Search

The authors identify a KAT8 K145 lactylation switch that enhances TIP60 dependent p53 K120 acetylation and proapoptotic transcription, implicating this axis in doxorubicin cardiotoxicity and its mitigation by glimepiride.

Understanding the biological functions of the RNA modification pseudouridine relies on robust methods to map its distribution. Here, the authors identify a methyltransferase that specifically labels this modification and develop a pulldown approach to enrich modified RNAs, enabling transcriptome-wide profiling of pseudouridine sites.

Using artificial intelligence, authors model how air pollution may increase susceptibility to SARS-CoV-2. NPC1 is identified via genetic and laboratory analyses as a key pathway that enhances viral entry after exposure to fine particulate matter.

A two-photon-lithography hydrogel-infusion process prints 3D nickel nano-architectures with ~100-nm features and high specific strength, indicating that localized nanoporosity hotspots govern deformation and size-dependent strength.

The authors provide experimental evidence that Eu substitution in the spacer layer of Nd_1-xEu_xNiO₂ thin films enhances the superconducting gap, driving the system toward a strong-coupling regime. The Eu substitution also introduces exchange coupling between Eu 4f magnetic moments and Ni 3d_x²−y² electrons, leading to magnetic-field-enhanced “re-entrant” superconductivity.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Yu et al. develop and validate prediction models for speech-frequency hearing loss using cross-sectional and longitudinal data from noise-exposed shipyard workers. The models support early identification of high-risk individuals, enabling targeted prevention strategies and improved protection of hearing.

Cellular fate decisions are governed by the equilibrium between inhibitor of apoptosis proteins (IAPs) and pro-apoptotic proteins (PAPs). Li et al. reveal that histone acetylation homeodynamics orchestrates this critical decision-making process by shifting the balance toward either survival or apoptosis.

Operando imaging of chemical reactions typically requires the inclusion of an extrinsic handle such as a fluorescent probe. Here quantum-sensing-enabled chemical operando microscopy is developed to intrinsically image the photocatalytic generation of free radicals on TiO₂.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

A tool based on the Llama-3.1-8B-Instruct architecture called MOSAIC (Multiple Optimized Specialists for AI-assisted Chemical Prediction) is described, allowing chemists to use the collective intelligence of millions of reaction protocols to realize new compounds.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.

The study identifies PLUM, a uORF-encoded microprotein from Lin28b, as a key regulator that drives deterministic induction of naïve pluripotency through coordinated RNA regulation and metabolic remodeling.

Powdery mildew is a devasting disease for both common wheat and durum wheat. Here, the authors report the powdery mildew resistance locus derived from wild emmer wheat is conferred by the combined effect of two complementary nucleotide-binding and leucine-rich repeat genes.

Heterometallic nanomaterials in unusual crystal phases that are impossible to form in the bulk state can show interesting physical and chemical properties. Here, crystal-phase heterostructured 4H/fcc Au nanowires are used as seeds to epitaxially grow a variety of binary and ternary hybrid noble metal nanostructures on the phase boundary.

Non-oxidative alkene dehydrogenation is hindered by side reactions like cracking, iso- or polymerization, or alkyne formation. Here the authors report a Pd/TiO2 photocatalyst decorated with Ni single sites for selective ethane to ethylene production under simulated solar light conditions with high yields.

Twinning is a powerful approach to engineering the physicochemical properties of metallic nanomaterials. Here, the authors discover unusual non-close-packed twinning planes in 4H-phase gold nanokites and show that they can be used as templates to grow 4H-phase twinned nanostructures of other noble metals.

The origin of pseudocapacitance remains a topic of ongoing debate. In this Perspective, the authors offer a new understanding, proposing that metallic conduction, negligible energy barriers for ionic charge transport, and a unique interaction between the electrode and ionic charges are all indispensable contributors to the pseudocapacitive response.

The irreversible sintering of Cu catalyst for deactivation remains a persistent challenge under thermal or photothermal reverse water-gas shift reaction process. Now, a hydroxyl-engineered CuNi nanocatalyst, derived from CuNiMgAl-LDH, achieves high and stable CO evolution under solar light by preventing sintering through dynamic hydroxyl anchoring of the nanoparticles.

Using data from six population-scale cohorts involving more than 10 million individuals, a large language model-based aging signature is shown to outperform traditional aging biomarker indices and signatures in predicting multiple health outcomes, at general and organ-specific levels.

