Nature Search

Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Early favorable prostate-specific antigen response prediction in metastatic hormone sensitive prostate cancer

There is a need for an easy-to-use clinical tool, that could predict favorable early PSA response and subsequently enhance early risk stratification, as well as guide treatment planning. Here, the authors show that based on patient data from four phase III randomized trials, Nadir androgen receptor pathway inhibitor (APRI)- Derived Integrative Response (NADIR) model predicts favorable early PSA response to ≤0.2 ng/mL by 6 months in metastatic hormone sensitive prostate cancer (mHSPC) patients initiating treatment with an APRI.

Soumyajit Roy
Yilun Sun
Daniel E. Spratt
ResearchOpen Access17 Dec 2025
Nature Communications

Volume: 17, P: 1-10
Histopathology and proteomics are synergistic for high-grade serous ovarian cancer platinum response prediction

Oz Kilim
Alex Olar
István Csabai
ResearchOpen Access26 Jan 2025
npj Precision Oncology

Volume: 9, P: 1-15
Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D

Extrachromosomal circular DNAs (ecDNAs) are prevalent in human cancers and are thought to drive tumor evolution and drug resistance by amplifying oncogenes. Here, authors develop ec3D to reconstruct three-dimensional ecDNA structures, revealing how their spatial organization rewires regulatory circuits.

Biswanath Chowdhury
Kaiyuan Zhu
Vineet Bafna
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Research and development priorities for Nipah virus outbreak preparedness

Standardized clinical assays, diagnostic assays and, ultimately, a vaccine are needed to prepare for future Nipah virus outbreaks.

Michael S. Avumegah
Anthony Griffiths
Ali Azizi
Comments & Opinion15 Jan 2026
Nature Health

Volume: 1, P: 20-23
Investigation of energy, exergy and techno-environmental analysis of a hybrid PVT-based active direct solar dryer while drying henna leaves

Abdallah Elshawadfy Elwakeel
Awad Ali Tayoush Oraiath
Aml Abubakr Tantawy
ResearchOpen Access01 Dec 2025
Scientific Reports

Volume: 15, P: 1-21
Rh-negative Rate for Indians

S. D. S. GREVAL
A. B. ROY CHOWDHURY
Research30 Mar 1946
Nature

Volume: 157, P: 411
Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk

In this study, the authors develop a flavivirus vaccine strategy by introducing mutations into envelope glycoproteins resulting in structural changes that conceal the ADE-prone fusion loop epitope. They show that the Zika virus-specific construct protects mice against viral challenge and prevents ADE by Dengue virus.

Yimeng Wang
Andrey Galkin
Yuxing Li
ResearchOpen Access22 Dec 2025
Nature Communications

Volume: 16, P: 1-22
Septate Fibres in Angiosperms and their Length

K. A. CHOWDHURY
S. K. PURKAYASTHA
J. S. SOND
Research30 Jun 1956
Nature

Volume: 177, P: 1243-1244
Thermomechanical inferences from deep seismic sounding sections

P. S. KOCH
Research01 Apr 1982
Nature

Volume: 296, P: 586
Lactobacillus plantarum and Lactobacillus acidophilus enhance growth performance, immunity, cecal microbiota, and vital organs histomorphology in rabbits

Hitham Anas
Mahmmoud A. A. Mohamed
Fatma El-Zahraa A. Mustafa
ResearchOpen Access23 Jan 2026
Scientific Reports

Volume: 16, P: 1-16
Willow as Host-Plant of Crioceris merdigera

S. MAULIK
Research01 Nov 1947
Nature

Volume: 160, P: 609-610
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness

uPAR is a senescence-associated protein, and CAR T cells targeting uPAR exert senolysis. Here Eskiocak et al. identify uPAR⁺ cells as key targets of intestinal aging and show that CAR T-mediated elimination prevents and restores age-related decline in intestinal regeneration and barrier function.

Onur Eskiocak
Joseph Gewolb
Corina Amor
ResearchOpen Access25 Nov 2025
Nature Aging

Volume: 6, P: 108-126
Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens

The microbiota may mediate the differential responses to oral cholera vaccine (OCV). Here, the authors reveal that the presence of sphingolipid-producing bacteria is associated with the development of protective immune responses after OCV.

Denise Chac
Frederick J. Heller
Ana A. Weil
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 17, P: 1-15
mRNA engineering of allogeneic mesenchymal stem cells enables coordinated delivery of T cell engagers and immunotherapeutic cues

Allogenic mesenchymal stem cells are engineered with three mRNAs to bind to multiple myeloma B cells while activating T cells for cancer therapy.

