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The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

The cellular origin and developmental trajectory of DICER1 syndrome-associated tumors are currently unknown. Here, the authors employ a lineage-traceable genetically modified mouse model for DICER1 syndrome to identify universal fibroblasts as the likely cellular origin of mouse Dicer1 sarcoma and map their developmental trajectory, findings that are validated in human DICER1 mesenchymal tumors.

A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

Chronic diabetic wounds heal poorly due to impaired tissue repair and persistent inflammation. Here, authors demonstrate that a Smad7-based topical biologic accelerates diabetic wound healing by improving epithelial regeneration and reducing inflammatory neutrophil activity.

Preparation of phosphorescent materials from bio-based materials is desirable, but achieving the desired properties can be challenging. Here, the authors report the development of 3D printable woody materials by grafting carboxyl functional groups onto lignocellulose matrices.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

This long-term, large-scale intervention and follow-up MRI study suggests that sustained visceral fat loss, rather than weight loss, is linked to better cognition and attenuation of brain atrophy years later, mainly via improved glycaemic control.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific transcription factor binding and chromatin accessibility during human development.

In C. elegans, a p38 MAPK–ATF-7 pathway upregulates hypodermal CATP-3 during potassium scarcity, integrating neuronal signals to maintain homeostasis, enhance survival, and link potassium regulation to lifespan and immunity. This conserved mechanism is distinct from osmotic stress responses.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Recovery of 48 bat and 9 horse HeV genomes from Australia (2016–2020) identified four Hendra virus clades, offering insights into evolutionary dynamics.

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Accurate characterization of emerging quantum sensors requires an imaging technique that does not depend on defect-specific optical readout. Here, using a NV center in diamond, the authors detect and map boron vacancy defects in hBN via spin cross-relaxation, enabling quantitative nanoscale imaging and spectroscopy without detecting hBN emission.

DGAT1 controls sex-specific CD8⁺ T cell responses in tumours, reducing mitochondrial function and tumour control in female mice, but protecting against oxidative stress and tumour growth in male mice through androgen receptor signalling.

Mechanical modulation of protein conformation enables the reversible induction of strong plasmon-coupled circular dichroism in otherwise achiral plasmonic assemblies.

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

Argon-42 is a background in experiments that search for dark matter or neutrinoless double-beta decay. Now, the isotope’s abundance is measured by combining a laser-based atom trapping technique with isotope pre-enrichment.

A deep learning framework integrates protein language models, protein interactions and domains, medical knowledge graphs and electronic health records to map variants to phenotypes.

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads using a two-vector system of enveloped delivery vehicles and adeno-associated viruses.

A global study of 1602 soil samples identifies dominant bacterial plant pathogens and reveals microbial traits, soil carbon and climate that promote natural suppression, while climate change may increase disease risks in many regional hotspots.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

Polymer thin films that emit and absorb circularly polarised light are promising in achieving important technological advances, but the origin of the large chiroptical effects in such films has remained elusive. Here the authors demonstrate that in non-aligned polymer thin films, large chiroptical effects are caused by magneto-electric coupling, not structural chirality as previously assumed.

An outstanding question about the iron-based superconductors has been whether or not their magnetic characteristics are dominated by itinerant or localized magnetic moments. Absolute measurements and calculations of the magnetic response of undoped and Ni-doped BaFe₂As₂ indicate the latter.

Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

Here, the authors investigate the mechanism by which human aspartate/asparagine-β-hydroxylase (AspH), a 2OG-dependent oxygenase with an atypical Fe(II) coordination environment, catalyses hydroxylation of aspartate and asparagine residues in epidermal growth factor-like domains.

Tiki2 restrains Wnt5a/Ror signaling to limit inflammatory responses and immune cell infiltration in ischemia/reperfusion-induced acute kidney injury.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

High entropy spinel oxides host multiple metals in one crystal structure with tunable catalytic properties, but controlling coordination site occupancy of metal cations is difficult. Here, the authors exploit site preference energy differences to direct metal occupancy, boosting conductivity and oxygen evolution activity.

Microreactors are valued for efficient mixing and precise control in nanoparticle synthesis; however, when encapsulating sensitive proteins and enzymes, conventional fluidic shear causes serious damage and activity loss. Here, the authors show that gas-liquid slug-flow microchannels provide efficient mixing, narrow residence time distribution, and suitable shear compared to single-phase flow microchannels, microstructured continuous stirred-tank reactors, and batch reactors, reporting a low PDI and productivity equivalent to 100 lab-scale batch reactors for the preparation of catalase nanocapsules.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

KRAS mutations are keenly associated with pancreatic ductal adenocarcinoma and represent a potential therapeutic target. Here the authors present the findings from a phase I clinical trial testing pooled KRAS mutant peptides in combination with immune checkpoint blockade in patients with resected pancreatic ductal adenocarcinoma.

This study shows that promoter and enhancer functions are often linked within the same DNA sequences. Using a dual-reporter assay, the authors reveal shared sequence features and co-dependent activities supporting a unified model of gene regulation.

Ultrafast electron imaging shows full phase-space dynamics of optical singularities, which can reach superluminal velocities before annihilation and break the particle-like analogy of topological defects.

Whether weak brain rhythms carry information about ongoing behavior remains unclear. Here, the authors develop a neural network that finds subtle motifs in irregular brain rhythms arising from neural populations to read out where a rat is in its environment.

In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.

The paper reports a scalable, chemical-free plasma process that converts methane and water into high-purity, single-layer graphene oxide while co-producing hydrogen, cutting greenhouse emissions, and lowering cost compared with conventional methods.

Off-the-shelf, on-demand allogeneic CAR-T cells could represent a therapeutic alternative to autologous products for cancer therapy. Here the authors report the preclinical characterization of off-the-shelf CRISPR-Cas9– edited IL-13Rα2-specific allogeneic universal CAR-T cells and the results of a first-in-human phase I trial in patients with high-grade glioma.

Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous structure annotation.