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China’s CCER carbon offset program is associated with reductions in CO₂ emissions and PM₂.₅ concentrations, helping to narrow the air pollution gap between economically disadvantaged and more affluent counties, as well as between ethnic minority and Han counties.

Cutaneous tuberculosis is an infectious disease associated with extracellular matrix remodeling and granuloma-driven fibrosis. Here, the authors present an in vitro model of this disease using skin organoids infected with Mycobacterium tuberculosis, and describe infection-induced alterations in specific pathways and cell populations.

SARS-CoV-2 continues to evolve, necessitating updated vaccines and therapeutics. Here the authors identify three broadly binding antibodies from vaccinated or infected individuals, characterize their conserved non-overlapping RBD epitopes by structural analysis and demonstrate protective effects in a hamster model.

Applying concepts from non-Hermitian physics to diffusive systems enables the static control of heat transport. Now, this notion is expanded to dynamic control, including a demonstration of programmed thermal transport in a metamaterial.

Gold-based layered hybrid superlattices with tunable interlayer spacing are synthesized as an efficient strategy to modulate intersystem crossing (ISC). Reduced interlayer spacing enhances Au–π conjugation, accelerating the ISC to 0.26 ps and enabling tailored spin–orbit interactions for advanced optoelectronic applications.

Deuterium-labelled compounds are useful for mechanistic studies and pharmaceutical science, but syntheses are not trivial. Here, the authors report deuteration of unactivated alkyl (pseudo)halides driven by electrochemical force, using deuterium oxide as the source of the isotope.

The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

Researchers show inhibiting immune cell steroidogenesis enhances anti-tumour immunity in triple-negative breast cancer. Posaconazole showed promise in a humanised mouse model.

Spectroscopic observations of the CHASE mission reveal the differential rotation of the solar atmosphere, finding quantitively that the Sun rotates progressively faster from the bottom of the photosphere to the chromosphere.

Electrochemical cross-electrophile coupling with alkyl halides for the construction of C(sp³)–C(sp³) bonds is generally limited to activated alkyl halides. Now this approach is extended to coupling of unactivated alkyl halides using a nickel catalyst under mild conditions.

The authors find that Ag-rich nanoprecipitates with sizes up to tens of nanometers can be formed in metallic Ag/Ag₂Se composite flexible films after spark plasma sintering. Moreover, Ag-rich nanoprecipitates play a positive role in increasing the carrier concentration, enhancing the density-of-states effective mass, and mitigating carrier scattering.

Recently exceptional plasticity has been discovered in defective Bi₂Te₃ crystal. Here, the authors further investigate the plasticity of other Bi₂Te₃-family compounds and then determine the composition range with good plasticity, high power factor and figure-of-merit.

Free-standing nitrogen-doped amorphous monolayer carbon consisting of mixed five-, six- and seven-membered rings was prepared through the polymerization of pyrrole within the confined interlayer cavity of a removable layered-double-hydroxide template.

The probability of purchasing an energy-efficient air conditioner increases as the temperature deviates from 20–22 °C in the United States, with the response varying by electricity price, background climate, and demographic characteristics.

Estimating the costs of green home improvements is not possible without accurate estimates of their impact on house prices. Now, Shen et al. use the sales data of more than 400,000 properties in the United States to determine how heat pump installations increase house prices.

The incorporation of the desirable properties of graphene into three-dimensional materials remains challenging. Here, the authors report the scalable self-assembly of graphene sheets into spongy materials with very low densities, and near-zero and largely strain-independent Poisson's ratios in all directions.

A stable and recyclable BiVO₄ photoelectrode material was developed for the efficient Cl-mediated C(sp³)–H aminomethylation of hydrocarbons in a photoelectrochemical cell, which provides a promising method for efficient solar fuel conversion.

Neoadjuvant therapy is recommended for patients with locally advanced breast cancer. Here the authors report the results of a phase 2 clinical trial of oral neoadjuvant therapy with pyrotinib (pan-HER tyrosine kinase inhibitor), letrozole (aromatase inhibitor) and dalpiciclib (CDK4/6 inhibitor) in patients with treatment-naïve and stage II-III triple positive breast cancer.

Enhancing the kinetics and selectivity of CO₂/CO electroreduction towards valuable multi-carbon products poses a scientific challenge and is imperative for practical applicability. Here the authors report that modifying copper catalysts with surface thiol ligands significantly improves acetate selectivity.

Congenital vertebral malformation has a complex genetic architecture that isn’t fully understood. Here, the authors explore the genetic architecture of congenital vertebral malformation through case-control rare variant genetic analyses and embryonic transcriptome analyses of the developing spine.

The authors develop a liquid-phase sintering strategy to effectively enlarge material’s grain sizes, thereby achieving single crystal-like electronic transport properties in polycrystalline Mg₃(Bi, Sb)₂.

Interorgan communications play key roles in the regulation of whole-body energy metabolism. Here, the authors report the myokine Musclin as a negative regulator of beige adipose thermogenesis and systemic energy homeostasis through Tfr1/PKA signalling mediated muscle fat crosstalk.

The effects of expanding electric vehicle charging stations on housing values are unknown. This study fills the gap with data for California and finds that properties near charging stations show a higher price, while traffic slightly increases and particulate matter (PM_2.5) emissions decrease.

Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and therapeutics but assessing the mRNA packaging characteristics in LNPs is challenging. Here, the authors report that mRNA and lipid contents in LNP formulations can be quantitatively examined by multi-laser cylindrical illumination confocal spectroscopy at the single-nanoparticle level.

The authors develop a quantitative theory to model and tune the electrical transports during critical phase transitions by incorporating both the band broadening effect and carrier-soft TO phonon interactions.

Passivating contacts hold promise for silicon solar cells yet the simultaneous optimization of conductivity, defect passivation and optical transparency remains challenging. Now Köhler et al. devise a passivating contact based on a double layer of nanocrystalline silicon carbide that overcomes these trade-offs.

Power factor and figure-of-merit values are normally low in flexible thermoelectric materials. Here, the authors fabricate high-performance ductile thermoelectric materials with high power factor and figure-of-merit values near the morphotropic phase boundary in Ag₂Se-Ag₂S pseudobinary compound.

The development of a tandem catalyst, consisting of two distinct nanoscale-engineered layers, enables efficient multicarbon production with high CO₂ utilization in an acidic CO₂ electroreduction environment.

A study using a copper-in-silver dilute alloy catalyst in a high-pressure gas flow reactor reports highly selective electrosynthesis of acetate from carbon monoxide.

Today solid-state cooling technologies below 77 K are greatly limited. Here, the authors report the colossal Nernst power factor in NbSb₂ single crystal, providing a high performance thermomagnetic material for solid-state cooling at low temperature.

It is still challenging to discover plastically deformable inorganic semiconductors. Here, the authors report a high-throughput screening of tens of potential 2D van der Waals crystals that can deform plastically accompanied with experimental verification.

Lipid droplets (LDs) are fat storage organelles that are initiated and expanded by seipins at ER contact sites. Here the authors show that the C. elegans seipin ortholog SEIP-1 is recruited to these sites by certain dietary fatty acids to support the expansion of a subset of LDs.

Mixed ionic–electronic conductors are limited by material decomposition. Here the authors reveal the mechanism for atom migration and deposition in Cu_2–δ(S,Se) materials based on a critical chemical potential difference and propose electronically conducting, ion-blocking interfaces to enhance stability.

The authors show that bulk brittle semiconductors can be plastically manufactured like metals by warm metalworking into free-standing, metre-scale films with decent physical properties.