C. Andrew Stewart
Shaji Daniel
Christopher M. Jewell
Research28 Nov 2025
Nature Biomedical Engineering

P: 1-13
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
Gene Therapy for Inherited Hyperbilirubinemias

Namita Roy-Chowdhury
Ajit Kadakol
Jayanta Roy-Chowdhury
Research21 Jan 2002
Journal of Perinatology

Volume: 21, P: S114-S118
Generalized Probabilistic Approximate Optimization Algorithm

Finding solutions in rugged energy landscapes is hard. Here, authors introduce a generalized Probabilistic Approximate Optimization Algorithm, a classical variational Monte Carlo method that reshapes the landscape and runs on probabilistic computers, recovers simulated annealing, and learns multi-temperature schedules.

Abdelrahman S. Abdelrahman
Shuvro Chowdhury
Kerem Y. Camsari
ResearchOpen Access08 Dec 2025
Nature Communications

Volume: 17, P: 1-11
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Incidence of the Rh Factor in Indians

K. S. RANGANATHAN
C. S. RAMACHANDRA RAO
N. R. RATNAKANNAN
Research30 Mar 1946
Nature

Volume: 157, P: 411
Possibility of Alkylation of Coals and Chlorinated Coals

M. S. IYENGAR
D. D. BANERJEE
S. CHOUDHURY
Research17 Feb 1962
Nature

Volume: 193, P: 646-647
Green analytical evaluation of anticancer drug analysis: A multi-tool assessment of HPLC and LC–MS methods

Huma Sulthana
Judy Jays
Prakash Goudanavar
ResearchOpen Access13 Jan 2026
Scientific Reports

Volume: 16, P: 1-15
A Perchloric Acid–Naphthoquinone Method for the Histochemical Localization of Cholesterol

C. W. M. ADAMS
Research28 Oct 1961
Nature

Volume: 192, P: 331-332
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Sanna Gudmundsson
Moriel Singer-Berk
Anne O’Donnell-Luria
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-14
An Archaean sub-seafloor geothermal system, ‘calc-alkali’ trends, and massive sulphide genesis

P. J. MacGeehan
W. H. MacLean
Research01 Aug 1980
Nature

Volume: 286, P: 767-771
Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset

Kai Shi Lim
Maria Teresa Periñan
Masharip Atadzhanov
ResearchOpen Access02 Feb 2026
npj Parkinson's Disease

P: 1-12
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNA^Ala mutation (m.5019A>G) in mice and demonstrate that macrophages carrying this mutation display altered function and metabolism in vitro, along with increased type I IFN release following LPS challenge in vivo.

Eloïse Marques
Stephen P. Burr
Dylan G. Ryan
ResearchOpen Access20 Nov 2025
Nature Communications

Volume: 16, P: 1-24
Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation

Targeting individual DNA secondary structures in the genome with small molecules is challenging. Here, the authors develop ATENA, a CRISPR-based platform for targeting specific DNA structures in cells with high precision, helping to elucidate their biological roles and guide therapeutic design.

Sabrina Pia Nuccio
Enrico Cadoni
Marco Di Antonio
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 17, P: 1-23
Rapid polymer transport in concentrated solutions through the formation of ordered structures

B. N. Preston
T. C. Laurent
G. J. Checkley
Research09 Oct 1980
Nature

Volume: 287, P: 499-503
Multiplex gene-editing strategy to engineer allogeneic EGFR-targeting CAR T-cells with improved efficacy against solid tumors

Resistance signaling in the tumor microenvironment limits CAR T cell therapy in solid tumors. This study introduces a multiplex engineered CAR T cell strategy using six gene edits to overcome multiple inhibitory barriers.

Ryan Murray
Md Raihan Chowdhury
Stephen M. Hatfield
ResearchOpen Access23 Nov 2025
Nature Communications

Volume: 16, P: 1-17
Difference in the Behaviour of Tissues in Ancient Plant Remains and during Chemical Treatment

K. A. CHOWDHURY
S. S. GHOSH
G. M. VYAS
Research21 Sept 1957
Nature

Volume: 180, P: 612-613
Proteomic landscape of epithelial ovarian cancer

It remains essential to find clinically relevant biomarkers in epithelial ovarian cancer (EOC). Here, the authors perform a comprehensive proteomic profiling of tissue and plasma samples from EOC and control patients; they find potential biomarkers for EOC early detection and develop methods for tumour recurrence prediction.

