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Showing 1–50 of 441 results

Advanced filters: Author: Takashi Inoue Clear advanced filters

Host control of persistent Epstein–Barr virus infection

Using blood-based genome sequence data, non-genetic and genetic factors associated with control of Epstein–Barr virus during persistent infection are reported.

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
ResearchOpen Access19 Feb 2026
Nature

P: 1-13
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase including catalytic intermediates suggest an ordered Bi–Bi reaction mechanism

Kazuaki Matoba
Takeshi Nara
Tomoo Shiba
ResearchOpen Access02 Apr 2026
Scientific Reports

P: 1-12
Limitations of serial cloning in mammals

Here they show that extended serial somatic cell cloning imposes a threefold increase in de novo mutations compared to natural reproduction, progressively reducing birth rates and ultimately limiting clonal propagation to 58 generations.

Sayaka Wakayama
Daiyu Ito
Teruhiko Wakayama
ResearchOpen Access24 Mar 2026
Nature Communications

Volume: 17, P: 1-13
Role of the primate ventral striatum as a neural hub bridging option valuation and action selection

The neural mechanism by which internal value representations guide action selection remains poorly understood. This study shows that the ventral striatum transforms value signals into selection signals, and that dopamine input modulates this process.

Masafumi Nejime
Mengxi Yun
Masayuki Matsumoto
ResearchOpen Access28 Mar 2026
Nature Communications

Volume: 17, P: 1-18
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Triplet versus doublet therapy in patients with metastatic hormone-sensitive prostate cancer

Keita Hayakawa
Takashi Ueda
Osamu Ukimura
ResearchOpen Access16 Mar 2026
Scientific Reports

P: 1-8
The dynamic basis of G-protein recognition and activation by a GPCR

Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.

Kazuhiro Kobayashi
Kouki Kawakami
Hideaki E. Kato
Research11 Mar 2026
Nature

P: 1-10
Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

Michio Sato
Daishi Tanabu
Shigeru Yanagi
ResearchOpen Access20 Mar 2026
npj Aging

P: 1-19
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Natural images are reliably represented by sparse and variable populations of neurons in visual cortex

Natural scenes sparsely activate V1 neurons. Here, the authors show that a small number of active cells reliably represent visual contents of a natural image across trials regardless of response variability, due to the diverse and partially overlapping representations of individual cells.

Takashi Yoshida
Kenichi Ohki
ResearchOpen Access13 Feb 2020
Nature Communications

Volume: 11, P: 1-19
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Publisher Correction: Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model

Kosuke Sakamoto
Shinji Nakamura
Takashi Kusaka
Amendments and CorrectionsOpen Access06 Mar 2026
Scientific Reports

Volume: 16, P: 1-4
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Three-dimensional reconstruction of a biliary system in a bioengineered liver using decellularized scaffold

Hiroshi Horie
Ken Fukumitsu
Etsuro Hatano
ResearchOpen Access10 Feb 2026
Scientific Reports

Volume: 16, P: 1-11
Temperature Dependence of the Flory Interaction Parameter in a Single-Phase Mixture of Poly(hydroxy ether of bisphenol-A) and Poly(ether sulfone)

Hiromu Saito
Daisuke Tsutsumi
Takashi Inoue
Research01 Feb 1990
Polymer Journal

Volume: 22, P: 128-134
Ternary Copolymerization of Carbon Dioxide with Optical Isomers of 1,2-Epoxypropane and Phenylepoxyethane

Shohei Inoue
Takashi Hirano
Teiji Tsuruta
Research01 Jan 1977
Polymer Journal

Volume: 9, P: 101-106
Stress responsive miR-23a attenuates skeletal muscle atrophy by targeting MAFbx /atrogin-1

Shogo Wada
Yoshio Kato
Takayuki Akimoto
ResearchOpen Access15 Aug 2008
Nature Precedings

P: 1
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
A key gene modulating oxytocin efficacy in autism: genome-wide discovery and verification in randomized controlled trials datasets

Hitoshi Kuwabara
Masaki Kojima
Hidenori Yamasue
Research28 Mar 2026
Molecular Psychiatry

P: 1-8
Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement

Lineage switching (LS) facilitates acute myeloid leukemia (AML) escaping CD19 targeted immunotherapy, but the underlying mechanism are not well understood. The authors here analyze patients’ single-cell mass cytometry and single-cell transcriptomics data, and identify an LS AML with the MDSC-like phenotype which is associated with LS in AML with KMT2A rearrangement.

