Nature Search

Regulatory effect of China’s city hierarchy on urban redevelopment

Urban redevelopment is a key government policy and planning strategy to address various urban challenges. This study investigates where, how and to what extent China’s city hierarchy influences redevelopment activities within China’s rapidly evolving urban landscape.

Yu Deng
Kexin Cao
Bojie Fu
Research05 Jan 2026
Nature Cities

Volume: 3, P: 48-57
METTL3 safeguards cell identity and epigenome of human trophoblast stem cells

METTL3 promotes healthy placenta function by regulating m⁶A methylation and histone epigenetics. Deficiency in METTL3 leads to premature senescence, inflammation activation of trophoblasts, contributing to pregnancy complications like preeclampsia.

Haifeng Fu
Chunxiao Chen
Pentao Liu
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Neutrophil extracellular traps as biomarkers for predicting prognosis and chemotherapy response in colorectal cancer

Chen Wang
Junxiong Chen
Xiangling Yang
ResearchOpen Access23 Jan 2026
Scientific Reports

Volume: 16, P: 1-15
Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak

Wilson Nguyen
Narayan Gyawali
Daniel J. Rawle
ResearchOpen Access10 May 2024
npj Viruses

Volume: 2, P: 1-18
Author Correction: Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis

Man Cheng
Dan Lu
Xiaorong Zhang
Amendments and Corrections21 Mar 2025
Nature Neuroscience

Volume: 28, P: 913
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis

Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV induce ALS-like phenotypes in rats and highlight CIV deficiency as a potential risk factor and therapeutic target for ALS.

Man Cheng
Dan Lu
Xiaorong Zhang
Research11 Mar 2025
Nature Neuroscience

Volume: 28, P: 748-756
Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning

Developed on cytology images of hydrothorax and ascites from 57,220 cases at four hospitals, a deep-learning model shows high accuracy in tumor origin prediction and presents prognostic value when patient treatment is consistent with the cancer origin predicted by the model.

Fei Tian
Dong Liu
Xiangchun Li
ResearchOpen Access16 Apr 2024
Nature Medicine

Volume: 30, P: 1309-1319
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis

Kexin Fan
Shuting Zhou
Yilei Zhang
ResearchOpen Access27 Nov 2025
Cell Death & Differentiation

P: 1-16
Predictive modeling & mechanistic validation of synergistic pimodivir combinations for anti-influenza therapy via PB2cap affinity boost

Peng Luo
Kexin Li
Shuofeng Yuan
ResearchOpen Access21 Nov 2025
npj Digital Medicine

Volume: 8, P: 1-6
Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells

Phenotypic changes in exhausted T cells are linked to chromatin remodeling. Here the authors show that pharmacological inhibition of the H3K4me1/2 demethylase LSD1 promotes the persistence and enhances the therapeutic activity of adoptively transferred T cells for cancer therapy.

Fengqi Qiu
Peishan Jiang
Wanqiang Sheng
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-17
Isolated iridium oxide sites on modified carbon nitride for photoreforming of plastic derivatives

The photocatalytic reforming of plastics into value-added chemicals offers a promising strategy to address environmental challenges while providing significant energy benefits. Here, the authors develop modified carbon nitride with enhanced visible light absorption, effectively anchoring under-coordinated IrN₂O₂ sites to catalyze the oxidation of persistent plastic derivatives.

Pawan Kumar
Hongguang Zhang
Md Golam Kibria
ResearchOpen Access24 Mar 2025
Nature Communications

Volume: 16, P: 1-17
TMEM53 as an outer nuclear membrane regulator of cranial and tubular bone formation in craniotubular dysplasia

Kaitao Ren
Yiyang Fu
Long Guo
Reviews17 Dec 2025
Journal of Human Genetics

P: 1-7
Stable and homogeneous intermetallic alloys by atomic gas-migration for propane dehydrogenation

Intermetallic alloys (IMAs) hold significant potential for catalysis. Here, the authors present a robust gas-migration method for synthesizing stable and uniform IMAs, which exhibit exceptional stability over 1300 h in propane dehydrogenation.

Pingping Wei
Sai Chen
Jinlong Gong
ResearchOpen Access17 Sept 2024
Nature Communications

Volume: 15, P: 1-9
Knockdown of OLR1 weakens glycolytic metabolism to repress colon cancer cell proliferation and chemoresistance by downregulating SULT2B1 via c-MYC

Tiancheng Zhao
Yezhou Li
Jiayu Zhang
ResearchOpen Access17 Dec 2021
Cell Death & Disease

Volume: 13, P: 1-12
Activation and inhibition mechanisms of a plant helper NLR

In plant immunity, sensor NLR resistosomes can generate heterotrimer complexes comprising the helper NLR NRG1, and investigation of cryo-EM structures shows the mechanisms of these heterotrimers in immune activation and suppression.

Yinyan Xiao
Xiaoxian Wu
Li Wan
Research12 Feb 2025
Nature

Volume: 639, P: 438-446
Peer effects on appropriate antibiotic prescribing within a patient-sharing physician network in China

Gong et al. explore how physicians influence one another’s antibiotic prescription likelihood by applying patient-sharing network methods. Their findings indicate that physicians are more likely to prescribe antibiotics appropriately when their peers had previously, with the effect being particularly pronounced among physicians highly central to the network.

