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Tinengotinib is a spectrum-selective multi-kinase inhibitor targeting several oncogenic and immunoregulatory pathways, including FGFR1–3, JAK1/2, VEGFRs, and Aurora A/B kinases. Here the authors report the results of a phase Ib/II trial of tinengotinib as monotherapy or combined with anti-PDL1 atezolizumab in patients with advanced solid tumors.

How co-invading species facilitate one another remains largely unknown. This study shows that facilitation is often asymmetric and increases when co-invading plants differ in competitiveness and their ability to shape microbial communities.

This study reports real-space, layer-resolved magnetic imaging of the van der Waals antiferromagnet (Fe,Co)₃GaTe₂ using SPLEEM, revealing A-type interlayer coupling, intrinsic chiral spin textures and enabling controlled writing of antiferromagnetic skyrmions.

RUNX2⁺ keloid fibroblasts highly expressing ADRB1 produce bone matrix proteins in response to neurotransmitters from catecholaminergic nerves. Blocking this neuro-stromal interaction prevents fibro-osseous reprogramming and keloid progression.

The interface between perovskite and tin dioxide in perovskite solar cells suffers from interfacial defects and energy level mismatch that limit efficiency. Zhang et al. add a polymerized dimethyldiallylammonium chloride interlayer to passivate defects, tune band bending, and enhance charge extraction.

A randomised trial in metformin-treated type 2 diabetes found once-weekly efsubaglutide improved HbA1c and fasting glucose, reduced weight, and enhanced meal-stimulated insulin secretion with mainly mild GI side effects.

Laser-based surface treatment creates a hierarchical architecture in superelastic NiTi, integrating hard nitrides, graded grains and phases, and high compressive stress. This synergy suppresses cracking and extends bending fatigue life beyond 5 million cycles.

Here, the authors show that uridine enhances oocyte quality in aged mice by binding to PCBP1 to suppress ferroptosis and preserve mitochondrial function, suggesting a potential strategy to delay female reproductive aging.

A Co/CoO@NC catalyst with an interfacial built-in electric field can activate the endogenous PAA-H₂O₂ redox couple, establishing a self-sustaining catalytic loop that overcomes the activity-stability trade-off in advanced oxidation processes.

Idiopathic pulmonary fibrosis is a fatal lung disease driven by aberrant fibroblast activation, but the underlying metabolic changes remain unclear. Here, the authors show that dysregulated branched chain amino acid metabolism promotes lung fibrosis and can be therapeutically targeted.

Poor storage stability and soil survival limits agricultural application of non-spore forming bacteria. Here, the authors develop a hydrogel microcapsule which improves storage and soil survival, demonstrating application in improving plant salt tolerance under field conditions.

This study shows that maize hybrids exhibit increased transcriptome activity than inbred parents in an incomplete dominance manner, contributing to hybrid vigor. This increase is primarily regulated by transcription factors acting as trans-eQTLs.

Coordination materials play a pivotal role in advancing multidisciplinary fields within contemporary science. Here, the authors present a heterogeneous in situ approach that employs zero-valent metal as a cation source in aqueous media, coupled with linker supersaturation, as a scalable synthesis process for the discovery of crystalline coordination materials.

Yang et al. report a molecular confinement strategy that regulates self-assembled monolayer packing and stabilizes buried interfaces in inverted perovskite solar cells, enabling a power conversion efficiency of 26.84% with an 86.6% fill factor.

In this work, researchers identify a selective inhibitor of the urea transporter UT-A2 using hotspot pocket–based virtual screening combined with cryo-EM and pharmacological methods, thereby providing an efficient approach for developing UT-A-selective inhibitors as next-generation diuretics.

Developing noble-metal-free electrocatalysts for acidic water electrolysis is vital for hydrogen production. The authors design a Cr and Nd co-doped Co3O4 anode catalyst with enhanced activity and durability and introduce an in-situ acid circulation strategy to mitigate membrane poisoning.

Seawater electrolysis for green hydrogen is hindered by chloride-induced corrosion and local acidification of anodes. Here, the authors report an osmium-decorated cobalt phosphide anode that buffers protons and repels chloride, enabling stable ampere-level seawater electrolysis for 4500 h.

