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Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

Pre-existing hypoglycemia weakens the host’s interferon-based immune defense by downregulating the antiviral protein TRIM5 in the lung, thereby increasing the susceptibility to influenza infection.

Existing Janus hydrogels struggle to combine high-strength, asymmetric adhesion, and simple fabrication. Here, the authors develop a high-strength Janus hydrogel with bilateral asymmetric adhesion for wet tissue hemostasis and intestinal/intrauterine anti-adhesion.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

A room-temperature ferroelectricity with out-of-plane polarization is disclosed in chemical vapor deposition synthesized two-dimensional α-MnS, which exhibits large tunneling electroresistance, high endurance, and long retention time.

Stabilizing high-valence ruthenium sites is key for efficient acidic water splitting but remains challenging. Here, the authors report an interstitial nitrogen doping strategy to stabilize these sites in ruthenium dioxide, achieving enhanced activity and long-term stability for hydrogen production.

Waste plastics pose an escalating environmental challenge, and existing disposal solutions remain inadequate. Industrial composting is labor and energy intensive, while engineered enzyme systems have yet to be deployable outside controlled facilities. In this study, the authors introduce an enzyme@MOF platform that can be incorporated into biodegradable plastics using industry-compatible processes. This strategy enables controlled, rain-triggered degradation under weakly acidic conditions, eliminating the need for collection or specialized composting. Notably, the resulting degradation products are biocompatible and even promote plant growth, highlighting the platform’s potential for sustainable, field-scale plastic remediation

Zinc is an essential micronutrient for plants, however its excess causes cellular damage. Here, the authors report that natural variation of Trichome Birefringence (TBR) gene confers zinc toxicity tolerance through modulating root cell wall pectin methylesterification in Arabidopsis.

Grain chalkiness is an undesirable trait that severely compromises rice quality. Here, the authors report the cloning of an E3 ubiquitin ligase encoding gene Chalk9 and reveal its crucial role in regulating grain chalkiness through mediating the ubiquitination-dependent degradation of OsEBP89.

A macrolide resistant Bordetella pertussis lineage (MT28) carrying a high-virulence allele (ptxP3) has been reported as a predominant lineage in China. Here, the authors show that MT28 has enhanced colonization and inflammatory characteristics.

Sunlight-exposed dissolved organic matter generates photoelectrons that microbes capture to reduce antimonate in anoxic sediments, revealing an overlooked electron supply route that may shape antimony cycling in mining-impacted streams.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Rodents are frequently used as models of the human immune system, but not all immune functions are shared between the two evolutionary families. Here the authors provide evidence that the immune system of the tree shrew (Tupaia belangeri) is closer to humans than that of rodents and the single cell immune atlas they assemble support the wider employment of the tree shrew as immunological model.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

Seed size plays an important role in determining soybean yield. Here, the authors report GmSW17, encoding a homolog of Arabidopsis UBP22 that plays a role in deubiquitination, as a positive regulator of soybean seed width and seed weight through inhibition of the G1-to-S transition by interacting with GmSGF11 and GmENY2.

DeepDrugDiscovery is an AI-powered screening platform incorporating ADMET and blood–brain barrier penetrability predictions to successfully identify mTOR-independent autophagy enhancers that can cross the blood–brain barrier for Alzheimer’s disease therapy.

Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease in which macrophage-driven inflammation plays a central role. Here the authors show that macrophage Gsα promotes AAA by stabilizing NLRP3 inflammasome activity, while Gsα silencing via lipid nanoparticles suppresses inflammation and disease progression.

Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

Authors designed BaTiO₃-based multilayer ceramic capacitors through synergistic polymorphic nanodomain and defect optimization, achieving 18.7 J cm^-3 and 92.1% efficiency with excellent stability, offering a paradigm for synergistic domain and defect engineering.

