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High-order modes of hyperbolic polaritons – hybrid light-matter interactions – in anisotropic van der Waals materials hold potential for nanophotonics applications. Here, the authors report the observation of polariton mode conversion in step-shaped terraces of hexagonal boron nitride and α-MoO3.

A global synthesis of >600 studies finds that across agro-ecosystems, grasslands and forests in temperate and tropical zones, increasing plant diversity has a consistently positive effect on plant performance and the suppression of antagonists.

Effective drug delivery in bladder cancer remains challenging due to poor tissue penetration and rapid clearance. Here, the authors design a self-driven electrical system that activates tunneling nanotube formation, enhancing intercellular drug transport and therapeutic efficacy.

SARS-CoV-2 continues to evolve, necessitating updated vaccines and therapeutics. Here the authors identify three broadly binding antibodies from vaccinated or infected individuals, characterize their conserved non-overlapping RBD epitopes by structural analysis and demonstrate protective effects in a hamster model.

The authors experimentally demonstrate the coexistence of superconductivity and ferroelectricity at LaAlO₃/KTaO₃ interfaces. The superconducting transition temperature is enhanced due to ferroelectric polarization-induced reduction in dielectric constant, which narrows the interfacial potential well, confining carriers closer to the interface.

This study presents a flexible AI-based method for compressing microscopy images, achieving high compression while preserving details critical for analysis, with support for task-specific optimization and arbitrary-resolution decompression.

Disturbing the redox balance in anaerobic bacteria presents a promising but underdeveloped strategy for the treatment of difficult-to-cure diseases caused by anaerobic bacteria. Here, the authors report a photocatalytic system to perturb the redox balance in oxygen-free conditions, achieving photocatalytic therapy to treat periodontitis.

Magnetic semiconductors provide control of spin states in addition to charge states realized in conventional semiconductors, yet currently limited to weak magnetism at low temperature. Liuet al. introduce oxygen into a ferromagnetic metallic glass, resulting in a Curie temperature above 600 K.

Interferons are a key part of antiviral immunity. Here, the authors identify prefoldin and UBA3 as previously unrecognized regulators of interferon responses. Rotavirus VP3 effectively subverts this pathway to promote viral replication and represents a target for antiviral development.

Low-loss, high-speed and efficient optical modulators on a silicon platform are demonstrated.

Combining atomic-scale imaging and density-functional-theory defect phase diagrams, this study shows that boron at steel grain boundaries rearranges iron atoms, triggers defect phase transformations, and greatly increases resistance to embrittlement.

Ion transport properties are critical to some emerging technologies. Here, the authors show the controllable 2D movement and redistribution of Li-ions in metal oxides such as WO₃ by a magnetic field. The success is based on a current-driving model which also works for other cations including H⁺, Na⁺, Zn²⁺ and Ca²⁺.

Jujube is a perennial fruit crop with significant economic and medicinal values. Here, the author report genome assemblies of four jujube accessions, construct pan-genome together with four previously published genomes, and generate resequencing data to reveal genetic basis of domestication traits.

Computational modeling of fMRI data during narrative comprehension reveals a cortical organization and cross-level interaction supporting multilevel linguistic prediction.

Integrated analysis of metabolome and oxidative stress at single-cell level is challenging. Here, the authors develop SCLIMS, enabling simultaneous profiling of metabolome and oxidative stress levels and discoveries of key metabolites regulating oxidative stress, senescence, and healthy aging.

The amino acid transporter complex LAT1-4F2hc is considered a major drug target for many cancers. Here, the authors apply native mass spectrometry-based approaches to decode a complete LAT1-4F2hc assembly. To do this, they connect post-translational modification and endogenous phospholipid binding to super-dimerization, function and localisation of LAT1-4F2hc.

Stable inorganic solid-state electrolytes are crucial for reliable all-solid-state battery development. Here, the authors report a Li-In|Li_6.8Si_0.8As_0.2S₅I|Ti₂S lab-scale cell with a long cycle life of almost 62500 cycles at 2.44 mA cm⁻², 30 °C and 30 MPa.

Factors that determine the cellular tropism of SARS-CoV-2 beyond the host cell receptor, ACE2, are poorly defined. Here, the authors show that tonic activation of the cGAS-STING sensing pathway potently blocks SARS-CoV-2 replication in a subset of ACE2-expressing airway-derived cells.