Liujia Qian
Jianqing Zhu
Tiannan Guo
ResearchOpen Access31 Jul 2024
Nature Communications

Volume: 15, P: 1-20
Liebermann-Burchard Reaction for Steroids

M. C. NATH
M. K. CHAKRAVORTY
S. R. CHOWDHURY
Research26 Jan 1946
Nature

Volume: 157, P: 103-104
Optimizing irrigation and nitrogen levels for improved soil nitrogen dynamics and use efficiency in temperate ecology of Kashmir

Mohd Salim Mir
Waseem Raja
Samy Sayed
ResearchOpen Access30 Dec 2025
Scientific Reports

Volume: 16, P: 1-16
Dietary profiles and associated metabolic risk factors in India from the ICMR–INDIAB survey-21

Analyses of the nationally representative Indian Council of Medical Research–India Diabetes survey reported that Indian diets are characterized by high intakes of low-quality carbohydrates associated with 14–30% higher cardiometabolic risk, which can be reduced by substituting carbohydrates with protein.

Ranjit Mohan Anjana
Vasudevan Sudha
Viswanathan Mohan
ResearchOpen Access30 Sept 2025
Nature Medicine

Volume: 31, P: 3813-3824
Serum-dependent adhesion and cytotoxicity of cells to Litomosoides carinii microfilariae

D. SUBRAHMANYAM
Y. V. B. G. RAO
D. S. NELSON
Research08 Apr 1976
Nature

Volume: 260, P: 529-530
Seasonal variability and geochemical significance of organic matter in the River Ganges, Bangladesh

V. Ittekkot
S. Safiullah
R. Seifert
Research01 Oct 1985
Nature

Volume: 317, P: 800-802
Pushing the boundary of quantum advantage in hard combinatorial optimization with probabilistic computers

Probabilistic computing has emerged as a powerful route for tackling hard optimization. Here, authors show p-computers co-designed with modern hardware to run Monte Carlo algorithms solve hard optimization efficiently and establish a rigorous classical baseline to assess practical quantum advantage.

Shuvro Chowdhury
Navid Anjum Aadit
Kerem Y. Camsari
ResearchOpen Access16 Oct 2025
Nature Communications

Volume: 16, P: 1-10
Control of Glycolysis in Washed Suspensions of Streptococcus faecalis

W. W. FORREST
D. J. WALKER
Research03 Jul 1965
Nature

Volume: 207, P: 46-48
Dendroclimatological implications of isotope coherence in trees from Kashmir Valley, India

R. Ramesh
S. K. Bhattacharya
K. Gopalan
Research01 Oct 1985
Nature

Volume: 317, P: 802-804
A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1

Friedhelm Hildebrandt
Edgar Otto
Matthias Brandis
Research01 Oct 1997
Nature Genetics

Volume: 17, P: 149-153
Reversed Photoperiodic Seasons and Wool Growth

D. S. HART
J. W. BENNETT
MANIKA WODZICKA-TOMASZEWSKA
Research20 Apr 1963
Nature

Volume: 198, P: 310-311
Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

Enrichment for efferocytic macrophages in the islets of Langerhans promotes the accumulation of anergic-like CD4⁺ T cells and dampens autoimmune diabetes.

Pavel N. Zakharov
Chanchal S. Chowdhury
Kodi S. Ravichandran
Research01 Oct 2025
Nature

Volume: 647, P: 1014-1024
White Cats and Deafness

C. C. LITTLE
Research10 Feb 1934
Nature

Volume: 133, P: 215-216
Anisotropy of Spherical Sound Waves

S. Y. SKOMTAO
L. K. SU
Research10 Feb 1934
Nature

Volume: 133, P: 214-215
Effect of Cobalt on the Non-nodulated Legume

E. G. HALLSWORH
S. B. WILSON
W. A. ADAMS
Research16 Jan 1965
Nature

Volume: 205, P: 307-308
Substantially underestimated global health risks of current ozone pollution

This study assesses current global ozone pollution and reveals significant O₃-related health risks, with key focuses on population exposure and all-cause mortality burden, using the high-resolution estimation from a geo-ensemble learning model.

Yuan Wang
Yuanjian Yang
Liangpei Zhang
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Elliptic anisotropy measurement of the f₀(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A. Hayrapetyan
A. Tumasyan
A. Zhokin
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-19
TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons

Laurent Fasano and colleagues identify TSHZ3 deletions in patients with autism spectrum disorder. Tshz3-mutant mice show functional changes at synapses established by cortical projection neurons and exhibit autism-like behavioral patterns.

Xavier Caubit
Paolo Gubellini
Laurent Fasano
Research26 Sept 2016
Nature Genetics

Volume: 48, P: 1359-1369
Tuning the surface Fermi level on p-type gallium nitride nanowires for efficient overall water splitting

One of the obstacles in implementing solar water splitting is the requirement for materials with high internal quantum efficiency. Here, the authors investigate the effects of magnesium doping on the Fermi levels of gallium nitride nanowires, and tune this value to maximize redox efficiency.

M. G. Kibria
S. Zhao
Z. Mi
Research30 Apr 2014
Nature Communications

Volume: 5, P: 1-6

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