Nature Search

OBITUARY: Howard M. Temin (1934–94)

Robert C. Gallo
News & Views03 Mar 1994
Nature

Volume: 368, P: 17
Enterocytes rely on purine biosynthesis/salvage pathway to facilitate dietary fat absorption

This study shows that the intestine uses a specific pathway to generate the energy (ATP) needed to move dietary fat out of intestinal cells. A protein called ANKRD9 helps regulate this energy supply; without it, fat builds up in the intestine, and the body remains lean.

Yu Wang
Li Chen
Svetlana Lutsenko
ResearchOpen Access13 Mar 2026
Nature Communications

P: 1-17
A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

Yang Yi
Yanqiang Li
Qi Cao
ResearchOpen Access26 Mar 2026
Nature Communications

P: 1-19
Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward

It remains unclear how opponent serotonin and dopamine signals regulate striatal activity to exert opposing effects on behavior. This study reveals how the complement of serotonin and dopamine receptors expressed by cells in the striatum enable the two neuromodulators to exert opposing functions during reward learning.

Daniel F. Cardozo Pinto
Michaela Y. Guo
Robert C. Malenka
ResearchOpen Access14 Mar 2026
Nature Communications

P: 1-12
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

Volume: 17, P: 1-17
CF2H: a cell-free two-hybrid platform for rapid protein binder screening

Faster and cheaper experimental screening methods will democratize and accelerate the identification of high-affinity binders with biomedical applications. Here the authors present Cell-Free Two-Hybrid (CF2H), a rapid and sensitive method for detecting high-affinity protein-protein interactions.

Julien Capin
Pauline Mayonove
Jerome Bonnet
ResearchOpen Access10 Mar 2026
Nature Communications

P: 1-14
A systematic review of the global and regional estimates of the prevalence of sexual violence against children

A global analysis of 1,412 studies shows that one in five women and one in six men experienced sexual violence as children, highlighting the urgent need for evidence-based prevention and intervention programmes worldwide.

Xiangming Fang
Jingru Ren
Inga Vermeulen
Research02 Apr 2026
Nature Human Behaviour

P: 1-13
Stereospecificity of Certain Soluble and Particulate Preparations of Mitochondrial Reduced Nicotinamide-Adenine Dinucleotide Dehydrogenase From Beef Heart

LARS ERNSTER
HENRY D. HOBERMAN
GIANLUIGI SOTTOCASA
Research28 Aug 1965
Nature

Volume: 207, P: 940-941
Formation and resolution of recombination intermediates by E. coliRecA and RuvC proteins

Hazel J. Dunderdale
Fiona E. Benson
Stephen C. West
Research26 Dec 1991
Nature

Volume: 354, P: 506-510
Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

Beta-arrestins are key transducers of G-protein coupled receptors, but the mechanisms of beta-arrestin signaling are poorly understood. Here, authors use cryo-electron microscopy to show how beta-arrestin 1 binds and activates Src kinase

Natalia Pakharukova
Brittany N. Thomas
Robert J. Lefkowitz
ResearchOpen Access20 Feb 2026
Nature Communications

Volume: 17, P: 1-19
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions

Genome-wide analysis coupled with long-read sequencing identifies a repeat expansion in GOLGA8A associated with high risk for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Wouter De Coster
Marleen Van den Broeck
Rosa Rademakers
ResearchOpen Access12 Mar 2026
Nature Genetics

P: 1-11
PULMONARY May 17, 1973, 2:00 P.M. Continental Ballroom 6

Robert B Mellins
Research01 Apr 1973
Pediatric Research

Volume: 7, P: 59-168
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
DNA Ligase and Exonuclease Activities in Virions of Rous Sarcoma Virus

SATOSHI MIZUTANI
HOWARD M. TEMIN
ROBERT T. WELLS
Research21 Apr 1971
Nature New Biology

Volume: 230, P: 232-236
Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk

In this study, the authors examine the potential shared genetic vulnerability across externalizing traits related to substance use and to substance use disorders.

Holly E. Poore
Chris Chatzinakos
Peter B. Barr
ResearchOpen Access20 Mar 2026
Nature Mental Health

P: 1-12
Evidence for Repair of Ultra-Violet Damaged Deoxyribonucleic Acid in Cultured Mammalian Cells

RONALD E. RASMUSSEN
ROBERT B. PAINTER
Research26 Sept 1964
Nature

Volume: 203, P: 1360-1362
In vivo site-specific engineering to reprogram T cells

Stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads using a two-vector system of enveloped delivery vehicles and adeno-associated viruses.

William A. Nyberg
Pierre-Louis Bernard
Justin Eyquem
ResearchOpen Access18 Mar 2026
Nature

P: 1-10
A sorghum pangenome reference improves global crop trait discovery

A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that are better adapted to changing environments.

Geoffrey P. Morris
Avril M. Harder
John T. Lovell
ResearchOpen Access11 Mar 2026
Nature

P: 1-9
Combinatorial libraries on the Web

Richard Peters
Robert S. Sikorski
Research01 Aug 1996
Nature Biotechnology

Volume: 14, P: 1031
Adaptable, quantitative CRISPR/Cas12a-based assay for cytomegalovirus DNA in infant saliva

Karissa Chao
Monika L. Dietrich
Robert F. Garry
ResearchOpen Access13 Mar 2026
Scientific Reports

P: 1-16
SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads

In this study, long-read RNA sequencing achieves accurate single-nucleotide polymorphism calling, haplotype phasing and allele-specific expression analysis.