Hygroscopic gels can harvest atmospheric water but face efficiency challenges. Here, authors developed a heterogeneous gel with a pectin shell and graphene oxide core, enhancing water uptake and release. This design achieves high water yield and rapid desorption, outperforming existing systems.

A room-temperature ferroelectricity with out-of-plane polarization is disclosed in chemical vapor deposition synthesized two-dimensional α-MnS, which exhibits large tunneling electroresistance, high endurance, and long retention time.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

A “confined molecular encapsulation” strategy enables one-step fabrication of biomimetic ion-selective membranes. The in-situ formed MOFs with tunable sizes facilitate highly precise ion differentiation.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

A de novo genome assembly of drought-resistant wheat (Triticum aestivum L.) genotype JIN50 and genomic analyses across other wheat germplasms identify structural variations contributing to drought responses and adaptation.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Understanding the subcellular distribution of RNA-binding proteins can shed light on their structural and functional features. Here, the authors map RNA-binding proteins across cellular compartments, revealing hierarchies and atypical functions.

Here the authors identify CLEC12B, a natural killer cell inhibitory checkpoint that limits antitumor immunity. They also develop a nanobody to target it, activating natural killer cell killing of tumors in humanized mice.

In this study, the authors find that SHANK3’s large intrinsically disordered region mediates phase separation to support postsynaptic density remodeling during long-term potentiation, providing an insight into how autism spectrum disorder-linked SHANK3 mutations disrupt synaptic plasticity.

Abdominal aortic aneurysm (AAA) is a life-threatening condition, but its underlying mechanisms are unclear. Here, the authors show that PDK4 contributes to abdominal aortic aneurysm by promoting metabolic reprogramming in vascular smooth muscle cells, leading to activation of NLRP3.

This study shows that novelty exposure alleviates pain and anxiety in mice by activating a specific ensemble of neurons in the lateral hypothalamus, revealing distinct neural circuits that mediate the therapeutic benefits of attention distraction.

This study reports an electrochemical coordination polymerization strategy that forms a nanoscale bilayer protective film on copper, greatly improving corrosion resistance while enabling industrial-scale processing such as roll-to-roll manufacturing.

CAR-T therapy remains poorly effective in glioblastoma (GBM) due to the tumor’s high antigen heterogeneity and immunosuppressive microenvironment. This study reports a multimodal platform for GBM immunotherapy that combines dual-antigen oncolytic viruses with bispecific CAR-T (BiCAR-T) and CAR-NK cells.

Japonica subspecies has a lower nitrogen use efficiency (NUE) than that of indica rice. Here, the authors show that natural variations in the NIN-like protein 4 (OsNLP4) encoding gene are responsible for the divergence and introgression of the indica OsNLP4 allele into elite japonica cultivar can increase NUE and grain yield.

Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The exchange is needed for testosterone production.

Cargo transport from the ER to the Golgi is highly selective. Here the authors identify three secretory pathway localized proteins that regulate ER sorting of receptor kinases in Arabidopsis and are required to support pollen tube growth.

Genomic epidemiology of 1,029 Streptococcus pyogenes emm1 and emm12 genome sequences collected between 1993 and 2024 in China reveals dominance of distinct lineages with mobile genetic element-encoded antibiotic resistance and virulence factor genes.

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8⁺ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.

Global forests show extensive tree-cover loss. Here, the authors report that plant attributes and functions can increase under limited tree-cover loss, but also that this safety margin due to edge effects from fragmentation has already been exceeded in 35.7% of forests globally.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Mechanisms confer to the enhanced cold tolerance in japonica rice have not been fully elucidated. Here, the authors report a homeodomain-leucine zipper (HD-Zip) I transcription factor encode gene CTB5 is responsible for japonica rice cold tolerance by interacting with genes in gibberellin and abscisic acid pathways.

Women with diminished ovarian reserve face persistently low success rates during in vitro fertilization. Here, the authors show that a modified letrozole protocol yields cumulative clinical pregnancy rates and cumulative live birth rates comparable to those of the GnRH antagonist protocol.

CDK4/6 inhibitors response is limited by frequent resistance in hormone receptor– positive cancers. Here, the authors show that a super enhancer driven increase in aldehyde dehydrogenase creates a vitamin A/retinoic acid feedback loop that promotes resistance in breast and endometrial cancer.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1α, and designs a small molecule to export this mechanism across tissues.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.