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This study presents a programmable mRNA nanomedicine that induces tumour-specific immunogenic cell death in immunologically cold and metastatic tumours with enhanced safety, advancing next-generation strategies for personalized cancer immunotherapy

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Model thiophene-decorated nickel porphyrins are synthesized to examine how sulfur promotes CO₂-to-CO conversion and tandem CO₂-to-C₂ product conversion in electrocatalytic CO₂ reduction. Combined theoretical and experimental analyses show that thiophene substituents generate a ligand hole character that modulates the nickel-centred electronic structure, enhancing overall catalytic performance.

Here, the authors develop an integrated mass spectrometry-based strategy that allows metabolic biomarker discovery based on nanoliter-scale biofluids in seconds. Biomarkers of diabetic cataracts are detected in trace ocular fluids with high diagnostic performance revealed to have and anti-cataract activity.

Array microscope with mirrored well plates enables automated, scalable 3D behavioral analysis of 48 zebrafish larvae in parallel, revealing complex kinematics and phenotypes missed by conventional 2D methods.

Pseudocapacitors are emerging as alternatives to conventional supercapacitors. Here, authors showed an uncommon charge storage mechanism in a high-rate conjugated polyelectrolyte and demonstrated practical pouch and solid-state pseudocapacitor devices with competitive energy up to 71 μWh cm⁻² and power performance up to 160 mW cm⁻².

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Topological states are exploited based on crystalline symmetry, but under artificial gauge fields, symmetries may satisfy projective algebras, which remains less studied. Here, the authors reveal that projective symmetry algebra leads to momentum-space nonsymmorphic symmetry, resulting in new topological states over a momentum-space Klein bottle.

Xue et al. report self-powered photoelectrochemical photodetectors based on CuOx decorated AlGaN nanowires with staggered energy band structure. High-energy photons can be absorbed by CuOx to trigger the multiexciton generation effect, enabling an external quantum efficiency of 131.5% at 255 nm.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The understanding of the reemergence of pressure induced superconductivity in alkali-metal intercalated FeSe is hampered by sample complexities. Here, Sun et al. report the electronic properties of (Li_1–xFe _x )OHFe_1–ySe single crystal not only in the reemerged superconducting state but also in the normal state.

This work proposes a wet-chemical etching assisted aberration-enhanced single-pulsed femtosecond laser nanolithography, named “WEALTH”, for manufacturing small-size, large-area, deep holey nanostructures, promising for emerging nanophotonic devices.

Through the sonochemical exfoliation of grown black phosphorus crystals, high-quality, narrow and clean black phosphorus nanoribbons with smooth edges and defined edge chirality are achieved, enabling the realization of high-performance transistors and photodetectors.

PMEL fibril structure is a long-standing question. Here, the authors resolve the atomic structure and in situ organization of native PMEL lamellae, revealing the assembly mechanism of these functional amyloid fibrils in melanosomes.

Parity-time symmetry breaking and related non-Hermitian phenomena, such as high-order exceptional points, have attracted significant interest across various experimental platforms. Here the authors demonstrate a third-order exceptional point induced by parity-time symmetry breaking in a dissipative trapped ion.

The understanding of charge density wave (CDW) correlations in cuprate superconductors remains hampered due to the lack of scattering phase information. Here, Chen et al. discover a reproducible CDW domain memory effect upon repeated cycling to temperatures well above the CDW ordering temperature.

A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.

The electronic structure of superconducting magnesium diboride is predicted theoretically to have a distribution of energy gap values. Chenet al. observe this distribution of values experimentally, by means of high-resolution electron tunnelling spectroscopy.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Vasomotor function is regulated by the autonomic nervous system, but its electrophysiological basis remains poorly captured, especially post-stenting. Here, the authors develop a bioadhesive bioelectronic interface for precise monitoring and modulation of vasomotor activity.

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Ytterbium oxide buffer layer for use in perovskite solar cells yields a certified power conversion efficiency of more than 25%, which enhances stability across a wide variety of perovskite compositions.

Discontinuity in haptic displays, caused by the loss of haptic information between pixels, compromises the user experience in thin wearable devices. Here, the authors employ beams to interpolate haptic information across pixel gaps, enhancing display continuity, especially for moving objects.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic processes in living cells.

The instability of quantum dot inks hinders the scaling up of colloidal quantum dot electronics. Now, Shi and team stabilize the inks with an iodine-rich environment in a weakly coordinating solvent, achieving 13.4% in small-area solar cells and over 10% in modules.

Combining atomic-scale imaging and density-functional-theory defect phase diagrams, this study shows that boron at steel grain boundaries rearranges iron atoms, triggers defect phase transformations, and greatly increases resistance to embrittlement.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Cooperative paramagnetism refers to a strongly correlated state without long range magnetic order that occurs in frustrated magnetic systems between the Neel temperature and Curie-Weiss temperature. Here, using resonant elastic magnetic and inelastic x-ray scattering, Terilli et al find a spectrally sharp gapped magnetic excitations that persists above the Neel temperature in Y₂Ir₂O₇, implying a cooperative paramagnetic phase.

The authors identify feeblin, an inhibitory compound of the proinflammatory TLR7/8/9-IRF5 pathway with therapeutic potential, which acts by binding SLC15A4 via an allosteric mechanism mediating degradation of its signaling partner TASL.

A pangenome of oat, assembled from 33 wild and domesticated oat lines, sheds light on the evolution and genetic diversity of this cereal crop and will aid genomics-assisted breeding to improve productivity and sustainability.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

Solution-grown perovskite heterojunctions and quantum wells bring new opportunities for exploring semiconductor physics in a convenient manner

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Here, the authors show that van der Waals isotopic heterostructures based on few-layer h¹⁰BN and h¹¹BN can be tuned to modulate the energy-momentum dispersions of hyperbolic phonon polaritons, offering an alternative approach to engineer the nanophotonic properties of 2D materials.

Electrophilic halogenation approaches often suffer from low reactivity and chemoselectivity when it comes to complex compounds. Now a class of halogenating reagents based on anomeric amides that can halogenate complex bioactive molecules with diverse functional groups and heterocycles has been developed. The higher reactivity of these anomeric amide reagents is attributed to the energy stored in the pyramidalized nitrogen.

The brightness of lanthanide-doped upconversion nanoparticles is limited by concentration quenching. Here the authors separate activator and sensitizer lanthanides in a core-shell-shell system, which optimizes energy transfer and concentration quenching.

Immune interactions are complex, dynamic and difficult to capture using static imaging modalities on in vitro or ex vivo tissue cultures. In this Review, the authors discuss techniques for in vivo imaging of the immune system including one-photon near-infrared II fluorescence and two-photon and multiphoton microscopy for longitudinal tracking of immune cells, as well as a translational path that integrates near-infrared II, positron-emission tomography or MRI and artificial intelligence-enabled analysis towards quantitative, clinically compatible, multimodal immuno-imaging.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

Intercalating alkali metals into picene—a hydrocarbon with five linearly fused benzene rings—results in superconducting materials. Now, alkali-metal-doped phenanthrene, which consists of three fused benzene rings, is also found to be superconducting, opening up a broader class of organic superconductors.