Search

A computational workflow, LyMOI, uses LLM, knowledge graphs and other tools to facilitate ’omic analysis and hypothesis generation related to autophagy.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Materials that combine high mechanical strength with stable and reversible switching states are highly desirable for advanced technology applications. Here, the authors reported hydrogen-bond nanoconfined self-destructive polymers that have reversible solid-fluid switching capability at 25 °C and maintain good mechanical properties.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

Some colon carcinomas with microsatellite instability carry a frameshift mutation in a tumour suppressor UVRAG. Here the authors show that mutant UVRAG triggers colorectal cancer by antagonizing the activity of normal UVRAG in autophagy and chromosomal stability, but also sensitizes the cancer to DNA damage-inducing chemotherapeutic drugs.

Yang et al. use cryo-ET and resolve a unique native architecture of microtubule singlet-to-doublet transition in the basal body of Plasmodium. They reveal the key role of δTubulin and ε-Tubulin in this transition during Plasmodium male gametogenesis.

Hydrogen adsorption/desorption behavior plays a key role in hydrogen evolution reaction catalysis. Here, the authors demonstrate the rational balancing of hydrogen adsorption/desorption by orbital modulation for significantly enhanced hydrogen evolution performance.

RNA splicing is crucial for gene expression diversity and can be altered by mutations. Here, the authors present SpTransformer, a deep learning tool that predicts tissue-specific RNA splicing with high accuracy, revealing splicing’s role in pathogenic mutations and aiding clinical interpretations.

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.

Here the authors identify a unique bacterial Argonaute protein, CpAgo, that uses both guide-dependent and guide-independent mechanisms to degrade DNA/RNA via a previously unidentified PAZ pocket, offering insight into microbial immunity and potential biotechnology applications.

Isoprene is a key component of the atmosphere, with impacts on oxidation, ozone and organic aerosols, but in-situ measurements are limited. Here, the authors present a full-physics measurement framework based on satellite data that enables the direct observation of atmospheric isoprene from space.

Achieving high permeance and precise separation in thin-film composite polyamide (TFC PA) membranes remains challenging. Here, the authors demonstrate the use of lignin alkali derived from waste of paper pulp as an aqueous phase additive to regulate interfacial polymerization process for achieving high performance nanofiltration membranes.

Gold-nanoparticle-coated titania nanowire arrays subretinally implanted in blind mice and monkeys offer advantages in visual acuity and contrast sensitivity towards the restoration of visual function.

Effectively delivering medications to the renal tubule to delay or halt chronic kidney disease progression remains a significant unmet clinical challenge. Here, authors introduce an innovative strategy for renal tubule targeting using biomimetic high-density lipoprotein (bHDL) nanoparticles.

The inactivation of natural enzymes by radiation hinders their utility for radiotherapy. Here the authors report a single-atom copper nanozyme that can be utilized for enhanced radio-enzymatic therapy to resolve the crucial issues for the applications of natural enzymes.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

Despite the absence of frequent mutations of key components of Wnt/β-catenin signalling, this pathway is often constitutively activated in non-small cell lung carcinoma. In this study, the authors demonstrate the inhibitory effect of miR-582-3p on negative regulators of the Wnt/β-catenin pathway which is consequently triggered to sustain lung tumour growth.

Analysis of data from the Born in Guangzhou Cohort Study comprising mainly of trios and mother–infant pairs reveals novel East Asian-specific genetic associations with maternal bile acid, gestational weight gain and infant cord blood traits.

Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version with optimized pharmacokinetic and safety profile.

Min Deng, Kai Wang and colleagues report genome-wide association analyses of amyotrophic lateral sclerosis in the Han Chinese population. They identify two new risk loci at 1q32 and 22p11.

The metastatic tumour microenvironment in pancreatic ductal adenocarcinoma (PDAC) remains to be explored. Here, the authors perform single cell RNA sequencing analysis for synchronously resected PDAC primary tumours and matched liver metastases and find differences in cellular composition.

The genome of the tropical blue-petal water lily Nymphaea colorata and the transcriptomes from 19 other Nymphaeales species provide insights into the early evolution of angiosperms.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Senescent cells and their production of inflammatory cytokines (senescence-associated secretory phenotype) affects aging and disease, including cancer. Zhang et al. report that epigenomic remodeling by KDM4 controls the senescence-associated secretory phenotype, and KDM4 expression by stromal cells of the tumor microenvironment promotes prostate cancer.