Takashi Mikami
Itaru Kato
Junko Takita
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-15
DNA typing of HLA in the patients with moyamoya disease

Takuya K. Inoue
Kiyonobu Ikezaki
Masashi Fukui
Research01 Dec 1997
Japanese Journal of Human Genetics

Volume: 42, P: 507-515
Short-Range Order in a Miscible Polymer Blend

Hiromu Saito
Motoshi Matsuura
Takashi Inoue
Research01 Apr 1989
Polymer Journal

Volume: 21, P: 357-360
Carbon-13 NMR Analysis of the Tacticity of Polyacrylamide

Yoshio Inoue
Takashi Fukutomi
Riichiro Chûjô
Research01 Jan 1983
Polymer Journal

Volume: 15, P: 103-105
UCST and LCST Behavior in Polymer Blends and Its Thermodynamic Interpretation

Toshiaki Ougizawa
Takashi Inoue
Research01 Jul 1986
Polymer Journal

Volume: 18, P: 521-527
Morphology and Elastomeric Properties of Isotactic Polypropylene/Hydrogenated Polybutadiene Blends

Petr Svoboda
Hiromu Saito
Yasuhiko Takemura
Research01 Nov 2000
Polymer Journal

Volume: 32, P: 915-920
Efficacy and safety of cryoablation procedures using mouse models of bladder cancer

Shogo Inui
Saya Ito
Osamu Ukimura
ResearchOpen Access13 Jan 2026
Scientific Reports

Volume: 16, P: 1-9
Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model

Kosuke Sakamoto
Shinji Nakamura
Takashi Kusaka
ResearchOpen Access14 Jan 2026
Scientific Reports

Volume: 16, P: 1-10
Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota

In marine bacteria, carotenoids enhance rhodopsin function by acting as light-harvesting antennae and photocycle-accelerating pigments, a dual mechanism that enhances light energy capture and expands the known strategies of microbial phototrophy.

Takayoshi Fujiwara
Toshiaki Hosaka
Susumu Yoshizawa
Research04 Sept 2025
Nature Microbiology

Volume: 10, P: 2603-2615
Cell-free translation reconstituted with purified components

Yoshihiro Shimizu
Akio Inoue
Takuya Ueda
Research01 Aug 2001
Nature Biotechnology

Volume: 19, P: 751-755
Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting predisposition to abnormal antibody production.

Saori Sakaue
Etsuro Yamaguchi
Yukinori Okada
ResearchOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1-6
Enzyme Defect in a Case of Tyrosinemia Type I, Acute Form

Nobuaki Furukawa
Akihiko Kinugasa
Tetsuro Takamatsu
Research01 May 1984
Pediatric Research

Volume: 18, P: 463-466
Author Correction: Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication

Junichi Tanaka
Hidenobu Senpuku
Kenji Mishima
Amendments and Corrections21 Feb 2023
Nature Cell Biology

Volume: 25, P: 508
Impact of delayed diagnosis on surgical management and neurological outcomes in elderly patients with cervical spinal cord injury without radiographic evidence of trauma: a multicenter registry study

Tomohiro Yamada
Yu Yamato
Satoshi Kato
Research11 Mar 2026
Spinal Cord

P: 1-7
AdipoR1–AMPK axis suppresses breast cancer across molecular subtypes via multimodal cell death pathways, including ferroptosis and apoptosis

Shinya Sato
Takashi Yamanaka
Yohei Miyagi
ResearchOpen Access26 Mar 2026
Cell Death & Disease

Volume: 17, P: 1-14
The Sol-Gel Transition and the Liquid-Liquid Phase Separation in Poly(vinyl chloride) Solutions