This study reveals that Amphotericin B activates glucocerebrosidase to remodel late endosomal lipid and protein composition, promoting respiratory viral entry. This highlights a risk of secondary viral infections during antifungal therapy.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Lassa virus is a key pathogen that can cause haemorrhagic fever and further understanding of successful therapeutic strategies are needed. Here the authors explore the use of a Lassa virus glycoprotein-based vaccine and show B cell immunity as a correlate of protection in a mouse model of vaccination and subsequent viral challenge

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Higher-order interactions are shown to contribute to the decrease in species diversity from low to high latitudes in global forests, potentially explaining why this intricate phenomenon cannot be adequately explained by pairwise interactions alone.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Neuromorphic computing hardware normally makes an unideal trade-off between energy efficiency, scalability and reliability. Kim et al. report a ferroelectric heterostructure based memristor with near-zero nonlinearity, endurance beyond 10E7 cycles, rectifying ratio exceeding 10E6 and sub-pA off-current.

Tuning symmetry breaking in magnetic transitions via twist-angle engineering is challenging, as twisted two-dimensional magnets often inherit the magnetic ground states of their constituent parts. Now this tunability is achieved in a double-bilayer moiré magnet.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Deep brain stimulation tuned to cue-reactivity within the nucleus accumbens region reduced drug cravings, heralding an evocation-based programming strategy for opioid use disorder.

The authors uncover a noncanonical role for Arabidopsis POT1b in maintaining genome stability through ROS regulation, establishing an unexpected connection between telomere biology and cellular oxidative stress.

3Snet-CLID integrates signal-preserving deep learning denoising with direct Richardson–Lucy deconvolution to achieve over 5-fold resolution improvement on standard microscopes, enabling artifact-free nanoscale imaging of live-cell organelles and structures.

This study maps how insect wings form by charting cell fate changes in the silkworm wing disc over time. The authors identify a central fate-transition cell population and show how the hormone 20E rapidly accelerates wing development through coordinated gene regulation.

SpaMosaic is a mosaic integration method for spatial omics data that enables cross-modality and cross-batch integration using contrastive learning and graph neural networks.

SnRK1β1A in rice promotes susceptibility to multiple fungal diseases, and disrupting this infection-inducible gene confers broad-spectrum resistance without compromising growth or yield under normal field conditions.

KRASG12D -mutant pancreatic tumors are aggressive and resist therapy. Here the authors show that inhibiting KRASG12D weakens tumor DNA repair, sensitizing them to the PARP inhibitor olaparib, even in KRASG12D inhibitor-resistant tumors.

Plasmas can unlock unconventional reactivity for established catalytic systems, but understanding the resulting mechanistic changes is a complex endeavour. Here in situ characterization techniques allow us to rationalize the promotional role of non-thermal plasma on the catalytic hydrogenation of CO₂ to methanol on Cu–Zn systems.

C-14 hydroxyl group is critical for the function of ent-kaurane diterpenoids (ent-KTs). Here, the authors report discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-KTs.

A relatively high proportion of patients relapse following radiofrequency ablation. Here, authors show that neutrophils with high expression of CD177 and PAD4 promote progression of residual tumors after incomplete radiofrequency ablation via PPARγ-related lipid metabolism adaptation.

Sea urchins exhibit depth-mediated shifts in biodiversity, with temperature regulating patterns in shallow water and multi-factor drivers impacting deep water assemblages, according to integrated occurrence records and model-based predictions.

A cold-injection method based on pseudo-emulsion enables scalable synthesis of stable, pure-green perovskite nanocrystals with near-unity photoluminescence quantum yield, achieved through defect-suppressing slow polybromide plumbate assembly at cold temperatures.

As the properties of polymer gels are influenced by solvent as well as the network, choice of solvent is important for determination of properties. Here, the authors report the use of polyethylene glycol as a solvent for the formation of a dissipative gel, with coupling of elasticity and viscosity.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

A sedimentary δ15N record from the Banda Sea shows a higher contribution and a more direct pathway from southern high latitudes to the Indonesian Throughflow over the past 800,000 years than previously thought.