Neng Huang
Heng Li
Giulia Zunino
Research30 Mar 2026
Nature Methods

P: 1-6
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control

This work describes three people living with HIV-1 who maintain long-term immune-mediated control of HIV-1 after pausing antiretroviral therapy. Autologous neutralizing antibodies and polyfunctional HIV-1-specific CD4⁺ and CD8⁺ T cell responses, pre-programmed for antigen response, were present before, and persisted during, ART interruption. This serves as a model of ART-free control of HIV-1 and informs new HIV-1 cure strategies.

Katie Fisher
Mauro A. Garcia
Ole S. Søgaard
ResearchOpen Access03 Mar 2026
Nature Immunology

Volume: 27, P: 812-826
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Amendments and Corrections11 Mar 2026
Nature Medicine

Volume: 32, P: 1160
An Experimental Solution to the Paradox of Discontinuous Respiration in Insects

ROBERT I. LEVY
HOWARD A. SCHNEIDERMAN
Research23 Aug 1958
Nature

Volume: 182, P: 491-493
Protein databases on the WWW

Richard Peters
Robert S. Sikorski
Research01 Jan 1997
Nature Biotechnology

Volume: 15, P: 90
Microscopy resources on the WWW

Robert Sikorski
Richard Peters
Research01 Apr 1997
Nature Biotechnology

Volume: 15, P: 386
Chromatography on the WWW

Richard Peters
Robert S. Sikorski
Research01 Feb 1997
Nature Biotechnology

Volume: 15, P: 189
Apoptosis on the Web

Robert S. Sikorski
Richard Peters
Research01 Nov 1996
Nature Biotechnology

Volume: 14, P: 1606
Using the linear references from the pangenome to discover missing autism variants

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Yang Sui
Jiadong Lin
Evan E. Eichler
ResearchOpen Access23 Jan 2026
Nature Communications

Volume: 17, P: 1-16
Psychiatric Ward Behaviour and Geophysical Parameters

HOWARD FRIEDMAN
ROBERT O. BECKER
CHARLES H. BACHMAN
Research13 Mar 1965
Nature

Volume: 205, P: 1050-1052
Natural selection on human microRNA binding sites inferred from SNP data

Kevin Chen
Nikolaus Rajewsky
Research29 Oct 2006
Nature Genetics

Volume: 38, P: 1452-1456
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Thorsten Heinzel
Robert M. Lavinsky
Michael G. Rosenfeld
Research01 May 1997
Nature

Volume: 387, P: 43-48
Centrifugation on the Web

Richard Peters
Robert S. Sikorski
Research01 Jul 1996
Nature Biotechnology

Volume: 14, P: 899
Solution structure of the ets domain of Fli-1 when bound to DNA

Heng Liang
Xiaohong Mao
Stephen W. Fesik
Research01 Dec 1994
Nature Structural Biology

Volume: 1, P: 871-876
The structure of Bacillus subtilis pectate lyase in complex with calcium

Richard Pickersgill
John Jenkins
Janine Robert-Baudouy
Research01 Oct 1994
Nature Structural Biology

Volume: 1, P: 717-723
Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

Amin Fazeli
Stephanie L. Dickinson
Robert A. Weinberg
Research24 Apr 1997
Nature

Volume: 386, P: 796-804
Geomagnetic Parameters and Psychiatric Hospital Admissions

HOWARD FRIEDMAN
ROBERT O. BECKER
CHARLES H. BACHMAN
Research16 Nov 1963
Nature

Volume: 200, P: 626-628
Physiology and Pathogenesis of the Stein–Leventhal Syndrome

VIRENDRA B. MAHESH
ROBERT B. GREENBLATT
Research26 Aug 1961
Nature

Volume: 191, P: 888-890
A Cytological Study of the Neurones of Patella Vulgata by Light and Electron Microscopy

DENNIS LACY
ROBERT HORNE
Research03 Nov 1956
Nature

Volume: 178, P: 976-978
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

Volume: 23, P: 338-349
Release of Elastolytic Activity from Blood Platelets

B. ROBERT
M. SZIGETI
J. CAEN
Research19 Sept 1970
Nature

Volume: 227, P: 1248-1249
Implications of fragile X expression in normal males for the nature of the mutation

David H. Ledbetter
Susan A. Ledbetter
Robert L. Nussbaum
Research13 Nov 1986
Nature

Volume: 324, P: 161-163
Crystal structure of four-stranded Oxytricha telomeric DNA

ChulHee Kang
Xiaohua Zhang
Alexander Rich
Research12 Mar 1992
Nature

Volume: 356, P: 126-131
World Wide Web sites in biotechnology

Robert Skikorski
Richard Peters
Research01 May 1997
Nature Biotechnology

Volume: 15, P: 475
Ether lipids influence cancer cell fate by modulating iron uptake

The contribution of ether lipid species in cancer cell fate has not been fully understood yet. Here the authors show that malignant cancer cells employ ether lipids to modulate membrane biophysical properties, enhancing iron endocytosis and ferroptosis susceptibility.

Ryan P. Mansell
Sebastian Müller
Whitney S. Henry
ResearchOpen Access27 Jan 2026
Nature Communications

Volume: 17, P: 1-19
Volcanic growth faults and the origin of Pacific abyssal hills

Ken C. Macdonald
P. J. Fox
Pascal Gente
Research14 Mar 1996
Nature

Volume: 380, P: 125-129
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein

William G. Rice
Jim A. Turpin
Edward A. Sausville
Research01 Mar 1997
Nature Medicine

Volume: 3, P: 341-345
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Very large array observations of solar active regions

Kenneth R. Lang
Robert F. Willson
Research01 Mar 1979
Nature

Volume: 278, P: 24-28
Analysis of regulation of Klebsiella pneumoniae nitrogen fixation (nif) gene cluster with gene fusions

Ray Dixon
Robert R. Eady
Mike Merrick
Research10 Jul 1980
Nature

Volume: 286, P: 128-132

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