CRISPR base editors directly modify the non-target strand (NTS). Here, authors reveal an activity by miniature Cas12f cytosine base editor (CBE) to also edit the TS, and next engineer a TS-preferential CBE. The work establishes a strand-selectable miniature CBE toolkit with therapeutic potential.

Operando monitoring of thermal runaway in Li-ion batteries is critical. Here, authors develop an optical fiber sensor capable of insertion into 18650 batteries to monitor internal temperature and pressure during thermal runaway, facilitating battery safety assessment and early warning capability.

Quantized vortices are observed in a Bose–Einstein condensate.

Modulating the microenvironment of the Helmholtz plane, especially the anion transport, is crucial and challenging for CO₂ electrocatalytic systems. Here, the authors report a metal chelate to break diffusion limits and enrich the anions in the Helmholtz plane, promoting ethanol electrosynthesis.

Oncogenic KRAS mutations can dictate the formation of an immune-suppressive tumor microenvironment. Here the authors report that, in KRAS mutant colorectal cancer, the upregulation of circATXN7 in tumor-specific cytotoxic T lymphocytes is associated with increased sensitivity to activation-induced cell death and resistance to immunotherapy.”

Brown adipose tissue β3AR plays a functional role in regulating susceptibility to social stress, which is controlled by neural inputs from the paraventricular hypothalamus.

In free radical polymerization, poorly connected nanoclusters lead to heterogeneous polymer networks with diminished mechanical properties. Now, a photogenerated nitroxide that couples propagating radicals during polymerization is reported, converting these otherwise unfavourable nanoclusters into robustly interconnected phases, thereby enhancing the network structure and improving mechanical performance.

Selective protein degradation in disease-relevant cells or tissues has seen limited success. Hence, the authors develop Folate Receptor Targeting Chimeras (FRTACs) to specifically target proteins in cancer cells, aiming to reduce on-target, off-tumor toxicity.

Tumour-derived lactate activates adipose GPR81, which in turn leads to cachexia. Targeting GPR81 and its downstream signalling pathway holds therapeutic potential for treating cancer cachexia.

Ultrawideband beamforming is essential for next generation radar and communication. Here, authors demonstrate a photonic beamforming approach using frequency combs that enables beamforming and continuous beam-steering of LFM waveforms, supporting high-performance integrated sensing and communication.

Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promoting stress resilience in adolescent mice.

The aryl hydrocarbon receptor, AhR, can regulate Oct4, which is often expressed in cancer stem cells and promotes pluripotency and tumorigenesis. Here, in cancer stem cells, AhR is shown to be activated by the tryptophan derivative ITE, which causes transcriptional repression of Oct4 and reduced tumorigenesis.

By map-based cloning and knockout experiments, a study identified and validated ZmDMP to be one of the two genes known to control haploid induction in maize. A single-nucleotide mutation in ZmDMP causes a 2–3-fold increase in the haploid induction rate.

Intestinal microbiota alterations may affect heart function through the production of gut-derived metabolites. Here the authors found that gut microbiota-derived TMAVA is a key determinant for the development of cardiac hypertrophy through inhibition of carnitine synthesis and subsequent fatty acid oxidation.

Identification of a broadly therapeutic antibody h1A6.2 against enteroviruses, which mimics the entry receptor SCARB2 and triggers monocyte/macrophage-dependent Fc effector functions in mice.

Using a behaviorally obtained reference point to compute social value, Ma et al. show that social-value distance is encoded by the amygdala in prosocials. Oxytocin amplifies this amygdala representation and increases prosociality in individualists.

The rational design of chiroplasmonic nanomaterials with near-infrared (NIR) responses remains a challenge. Here, the authors propose a strategy utilizing chiral plasmonic-dielectric coupling to achieve strong chiroptical responses in the NIR region.

Here, the authors identify a copy number variation containing three enhancers (PIHEC) that drives bilateral constricted ear by co-ordinately regulating HMX1 expression, revealing how aberrant Hmx1 expression in neural crest-derived fibroblasts disrupts outer ear development.

Strategies for the synthesis of chiral metal nanoparticles were mainly limited to gold. Here, the authors present the enantioselective synthesis of chiroplasmonic helicoidal nanoparticles beyond gold using chiral silica shells.

Variants of SARS-CoV-2 present the potential for differential response and performance to delivered vaccine regimens. Here the authors characterise the neutralising antibody response to the inactivated SARS-CoV-2 vaccine BBIBP-CorV and assess functionality against a range of key SARS-CoV2 variants.