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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

A click-locking strategy inspired by click chemistry is reported that enables automated, high-throughput and industrially scalable synthesis of single-atom catalysts. By combining molecular clicking auxiliaries with robotic platforms, this approach delivers atom-precise catalysts with high activity and stability, as well as kilogram-scale manufacturability across electrocatalytic, photocatalytic and thermocatalytic reactions.

Micromitophagy is found to occur in plant male germline cells, mediated by ATG5–HSP90.2 signalling, and is evolutionarily conserved in angiosperms. This mechanism underpins paternal mitochondrial elimination and supports the zygote-to-embryo transition.

Targeted deletion of integrin-associated protein CD47 enhances long-term engraftment of human CD34⁺ cells in immunodeficient pigs lacking IL2RG and RAG2, enabling large-scale production of functional human immune cells.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Interleukin-2 (IL-2) and checkpoint inhibitors such as anti-TIGIT have been used individually as tumour therapies. Here the authors fuse IL-2 and anti-TIGIT in a combined therapeutic and show that this promotes Treg cell fragility in the tumour environment which in turn promotes neutrophil function to enhance CD8 T cell anti-tumour function in mouse models.

Photonic time crystals provide a time equivalent to standard spatial crystals. Here, authors observe wave amplification induced by the time modulation and provide experimental proof of a nontrivial temporal topology in the middle of a momentum bandgap.

The basis for inefficient Mtb control in PLWH despite treatment is unclear. Here, the authors show that combined TB/HIV therapy in Mtb/SIV co-infected macaques reduces bacterial and viral burden and improved lung pathology, but failed to fully restore immune balance, revealing persistent inflammation.

Here, the authors find that the brain recovers during sleep in a hierarchical pattern: higher association areas quiet down while primary sensory regions ramp up during early sleep, with these differences diminishing as slow waves decline.

TransBrain translates brain phenotypes between mouse and human via homology mapping, thus making it possible to capitalize on the wealth of knowledge about the mouse brain and gain insights into the human brain.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Developing efficient non-precious catalysts is key to advancing water electrolysis. Here, the authors report a microbial vulcanization strategy that co-dopes cobalt hydroxide with sulfur and organic molecules to optimize O–O coupling and accelerate the electrocatalytic oxygen evolution reaction.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Alcohols are ubiquitous molecules throughout the chemical sciences, making them highly attractive starting materials for creating new C − C bonds. Herein, a method for the photoelectrochemical C − C functionalization of various alcohols was developed.

Narrowband blue afterglow materials are critical in optoelectronic applications. Here, the authors realized efficient ultra-narrowband deep blue afterglow by short-range charge transfer in a series of indolocarbazole emitters.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

The pursuit of methods to rapidly construct of molecular complexity from easy-to-obtain starting materials drives chemical synthesis. Here, the authors report an asymmetric three-component coupling of simple alkanes, alkenes, and aryl halides, using asymmetric paired oxidative and reductive catalysis.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Mars’ bow shock, where the solar wind meets the planet’s plasma environment, responds dynamically to solar wind conditions. Here, the authors show that even under relatively calm solar wind, it globally oscillates within minutes and shifts by hundreds of kilometers.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Current bosonic quantum error correction codes exploit displacement or rotational symmetries in the quadrature phase space. Here, the authors generalise the concept by looking at potential symmetries and encoding in a broader number-phase space, where the known cat and binomial codes would correspond to rectangular lattices and be completed by other lattice codes like oblique and diamond.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

The complete biosynthetic pathway of Prim-O-Glucosylcimifugin and 5-O-Methylvisamminoside in Saposhnikovia divaricata is resolved and their de novo biosynthesis is reconstructed in Nicotiana benthamiana leaves. The evolutionary mechanisms of furochromone biosynthesis among Apiaceae plants is further analyzed.

Wafer-scale 3R-MoS₂ with high phase purity is achieved through a homoepitaxy strategy, which demonstrates ferroelectricity and holds promise for multifunctional integration.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

This study reports an adsorption-independent O₂ activation pathway for superior ¹O₂ electrosynthesis via an O₂ mono-hydrogenation process on compressive-strained rutile TiO₂. The compressive-strained TiO₂ suppresses the formation of reductive unsaturated sites for O₂ adsorption and enhances the reductive ability of atomic hydrogen, thereby enabling direct O₂ hydrogenation into free ^•OOH without the O₂ adsorption.

By using scanning tunnelling microscopy and spectroscopy, researchers observe layer-dependent electronic correlations in rhombohedral graphene multilayers at 77 K, revealing the layer-enhanced low-energy flat bands and interlayer interactions.

Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-reactive adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.

Wang, Wang, Pan and colleagues uncover a C864–C869 disulfide linkage stimulated by viral RNA that drives RIG-I activation, phase separation and stimulates downstream innate immune signalling.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Amnesic screening methods are useful to discover host factors that are important for SARS-CoV2 infection. Here the authors use a CRISPR screen to identify three anti-viral factors, which are associated with the coagulation system, and two pro-viral candidates and then use individual genetic deletion experiments to characterise their effect.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.