Zhiwen Gong
Mengyuan Fu
Xiaodong Guan
ResearchOpen Access18 Nov 2025
Communications Medicine

Volume: 5, P: 1-9
A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge

Jessica J. Harrison
Wilson Nguyen
Jody Hobson-Peters
ResearchOpen Access31 Jul 2024
npj Vaccines

Volume: 9, P: 1-14
Publisher Correction: Scientific discovery in the age of artificial intelligence

Hanchen Wang
Tianfan Fu
Marinka Zitnik
Amendments and Corrections30 Aug 2023
Nature

Volume: 621, P: E33
The mining and construction of a knowledge base for gene-disease association in mitochondrial diseases

Wei Wang
Junying Song
Lei Zhang
ResearchOpen Access13 Dec 2021
Scientific Reports

Volume: 11, P: 1-10
TrialBench: Multi-Modal AI-Ready Datasets for Clinical Trial Prediction

Jintai Chen
Yaojun Hu
Tianfan Fu
ResearchOpen Access26 Sept 2025
Scientific Data

Volume: 12, P: 1-17
Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates

Environmental adaptation is generally studied at the genomic level, but it may also be driven by transcriptional processes. Here, the authors investigate variation in gene expression and RNA editing across diverging populations of Drosophila melanogaster from two microclimates.

Arielle L. Yablonovitch
Jeremy Fu
Jin Billy Li
ResearchOpen Access17 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously reported associations.

Qing Lan
Chao A Hsiung
Nathaniel Rothman
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1330-1335
A new approach to MADM problem using interval-valued hesitant Fermatean fuzzy Hamacher operators and statistical variance

Xiuqin Ma
Xuli Niu
Kexin Tang
ResearchOpen Access18 Mar 2025
Scientific Reports

Volume: 15, P: 1-25
Artificial intelligence foundation for therapeutic science

Artificial intelligence (AI) is poised to transform therapeutic science. Therapeutics Data Commons is an initiative to access and evaluate AI capability across therapeutic modalities and stages of discovery, establishing a foundation for understanding which AI methods are most suitable and why.

Kexin Huang
Tianfan Fu
Marinka Zitnik
Comments & Opinion21 Sept 2022
Nature Chemical Biology

Volume: 18, P: 1033-1036
Prospective cohort study evaluating the association between influenza vaccination and neurodegenerative diseases

Houyu Zhao
Xuan Zhou
Siyan Zhan
ResearchOpen Access02 Mar 2024
npj Vaccines

Volume: 9, P: 1-9
Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells

Sen Wang
Kexin Wang
Youquan Bu
ResearchOpen Access05 Oct 2017
Cell Death & Disease

Volume: 8, P: e3087
Interrogation of gender disparity uncovers androgen receptor as the transcriptional activator for oncogenic miR-125b in gastric cancer

Ben Liu
Meng Zhou
Kexin Chen
ResearchOpen Access04 May 2021
Cell Death & Disease

Volume: 12, P: 1-22
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Seamless site-directed mutagenesis in complex cloned DNA sequences using the RedEx method

RedEx achieves seamless genetic modification of large, highly repetitive, DNA targets by combining Redαβ-mediated linear–circular homologous recombination, ccdB counterselection and exonuclease-mediated in vitro annealing.

Ji Luan
Chaoyi Song
Hailong Wang
Protocols15 Jul 2024
Nature Protocols

Volume: 19, P: 3360-3388
Research on blasting mechanism and blasting effect of aqueous media in open pit coal mines

Xiaohua Ding
Xin Liu
Chun Zhu
ResearchOpen Access06 Nov 2023
Scientific Reports

Volume: 13, P: 1-17
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism

Wei Fu
Yuanting Lai
Jin Li
ResearchOpen Access03 Jan 2025
Cell Research

Volume: 35, P: 117-131
Scientific discovery in the age of artificial intelligence

The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.

Hanchen Wang
Tianfan Fu
Marinka Zitnik
Reviews02 Aug 2023
Nature

Volume: 620, P: 47-60
Motion error analysis of a shield machine tool-changing robot based on a screw-vector method

Wenxue Qian
Shuai Song
Liyang Xie
ResearchOpen Access28 Nov 2022
Scientific Reports

Volume: 12, P: 1-21
SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice

Shuai Wang
Ting He
Boan Li
ResearchOpen Access15 Oct 2024
Cell Death & Differentiation

Volume: 32, P: 447-465
A photovoltaic cell defect detection model capable of topological knowledge extraction

Zhaoyang Qu
Lingcong Li
Kexin Fu
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-22
FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling

Rui Zhao
Linli Tian
Ming Liu
ResearchOpen Access24 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-14
The miR-641-STIM1 and SATB1 axes play important roles in the regulation of the Th17/Treg balance in ITP

Hongkai Zhu
Xueqin Ruan
Hongling Peng
ResearchOpen Access16 May 2024
Scientific Reports

Volume: 14, P: 1-13
Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
ResearchOpen Access14 Jan 2022
European Journal of Human Genetics

Volume: 30, P: 349-362
Primed atypical ductal hyperplasia-associated fibroblasts promote cell growth and polarity changes of transformed epithelium-like breast cancer MCF-7 cells via miR-200b/c-IKKβ signaling

Yan Sun
Dan Yang
Yixuan Hou
ResearchOpen Access26 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-14
Artificial intelligence defines protein-based classification of thyroid nodules

Yaoting Sun
Sathiyamoorthy Selvarajan
Tiannan Guo
ResearchOpen Access06 Sept 2022
Cell Discovery

Volume: 8, P: 1-17
Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
Amendments and CorrectionsOpen Access22 Mar 2022
European Journal of Human Genetics

Volume: 30, P: 630-631

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