Kazuo Kawanishi
Yuji Takeda
Takashi Inoue
Research01 May 1986
Polymer Journal

Volume: 18, P: 411-416
Whole exome sequencing in Japanese spinocerebellar ataxia identifies novel variants

Tomoaki Watanabe
Kodai Kume
Hideshi Kawakami
ResearchOpen Access12 Sept 2025
Journal of Human Genetics

Volume: 71, P: 35-39
Inversion of supramolecular chirality by photo-enhanced secondary nucleation

By controlling the contribution of secondary nucleation in the self-assembly of chiral photoswitch molecules using light, it is possible to preferentially generate metastable aggregates, thereby reversing the supramolecular chirality.

Takuho Saito
Daisuke Inoue
Shiki Yagai
Research11 Apr 2025
Nature Nanotechnology

Volume: 20, P: 825-834
Publisher Correction: A non-canonical BZR/BES transcription factor regulates the development of haploid reproductive organs in Marchantia polymorpha

Tomoyuki Furuya
Natsumi Saegusa
Yuki Kondo
Amendments and Corrections22 Apr 2024
Nature Plants

Volume: 10, P: 828
Mechanism of metal activation of human hematopoietic prostaglandin D synthase

Tsuyoshi Inoue
Daisuke Irikura
Yoshihiro Urade
Research03 Mar 2003
Nature Structural & Molecular Biology

Volume: 10, P: 291-296
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Reprogramming of the histone H3.3 landscape in the early mouse embryo

Ultra-low-input native ChIP-seq analyses of genome-wide histone H3.3 distribution during early mouse development reveal a CAF-1-dependent transition from a non-canonical pattern in the oocyte and zygote to a canonical distribution at the two-cell stage.

Takashi Ishiuchi
Shusaku Abe
Hiroyuki Sasaki
Research09 Nov 2020
Nature Structural & Molecular Biology

Volume: 28, P: 38-49
Stimulation of hypothalamic nuclei has differential effects on lipid synthesis in brown and white adipose tissue

Takashi Shimazu
Akira Takahashi
Research06 Mar 1980
Nature

Volume: 284, P: 62-63
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models.

Toshiko Yamazawa
Takuya Kobayashi
Takashi Murayama
ResearchOpen Access13 Jul 2021
Nature Communications

Volume: 12, P: 1-14
A non-canonical BZR/BES transcription factor regulates the development of haploid reproductive organs in Marchantia polymorpha

The ‘non-canonical’ type-B BZR/BES transcription factor, MpBZR3, has been shown to be a regulator of the development of female and male reproductive organs in the model bryophyte Marchantia polymorpha.

Tomoyuki Furuya
Natsumi Saegusa
Yuki Kondo
Research11 Apr 2024
Nature Plants

Volume: 10, P: 785-797
Artificial photosynthesis directed toward organic synthesis

Emulating the concept of natural photosynthesis has long been a focus of chemists in an effort to harness solar light as an energy source using water as an electron donor and a source material. Here, the authors present an artificial photosynthetic system that can functionalize styrenes via C–H activation and water splitting.

Shogo Mori
Riku Hashimoto
Susumu Saito
ResearchOpen Access27 Feb 2025
Nature Communications

Volume: 16, P: 1-8
Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study

Takuya Takahashi
Takashi Hirai
Takeo Furuya
ResearchOpen Access06 Jul 2025
Scientific Reports

Volume: 15, P: 1-7
Structure of Cuprammonium Regenerated Cellulose Hollow Fiber (BMM Hollow Fiber) for Virus Removal

Takashi Tsurumi
Naoki Osawa
Takashi Yamashiki
Research01 Aug 1990
Polymer Journal

Volume: 22, P: 751-758
Mechanism of Removing Monodisperse Gold Particles from a Suspension Using Cuprammonium Regenerated Cellulose Hollow Fiber (BMM Hollow Fiber)

Takashi Tsurumi
Naoki Osawa
Takashi Yamashiki
Research01 Apr 1990
Polymer Journal

Volume: 22, P: 304-311

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