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In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.

Asparagales is the largest monocot order. Here, the authors produce the phylogeny of Asparagales with transcriptomic data from 455 species and investigate the evolution of genes involved with allium flavor biosynthesis.

XPR1 is the sole known phosphate exporter in human. Here, the authors provide structural evidence on how KIDINS220 and inositol pyrophosphate synergistically regulate the conformation and phosphate efflux activity of XPR1.

Transposable elements (TEs) play important role in plant adaptive evolution. Here, the authors assemble pangenomes consisting of 10 rice accessions with a broad spectrum of temperature adaptability and reveal TE insertion polymorphisms of the candidate genes in cold tolerance.

Early regional sauropodomorph fossils from 200.17 Ma suggest post-Triassic mass extinction dinosaur colonization in low paleolatitudes, likely due to Central Atlantic Magmatic Province stressors and increased climate seasonality, according to chemostratigraphic and astrochronological analysis of a core from the Kunming Basin in China.

XPR1 is the only known protein that exports inorganic phosphate from cells. This study demonstrates that XPR1 uses a channel-like mechanism for phosphate transport, offering insights into potential therapeutic strategies for XPR1-linked diseases.

Lanthanide ions possess similar chemical properties, making their separation from one another challenging. Here the authors show that a tris-tridentate ligand causes high-precision metal ion self-sorting, leading to the selective assembly of tetrahedral M₄L₄ cages across the lanthanide series.

Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.

Optoretinography-based detection of phototransduction and cell deformations in the retina has been mostly centered on photoreceptors. Here, the authors use prolonged and multilayered optoretinography to study light-evoked deformations in rod photoreceptors, retinal pigment epithelium, and subretinal space.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

A deep learning model provides high accuracy in detecting pancreatic lesions in multicenter data, outperforming radiology specialists.

Oxide-based resistive switching memory is known to depend on the formation and rupture of a conducting filament, although the mechanism behind this remains debated. Here, the authors measure the Seebeck effect to understand the intrinsic electronic transport mechanism in the conducting filament.

Controlled synthesis of supramolecular structures within lysosomes holds promise for cancer imaging and treatment. The authors introduce a programmable assembly strategy to generate fluorescent nanofibres in tumour cell lysosomes, enabling targeted tumour accumulation and inducing pyroptosis for precise cancer imaging and immunotherapy.

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tumours and cell lines and identify a class of ‘Amplification-Related Gain Of Sensitivity’ (ARGOS) genes, with potential therapeutic applications.

MRI contrast agents containing the rare earth metal gadolinium are very effective, yet unstable and thus potentially hazardous. Here, the authors developed complexes between gadolinium and the scaffolding compound DOTA with increased stability, which also lend themselves to radiometal labelling.

The CD47/SIRPα axis is well known to mediate immune escape by promoting cancer resistance to phagocytosis. Here the authors show that low CD47-expressing prostate cancer cells still allow phagocytosis but the process is incomplete leading to the formation of macrophage:tumor hybrid cells with immune evasive and pro-metastatic properties.

Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.

Glycosylated asparagine residues that mediate the function of the B7H3 protein are unclear. Here the authors identify the important N-glycosylation sites for B7H3 cell surface localization and T cell inhibition, followed by the development of N91/309 and N104/322 preferentially targeting monoclonal antibody manifesting enhanced antitumor immunity.

A strategy using engineered functional customized viral receptors enables the development of functional infection models for coronaviruses whose native cellular receptors are unknown.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

A globally interconnected solar-wind power system can meet future electricity demand while lowering costs, enhancing resilience, and supporting a stable, sustainable transition to net-zero emissions.

Spatiotemporal beams differ from standard spatial structured light. The authors introduce 2D spacetime duality to uncover the conventional–spatiotemporal beam connection, enabling the development of high-fidelity spatiotemporal beams.

The use of Li or Na as electrodes in Li-Na alloy–O₂ batteries creates formidable challenges for both safety and stability because of their oxidative corrosion and the growth of dendrites and cracks on their surface. Now, an aprotic bimetal Li-Na alloy–O₂ battery with high cycling stability has been developed using a Li-Na eutectic alloy anode and an electrolyte additive.

Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Electron microscopy of native hydrated biological samples close to physiological temperature is challenging. Here, authors encapsulate proteins and cells as an efficient, cost-effective complement to other microscopy technique in addressing biological questions at the molecular level.

Si et al. demonstrated that wheat TaNHLP1 interacts with ABA regulators and RACK1A to increase tiller number, and that promoter variants that elevate TaNHLP1 expression enhance yield. This regulatory module is conserved across plants.

Neutralizing antibodies binding the domain III of Zika virus envelope protein (EDIII) are desired in vaccine development. Here, the authors express dimeric EDIII fused to human IgG1 Fc fragment from circular RNA, and show immunogenicity and protection in mice.

Materials exhibiting three-dimensional (3D) linear dispersion relations between frequency and wavevector are expected to display a wide range of interesting phenomena. 3D linear point degeneracies between two bands (“Weyl points”) have yet to be observed. Based on analytical and numerical analysis, researchers predict Weyl point formation in 3D photonic crystals.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Genome sequences from 112 patients with confirmed SARS-CoV-2 infection showed two clades of SARS-CoV-2 virus with similar virulence and clinical outcome, and clinical data from 326 cases suggest that T cell depletion and cytokine bursts are associated with a worse prognosis.

Genomic analyses of 2,191 global common wheat accessions and over 47,000 yellow rust (YR) response data points across several environments and pathogen races provide a genome-wide landscape of YR resistance genes and effective alleles.

In a randomized controlled trial involving patients with heart failure with reduced ejection fraction, treatment with Qiliqiangxin, a traditional Chinese medicine derived from 11 types of plants, decreased the incidence of cardiac events, as compared to placebo.

Stable and robust topological edge modes are observed at finite temperatures in an array of 100 programmable superconducting qubits because of emergent symmetries present in the prethermal regime of this system.

Previous studies have suggested that branched chain amino acids (BCAA) may contribute to the development of diabetic kidney disease (DKD).Here the authors report that genetic disruption of BCAA catabolism in podocytes or exogenous BCAA supplementation can trigger DKD initiation via rewiring of glucose metabolism in mice.

Zhang, Chang et al. identify the protein TMEM65 as the mitochondrial Na⁺/Ca²⁺ exchanger, showing that it dimerizes to mediate ion transport and contains a binding site for a well-known inhibitor of mitochondrial Na⁺/Ca²⁺ exchange.

In highly myopic eyes, early formation of nuclear cataracts with polarized and compacted lens fiber alignment is observed, yet the underlying mechanism is largely unknown. Here, the authors show that TGF-β1-induced m6A modifications contribute to this process by modulating the PCP pathway.