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Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Using sunlight to turn carbon dioxide into fuels is appealing, but reactions are often inefficient. This study shows a photothermal catalyst that lets hydrogen move between sites, enabling selective conversion of carbon dioxide to methane.

Boron-dipyrromethenes (BODIPYs) are fluorophores applicable for imaging and sensing, though are sensitive to acidic deboronation. Here the authors design macrocyclic BODIPYs resistant to acid, and have stable photophysical properties.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

The authors identify AMsh glia, expressing both cold and heat receptors, function as a dual-mode thermosensory hub, bidirectionally modulating neural circuits to regulate various thermal behaviors in C. elegans.

This study designs covalent organic frameworks with robust dipole moments, enabling efficient hydrogen and hydrogen peroxide production from pure water using mechanical vibration and light.

3D printing is useful for the preparation of soft materials with specific architectures, but can be limited by rheological complexity and nozzle limitations. Here, the authors report the development of a method using yield-stress inks in a fluid bath, with the filaments driven upwards or downwards.

This work identifies the key electron-transfer limitation in electrocatalytic contaminant removal and delivers a dual-function strategy that boosts efficiency by combining molecular enrichment with precisely controlled charging-discharging.

The implementation of asymmetric Heck/cross coupling cascades of highly flexible haloalkene substrates remains a challenging and long-standing goal. Here the authors report an asymmetric domino Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-dienes enabled by palladium catalysis.

High-voltage lithium-metal batteries face safety and stability challenges. Here, authors develop a non-flammable triethyl phosphate-based electrolyte using a triple-salt solute strategy to induce a bilayer solid electrolyte interphase, enabling long-term cycling of 4.5 V Li metal batteries.

The coupling of nitrogen-vacancy centres with plasmonic and photonic nanostructures is usually studied by top-down preparation. Here, Gong et al. use a bottom-up approach to grow metallic and semiconducting nanoparticles on nanodiamonds, controlling the nanoparticle coverage, size and composition.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Transient R-loops form around DSBs must be timely removed for HR repair. Here, the authors show that SART3 promotes DDX1 helicase binding to DSBs for optimal DNA-RNA hybrid removal, and enhances USP15-BARD1 association for efficient DNA end resection.

It remains unclear why a heightened proinflammatory cytokine response is observed during coronavirus infection. Here, Liu et al show that the envelope protein of severe coronaviruses triggers hyperinflammation by activating TMED10-mediated release of inflammatory factors.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

A method for acetylome profiling requiring a low quantity of hematopoietic stem cells (HSCs) was developed, revealing a significant reduction in H4K77ac in aged HSCs, associated with decreased lymphocyte differentiation potential.

Seawater electrolysis is highly promising for hydrogen production, yet it suffers from severe chloride-induced corrosion. This study reports a Co-based anode with triple defense that achieves durable seawater oxidation for 3000 h.

Atropisomers with a chiral C-N axis are useful for natural products synthesis and as ligands in asymmetric catalysis. Here, the authors reportt a π-π interaction and dual H-bond concerted control strategy in enantioselective C-H amination affording configurationally stable N-C atropisomers.

Ionic gels have promise in a range of applications but are limited in extreme environments. Here, the authors report a method for preparation of an ionic gel with improved mechanical properties, by formation of a micro-orientated structure and increase crystallisation and aggregation of polymer chains.

Tumor-derived extracellular vesicles (EVs) critically regulate tumor development and progression. Here the authors show that, in a mouse model of breast cancer, miR-9-5p-loaded EVs promote cholesterol biosynthesis and conversion into the oncometabolite 25-hydroxycholesterol, favoring immune evasion and promoting liver metastasis.

Metabolism is tightly regulated through communication among cells and organs. Here Gong and colleagues show that a liver-secreted factor, Gpnmb, promotes lipogenesis in adipose tissue and worsens metabolic dysfunctions during diet-induced obesity, whereas its inhibition reduces weight gain and insulin resistance.

Immune checkpoint inhibitors have shown some activity in patients with adrenocortical carcinoma (ACC), a rare aggressive malignancy with limited treatment options. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib (VEGFR inhibitor) for previously treated ACC.

Achieving high output-power-density in Gallium-nitride transistors is challenging due to high thermal resistances and thick nitride layers. Here, the authors propose ion-implantation on silicon-carbide substrates, achieving high performance and reduced thermal resistance.

To find materials with large anomalous Nernst coefficients, which is useful for energy harvesting, it is common to focus on materials with large anomalous Hall coefficients. Here, Gong et al. find a material where the anomalous Nernst effect does not show the same antisymmetric behaviour as the anomalous Hall effect.

How cells transduce nutrient availability to appropriate gene expression remains poorly understood. Here the authors show that the nutrient sensor, protein kinase A modulates histone modifications and gene transcription by phosphorylating histone demethylase.

Single atom catalysts offer a promising approach for CO₂ electroreduction to CO, but achieving high efficiency remains challenging. Here, the authors report lanthanide single atom catalysts with the transition ability from bridge to linear adsorption that exhibit efficient CO production.

Infected bone defects are a major challenge in orthopedic treatment. Here, the authors develop an electroactive mineralized scaffold that achieves nearly complete in situ healing of infected bone in rats, rabbits and beagle dogs.

The immune response has been suggested to be involved in the pathology of Ménière’s disease. Here the authors implicate serum glucocorticoid-inducible kinase 1 as a regulator of the NLRP3 inflammasome and link to macrophage function in a model of Ménière’s disease pathology.

HPCA1, a member of a previously uncharacterized subfamily of leucine-rich-repeat receptor-like kinases, is the hydrogen-peroxide sensor at the plasma membrane in Arabidopsis.

Magnesium chelatase catalyses Mg insertion into the centre of protoporphyrin IX during chlorophyll synthesis. The crystal structure of magnesium chelatase from the cyanobacterium Synechocystis shows an active site deeply buried within protein lined with evolutionary conserved residues.

Reversed Cherenkov radiation has not been observed due to the absence of suitable all-metal left-handed materials for beam transport and suitable couplers for extracting the signal. Here, Duanet al. develop a metamaterial to observe reversed Cherenkov radiation using real charged particles.

The spatial single-cell multiomic atlas of the first trimester human placenta at molecular resolution provides a blueprint for future studies on early placental development and pregnancy.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Multi-omics analysis of mouse livers shows that protein β-hydroxybutyrylation (Kbhb) is strongly affected by the ketogenic diet. Combining bioinformatics with experimental validation, a role of Kbhb sites in modulating mammalian target of rapamycin signalling and cancer cell metabolism is identified.

Cyclotelomerization of isoprene can lead to many isomers and controlling the selectivity in this reaction has been challenging for chemical methods. Now, Ni-catalysed nucleophilic cyclotelomerization of isoprene with heterocycles provides cyclic monoterpene derivatives with high selectivity.

A variational-autoencoder-based diffusion architecture that enables topological controls on the diffusion-based protein structure generation is proposed. As a result, novel folds of mainly beta proteins can be designed with experimental validation.

High-density, intrinsically stretchable transistors with high driving ability and integrated circuits with high operation speed and large-scale integration were enabled by a combination of innovations in materials, fabrication process design, device engineering and circuit design.

Kucha is a rare variety of tea tree that produces the non-stimulatory theacrine instead of caffeine. Here the authors show that theacrine synthase from Kucha has N9-methyltransferase activity resulting from amino acid substitutions that explain substrate specificity and could potentially guide production of caffeine-free tea.