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Microalgae‑based hydrogen production faces challenges including oxygen sensitivity, high water demand, and low efficiency. The authors develop a symbiotic hydrogel system that enhances hydrogen production by using coaxial 3D bioprinting to spatially separate microalgae and bacteria.

Room-temperature multiferroic materials are highly demanded for designing next-generation of spintronic devices. Here, the authors demonstrate an emergent room-temperature ferrimagnetism and polar phase in highly strained La₂CoRuO₆ epitaxial films through engineered 3d−4d cation ordering.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

The operational stability of perovskite solar cells remains a challenge. Zhang et al. incorporate photoswitchable isomers at grain boundaries to improve their resilience and the stability of the solar cells under light cycling and ultraviolet exposure.

Gestational choline supplementation shows that glutamate and MIF signaling pathways regulate granule neuron development, leading to improved emotional-like behaviors in the offspring

Ge, Liu et al. develop and validate a survival model (SM-CRT) using multicentre data from 30,947 cancer patients to predict catheter-related thrombosis (CRT) risk. The model accurately identifies high-risk patients and high-risk time periods, supporting personalised thromboprophylaxis and optimised catheter removal timing.

An in situ computational spectrometer, implemented on a fully integrated 576-Kb memristor chip, can reconstruct a single spectrum in 125.0 ns and consumes only 6.7 nJ of energy, achieving software-equivalent accuracy.

The efficiency of selenium photovoltaics is hindered by the poor crystallization of the Se film. Wen, Li, Lu and colleagues use light to initiate Se crystallization, suppressing dewetting and enabling the formation of a continuous film, which achieves a certified efficiency of 10.3%.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Flatband-induced localisation generally does not apply to complex wavefunctions carrying orbital angular momentum. Here, authors develop a general framework for constructing highly degenerate flatbands in 2D and 3D acoustic crystals, enabling the localisation of OAM-carrying wavefunctions.

It was shown that early-day stem cell infusions reduced the severity of acute graft-versus-host disease (aGVHD). Our result suggested early morning cord blood transplantation reduces aGVHD severity and correlated with circadian sCD26 fluctuations.

This study presents EM2PA, an explainable mechanism for analysing production process anomalies. It enables trace-back analysis by identifying abnormal production, clarifying the relationships among manufacturing factors, and providing explanations for their causes.

Beta-hydride elimination is a crucial elementary step in transition-metal catalysis, but controlling the stereochemistry of this process has been underdeveloped. Here, the authors report a Trost-ligand-enabled enantioselective desymmetric beta-hydride elimination reaction from π-allyl-palladium species, providing rapid access to cyclohexenes bearing a remote C4 stereocenter.

The commercialization of organic solar cells has been hindered by the limited device stability. Here, authors show that the connectivity of electron transport network is a key factor determining electron transport and device stability, with polymeric acceptors likely to establish such a network.

CRISPR-Cas12a diagnostics are limited by strict PAM requirements. Here, authors show that higher temperatures activate numerous noncanonical PAMs, enabling a versatile one-pot platform that improves sensitivity, specificity, and rapid on-site pathogen detection.

Piracetam improves wide-bandgap perovskite crystallinity and uniformity, enabling monolithic all-perovskite tandem solar cells with efficiencies of 28.71% (0.07 cm²) and 28.20% (1.02 cm²), ensuring minimal efficiency loss during scale-up.

CD36 drives lymph node metastasis in breast cancer by activating YAP signaling-mediated anoikis resistance via inducing the PPARα-CYP7A1 bile acid biosynthesis pathway.

Molecular mechanisms determining soybean seed weights remain largely elusive. Here, the authors identify a 14-3-3 protein encoding gene GmSMS6 negatively regulates soybean seed weight and size via the possible interactions with the transcription factor GmbZIP151 and the RING-type E3 ligase GmUBQ1.

Here, the authors report a high-performance broadband spectrometer based on a van der Waals heterostructure tunnel diode containing MoS₂ and and black phosphorus, leveraging their electrically tunable photoresponse and advanced computational algorithms for spectral reconstruction.

