of cell cycle proteins, and resulting in mitotic exit.

A data-validated model for the lunar radiation environment is used to draw guidelines for safe future activities on the Moon, depending on the thickness and type of habitat shielding. Unless the base is at a depth of at least 3 m, some degree of crew rotation is needed, up to several times per year.

Chemical vapor deposition (CVD) of graphene on widely used insulators can promote its application for functional composite materials. Here, the authors report the large-scale production of graphene alumina fibers/fabrics via a metalloid-catalytic CVD growth process on commercial alumina, showing their application for electrical heating and electromagnetic shielding.

Powdery mildew is a devastating disease that affects global wheat production. Here, the authors report the cloning of the Aegilops searsii-derived powdery mildew resistance gene Pm57 that encodes a tandem kinase protein.

Molecular scale force application in physiological environments is important for studying mechanotransduction. Here, the authors use a molecular machine to apply forces at cell-matrix and cell-cell junctions using light to trigger twisting actuation which then pulls on cell membrane receptors.

Ternary-blend organic photovoltaics enable solar cell performances exceeding binary blends due to the multiple light-harvesting materials, yet challenges remain in controlling their morphology. Now, Zhou et al. exploit hierarchical morphology to build all-small-molecule ternary-blend devices with high performance.

Fungi that infect insects can potentially be exploited for disease vector control. Here the authors show that the fungus Beauveria bassiana exports a microRNA-like RNA into mosquito cells that modulates host immunity by suppressing expression of Toll receptor ligand Spätzle 4.

The batch reproducibility of polymer donor materials limits the performance of polymer solar cells. Here Wu et al. develop a polymer donor PM1 by random terpolymerization strategy with a high efficiency of 17.6% in the device and excellent batch-to-batch reproducibility.

Sulfate aerosols are an important component of wintertime haze events in China, but their production mechanisms are not well known. Here, the authors show that transition metal-catalyzed oxidation of SO₂ on aerosol surfaces could be the dominant sulfate formation pathway in Northern China.

The microscopic origin and valley physics of quantum emitters (QEs) in 2D semiconductors are still not fully understood. Here, the authors report an anomalous magneto-optical behaviour of QEs in WSe₂ monolayers coupled to chiral plasmonic nanocavities, suggesting the absence of intrinsic valley symmetry of the emitters.