Introducing spin–orbit coupling by substrate proximity effect leads to an enhancement of superconducting phases in rhombohedral trilayer graphene.

The application of dietary methionine intervention is of particular interest in the field of cancer therapy. Here the authors show that intermittent but not sustained deprivation of methionine promotes tumor ferroptosis and improves response to checkpoint inhibitors.

Itinerant magnetism in rhombohedral multilayer graphene shows a large excess entropy from magnetic fluctuations above its critical temperature—typically only associated with local moments—which implies the decoupling of charge and isospin degrees of freedom, and results in the isospin Pomeranchuk effect.

Myocardial infarction treatment strategies remain challenged in effectiveness. Here we present a bioelectronic interface capable of producing on-demand abundant bioactive extracellular vesicles near the disease area for in situ localized treatment.

Osteocytes are the key cellular components of cortical bone. Here they show that osteocytes transfer mitochondria to the endothelial cells of transcortical vessels (TCVs), which promotes angiogenesis and increases function of the TCV network.

Current CRISPR diagnostic approaches can be hampered by several limitations, including low signal transduction efficiency and limited sensitivity. Here, the authors present CrisprAIE, an approach based on CRISPR/Cas-mediated “one to more” lighting-up nucleic acid detection using aggregation-induced emission luminogens.

This study comprehensively benchmarks 18 state-of-the-art methods for cellular deconvolution of spatial transcriptomics and provide decision-tree-style guidelines and recommendations for method selection.

Software tools for larger-scale intact glycopeptide quantification lag far behind, which hinders exploring the differential sitespecific glycosylation. Here, the authors report pGlycoQuant, a generic tool with a deep learning model for quantitative glycoproteomics at intact glycopeptide level.

Ion trapping has been found to be responsible for the performance degradation in electrochromic oxide thin films. This paper visualizes ion trapping and detrapping dynamics, and provides a general picture of electrochromism in amorphous WO₃.

Cell spatial organization in tissue provides essential insights into diseases. Here, the authors show Ceograph, a graph convolutional network, for the analysis of pathology images to predict patient outcomes, highlighting cellular markers to guide personalized treatments and enhance biological understanding.

Data independent acquisition (DIA) proteomics provides deep coverage and high quantitative accuracy, but is not yet well established in glycoproteomics. Here, the authors develop a DIA-based glycoproteomics workflow with stringent statistical controls to enable accurate glycopeptide identification.

De Ravin et al. report an unplanned interim analysis of a secondary safety outcome for an ongoing clinical trial on lentiviral gene therapy for the treatment of X-linked Severe Combined Immunodeficiency (NCT01306019). Vector induced alternative splicing events are identified that cause aberrant fusion transcripts, leading to clonal dominance in a single patient and clonal expansion in others. This can be mitigated by the removal of the lentivector cryptic splice acceptor.

Host factors required for parechovirus entry are not well understood. Here, the authors identify MYADM as an essential host entry factor that directly binds human parechovirus 1 and that is required for PeV-A infection in cell lines and human gastrointestinal epithelial organoids.

This study demonstrates that tuning the grain boundary density in nanoparticle assemblies by controlling nanoparticle collisions significantly enhances their activity, selectivity, and stability towards electrocatalytic reactions.

Here, the authors employed Hi-C and low-input itChIP-seq in four rare populations of the hematopoietic stem cell (HSC) ontogeny trajectory across early arterial endothelial cells (eAECs), hemogenic endothelial cells (HECs), pre-HSCs, and long-term HSCs (LT-HSCs) from mouse embryos to show that active histone modifications are largely set up in eAECs and 3D genome is then subsequently configured.

The molecular classification and tumour microenvironment in intrahepatic cholangiocarcinoma (iCCA) need further characterisation. Here, the authors perform single cell RNA-sequencing from 14 pairs of iCCA tumours and non-tumour liver tissues and propose S100P and SPP1 as markers for patient classification.

Intra-cell line heterogeneity remains to be characterized. Here, the use of single multi-omics on a large panel of human cell lines identifies copy number variation, epigenetic variation and extrachromosomal DNA distribution as the main contributors to intra-cell line heterogeneity.

Tumour cells can communicate with cells from distant organs through extracellular vesicles. Here the authors show that breast cancer cells derived exosomal miR-204-5p induce leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia.