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Water and oxygen jointly influence the oxidation of copper, but their respective roles are difficult to disentangle. Here, the authors show that hydroxyl species adsorb at the Cu/CuO_x interface, roughen the surface, and enable deeper oxygen penetration and higher Cu mobility.

RSV hijacks cholesterol or autophagy pathways to facilitate optimal replication. Here, the authors show that RSV-mediated changes in lysosomal cholesterol metabolism promote RSV-F accumulation in lysosomes by blocking autophagy flux, thereby facilitating viral replication.

Researchers developed a porous material ZU-921 that solves a key challenge in removing multiple different types of impurities through fine-tuning pore chemistry, enabling the one-step production of high-purity propylene.

In-phase/quadrature (IQ) electro-optic modulators are underpinning devices for coherent transmission technology. Here the authors present IQ modulators in the lithium-niobate-on-insulator platform, which provide improved overall performance and advanced modulation formats for future coherent transmission systems.

Selective paraffin capture to afford high-purity olefins directly is critical but still challenging. Herein, the authors discover a distinctive ultramicroporous material featuring closely packed and linearly-extended isophthalic acid units and thus serving as a paraffin nano-trap for the efficient production of ultra-high purity olefins from paraffins.

Xiang et al. use patient samples and mouse models of osteoarthritis to examine the link with muscle atrophy. They identify that, in osteoarthritis, senescent macrophages promote ferroptosis in skeletal muscle cells, and they show the therapeutic value of targeting this pathological mechanism.

Fast keying and mode switching exploiting the orbital angular momentum of light are sought after in optical communications and quantum key distribution for larger transmission capacity and higher security. Here Strain et al., propose a compact thermo-optically tunable vortex emitter with microsecond switching rates.

Boundary effects play a strong role in the electronic properties of structured manganites. Here, Du et al. demonstrate the existence of ferromagnetic metallic edge states and an enhanced metal–insulator transition temperature in patterned strips of manganite which emerge because of broken symmetry effects.

Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.

A three-photon miniature microscope with optimized light-collection efficiency facilitates imaging of neuronal activity throughout the cortex, as well as in the hippocampus, in freely moving mice.

The quality of immune response to SARS-CoV-2 is thought to wane over time, but it is unclear how long it can persist. Here the authors show persistent immune responses in a large number of patients over the course of a 1-year follow-up from the time of recovery from COVID-19.

PPEFs are highly conserved phosphatases. Here, authors use cryo-EM to solve the holoenzyme structures of the initially characterized PPEF family member, Drosophila RDGC, with/without Ca²⁺, uncovering a dual Ca²⁺-sensor-mediated activation mechanism.

Stem cell therapies face immune rejection risks with allogeneic ESCs. Here, the authors establish genetically matched autologous ESCs in monkeys via embryo splitting, showing potentially superior genomic stability over iPSCs and ntESCs.

A radical-mediated dynamic remedial strategy based on bio-inspired disulfide metathesis has been developed to construct metal–organic frameworks with crystalline dynamicity. The disulfide exchange-based crystal dynamics of the metal–organic frameworks allows for sustained gas separation.

Training foundation models often requires a costly budget and excessive computational resources. In this study, a low-cost instruction learning framework is proposed that could enable the rapid adoption of visual-language pathology applications.

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

Single-cell RNA sequencing technology offers a unique opportunity to dissect cell heterogeneity of animals. Here, the authors construct a Xenopus cell landscape including larval and adult organs to dissect cell heterogeneity of the amphibian.

Internucleosomal linker length alters the stability and dynamics of chromatin condensates by shifting the balance between inter- and intramolecular interactions. Further, by changing the linker lengths, a remodeler can induce or suppress chromatin phase separation.

FHIRM-TPM 3.0 is a miniature microscope for multicolor two-photon imaging in freely moving mice. In addition to the multicolor imaging abilities achieved with the help of a specially designed optical fiber, the microscope is also compatible with multiple lenses for a choice of field of view and resolution.

Single-cell RNA-sequencing of seven mouse developmental stages identifies lineage-specific and shared regulatory programs controlling cell-fate decisions. Cross-species analysis associates differentiation potency with ribosomal protein gene expression.

Accurate end-to-end deep learning models for adsorption prediction in porous materials would help its discovery. Here, the authors present DeepSorption, a spatial atom interaction learning network to predict structure-adsorption from atomic coordinates and chemical element types.

This study proposes a new concept, housing utilization efficiency (HUE), to assess urban housing supply and demand. It found that the overall HUE in China has decreased since 2010, coupled with an over-supply of housing in most cities and processes of depopulation in others.

Lou and colleagues describe the role of METTL16 in homologous recombination repair and demonstrate that PARP inhibition may be beneficial in the treatment of PDAC that is characterized by high METTL16.

The development of flexible pressure sensors with a wide linear range and high sensitivity is challenging. Chen et al. demonstrate a sensor for robotics and wearable devices, using nonlinear elasticity of an elastic spacer as a stiffness regulator and a microstructured sensing layer with non-linear piezoresistivity.

Extraembryonic mesoderm (ExM) is crucial but its formation is unclear. Here, authors develop efficient systems to specify ExM from hESCs and dissect the signaling mechanisms, specification dynamics, and impact of pluripotent states in ExM formation.

Infusion of CD19-directed chimeric antigen receptor T cells into two patients with chronic lymphocytic leukaemia resulted in complete tumour remission and persistence of the infused cells more than ten years later.

Influenza surveillance over 15 cities across 5 provinces in China from October 2013 to July 2014 shows that the virus has diverged into distinct clades, becoming established in chickens and also disseminating to wider geographic regions.

Weak electron-phonon scattering that can enable long-lived hot electrons in semiconductors is of interest in hot carrier solar cells. Here, the authors report copper-doped colloidal cadmium-selenide quantum dots with hot electron lifetime extended by more than 30-fold compared to undoped dots.

The root-related changes in maize domestication, improvement and modern breeding were systematically investigated, and candidate genes related to maize root system architecture were identified for future genetic improvement.

Sequencing and analysing the diploid genome and transcriptome of Aegilops tauschii provide new insights into the role of this genome in enabling the adaptation of bread wheat and are a step towards understanding the very large and complicated hexaploid genomes of wheat species.

In laser-driven inertial fusion, finding optimal driving pressure is a major challenge. Here, the authors use a 100 kJ SG laser and a hybrid-drive scheme to demonstrate such driving pressure with the help of the direct-drive laser such that the indirect-drive radiation ablation pressure is turned into a well-smoothed hybrid-drive pressure much greater than the radiation ablation pressure.

The recharging and rapid self-discharge of supercapacitors imposes constraints on their application. In response, the authors have developed a moisture-powered supercapacitor capable of self-charging and voltage stabilizing by absorbing water in air.

Microwell-seq is used to generate single-cell, whole-body expression landscapes of zebrafish, Drosophila and earthworm. A deep-learning model, Nvwa, predicts gene expression from DNA sequence and identifies regulatory programs shared across eight species.

The Mexican axolotl is a well-established tetrapod model for regeneration and development. Here the authors report a scRNA-seq method to profile neotenic, metamorphic and limb development stages, highlighting unique perturbation patterns of cell type-related gene expression throughout metamorphosis.

Designing efficient tactile sensors under high-frequency dynamic stimuli remains a challenge. Here, the authors demonstrate piezoelectric tactile sensor with sensitivity of 346.5 pCN−1, wide bandwidth of 5–600 Hz and a linear force detection range of 0.009–4.3 N using a rigid-soft hybrid force-transmission-layer in combination with a soft bottom substrate.

Solid-phase synthesis strategy is promising for fabricating desired complex metal nanoparticles on supports. Here, the authors synthesize CoFe@FeOx core-shell nanoparticles as the separator coatings via precise solid-phase method which effectively regulates polysulfides for lithium/ sodium-sulfur batteries.

The therapeutic approaches directly targeting activated β-catenin in liver cancers are restricted by toxicities. Here the authors identify that the solute carrier transporter SLC13A3 is upregulated by activation of β-catenin and silencing of SLC13A3 induces ferroptosis, which could be exploited as a therapeutic opportunity in β-catenin-driven liver cancers.