Xu, Yu, Zhang, Ma, He and colleagues show that SHP-1 inhibition causes increased glycolysis and oxidative phosphorylation through PFKP in leukaemia stem cells, thereby promoting immunosurveillance and chemosensitivity in acute myeloid leukaemia.

Manufacturing of perovskite solar cells under ambient conditions is desirable. Meng et al. show that dimethylammonium formate suppresses halide oxidation and deprotonation of organic cations, enabling air-processed inverted solar cells with 24.7% efficiency.

Large perovskite nanocrystals are synthesized to increase the cryogenic exciton radiative rate. At liquid helium temperatures, single photons from perovskite nanocrystals coalesce at a beam splitter, signalling the existence of indistinguishable photon emission.

Metallic molybdenum disulfide is a metastable phase of the material. Here, the authors synthesize two-dimensional metallic molybdenum disulfide nanosheets, stabilized by adsorbed aqueous monolayers, and evaluate their catalytic hydrogen evolution activity.

The authors report lensless holography lithography with diffraction-limited resolution by proposing a phase-probability shaping mechanism to suppress speckle noise efficiently.

Using a causality-guided explainable AI framework, Liu et al. show soil moisture dominates vapour pressure deficit in shaping global photosynthesis during water-limited conditions.

A donor–acceptor molecule assembles with different molecular packing to form photocatalysts which selectively produce either H₂ or H₂O₂, depending on the aggregate structure, a proof-of-concept of photoactivity polymorphism.

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

The regulation of perovskite crystallization is essential for achieving efficient solar cells. Here, authors introduce K₂SnO₃ to induce formation of KI and PbSnO₃ with an ABX₃ structure to enhance film uniformity, achieving efficiency of 28.81% for four-terminal all-perovskite tandem solar cells.

Terahertz (THz) pulses are generated by irradiating a metal wire with femtosecond laser pulses. For incident laser energy of 3 mJ, a THz pulse with energy of 28 μJ is obtained from a 10-cm-long wire. The spectrum of the THz pulse covers 0.1–1.5 THz.

A combination of Floquet engineering and higher-order topological insulators has been lately only theoretically proposed. Here the authors experimentally realize an acoustic waveguides array to demonstrate a Floquet higherorder topological insulator extending its band topology from first order to higher order.

Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF₃Et₂O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF₃·Et₂O as the fluorine reagent in the presence of chiral iodine catalyst.

CRISPR systems are powerful tools for gene editing and diagnostics, but their regulation is challenging. Here, the authors present DNACas, a light-controlled method using photocleavable phosphorothioate DNA to modulate CRISPR activity, enabling precise gene editing and one-pot diagnostic detection.

Xu, Zhang, Xuan et al. show that PD-1 signalling defines a population of leukaemia stem cells with features of quiescence, drug resistance and protection against cell death, ablation of which suppresses disease progression of mouse and human T-ALL.

AspCl doping in Sn–Pb perovskite solar cells improves their performance and stability.

Anti-malarial immune responses involve type I IFN responses and innate immune pathways. Here the authors show the palmitoylation of TANK-binding kinase 1 (TBK1), a kinase which promotes the type I IFN pathway, is disrupted in malaria infection and that this disruption leads to less effective anti-malarial responses.

The spin-dependent thermal and electrical transport properties of nanostructures are central for future applications of spintronic devices. Here, Linet al. report an enhanced spin-dependent thermoelectric effect in an Al₂O₃-based magnetic tunnel junction.

Comparative analyses of rice centromeres from 70 high-quality genomes of the Oryza AA group provide insights into rice centromere evolution and genetic factors that shape these genomic regions.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

PEDF impairs insulin secretion in β-cells by downregulating the SNARE complex, thereby suppressing the PI3K/Akt signaling pathway, suggesting that PEDF is a therapeutic target for T2DM.

Preclinical studies have shown synergy in the combination of tifcemalimab (anti-BTLA antibody) with toripalimab (anti-PD-1 antibody) in lymphoma. Here, the authors report a clinical trial investigating tifcemalimab alone and in combination with toripalimab in patients with relapsed or refractory lymphoma.