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A uniform distribution of interfacial dipole molecules is essential to regulate interfacial energy levels and carrier extraction. Here, authors incorporate a bifunctional antisymmetric molecule anchoring on tin oxide and perovskite, achieving maximum efficiency of 26.43% in perovskite solar cells.

Here, the authors report an exome-wide association study for multi-organ imaging traits by leveraging recent bioinformatic tools such as AlphaMissense. The identified signals elucidate the genetic effects from rare variants on human organs and their connections to complex diseases

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

Bi, Mo, Liu et al. carry out high-throughput screening and analysis to profile genome-wide pro-tumour enhancers and uncover enhancer connectomes in glioma. In particular, they identify specific single-nucleotide polymorphisms associated with glioma risk and progression.

A layer-by-layer thermal evaporation strategy enables thermally evaporated inverted perovskite solar cells with a power conversion efficiency of 25.19%, maintaining about 95% of their initial efficiency after 1,000 h of operation.

Marine mercury, from atmospheric Hg0 /HgII deposition, threatens ecosystems. Isotope studies proposed 1:1 HgII/Hg0 ratios but ignored spatial variability. Here, a 3D isotope model reveals HgII deposition exceed Hg0 by >2:1, revising mercury budgets.

This manuscript provides a robust and comprehensive oxygen concentration control strategy using Kriging to Kolmogorov-Arnold Networks, determining feasible concentration ranges and optimal values to support the safe operation of Lead-based Fast Reactors (LFR).

The uptake of gaseous elementary mercury by terrestrial vegetation in 2100 is likely to decrease by more than half compared to present-day conditions. This decrease is caused by the reduced stomatal conductance associated with increasing CO₂ levels.

Differentiating the structural order of the commensurate modulated antiferroelectric can double the energy storage density of ceramics to over 23 J/cm³ while maintaining their efficiency.

Artificial photobiocatalytic reactions are appealing but sometimes suffer from non-enzymatic side reactions. Now a photoenzyme for enantioselective [2 + 2] photocycloaddition of 2-naphthyl derivatives is reported and combined with designed quenchers that shut down the competing enzyme-free racemic reaction.

Membraneless organelles formed by liquid–liquid phase separation regulate cellular processes. Here Bai et al. show that mitochondria-associated translation organelles (MATOs) consisting of RNA-binding proteins and translation machinery mediate localized synthesis of mitochondrial proteins to promote mitochondrial health and extend lifespan in worms.

Subduction-driven warming and uplift are linked to the Cambrian Explosion, and Li-Os-Sr isotopes trace enhanced erosion of phosphorus-rich juvenile rocks that boosted productivity and oxygen levels to fuel animal diversification.

Rich and colleagues show that glioblastoma stem cells have increased global protein translation, which is achieved via the tRNA modifier YRDC. They show that targeting it or reducing its substrate threonine suppresses tumor growth.

Semiconductor quantum dots that simultaneously support blue and yellow emission offer a route to realizing efficient white light-emitting diodes.

The use of conventional X-ray scattering techniques is challenging to detect donor-acceptor contrast within amorphous intermixing regions. Here, the authors apply neutron scattering and targeted deuteration to enhance the contrast by one order of magnitude and reveal short-range aggregations of d-Y6.

In situ real-time water pollution monitoring provides a fast and convenient way to detect water pollutants, but the development of detectors with high sensitivity is still challenging. Portable organic photodetectors fabricated with a colloid processing approach achieve highly sensitive and accurate monitoring of trace pollutants in water.

The relatively larger steric hindrance and excessive crystallinity of bromides could lead to undesirable film morphologies. Here, the authors take advantage of bromides and construct small molecule acceptors with stepwise bromination and realize maximum efficiency of 19% in organic solar cells.

The authors image non-equilibrium exciton phase-transition dynamics in moiré superlattices, revealing how strong long-range dipolar repulsion freezes the motion of the Mott insulator over a timescale of tens of nanoseconds.

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

Phytophthora secretes a conserved trypsin-like serine protease, PsTry1, that suppresses apoplastic immunity by cleaving the extracellular domain of the co-receptor BAK1, revealing a novel mechanism by which pathogens overcome apoplastic immune defences.

Developing high-performance Pt-based catalysts with low Pt loading is crucial but challenging for CO oxidation. Here, the authors report a novel Pt/TiO₂ catalyst consisting of Pt–Ti intermetallic single-atom alloy and Pt nanoparticles to efficiently catalyze CO oxidation.

Yin et al. harmonized 1,091 fMRI scans across five imaging cohorts to map developmental trajectories of brain functional connectivity in early childhood, revealing early brain development and its links to cognitive abilities.

Silicon electrodes in lithium-ion batteries are severely limited by the stress that arises from large volume changes during cycling. Here, authors exploit the inherent volume change dynamics of silicon and sulfur electrodes and design a stress-neutralized solid-state battery.

Here the authors show that arbovirus vector competence of Aedes mosquitoes is modulated by the midgut microbiota and identify the metabolite sphingosine from the gut symbiotic bacterium Enterobacter hormaechei_B17 (Eh_B17) as a factor mediating resistance to ZIKV and DENV infection.

In optoelectronic oscillators used to produce chirps for radar or communications, low phase noise usually comes at a cost of slow tuning due to mode-building time. The authors use Fourier-domain mode locking to break this limitation and enable fast-tunable chirp production for microwave photonics.

Tropane alkaloids (TAs) are synthesized by some species in Solanaceae. Here, the authors assemble the genomes of two representative TAs producing species, show that gene loss shapes uneven distribution of TAs in Solanaceae, and identify a cytochrome P450 gene catalyzing N-demethylation of hyoscyamine to generate norhyoscyamine.

Water electrolysis can generate carbon-neutral hydrogen gas from water, yet the required catalysts are often expensive, scarce, and poor at gas release. Here, the authors prepared nitrogen-doped carbon tungstide nanoarrays with high water-splitting activities and bubble-releasing surfaces.

Association analyses using resting-state functional magnetic resonance images identify common genetic variants influencing intrinsic brain activity. Variation in brain function is genetically correlated with several neuropsychiatric traits.

Liu et al. optimize vindoline biosynthesis in yeast from tabersonine by altering the copy numbers of pathway genes, pairing CYPs with CPRs, engineering the microenvironment for functional expression of CYPs, enhancing cofactor supplies, and optimizing fermentation conditions. By doing so, the authors increased the production of vindoline to a final titer as high as ∼16.5 mg/L.